Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristics

Oral Oncology

Volumn 45, Issue 12, 2009, Pages

  Tao, Qian ^a   Lv, Biao ^a   Qiao, Bin ^b   Zheng, Chao qun ^a   Chen, Zhi feng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

Ameloblastoma; hTERT; Immortalization; Telomerase; Transfection

Indexed keywords

PROTEIN P16; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

AMELOBLASTOMA; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; CELL IMMORTALIZATION; CELL TRANSFORMATION; ENZYME REACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMELOBLASTOMA; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, VIRAL; ENZYME ACTIVATION; EPIGENESIS, GENETIC; HUMAN PAPILLOMAVIRUS 16; HUMANS; JAW NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE; TRANSFECTION;

EID: 70449697905     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2009.08.007     Document Type: Article

References (34)

1. Bodnar A.G., Ouellette M., Frolkis M., Frolkis S.F., Holt S.E., Chiu C.P., et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279 5349 (1998) 349-352
2. Wei W., and Sedivy J.M. Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Exp Cell Res 253 2 (1999) 519-522
3. Lendvay T.S., Morris D.K., Sah J., Balasubramanian B., and Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144 4 (1996) 1399-1412
4. Feng J., Funk W.D., Wang S.S., Weinrich S.L., Avilion A.A., Chiu C.P., et al. The RNA component of human telomerase. Science 269 5228 (1995) 1236-1241
5. Aisner D.L., Wright W.E., and Shay J.W. Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev 12 1 (2002) 80-85
6. Forsyth N.R., Wright W.E., and Shay J.W. Telomerase and differentiation in multicellular organisms: turn it off, turn it on and turn it off again. Differentiation 69 4-5 (2002) 188-197
7. Shay J.W., and Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26 5 (2005) 867-874
8. Lee K.M., Choi K.H., and Ouellette M.M. Use of exogenous hTERT to immortalize primary human cells. Cytotechnology 45 1-2 (2004) 33-38
9. Schneider-Stock R., Jaeger V., Rys J., Epplen J.T., and Roessner A. High telomerase activity and high HTRT mRNA expression differentiate pure myxoid and myxoid/round-cell liposarcomas. Int J Cancer 89 1 (2000) 63-68
10. Song Z., Wang Y., Xie L., Zang X., and Yin H. Expression of senescence-related genes in human corneal endothelial cells. Mol Vis 14 (2008) 161-170
11. Robertson D.M., Li L., Fisher S., Pearce V.P., Shay J.W., Wright W.E., et al. Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci 46 2 (2005) 470-478
12. Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z., Tsao H., et al. A two-stage, p16INK4A- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol 22 14 (2002) 5157-5172
13. Kamata N., Fujimoto R., Tomonari M., Taki M., Nagayama M., and Yasumoto S. Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase. J Oral Pathol Med 33 7 (2004) 417-423
14. Ramirez R.D., Morales C.P., Herbert B.S., Rohde J.M., Passons C., Shay J.W., et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 15 4 (2001) 398-403
15. Lee K.M., Nguyen C., Ulrich A.B., Pour P.M., and Ouellette M.M. Immortalization with telomerase of the nestinpositive cells of the human pancreas. Biochem Biophys Res Commun 301 4 (2003) 1038-1044
16. Carney S.A., Tahara H., Swartz C.D., Risinger J.I., He H., Moore A.B., et al. Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics. Lab Invest 82 6 (2002) 719-728
17. Kitagawa M., Ogawa I., Shima K., Hashimoto S., Kudo Y., Miyauchi M., et al. Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene. Int J Oncol 31 2 (2007) 339-344
18. Harada H., Mitsuyasu T., Nakamura N., Higuchi Y., Toyoshima K., Taniguchi A., et al. Establishment of ameloblastoma cell line, AM-1. J Oral Pathol Med 27 5 (1998) 207-212
19. Sdek P., Zhang Z.Y., Cao J., Pan H.Y., Chen W.T., and Zheng J.W. Alteration of cell-cycle regulatory proteins in human oral epithelial cells immortalized by HPV16 E6 and E7. Int J Oral Maxillofac Surg 35 7 (2006) 653-657
20. Kumamoto H., Kinouchi Y., and Ooya K. Telomerase activity and telomerase reverse transcriptase (TERT) expression in ameloblastomas. J Oral Pathol Med 30 4 (2001) 231-236
21. Liu J.P. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 13 15 (1999) 2091-2104
22. García-Cao M., Gonzalo S., Dean D., and Blasco M.A. A role for the Rb family of proteins in controlling telomere length. Nat Genet 32 3 (2002) 415-419
23. Horikawa I., Michishita E., and Barrett J.C. Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis. Cytotechnology 45 1-2 (2004) 23-32
24. Kumamoto H., Kimi K., and Ooya K. Detection of cell cycle-related factors in ameloblastomas. J Oral Pathol Med 30 5 (2001) 309-315
25. Artese L., Piattelli A., Rubini C., Goteri G., Perrotti V., Iezzi G., et al. P16 expression in odontogenic tumors. Tumori 94 5 (2008) 718-723
26. ARF proteins in ameloblastoma. J Oral Pathol Med 33 5 (2004) 292-299
27. Abiko Y., Nagayasu H., Takeshima M., Yamazaki M., Nishimura M., Kusano K., et al. Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 1 (2007) 72-76
28. Li N.F., Broad S., Lu Y.J., Yang J.S., Watson R., Hagemann T., et al. Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression. Cell Prolif 40 5 (2007) 780-794
29. Herbert B.S., Wright W.E., and Shay J.W. P16INK4a inactivation is not required to immortalize human mammary epithelial cells. Oncogene 21 51 (2002) 7897-7900
30. Terai M., Uyama T., Sugiki T., Li X.K., Umezawa A., and Kiyono T. Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol Biol Cell 16 3 (2005) 1491-1499
31. Kiyono T., Foster S.A., Koop J.I., McDougall J.K., Galloway D.A., and Klingelhutz A.J. Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396 6706 (1998) 84-88
32. Farwell D.G., Shera K.A., Koop J.I., Bonnet G.A., Matthews C.P., Reuther G.W., et al. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol 156 5 (2000) 1537-1547
33. Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 20 4 (2000) 1436-1447
34. Veitonmäki N., Fuxe J., Hultdin M., Roos G., Pettersson R.F., and Cao Y. Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb. FASEB J 17 6 (2003) 764-766