Dipeptide hydrolysis by the dinuclear zinc enzyme human renal dipeptidase: Mechanistic insights from DFT calculations

Journal of Inorganic Biochemistry

Volumn 104, Issue 1, 2010, Pages 37-46

  Liao, Rong Zhen ^a,b   Himo, Fahmi ^b   Yu, Jian Guo ^a   Liu, Ruo Zhuang ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Density functional theory; Dinuclear zinc enzymes; Dipeptidase; Reaction mechanism

Indexed keywords

ASPARTIC ACID; BETA LACTAM ANTIBIOTIC; CARBON; CARBONYL DERIVATIVE; CARBOXYLIC ACID; DIPEPTIDASE; DIPEPTIDE; ENZYME; HYDROXIDE; NITROGEN; PEPTIDE; ZINC; ZINC ION;

ARTICLE; CALCULATION; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; ENERGY; HYDROLYSIS; PROTON TRANSPORT;

ASPARTIC ACID; CATALYTIC DOMAIN; CILASTATIN; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDASES; DIPEPTIDES; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ZINC;

EID: 70449687844     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.09.025     Document Type: Article

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