Proton transfer dynamics of GART: The ph-dependent catalytic mechanism examined by electrostatic calculations

Protein Science

Volumn 10, Issue 11, 2001, Pages 2379-2392

  Morikis, Dimitrios ^a   Elcock, Adrian H ^b   Jennings, Patricia A ^c   Mccammon, J Andrew ^c,d  

^a University of California   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Catalysis; Electrostatic calculations; GART; Glycinamide ribonucleotide transformylase; pKa; Poisson Boltzmann

Indexed keywords

ASPARTIC ACID; HISTIDINE; IMIDAZOLE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE;

ARTICLE; CALCULATION; CATALYSIS; CRYSTALLOGRAPHY; DYNAMICS; ELECTRICITY; ENZYME BINDING; ENZYME STRUCTURE; GEOMETRY; MOLECULAR INTERACTION; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY; ELECTROSTATICS; GLYCINE; HISTIDINE; HYDROGEN-ION CONCENTRATION; HYDROXYMETHYL AND FORMYL TRANSFERASES; MATHEMATICS; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PROTON PUMPS; PROTONS; RIBONUCLEOTIDES; TITRIMETRY;

EID: 0034779681     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.17301     Document Type: Article

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