The prediction of human acute systemic toxicity by the EDIT/MEIC in vitro test battery: The importance of protein binding and of partitioning into lipids

Alternatives to Laboratory Animals

Volumn 31, Issue 3, 2003, Pages 245-256

  Clemedson, Cecilia ^a   Dierickx, Paul J ^b   Sjöström, Michael ^c  

^a Expertradet AB   (Sweden)

^b Afdeling Toxikologie   (Belgium)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Acute toxicity; Blood brain barrier; Human toxicity; Kinetics; MEIC chemicals; Octanol water partition coefficient; Partial least squares analysis; Protein binding; Toxicity testing

Indexed keywords

ACETYLSALICYLIC ACID; AMITRIPTYLINE; AMPHETAMINE; BARIUM; CHLORAMPHENICOL; CHLOROQUINE; DIAZEPAM; DIGOXIN; FERROUS SULFATE; HEXACHLOROPHENE; ISONIAZID; LINDANE; LIPID; LITHIUM SULFATE; MALATHION; MERCURIC CHLORIDE; NICOTINE; PARACETAMOL; PHENOBARBITAL; PHENYTOIN; POTASSIUM CYANIDE; PROPRANOLOL; PROTEIN; QUINIDINE; THALLIUM SULFATE; THEOPHYLLINE DERIVATIVE; THIORIDAZINE; UNINDEXED DRUG; VERAPAMIL; WARFARIN;

ACUTE TOXICITY; ANIMAL CELL; BLOOD BRAIN BARRIER; CALCULATION; CONFERENCE PAPER; CORRELATION ANALYSIS; CULTURE MEDIUM; CYTOTOXICITY; FETAL CALF SERUM; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; LIPID ANALYSIS; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TOXICITY TESTING; TOXICOKINETICS;

ANIMALIA;

EID: 0042697181     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290303100306     Document Type: Conference Paper

References (22)

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