Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERα

Breast Cancer Research and Treatment

Volumn 118, Issue 3, 2009, Pages 605-621

  Lam, Le ^a   Hu, Xiuying ^a   Aktary, Zackie ^a   Andrews, David W ^b   Pasdar, Manijeh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Bcl 2; Cadherin; ERK; Estrogen receptor; ICI; IGF 1R; PI3K AKT; Tamoxifen

Indexed keywords

ANTIESTROGEN; FULVESTRANT; TAMOXIFEN;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER GROWTH; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DRUG INHIBITION; EPITHELIUM CELL; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CONNEXINS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, IGF TYPE 1; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SIGNAL TRANSDUCTION; TAMOXIFEN;

EID: 70449556724     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0231-y     Document Type: Article

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