The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules

Reproductive Biology and Endocrinology

Volumn 1, Issue , 2003, Pages

  Oliveira, Cleida A ^a,b   Nie, Rong ^a   Carnes, Kay ^a   Franca, Luiz R ^b   Prins, Gail S ^c   Saunders, Philippa T K ^d   Hess, Rex A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c UNIVERSITY OF ILLINOIS   (United States)

^d MRC Reproductive Biology Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; DRUG DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANIMAL CELL; ANIMAL TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; MALE; MALE GENITAL SYSTEM; MOLECULAR MECHANICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; REVIEW; TESTIS; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMICAL PHENOMENA; CYTOLOGY; DRUG EFFECT; EPIDIDYMIS; GENE EXPRESSION REGULATION; GENETICS; LEYDIG CELL; METABOLISM; SERTOLI CELL; SPERMATOZOON; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; DEPRESSION, CHEMICAL; EPIDIDYMIS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR MODULATORS; GENE EXPRESSION REGULATION; LEYDIG CELLS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; SERTOLI CELLS; SPERMATOZOA; TESTIS;

EID: 4344711332     PISSN: 14777827     EISSN: None     Source Type: Journal    
DOI: 10.1186/1477-7827-1-75     Document Type: Review

References (75)

1. Hess RA, Gist DH, Bunick D, Lubahn DB, Farrell A, Bahr J, Cooke PS, Greene GL: Estrogen receptor (a & b) expression in the excurrent ducts of the adult male rat reproductive tract. J Androl 1997, 18:602-611.
2. Nie R, Zhou Q, Jassim E, Saunders PT, Hess RA: Differential expression of estrogen receptors a and b in the reproductive tracts of adult male dogs and cats. Biol Reprod 2002, 66:1161-1168.
3. Atanassova N, McKinnell C, Williams K, Turner KJ, Fisher JS, Saunders PT, Millar MR, Sharpe RM: Age-, cell- and region-specific immunoexpression of estrogen receptor alpha (but not estrogen receptor beta) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol. Endocrinology 2001, 142:874-886.
4. Williams K, Saunders PTK, Atanassova N, Fisher JS, Turner KJ, Millar MR, McKinnell C, Sharpe RM: Induction of progesterone receptor immunoexpression in stromal tissue throughout the male reproductive tract after neonatal oestrogen treatment of rats. Mol Cell Endocrinol 2000, 164:117-131.
5. Saunders PT, Sharpe RM, Williams K, Macpherson S, Urquart H, Irvine DS, Millar MR: Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates. Mol Hum Reprod 2001, 7:227-236.
6. Zhou Q, Nie R, Prins GS, Saunders PT, Katzenellenbogen BS, Hess RA: Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J Androl 2002, 23:870-881.
7. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O: Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 1993, 90:11162-11166.
8. Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB, Korach KS: Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinol 1996, 137:4796-4805.
9. Hess RA, Bunick D, Lee KH, Bahr J, Taylor JA, Korach KS, Lubahn DB: A role for oestrogens in the male reproductive system. Nature 1997, 390:509-512.
10. Couse JF, Korach KS: Exploring the role of sex steroids through studies of receptor deficient mice [see comments]. J Mol Med 1998, 76:497-511.
11. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M: Effect of single and compound knockouts of estrogen receptors a (ER a) and b (ER b) on mouse reproductive phenotypes. Development 2000, 127:4277-4291.
12. Zhou Q, Clarke L, Nie R, Carnes K, Lai LW, Lien YH, Verkman A, Lubahn D, Fisher JS, Katzenellenbogen BS, Hess RA: Estrogen action and male fertility: Roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A 2001, 98:14132-14137.
13. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O: Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA 1998, 95:15677-15682.
14. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA: Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:5925-5930.
15. Mosselman S, Polman J, Dijkema R: ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996, 392:49-53.
16. Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguere V: Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 1997, 11:353-365.
17. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinol 1997, 138:863-870.
18. Harris HA, Bapat AR, Gonder DS, Frail DE: The ligand binding profiles of estrogen receptors a and b are species dependent. Steroids 2002, 67:379-384.
19. Paech K, Webb P, Kuiper Ggjm, Nilsson S, Gustafsson J, angst, Kushner PJ, Scanlan TS: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997, 277:1508-1510.
20. Pennie WD, Aldridge TC, Brooks AN: Differential activation by xenoestrogens of ERa and ERb when linked to different response elements. J Endocrinol 1998, 158:R11-R14.
21. Loven MA, Wood JR, Nardulli AM: Interaction of estrogen receptors alpha and beta with estrogen response elements. Mol Cell Endocrinol 2001, 181:151-163.
22. Schultz JR, Loven MA, Melvin VM, Edwards DP, Nardulli AM: Differential modulation of DNA conformation by estrogen receptors alpha and beta. J Biol Chem 2002, 277:8702-8707.
23. Lee KH, Hess RA, Bahr JM, Lubahn DB, Taylor J, Bunick D: Estrogen receptor alpha has a functional role in the mouse rete testis and efferent ductules. Biol Reprod 2000, 63:1873-1880.
24. Lee KH, Finnigan-Bunick C, Bahr J, Bunick D: Estrogen Regulation of Ion Transporter Messenger RNA Levels in Mouse Efferent Ductules Are Mediated Differentially Through Estrogen Receptor (ER) alpha and ERbeta. Biol Reprod 2001, 65:1534-1541.
25. Oliveira CA, Carnes K, Franca LR, Hess RA: Infertility and testicular atrophy in the antiestrogen-treated adult male rat. Biol Reprod 2001, 65:913-920.
26. Oliveira CA, Zhou Q, Carnes K, Nie R, Kuehl DE, Jackson GL, Franca LR, Nakai M, Hess RA: ER Function in the Adult Male Rat: Short- and Long-Term Effects of the Antiestrogen ICI 182,780 on the Testis and Efferent Ductules, without Changes in Testosterone. Endocrinology 2002, 143:2399-2409.
27. Wakeling AE: Similarities and distinctions in the mode of action of different classes of antioestrogens. Endocr Relat Cancer 2000, 7:17-28.
28. Paige LA, Christensen DJ, Gron H, Norris JD, Gottlin EB, Padilla KM, Chang CY, Ballas LM, Hamilton PT, McDonnell DP, Fowlkes DM: Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci U S A 1999, 96:3999-4004.
29. Hess RA, Bunick D, Bahr J: Oestrogen, its receptors and function in the male reproductive tract - a review. Mol Cell Endocrinol 2001, 178:29-38.
30. Hess RA: Estrogen in the adult male reproductive tract: A review. Reprod Biol Endocrinol 2003, 1:52-65.
31. Sar M, Welsch F: Oestrogen receptor alpha and beta in rat prostate and epididymis. Andrologia 2000, 32:295-301.
32. Turner KJ, Morley M, MacPherson S, Millar MR, Wilson JA, Sharpe RM, Saunders PT: Modulation of gene expression by androgen and oestrogens in the testis and prostate of the adult rat following androgen withdrawal. Mol Cell Endocrinol 2001, 178:73-87.
33. Newbold RR, Bullock BC, McLachlan JA: Mullerian remnants of male mice exposed prenatally to diethylstilbestrol. Teratog Carcinog Mutagen 1987, 7:377-389.
34. Tena-Sempere M, Navarro J, Pinilla L, Gonzalez LC, Huhtaniemi I, Aguilar E: Neonatal exposure to estrogen differentially alters estrogen receptor alpha and beta mRNA expression in rat testis during postnatal development. J Endocrinol 2000, 165:345-357.
35. Prins GS, Birch L, Greene GL: Androgen receptor localization in different cell types of the adult rat prostate. Endocrinol 1991, 129:3187-3199.
36. NRC: Guide for the care and use of laboratory animals. National Research Council Washington, D.C., National Academy Press 1996, 125.
37. Fisher JS, Millar MR, Majdic G, Saunders PT, Fraser HM, Sharpe RM: Immunolocalisation of oestrogen receptor-alpha within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. J Endocrinol 1997, 153:485-495.
38. Prins GS: Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression. Endocrinology 1992, 130:3703-3714.
39. Prins GS, Birch L: The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen. Endocrinology 1995, 136:1303-1314.
40. Cooke PS, Young P, Hess RA, Cunha GR: Estrogen receptor expression in developing epididymis, efferent ductules, and other male reproductive organs. Endocrinology 1991, 128:2874-2879.
41. Roselli CE, West NB, Brenner RM: Androgen receptor and 5 alpha-reductase activity in the ductuli efferentes and epididymis of adult rhesus macaques. Biol Reprod 1991, 44:739-745.
42. Zhu LJ, Hardy MP, Inigo IV, Huhtaniemi I, Bardin CW, Moo-Young AJ: Effects of androgen on androgen receptor expression in rat testicular and epididymal cells: a quantitative immunohistochemical study. Biol Reprod 2000, 63:368-376.
43. Saunders PT, Fisher JS, Sharpe RM, Millar MR: Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis. J Endocrinol 1998, 156:R13-7.
44. van Pelt AM, de Rooij DG, van der Burg B, van der Saag PT, Gustafsson JA, Kuiper GG: Ontogeny of estrogen receptor-beta expression in rat testis. Endocrinology 1999, 140:478-483.
45. Taylor AH, Al-Azzawi F: Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol 2000, 24:145-155.
46. Sar M, Lubahn DB, French FS, Wilson EM: Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinol 1990, 127:3180-3186.
47. Pelletier G: Localization of androgen and estrogen receptors in rat and primate tissues. Histol Histopathol 2000, 15:1261-1270.
48. Suarez-Quian CA, Martinez-Garcia F, Nistal M, Regadera J: Androgen receptor distribution in adult human testis. J Clin Endocrinol Metab 1999, 84:350-358.
49. Hansen LA, Clulow J, Jones RC: The role of Na+-H+ exchange in fluid and solute transport in the rat efferent ducts. Exp Physiol 1999, 84:521-527.
50. Sierralta WD, Bonig I, Thole HH: Immunogold labeling of estradiol receptor in MCF7 cells. Cell Tissue Res 1995, 279:445-452.
51. Qualmann B, Kessels MM, Thole HH, Sierralta WD: A hormone pulse induces transient changes in the subcellular distribution and leads to a lysosomal accumulation of the estradiol receptor alpha in target tissues. Eur J Cell Biol 2000, 79:383-393.
52. Sierralta WD, Thole HH: Retrieval of estradiol receptor in paraffin sections of resting porcine uteri by microwave treatment. Immunostaining patterns obtained with different primary antibodies. Histochem Cell Biol 1996, 105:357-363.
53. Goyal HO, Bartol FF, Wiley AA, Khalil MK, Chiu J, Vig MM: Immunolocalization of androgen receptor and estrogen receptor in the developing testis and excurrent ducts of goats. Anat Rec 1997, 249:54-62.
54. Clulow J, Jones RC, Hansen LA, Man SY: Fluid and electrolyte reabsorption in the ductuli efferentes testis. J Reprod Fertil Suppl 1998, 53:1-14.
55. Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP: Comparative analyses of mechanistic differences among antiestrogens. Endocrinology 1999, 140:5828-5840.
56. Bentrem D, Dardes R, Liu H, MacGregor-Schafer J, Zapf J, Jordan V: Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology 2001, 142:838-846.
57. Stenoien DL, Patel K, Mancini MG, Dutertre M, Smith CL, O'Malley BW, Mancini MA: FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent. Nat Cell Biol 2001, 3:15-23.
58. Wijayaratne AL, McDonnell DP: The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem 2001, 276:35684-35692.
59. Gibson MK, Nemmers LA, Beckman W. C., Jr., Davis VL, Curtis SW, Korach KS: The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology 1991, 129:2000-2010.
60. Dauvois S, Danielian PS, White R, Parker MG: Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover. Proc Natl Acad Sci U S A 1992, 89:4037-4041.
61. Borras M, Laios I, el Khissiin A, Seo HS, Lempereur F, Legros N, Leclercq G: Estrogenic and antiestrogenic regulation of the half-life of covalently labeled estrogen receptor in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 1996, 57:203-213.
62. Alarid ET, Bakopoulos N, Solodin N: Proteasome-mediated proteolysis of estrogen receptor: a novel component in autologous down-regulation. Mol Endocrinol 1999, 13:1522-1534.
63. Lonard DM, Nawaz Z, Smith CL, O'Malley BW: The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell 2000, 5:939-948.
64. Preisler-Mashek MT, Solodin N, Stark BL, Tyriver MK, Alarid ET: Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-alpha. Am J Physiol Endocrinol Metab 2002, 282:E891-8.
65. Dauvois S, White R, Parker MG: The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 1993, 106:1377-1388.
66. Htun H, Holth LT, Walker D, Davie JR, Hager GL: Direct visualization of the human estrogen receptor alpha reveals a role for ligand in the nuclear distribution of the receptor. Mol Biol Cell 1999, 10:471-486.
67. Fournier B, Gutzwiller S, Dittmar T, Matthias G, Steenbergh P, Matthias P: Estrogen receptor (ER)-alpha, but not ER-beta, mediates regulation of the insulin-like growth factor I gene by antiestrogens. J Biol Chem 2001, 276:35444-35449.
68. Pace P, Taylor J, Suntharalingam S, Coombes RC, Ali S: Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha. J Biol Chem 1997, 272:25832-25838.
69. Van Den Bemd GJ, Kuiper GG, Pols HA, Van Leeuwen JP: Distinct Effects on the Conformation of Estrogen Receptor alpha and beta by Both the Antiestrogens ICI 164,384 and ICI 182,780 Leading to Opposite Effects on Receptor Stability. Biochem Biophys Res Commun 1999, 261:1-5.
70. Pike AC, Brzozowski AM, Walton J, Hubbard RE, Thorsell A, Li Y, Gustafsson J, Carlquist M: Structural Insights into the Mode of Action of a Pure Antiestrogen. Structure (Camb) 2001, 9:145-153.
71. Wade JB, Welling PA, Donowitz M, Shenolikar S, Weinman EJ: Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. Am J Physiol Cell Physiol 2001, 280:C192-8.
72. Prins GS, Birch L, Couse JF, Choi I, Katzenellenbogen B, Korach KS: Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice. Cancer Res 2001, 61:6089-6097.
73. Hall JM, McDonnell DP: The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 1999, 140:5566-5578.
74. Weihua Z, Saji S, Makinen S, Cheng G, Jensen EV, Warner M, Gustafsson JA: Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus. Proc Natl Acad Sci U S A 2000, 97:5936-5941.
75. Gorodeski GI, Pal D: Involvement of estrogen receptors alpha and beta in the regulation of cervical permeability. Am J Physiol Cell Physiol 2000, 278:C689-96.