Responses of estrogen sensitive tissues in female Wistar rats to pre- and postnatal isoflavone exposure

Toxicology Letters

Volumn 191, Issue 2-3, 2009, Pages 181-188

  Hertrampf, T ^a   Ledwig, C ^a   Kulling, S ^b   Molzberger, A ^a   Moller F J ^c   Zierau, O ^c   Vollmer, G ^c   Moors, S ^d   Degen, G H ^d   Diel, P ^a  

^a Institut fur Kreislaufforschung und Sportmedizin   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Bone mineral density; Genistein; Isoflavones; Lifelong exposure; Nutrition; Osteoporosis

Indexed keywords

CALCIUM BINDING PROTEIN; DAIDZEIN; EQUOL; ESTROGEN; GENISTEIN; ISOFLAVONE; UNCLASSIFIED DRUG; VITAMIN D DEPENDENT CALCIUM BINDING PROTEIN 9K;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BONE DENSITY; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HEALTH HAZARD; HORMONE SENSITIVITY; LIVER PARENCHYMA; MALE; MATING; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUBERTY; RAT; TIBIA; TISSUE SPECIFICITY; TRABECULAR BONE; UTERUS WEIGHT; VAGINA EPITHELIUM; WEANING; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; BONE DENSITY; BONE DEVELOPMENT; DIET; EPITHELIUM; ESTROGENS; FEMALE; FETUS; GENISTEIN; ISOFLAVONES; LIVER; MALE; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; UTERUS; VAGINA;

ANIMALIA; RATTUS NORVEGICUS;

EID: 70449533090     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.08.019     Document Type: Article

References (43)

1. Adlercreutz H., and Mazur W. Phyto-oestrogens and Western diseases. Ann. Med. 29 2 (1997) 95-120
2. Atkinson C., Frankenfeld C.L., and Lampe J.W. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp. Biol. Med. (Maywood) 230 3 (2005) 155-170
3. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., and Fukami Y. Genistein, a specific inhibitor of tyrosine-protein kinases. J. Biol. Chem. 262 12 (1987) 5592-5595
4. Balmain N. Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues. Clin. Orthop. Relat. Res. 265 (1991) 265-276
5. Barkhem T., Carlsson B., Nilsson Y., Enmark E., Gustafsson J., and Nilsson S. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol. Pharmacol. 54 1 (1998) 105-112
6. Bouker K.B., and Hilakivi-Clarke L. Genistein: does it prevent or promote breast cancer?. Environ. Health Perspect. 108 (2000) 701-708
7. Branca F. Dietary phyto-oestrogens and bone health. Proc. Nutr. Soc. 62 4 (2003) 877-887
8. Bruns M.E., Overpeck J.G., Smith G.C., Hirsch G.N., Mills S.E., and Bruns D.E. Vitamin D-dependent calcium binding protein in rat uterus: differential effects of estrogen, tamoxifen, progesterone, and pregnancy on accumulation and cellular localization. Endocrinology 122 6 (1988) 2371-2378
9. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 1 (1987) 156-159
10. Cos P., De Bruyne T., Apers S., Vanden Berghe D., Pieters L., and Vlietinck A.J. Phytoestrogens: recent developments. Planta. Med. 69 (2003) 589-599
11. Degen G.H., Janning P., Diel P., Michna H., and Bolt H.M. Transplacental transfer of the phytoestrogen daidzein in DA/Han rats. Arch. Toxicol. 76 1 (2002) 23-29
12. Degen G.H., Janning P., Diel P., and Bolt H.M. Estrogenic isoflavones in rodent diets. Toxicol. Lett. 128 1-3 (2002) 145-157
13. Diel P., Walter A., Fritzemeier K.H., Hegele-Hartung C., and Knauthe R. Identification of estrogen regulated genes in Fe33 rat hepatoma cells by differential display polymerase chain reaction and their hormonal regulation in rat liver and uterus. J. Steroid Biochem. Mol. Biol. 55 3-4 (1995) 363-373
14. Diel P., Smolnikar K., Schulz T., Laudenbach-Leschowski U., Michna H., and Vollmer G. Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium. Hum. Reprod. 16 May (5) (2001) 997-1006
15. Diel P., Schmidt S., Vollmer G., Janning P., Upmeier A., Michna H., Bolt H.M., and Degen G.H. Comparative responses of three rat strains (DA/Han, Sprague-Dawley and Wistar) to treatment with environmental estrogens. Arch. Toxicol. 78 April (4) (2004) 183-193
16. Eisenbrand G. Isoflavones as phytoestrogens in food supplements and dietary foods for special medical purposes. Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG)-(shortened version). Mol. Nutr. Food Res. 51 10 (2007)
17. Fritz W.A., Coward L., Wang J., and Lamartiniere C.A. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19 12 (1998) 2151-2158
18. Geis R.B., Diel P., Degen G.H., and Vollmer G. Effects of genistein on the expression of hepatic genes in two rat strains (Sprague-Dawley and Wistar). Toxicol. Lett. 157 1 (2005) 21-29
19. Helferich W.G., Andrade J.E., and Hoagland MS. Phytoestrogens and breast cancer: a complex story. Inflammopharmacology 16 5 (2008) 219-226
20. Hertrampf T., Degen G.H., Kaid A.A., Laudenbach-Leschowsky U., Seibel J., Di Virgilio A.L., and Diel P. Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats. Planta. Med. 72 6 (2006) 484-487
21. Hotchkiss C.E., Weis C., Blaydes B., Newbold R., and Delclos K.B. Multigenerational exposure to genistein does not increase bone mineral density in rats. Bone 37 5 (2005) 720-727
22. Janning P., Schuhmacher U.S., Upmeier A., Diel P., Michna H., Degen G.H., and Bolt H.M. Toxicokinetics of the phytoestrogen daidzein in female DA/Han rats. Arch. Toxicol. 74 8 (2000) 421-430
23. Krebs E.E., Ensrud K.E., MacDonald R., and Wilt T.J. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet. Gynecol. 104 4 (2004) 824-836
24. Krisinger J., Setoyama T., and Leung P.C. Expression of calbindin-D9k in the early pregnant rat uterus: effects of RU 486 and correlation to estrogen receptor mRNA. Mol. Cell Endocrinol. 102 1-2 (1994) 15-22
25. Levy J.R., Faber K.A., Ayyash L., and Hughes C.L. The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats. Proc. Soc. Exp. Biol. Med. 208 1 (1995) 60-66
26. Limer J.L., and Speirs V. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Res. 3 (2004) 119-127
27. Mardon J., Mathey J., Kati-Coulibaly S., Puel C., Davicco M.J., Lebecque P., Horcajada M.N., and Coxam V. Influence of lifelong soy isoflavones consumption on bone mass in the rat. Exp. Biol. Med. 233 2 (2008) 229-237
28. Mathey J., Mardon J., Fokialakis N., Puel C., Kati-Coulibaly S., Mitakou S., Bennetau-Pelissero C., Lamothe V., Davicco M.J., Lebecque P., Horcajada M.N., and Coxam V. Modulation of soy isoflavones bioavailability and subsequent effects on bone health in ovariectomized rats: the case for equol. Osteoporos. Int. 18 5 (2007) 671-679
29. Möller F., Hertrampf T., Ledwig C., Zierau O., Diel P., and Vollmer G. Long-term effects of dietary isoflavones on uterine gene expression profiles. J. Steroid Biochem. Mol. Biol. 113 (2009) 296-303
30. Moors S., Blaszkewicz M., Bolt H.M., and Degen G.H. Simultaneous determination of daidzein, equol, genistein and bisphenol A in human urine by a fast and simple method using SPE and GC-MS. Mol. Nutr. Food Res. 51 7 (2007) 787-798
31. Mousavi Y., and Adlercreutz H. Genistein is an effective stimulator of sex hormone-binding globulin production in hepatocarcinoma human liver cancer cells and suppresses proliferation of these cells in culture. Steroids 58 7 (1993) 301-304
32. Nguyen T., Tran E., Nguyen T.H., Do P.T., Huynh T.H., and Huynh H. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25 5 (2004) 647-659
33. Olson S.H., Bandera E.V., and Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review. Am. J. Epidemiol. 165 3 (2007) 235-245
34. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 9 (2001) e45
35. Rice S., and Whitehead S.A. Phytoestrogens oestrogen synthesis and breast cancer. J. Steroid Biochem. Mol. Biol. 108 3-5 (2008) 186-195
36. Setchell K.D., Brown N.M., and Lydeking-Olsen E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J. Nutr. 132 12 (2002) 3577-3584
37. Somekawa Y., Chiguchi M., Ishibashi T., Wakana K., and Aso T. Efficacy of ipriflavone in preventing adverse effects of leuprolide. J. Clin. Endocrinol. Metab. 86 7 (2001) 3202-3206
38. Shu X.O., Jin F., Dai Q., Wen W., Potter J.D., Kushi L.F., Ruan Z., Gao Y.T., and Zheng W. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol. Biomarkers Prev. 10 5 (2001) 483-488
39. Trock B.J., Hilakivi-Clarke L., and Clarke R. Meta-analysis of soy intake and breast cancer risk. J. Natl. Cancer Inst. 98 (2006) 459-471
40. Vastag B. Soy and prostate cancer study results mixed. J. Natl. Cancer Inst. 99 (2007) 1364-1365
41. Wassermann R.H., and Taylor A.N. Vitamin D-induced calcium-binding protein in chick intestinal mucosa. Science 152 (1966) 791-794
42. Wilson T., March H., Ban W., Hou Y., Adler S., Meyers C.Y., Winters T.A., and Maher M.A. Antioxidant effects of phyto- and synthetic-estrogens on cupric ion-induced oxidation of human low-density lipoproteins in vitro. Life Sci. 70 19 (2002) 2287-2297
43. Yuan J.P., Wang J.H., and Liu X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora-implications for health. Mol. Nutr. Food Res. 51 7 (2007) 765-781