Phytoestrogens and carcinogensis - Differential effects of genistein in experimental models of normal and malignant rat endometrium

Human Reproduction

Volumn 16, Issue 5, 2001, Pages 997-1006

  Diel, Patrick ^a   Smolnikar, Kai ^a   Schulz, Thorsten ^a   Laudenbach Leschowski, Ute ^a   Michna, Horst ^a   Vollmer, Günter ^b  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Endometrial adenocarcinoma; Gene expression; Phytoestrogen; Rat model; Uterus

Indexed keywords

ETHINYLESTRADIOL; GENISTEIN; MESSENGER RNA; SELECTIVE ESTROGEN RECEPTOR MODULATOR; CHAPERONE; CLUSTERIN; COMPLEMENT COMPONENT C3; ESTROGEN; GLYCOPROTEIN; ISOFLAVONE DERIVATIVE; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENDOMETRIUM CARCINOMA; EXPERIMENTAL MODEL; GENE EXPRESSION; IN VIVO STUDY; MORPHOLOGY; NONHUMAN; OVARIECTOMY; RAT; TUMOR GROWTH; UTERINE CERVIX EPITHELIUM; UTERUS; UTERUS GROWTH; UTERUS WEIGHT; VAGINA; ADENOCARCINOMA; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; ENDOMETRIUM TUMOR; EPITHELIUM; FEMALE; GENETICS; ORGAN SIZE; PATHOLOGY;

ADENOCARCINOMA; ANIMALS; CLUSTERIN; COMPLEMENT C3; ENDOMETRIAL NEOPLASMS; EPITHELIUM; ESTROGENS, NON-STEROIDAL; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION; GENISTEIN; GLYCOPROTEINS; ISOFLAVONES; MOLECULAR CHAPERONES; ORGAN SIZE; OVARIECTOMY; PHYTOESTROGENS; PLANT PREPARATIONS; RATS; RNA, MESSENGER; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TUMOR CELLS, CULTURED; UTERUS; VAGINA;

EID: 0034744226     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/16.5.997     Document Type: Article

References (54)

1. Anderson, J.J., Anthony, M.S. Cline J.M. et al. (1999) Health potential of soy isoflavones for menopausal women. Public Health Nutr., 2, 489-504.
2. Balabhadrapathruni, S. Thomas, T.J., Yurkow, E.J. et al. (2000) Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol. Rep., 7, 3-12.
3. Barnes, S. (1997) The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res. Treat., 46, 169-179.
4. Cassidy, A. (1996) Physiological effects of phyto-oestrogens in relation to cancer and other human health risks. Proc. Nutr. Soc., 55, 399-417.
5. Cassidy, A., Bingham, S. and Setchell, K.D.R. (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am. J. Clin. Nutr., 60, 333-340.
6. Chirgwin, J.M., Przybyla A.E., MacDonald, R.J. et al. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
7. Cline, J.M. and Hughes, C.L. Jr (1998) Phytochemicals for the prevention of breast and endometrial cancer. Cancer Treat Res., 94, 107-134.
8. Colborn, C. and Clement C. (eds) (1991) Chemically-induced alterations in sexual and functional development: the wildlife/human connection. Princeton Scientific Publishing Co. Inc., Princetown.
9. Coldham, N.G. and Sauer, M.J. (2000) Pharmacokinetics of [(14)C]Genistein in the rat: gender-related differences, potential mechanisms of biological action, and implications for human health. Toxicol. Appl. Pharmacol., 164, 206-215.
10. Constantinou, A.I., Metha, R.G. and Vaughan, A. (1996) Inhibition of N-methyl-N-nitrosourea-induced mammary tumours in rats by the soybean isoflavones. Anticancer Res., 16, 3293-3298.
11. Constantinou, A.I., Krygier, A.E. and Mehta. R.G. (1998) Genistein induces maturation of cultured human breast cancer cells and prevents tumour growth in nude mice. Am. J. Clin. Nutr., 68 (6 suppl.), 1426S-1430S.
12. Deerberg, F., Rehm, S. and Rapp, K.G. et al. (1985) Survival data and age-associated spontaneous diseases of two strains of rats. In Archibald, J., Ditchfield, J. and Rowsell, H.C. (eds) The contribution of laboratory animal science to the welfare of man and animals. Fischer Verlag, Stuttgart, pp. 171-179.
13. Diel, P., Scholz, T., Smolnikar, K. et al. (2000) The ability of xeno and phytoestrogens to modulate the expression of oestrogen sensitive genes in the rat uterus: oestrogenicity profiles and uterotropic activity. J. Steroid Biochem. Mol. Biol., in press.
14. Fanti, P., Monier-Faugere M.C., Geng, J. et al. (1998) The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int., 8, 274-281.
15. Farmakalidis, E., Hathcock, J.N. and Murphy, PA. (1985) Oestrogenic potency of genistin and daidzin in mice. Food Chem. Toxicol., 23, 741-745.
16. Foth, D., Cline, J.M. and Romer, T. (2000) Effect of isoflavones on mammary gland and endometrium of postmenopausal macaques. Zentralbl Gynakol., 122, 96-102.
17. Fritz, W.A., Coward, L., Wang, J. et al. (1998) Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis, 19, 2151-2158.
18. Gaido, K.W., Leonard, L.S., Lovell, S. et al. (1997) Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol., 143, 205-212.
19. Golden, R.J., Noller, K.L., Titus-Ernstoff, L. et al. (1998) Environmental endocrine modulators and human health: an assessment of the biological evidence. Crit. Rev. Toxicol., 28, 109-227.
20. Goodman, M.T., Wilkens, R.L., Hankin, J.H. et al. (1997) Association of soy and fiber consumption with the risk of endometrial cancer. Am. J. Epidemiol., 146, 294-306.
21. Guenette, R.S., Daehlin, L., Mooibroek, M. et al. (1994a) Thanatogen expression during involution of the rat ventral prostate after castration. J. Androl., 15, 200-211.
22. Guenette, R.S., Corbeil, H.B., Leger, J. et al. (1994b) Induction of gene expression during involution of the lactating mammary gland of the rat. J. Mol. Endocrinol., 12, 47-60.
23. Hopert, A-C., Beyer, A., Frank, K. et al. (1998) Characterization of oestrogenicity of phytoestrogens in an endometrial-derived experimental model. Environ. Health Perspect., 106, 581-586.
24. Horn, D.A., Vollmer, G., von Angerer, E. et al. (1994) Effect of the nonsteroidal antiestrogen ZK 119.010 on growth and metastasis of the EnDA endometrial carcinoma. Int. J. Cancer, 58, 426-429.
25. Howdeshell, K.L., Hotchkiss, A.K., Thayer, K.A. et al. (1999) Exposure to bisphenol A advances puberty. Nature, 401, 763-764.
26. Ingram, D., Sanders. K., Kolybaba, M. et al. (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet, 350, 990-994.
27. Jones, L.A. and Hajek, R.A. (1995) Effects of oestrogenic chemicals on development. Environ. Health Perspect., 103 (suppl. 7), 63-67.
28. Knauthe, R., Diel, P., Hegele-Hartung, C. et al. (1996) Sexual dimorphism of steroid hormone receptor messenger ribonucleic acid expression and hormonal regulation in rat vascular tissue. Endocrinology, 137, 3220-3227.
29. Kurzer, M.S. and Xu, X. (1997) Dietary phytoestrogens. Annu. Rev. Nutr., 17, 353-381.
30. Lamartiniere, C.A., Murrill, W.B., Manzolillo, P.A. et al. (1998b) Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in rats. Proc. Soc. Exp. Bid. Med., 217, 358-364.
31. Lamartiniere, C.A., Zhang, X.J. and Cotroneo, M.S. (1998a) Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity. Am. J. Clin. Nutr., 68 (6 suppl.), 1400S-1405S.
32. Makela, S., Davis, V.L., Tally, W.C. et al. (1994) Dietary oestrogens act through oestrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells. Environ. Health Perspect., 102, 572-578.
33. Makela, S., Pylkkanen, L.H., Santti, R.S. et al. (1995) Dietary soybean may be antiestrogenic in male mice. J. Nutr., 125, 437-445.
34. Makela S, Savolainen H., Aavik, E. et al. (1999) Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to oestrogen receptors alpha and beta. Proc. Natl Acad. Sci. USA, 96, 7077-7082.
35. McLachlan, J.A. and Newbold, R.R. (1987) Oestrogens and development. Environ. Health Perspect., 75, 25-27.
36. McLachlan, J.A., Korach, K.S., Newbold, R.R. et al. (1984) Diethylstilbestrol and other estrogens in the environment. Fundam. Appl. Toxicol., 4, 69-76.
37. Murphy, L.D., Herzog, C.E., Rudick, J.B. et al. (1990) Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochemistry, 29, 10351-10356.
38. Ramsey, L.A., Ross, B.S. and Fischer, R.G. (1999) Phytoestrogens and the management of menopause. Adv. Nurse Pract., 7, 26-30.
39. Sambrook, J., Fritsch, E.F. and Maniatis, T. (eds) (1989) Molecular cloning -a laboratory manual, 2nd edn, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
40. Santell, R.C., Chang, Y.C., Nair, M.G. et al. (1997) Dietary genistein exerts oestrogenic effects upon the uterus, mammary gland and the hypothalamic/ pituitary axis in rats. J. Nutr., 127, 263-269.
41. Schütze, N., Kraft, V., Deerberg, F. et al. (1992) Functions of oestrogens and anti-estrogens in the rat endometrial adenocarcinoma cell lines RUCA-I and RUCA-II. Int. J. Cancer, 52, 942-949.
42. Setchell, K.D.R. and Cassidy, A. (1999) Dietary isoflavones: biological effects and relevance to human health. J. Nutr., 129, 758S-767S.
43. Setchell, K.D., Boriello, S.D., Hulme, P. et al. (1984) Nonsteroidal oestrogens of dietary origin: possible roles in hormone-dependent disease. Am. J. Clin. Nutr., 40, 569-578.
44. Setchell, K.D., Gosselin, S.J., Welsh, M.B. et al. (1987) Dietary oestrogens-a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology, 93, 225-233.
45. Sheehan, D.M, Willingham, E., Gaylor, D. et al. (1999) No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much? Environ. Health Perspect., 107, 155-159.
46. Shutt, D.A. (1976) The effects of plant estrogens on animal reproduction. Endeavour, 35, 110-113.
47. Soto, A.M., Sonnenschein, C., Chung, K.L. et al. (1995)The E-SCREEN assay as a tool to identify oestrogens: an update on oestrogenic environmental pollutants. Environ. Health Perspect., 103 (suppl. 7), 113-122.
48. Squadrito, F., Altavilla, D., Squadrito, G. et al. (2000) Genistein supplementation and oestrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc. Res., 45, 454-462.
49. Vollmer, G. and Schneider, M.R. (1996) The rat endometrial adenocarcinoma cell line RUCA-I: a novel hormone-sensitive in vivo/in vitro tumour model. J. Steroid. Biochem. Mol. Biol., 58, 103-115.
50. Vollmer, G., Ellerbrake, N., Hopert, A.-C. et al. (1995) Extracellular matrix induces hormone responsiveness and differentiation in RUCA-I rat endometrial adenocarcinoma cells. J. Steroid Biochem. Mol. Biol., 52, 259-269.
51. Whitten, P.L., Russel, E. and Naftolin, F. (1994) Influence of phytoestrogen diets on estradiol action in the rat uterus. Steroids, 59, 443-449.
52. Whitten, P.L., Lewis, C., Russell, E. et al. (1995) Potential adverse effects of phytoestrogens. J. Nutr., 125 (suppl.), 771S-776S.
53. Wunsche, W., Tenniswood, M.P., Schneider, M.R. et al. (1998) Oestrogenic regulation of clusterin mRNA in normal and malignant endometrial tissue. Int. J. Cancer, 76, 684-688.
54. Yang, J., Nakagawa, H. et al. (2000) Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett., 149, 171-179.