Nod2 mutation enhances NF-kappaB activity and bacterial killing activity of macrophages

Inflammation

Volumn 32, Issue 6, 2009, Pages 372-378

  Tsay, Tzyy Bin ^a   Chang, Chien Jen ^b   Chen, Pei Hsuan ^c   Hsu, Ching Mei ^d   Chen, Lee Wei ^b,c  

^a ZUOYING ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Bacterial killing activity; IL 1 ; NF B; NOD2; Phagocytic activity; TNF

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CROHN DISEASE; DNA BINDING; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; WILD TYPE;

ANIMALS; CROHN DISEASE; DNA-BINDING PROTEINS; IMMUNITY, INNATE; MACROPHAGES, ALVEOLAR; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; NF-KAPPA B; NOD2 SIGNALING ADAPTOR PROTEIN; PSEUDOMONAS AERUGINOSA;

BACTERIA (MICROORGANISMS); MUS;

EID: 70449521012     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-009-9145-z     Document Type: Article

References (20)

1. J. P. Hugot M. Chamaillard H. Zouali S. Lesage J. P. Cezard J. Belaiche S. Almer C. Tysk C. A. O'Morain M. Gassull, et al. 2001 Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 6837 599 603 10.1038/35079107 1:CAS:528:DC%2BD3MXksVShtLY%3D 11385576 (Pubitemid 32531408)
2. Y. Ogura D. K. Bonen N. Inohara D. L. Nicolae F. F. Chen R. Ramos H. Britton T. Moran R. Karaliuskas R. H. Duerr, et al. 2001 A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 6837 603 606 10.1038/35079114 1:CAS:528:DC%2BD3MXksVShur8%3D 11385577 (Pubitemid 32531409)
3. S. E. Girardin I. G. Boneca J. Viala M. Chamaillard A. Labigne G. Thomas D. J. Philpott P. J. Sansonetti 2003 Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J. Biol. Chem. 278 11 8869 8872 10.1074/jbc.C200651200 1:CAS:528:DC%2BD3sXhvVyqsbs%3D 12527755 (Pubitemid 36800360)
4. L. C. Hsu S. R. Ali S. McGillivray P. H. Tseng S. Mariathasan E. W. Humke L. Eckmann J. J. Powell V. Nizet V. M. Dixit, et al. 2008 A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide Proc. Natl. Acad. Sci. U. S. A. 105 22 7803 7808 10.1073/pnas.0802726105 1:CAS:528:DC%2BD1cXntF2ru7k%3D 18511561 (Pubitemid 351872719)
5. S. Traub N. Kubasch S. Morath M. Kresse T. Hartung R. R. Schmidt C. Hermann 2004 Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction J. Biol. Chem. 279 10 8694 8700 10.1074/jbc.M310556200 1:CAS:528:DC%2BD2cXhs1Ont7g%3D 14668350 (Pubitemid 38295924)
6. A. Uehara S. Yang Y. Fujimoto K. Fukase S. Kusumoto K. Shibata S. Sugawara H. Takada 2005 Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture Cell. Microbiol. 7 1 53 61 10.1111/j.1462-5822.2004.00433.x 1:CAS:528: DC%2BD2MXotlWrsA%3D%3D 15617523
7. D. M. Rothwarf M. Karin 1999 The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus Sci. STKE 1999 5 RE1 10.1126/stke.1999.5.re1 1:STN:280:DC%2BD387mtVektw%3D%3D 11865184
8. M. Karin Y. Ben-Neriah 2000 Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity Annu. Rev. Immunol. 18 621 663 10.1146/annurev.immunol.18.1.621 1:CAS:528:DC%2BD3cXjs1Gmtro%3D 10837071 (Pubitemid 30365393)
9. H. T. Gan Y. Q. Chen Q. Ouyang 2005 Sulfasalazine inhibits activation of nuclear factor-kappaB in patients with ulcerative colitis J. Gastroenterol. Hepatol. 20 7 1016 1024 1:CAS:528:DC%2BD2MXmvF2ktbc%3D 15955209
10. S. Maeda L. C. Hsu H. Liu L. A. Bankston M. Iimura M. F. Kagnoff L. Eckmann M. Karin 2005 Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing Science 307 5710 734 738 10.1126/science. 1103685 1:CAS:528:DC%2BD2MXpt1WqtA%3D%3D 15692052 (Pubitemid 40194645)
11. I. Sayek 1997 Animal models for intra-abdominal infection Hepatogastroenterology 44 16 923 926 1:STN:280:DyaK2svgsVyrtw%3D%3D 9261579
12. D. J. van Westerloo S. Weijer M. J. Bruno A. F. de Vos C. Van't Veer T. van der Poll 2005 Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis Crit. Care Med. 33 5 1036 1043 10.1097/01.CCM.0000162684.11375.85 15891333 (Pubitemid 40638177)
13. L. W. Chen L. Egan Z. W. Li F. R. Greten M. F. Kagnoff M. Karin 2003 The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion Nat. Med. 9 5 575 581 10.1038/nm849 1:CAS:528:DC%2BD3sXjtlamtL8%3D 12692538 (Pubitemid 36597104)
14. N. Li M. Karin 1998 Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms Proc. Natl. Acad. Sci. U. S. A. 95 22 13012 13017 10.1073/pnas.95.22.13012 1:CAS:528:DyaK1cXntFWktbs%3D 9789032 (Pubitemid 28509515)
15. C. Fiocchi 1998 Inflammatory bowel disease: etiology and pathogenesis Gastroenterology 115 1 182 205 10.1016/S0016-5085(98)70381-6 1:STN:280:DyaK1czitlGjtg%3D%3D 9649475 (Pubitemid 28307304)
16. D. K. Podolsky 2002 Inflammatory bowel disease N. Engl. J. Med. 347 6 417 429 10.1056/NEJMra020831 1:CAS:528:DC%2BD38XlvFKrt7s%3D 12167685 (Pubitemid 34851835)
17. C. Wahl S. Liptay G. Adler R. M. Schmid 1998 Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B J. Clin. Invest. 101 5 1163 1174 10.1172/JCI992 1:CAS:528:DyaK1cXhs1yqsbg%3D 9486988
18. T. Hisamatsu M. Suzuki H. C. Reinecker W. J. Nadeau B. A. McCormick D. K. Podolsky 2003 CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells Gastroenterology 124 4 993 1000 10.1053/gast.2003. 50153 1:CAS:528:DC%2BD3sXjsFOju7g%3D 12671896 (Pubitemid 36389802)
19. T. Watanabe A. Kitani P. J. Murray W. Strober 2004 NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses Nat. Immunol. 5 8 800 808 10.1038/ni1092 1:CAS:528:DC%2BD2cXmtVCgtL8%3D 15220916 (Pubitemid 39172973)
20. Y. R. Mahida V. E. Rolfe 2004 Host-bacterial interactions in inflammatory bowel disease Clin. Sci. (Lond.) 107 4 331 341 10.1042/CS20040136 1:CAS:528:DC%2BD2cXnslOqurk%3D (Pubitemid 39389300)