Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis

Critical Care Medicine

Volumn 33, Issue 5, 2005, Pages 1036-1043

  Van Westerloo, David J ^a   Weijer, Sebastiaan ^a   Bruno, Marco J ^a   De Vos, Alex F ^a   Van't Veer, Cornelis ^a   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Bacterial infections; Cytokines; Host defense; Inflammation; Rodent; Transgenic mice

Indexed keywords

CERULETIDE; TOLL LIKE RECEPTOR 4;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ESCHERICHIA COLI; FEMALE; HOST RESISTANCE; IN VIVO STUDY; MOUSE; MUTANT; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PERITONEAL FLUID; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN SECRETION; SEPSIS; WILD TYPE;

ACUTE DISEASE; ANIMALS; ESCHERICHIA COLI INFECTIONS; FEMALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; PANCREATITIS; PERITONITIS; RECEPTORS, CELL SURFACE; SEPSIS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 18344371541     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000162684.11375.85     Document Type: Article

References (39)

1. van der Poll T: Immunotherapy of sepsis. Lancet Infect Dis 2001; 1:165-174
2. Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:885-891
3. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
4. Bernard GR, Wheeler AP, Russell JA, et al: The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997; 336:912-918
5. Lorber B, Swenson RM: The bacteriology of intra-abdominal infections. Surg Clin North Am 1975; 55:1349-1354
6. Schmid SW, Uhl W, Friess H, et al: The role of infection in acute pancreatitis. Gut 1999; 45:311-316
7. Marshall JC, Innes M: Intensive care unit management of intra-abdominal infection. Crit Care Med 2003; 31:2228-2237
8. Volk HD, Reinke P, Docke WD: Clinical aspects: From systemic inflammation to "immunoparalysis." Chem Immunol 2000; 74:162-177
9. van Westerloo DJ, Schultz MJ, Bruno MJ, et al: Acute pancreatitis in mice impairs bacterial clearance from the lungs, whereas concurrent pneumonia prolongs the course of pancreatitis. Crit Care Med 2004; 32:1997-2001
10. Prass K, Meisel C, Hoflich C, et al: Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 2003; 198:725-736
11. Cicalese L, Sahai A, Sileri P, et al: Acute pancreatitis and bacterial translocation. Dig Dis Sci 2001; 46:1127-1132
12. Solomkin JS, Umanskiy K: Intraabdominal sepsis: Newer interventional and antimicrobial therapies for infected necrotizing pancreatitis. Curr Opin Crit Care 2003; 9:424-427
13. Renner IG, Savage WT III, Pantoja JL, et al: Death due to acute pancreatitis. A retrospective analysis of 405 autopsy cases. Dig Dis Sci 1985; 30:1005-1018
14. Bosscha K, van Vroonhoven TJ, van der Werken C: Surgical management of severe secondary peritonitis. Br J Surg 1999; 86:1371-1377
15. Isenmann R, Beger HG: Natural history of acute pancreatitis and the role of infection. Baillieres Best Pract Res Clin Gastroenterol 1999; 13:291-301
16. Janeway CA Jr, Medzhitov R: Innate immune recognition. Annu Rev Immunol 2002; 20:197-216
17. Qureshi ST, Lariviere L, Leveque G, et al: Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 1999; 189:615-625
18. Poltorak A, He X, Smirnova I, et al: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 1998; 282:2085-2088
19. Hoshino K, Takeuchi O, Kawai T, et al: Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol 1999; 162:3749-3752
20. Beutler B, Rietschel ET: Innate immune sensing and its roots: The story of endotoxin. Nat Rev Immunol 2003; 3:169-176
21. Cross AS, Sadoff JC, Kelly N, et al: Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin 1 alpha protects mice from lethal bacterial infection. J Exp Med 1989; 169:2021-2027
22. Evans TJ, Strivens E, Carpenter A, et al: Differences in cytokine response and induction of nitric oxide synthase in endotoxin-resistant and endotoxin-sensitive mice after intravenous Gram-negative infection. J Immunol 1993; 150:5033-5040
23. Haraoka M, Hang L, Frendeus B, et al: Neutrophil recruitment and resistance to urinary tract infection. J Infect Dis 1999; 180:1220-1229
24. Branger J, Knapp S, Weijer S, et al: Role of Toll-like receptor 4 in Gram-positive and Gram-negative pneumonia in mice. Infect Immun 2004; 72:788-794
25. Wang MJ, Jeng KC, Shih PC: Differential expression of inducible nitric oxide synthase gene by alveolar and peritoneal macrophages in lipopolysaccharide-hyporesponsive C3H/HeJ mice. Immunology 1999; 98:497-503
26. O'Brien AD, Rosenstreich DL, Scher I, et al: Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene. J Immunol 1980; 124:20-24
27. Weijer S, Sewnath ME, de Vos AF, et al: Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis. Infect Immun 2003; 71:5488-5497
28. Knapp S, de Vos AF, Florquin S, et al: Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice. Infect Immun 2003; 71:6747-6753
29. Sewnath ME, Olszyna DP, Birjmohun R, et al: IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J Immunol 2001; 166:6323-6331
30. Demols A, Le Moine O, Desalle F, et al: CD4(+)T cells play an important role in acute experimental pancreatitis in mice. Gastroenterology 2000; 118:582-590
31. Halangk W, Lerch MM, Brandt-Nedelev B, et al: Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000; 106:773-781
32. Lichtman SN, Wang J, Hummel B, et al: A rat model of ileal pouch-rectal anastomosis. Inflamm Bowel Dis 1998; 4:187-195
33. Knapp S, Leemans JC, Florquin S, et al: Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med 2003; 167:171-179
34. Zisman DA, Kunkel SL, Strieter RM, et al: Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis. Shock 1997; 8:349-356
35. Zanetti G, Heumann D, Gerain J, et al: Cytokine production after intravenous or peritoneal Gram-negative bacterial challenge in mice. Comparative protective efficacy of antibodies to tumor necrosis factor-alpha and to lipopolysaccharide. J Immunol 1992; 148:1890-1897
36. Oberholzer A, Oberholzer C, Moldawer LL: Sepsis syndromes: Understanding the role of innate and acquired immunity. Shock 2001; 16:83-96
37. Schmid SW, Uhl W, Kidd M, et al: Experimental models of acute pancreatitis and their clinical relevance. In: Acute Pancreatitis, Novel Concepts in Biology and Therapy. Buchler (Ed). Berlin, Blackwell Science, 1999, pp 41-63
38. Frossard JL, Hadengue A, Spahr L, et al: Natural history of long-term lung injury in mouse experimental pancreatitis. Crit Care Med 2002; 30:1541-1546
39. Pastor CM, Pugin J, Kwak B, et al: Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. Crit Care Med 2004; 32:1759-1763