From antidepressant drugs to beta-mimetics: Preclinical insights on potential new treatments for neuropathic pain

Recent Patents on CNS Drug Discovery

Volumn 4, Issue 3, 2009, Pages 182-189

  Barrot, Michel ^a   Yalcin, Ipek ^a   Choucair Jaafar, Nada ^a   Benbouzid, Malika ^a,b   Freund Mercier, Marie José ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

mimetic; 2 adrenergic receptor; Adrenoceptor; Allodynia; Antidepressant; Neuropathy; Nortriptyline; Pain; Salbutamol; Terbutaline; Treatment

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; DEXTROMETHORPHAN; DULOXETINE; GABAPENTIN; LAMOTRIGINE; MIRTAZAPINE; MONOAMINE OXIDASE INHIBITOR; NARCOTIC ANALGESIC AGENT; NORTRIPTYLINE; PREGABALIN; PROSTAGLANDIN E RECEPTOR; REBOXETINE; SALBUTAMOL; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SULFONAMIDE; TECIPTILINE; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; VALPROIC ACID; VENLAFAXINE; YOHIMBINE;

ADJUVANT THERAPY; ALLODYNIA; ASTHMA; ATAXIA; BLURRED VISION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONSTIPATION; DELIRIUM; DEPRESSION; DIABETIC NEPHROPATHY; DIZZINESS; DRUG ANTAGONISM; DRUG BINDING; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG RESPONSE; DRUG SCREENING; DRUG WITHDRAWAL; FATIGUE; FIBROMYALGIA; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERHIDROSIS; LONG TERM CARE; MEMORY DISORDER; NECROSIS; NERVOUS SYSTEM; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; ORTHOSTATIC HYPOTENSION; PAIN; PATHOPHYSIOLOGY; PERIPHERAL EDEMA; PERIPHERAL NEUROPATHY; POLYNEUROPATHY; PRIORITY JOURNAL; REVIEW; SEDATION; SEXUAL DYSFUNCTION; SIDE EFFECT; SOMATOSENSORY SYSTEM; SOMNOLENCE; TACHYCARDIA; TREATMENT DURATION; URINE RETENTION; WEIGHT GAIN; XEROSTOMIA;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANTIDEPRESSIVE AGENTS; HUMANS; NEURALGIA; RECEPTORS, ADRENERGIC, BETA-2; SOMATOSENSORY DISORDERS;

EID: 70449514123     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488909789104794     Document Type: Review

References (94)

1. Merksey H, Bogduk N, Ed. Pain terms, a current list with definitions and notes on usage. Classification of chronic pain. IASP Press 1994; 209-214.
2. Le Bars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev 2001; 53: 597-652.
3. Scholz J, Woolf CJ. Can we conquer pain? Nat Neurosci 2002; 5: 1062-1067.
4. Béjean S, Sultan-Taïeb H. Modeling the economic burden of diseases imputable to stress at work. Eur J Health Econ 2005; 6(1): 16-23. (Pubitemid 40543266)
5. Groholt EK, Stigum H, Nordhagen R, Köhler L. Recurrent pain in children, socio-economic factors and accumulation in families. L Eur J Epidemiol 2003; 18(10): 965-975. (Pubitemid 37288112)
6. Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain 2008; 137(3): 473-477.
7. Attal N, Cruccu G, Haanpaa M, et al. EFNS guidelines on pharmacological treatment of neuropathic pain. Eur J Neurol 2006; 13(11): 1153-1169. (Pubitemid 44581463)
8. Dworkin RH, O'Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain: Evidence-based recommendations. Pain 2007; 132(3): 237-251. (Pubitemid 350051570)
9. Attal N, Fermanian C, Fermanian J, Lanteri-Minet M, Alchaar H, Bouhassira D. Neuropathic pain: Are there distinct subtypes depending on the aetiology or anatomical lesion? Pain 2008; 138(2): 343-353.
10. Colombo B, Annovazzi PO, Comi G. Medications for neuropathic pain: Current trends. Neurol Sci 2006; 27(Suppl 2): S189. (Pubitemid 44390139)
11. Coluzzi F, Mattia C. Mechanism-based treatment in chronic neuropathic pain: The role of antidepressants. Curr Pharm Des 2005; 11(23): 2945-2960. (Pubitemid 41149935)
12. Micó JA, Ardid D, Berrocoso E, Eschalier A. Antidepressants and pain. Trends Pharmacol Sci 2006; 27(7): 348-354.
13. Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst 2005; Rev3: CD005454.
14. Davis JL, Lewis SB, Gerich JE, Kaplan RA, Schultz TA, Wallin JD. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA 1977; 238(21): 2291-2292. (Pubitemid 8259813)
15. Max MB, Culnane M, Schafer SC, et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987; 37(4): 589-596. (Pubitemid 17057933)
16. Sindrup SH, Otto M, Finnerup NB, Jensen TS. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol 2005; 96(6): 399-409.
17. Wolfe GI, Trivedi JR. Painful peripheral neuropathy and its nonsurgical treatment. Muscle Nerve 2004; 30(1): 3-19. (Pubitemid 38880320)
18. Briley M. Clinical experience with dual action antidepressants in different chronic pain syndromes. Hum Psychopharmacol Clin Exp 2004; 1: S21-S25. (Pubitemid 39386316)
19. Sesha, R.: US20070004795A1 (2007).
20. Marchand F, Alloui A, Chapuy E, et al. Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats. Pain 2003; 103(3): 229-235. (Pubitemid 36638812)
21. 2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. Neurobiol Dis 2009; 33(3): 386-394.
22. Dwight M, Arnold LM, O'Brien H, Metzger R, Morris-Park E, Keck PE Jr. An open clinical trial of venlafaxine treatment of fibromyalgia. Psychosomatics 1998; 39(1): 14-17. (Pubitemid 28152592)
23. Enggaard TP, Klitgaard NA, Gram LF, Arendt-Nielsen L, Sindrup SH. Specific effect of venlafaxine on single and repetitive experimental painful stimuli in humans. Clin Pharmacol Ther 2001; 69(4): 245-251. (Pubitemid 32382507)
24. Simpson DA. Gabapentin and venlafaxine for the treatment of painful diabetic neuropathy. J Clin Neuromusc Dis 2001; 3(2): 53-62. (Pubitemid 33130299)
25. Sindrup SH, Bach FW, Madsen C, Gram LF, Jensen TS. Venlafaxine versus imipramine in painful polyneuropathy: A randomized, controlled trial. Neurology 2003; 60(8): 1284-1289. (Pubitemid 36460983)
26. Wong A., Ahmed, S., Marshall, R.C., McArthur, R., Taylor, D.P.: US20087317011B2 (2008).
27. Houghton, A., Ruigt, G.S.F.: US20070270413A1 (2007).
28. Rao, S., Kranzler, J.D., Anderson, J.J.: WO2009023820A1 (2009).
29. Lewis, R.J.: US20090105129A1 (2009).
30. Liming, S., Fengjiang, W., Malcolm, S.C., Hewitt, M.C., Ma, J., Ribe, S., Varney, M.A., Campbell, U., Engel, S.R., Hardy, L.W., Koch, P., Schriber, R. Spear, K.: US20090005456A1 (2009).
31. Carliss, R., Lee, D.A.H.: US20046825217 (2004).
32. Annedi, S.C., Maddaford, S., Ramnauth, J., Renton, P., Rakhit, S., Andrews, J.S., Mladenova, G.: WO2009062318A1 (2009).
33. Dinan, T.: WO2007088473 (2007).
34. Bauer CS, Nieto-Rostro M, Rahman W, et al. The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. J Neurosci 2009; 29(13): 4076-4088.
35. Fink K, Dooley DJ, Mederet WP, et al. Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex. Neuropharmacol 2002; 42(2): 229-236.
36. Hildebrand, K.R., Page, L.M., Lane, D.S., Elsberry, D.D., Clarahan, D.A., Ratnayake, J.H.: US20060160900A1 (2006).
37. Field, M.J., Williams, R.G.: US20090036487A1 (2009).
38. Audoly, L.P.: US20090036495A1 (2009).
39. Singh, C.U.: WO2009021058A2 (2009).
40. Campbell FG, Graham JG, Zilkha KJ. Clinical trial of carbazepine (tegretol) in trigeminal neuralgia. J Neurol Neurosurg Psychiatry 1966; 29(3): 265-267.
41. Wiffen PJ, McQuay HJ, Moore RA. Carbamazepine for acute and chronic pain. Cochrane Database Syst Rev 2005; 20: CD005451.
42. Fulp, A.B., Johnson, M.S., Markworth, C.J., Marron, B.E., Seconi, D.C., West, C.W., Wang, X., Zhou, S.: US20090023740A1 (2009).
43. Cohen HW, Gibson G, Alderman MH. Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med 2000; 108(1): 2-8. (Pubitemid 30058271)
44. Jackson KE. Pharmacotherapy for neuropathic pain. Pain Pract 2006; 6(1): 27-33.
45. Maizels M, McCarberg B. Antidepressants and antiepileptic drugs for chronic non-cancer pain. Am Fam Physician 2005; 71(3): 483-490. (Pubitemid 40194067)
46. McQuay HJM, Tramer BA, Nye D, Carroll P, Wiffen P, Moore A. A systemic review of antidepressants in neuropathic pain. Pain 1996; 68(2-3): 217-227. (Pubitemid 27025878)
47. Roose SP, Glassman AH, Attia E, Woodring S, Giardina EG, Bigger JT Jr. Cardiovascular effects of fluoxetine in depressed patients with heart disease. Am J Psychiatry 1998; 155(5): 660-665. (Pubitemid 28225407)
48. Zaccara G, Gangemi PF, Cincotta M. Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies. Seizure 2008; 17(5): 405-421.
49. Dworkin RH, Corbin AE, Young JP Jr, et al. Pregabalin for the treatment of postherpetic neuralgia: A randomized, placebo-controlled trial. Neurology 2003; 60(8): 1274-1283. (Pubitemid 36460982)
50. Berton O, Nestler EJ. New approaches to antidepressant drug discovery: Beyond monoamines. Nat Rev Neurosci 2006; 7(2): 137-151. (Pubitemid 43151600)
51. von Kügelgen I, Allgaier C, Schobert A, Starke K. Co-release of noradrenaline and ATP from cultured sympathetic neurons. Neuroscience 1994; 61(2): 199-202. (Pubitemid 2043756)
52. Guieu R, Peragut JC, Roussel P, et al. Adenosine and neuropathic pain. Pain 1996; 68: 271-274.
53. Guieu R, Sampiéri F, Pouget J, Guy B, Rochat H. Adenosine in painful legs and moving toes syndrome. Clin Pharmacol 1994; 17: 460-469. (Pubitemid 24294473)
54. Frazer A, Morilak DA. What should animal models of depression model? Neurosci Biobehav Rev 2005; 29(4-5): 515-523.
55. Coyle JT, Duman RS. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 2003; 38(2): 157-160.
56. Duman RS. Pathophysiology of depression: The concept of synaptic plasticity. Eur Psychiatry 2002; 17(Suppl 3): 306-310.
57. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron 2002; 34(1): 13-25.
58. Tsankova N, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 2006; 9(4): 519-525.
59. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007; 8: 355-367.
60. Wallace DL, Huan MH, Graham DL, et al. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci 2009; 12(2): 200-209.
61. Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992; 326(19): 1250-1256.
62. Hempenstall K, Nurmikko TJ, Johnson RW, et al. Analgesic therapy in postherpetic neuralgia: A quantitative systematic review. PLoS Med 2005; 2(7): e164. (Pubitemid 46179274)
63. Gilron I, Watson CP, Cahill CM, Moulin DE. Neuropathic pain: A practical guide for the clinician. CMAJ 2006; 175(3): 265-275. (Pubitemid 44230827)
64. Moulin DE, Clark AJ, Gilron I, et al. Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society. Pain Res Manage 2007; 12(1): 13-21. (Pubitemid 46744774)
65. Micó JA, Gibert-Rahola J, Casas J, Rojas O, Serrano MI, Serrano JS. Implication of beta 1- and beta 2-adrenergic receptors in the antinociceptive effect of tricyclic antidepressants. Eur Neuropsychopharmacol 1997; 7(2): 139-145. (Pubitemid 27240347)
66. Ghelardini C, Galeotti N, Bartolini A. Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors. Jpn J Pharmacol 2000; 82(2): 130-137. (Pubitemid 30153594)
67. Gray AM, Pache DM, Sewell RD. Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds? Eur J Pharmacol 1999; 378(2): 161-168.
68. Ozdoǧan UK, Lähdesmäki J, Mansikka H, Scheinin M. Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice. Eur J Pharmacol 2004; 485(1): 193-196. (Pubitemid 38134414)
69. Bomholt SF, Mikkelsen JD, Blackburn-Munro G. Antinociceptive effects of antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology 2005; 48(2): 252-263. (Pubitemid 40208261)
70. Hersch EV, Kaplan P. Antinociceptive action of tricyclic antidepressant drugs in the rat. Anesth Prog 1990; 37(4): 186-189.
71. Zhao ZQ, Chiechio S, Sun YG, et al. Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J Neurosci 2007; 27(22): 6045-6053. (Pubitemid 46849764)
72. Acton J, McKenna JE, Melzack R. Amitriptyline produces analgesia in the formalin pain test. Exp Neurol 1992; 117(1): 94-96.
73. Esser MJ, Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain 1999; 80(3): 643-653. (Pubitemid 29182714)
74. Idänpään-Heikkilä JJ, Guilbaud G. Pharmacological studies on a rat model of trigeminal neuropathic pain: Baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuate the allodynia-like behaviour. Pain 1999; 79(2): 281-290. (Pubitemid 29076763)
75. Jett MF, McGuirk J, Walligora D, Hunter JC. The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. Pain 1997; 69(1-2):161-169. (Pubitemid 27081422)
76. Mosconi T, Kruger L. Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: Ultrastructural morphometric analysis of axonal alterations. Pain 1996; 64: 37-57. (Pubitemid 26062245)
77. Pitcher GM, Ritchie J, Henry JL. Nerve constriction in the rat: Model of neuropathic, surgical and central pain. Pain 1999; 83(1): 37-46. (Pubitemid 29446155)
78. Cheng HY, Pitcher GM, Laviolette SR et al. DREAM is a critical transcriptional repressor for pain modulation. Cell 2002; 108(1): 31-43.
79. Benbouzid M, Pallage V, Rajalu M, et al. Sciatic nerve cuffing in mice: A model of sustained neuropathic pain. Eur J Pain 2008; 12(5): 591-599. (Pubitemid 351615308)
80. Benbouzid M, Choucair-Jaafar N, Yalcin I, et al. Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice. Eur J Pain 2008; 12(8): 1008-1017.
81. 2- adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol 2009; 65: 218-225.
82. Benbouzid M, Gaveriaux-Ruff C, Yalcin I, et al. Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. Biol Psychiatry 2008; 63(6): 633-636. (Pubitemid 351273190)
83. Yoshimura M, Furue H. Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. J Pharmacol Sci 2006; 101(2): 107-117. (Pubitemid 43938761)
84. Crassous PA, Denis C, Paris H, Sénard JM. Interest of alpha2-adrenergic agonists and antagonists in clinical practice: Background, facts and perspectives. Curr Top Med Chem 2007; 7(2): 187-194. (Pubitemid 46062389)
85. Barrot, M., Yalcin, I., Freund-Mercier, M.J., Benbouzid, M., Choucair-Jaafar, N.: BF0800273 (2008).
86. Nicholson R, Dixon AK, Spanswick D, Lee K. Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons. Neurosci Lett 2005; 380(3): 316-321. (Pubitemid 40616103)
87. Diatchenko L, Anderson AD, Slade GD, et al. Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet 2006; 141B(5): 449-462. (Pubitemid 44024438)
88. Khasar SG, McCarter G, Levine JD. Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999; 81(3): 1104-1112.
89. Nackley-Neely AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 2007; 128(3): 199-208. (Pubitemid 46367417)
90. Parada CA, Yeh JJ, Joseph EK, Levine JD. Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur J Neurosci 2003; 17(9): 1847-1852.
91. Bentley GA, Starr J. The antinociceptive action of some beta-adrenoreceptor agonists in mice. Br J Pharmacol 1986; 88(3): 515-521. (Pubitemid 16066915)
92. 2-adrenergic receptor stimulation alleviates neuropathic pain. 2009 (Submitted).
93. O'Byrne PM, Parameswaran K. Pharmacological management of mild or moderate persistent asthma. Lancet 2006; 368(9537): 794-803. (Pubitemid 44279057)
94. 2-Adrenergic Agonists. In: Lieberman P, Anderson JA, Eds. Current clinical practice: Allergic Disease: Diagnosis and treatment. Humana Press 2007; 335-342.