메뉴 건너뛰기




Volumn 8, Issue 6, 2009, Pages 715-725

Ezetimibe/simvastatin

Author keywords

Atherosclerosis; Ezetimibe; Safety; Simvastatin

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; AMINOTRANSFERASE; ATORVASTATIN; C REACTIVE PROTEIN; CREATINE KINASE; CYTOCHROME P450 3A4; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EZETIMIBE; EZETIMIBE PLUS SIMVASTATIN; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; PRAVASTATIN; RHO FACTOR; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL;

EID: 70449470013     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740330903282745     Document Type: Review
Times cited : (9)

References (107)
  • 1
    • 70049110201 scopus 로고    scopus 로고
    • Interventions in the management of serum lipids for preventing stroke recurrence
    • Manktelow BN, Potter JF. Interventions in the management of serum lipids for preventing stroke recurrence. Cochrane Database Syst Rev 2009;(3): CD002091
    • (2009) Cochrane Database Syst Rev , Issue.3
    • Manktelow, B.N.1    Potter, J.F.2
  • 2
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Cholesterol and Recurrent Events Trial investigators
    • Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996;335:1001-1009
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 3
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S). Lancet 1994;344:1383-1389
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 4
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002;360:7-22
    • (2002) Lancet , vol.360 , pp. 7-22
  • 5
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med 1998;339:1349-1357
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 6
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995;333:1301-1307
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 7
    • 27644544308 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: Benefit beyond cholesterol reduction? A meta-regression analysis
    • Robinson JG, Smith B, Maheshwari N, et al. Pleiotropic effects of statins: Benefit beyond cholesterol reduction? A meta-regression analysis. J AmColl Cardiol 2005;46:1855-1862
    • (2005) J AmColl Cardiol , vol.46 , pp. 1855-1862
    • Robinson, J.G.1    Smith, B.2    Maheshwari, N.3
  • 8
    • 18444374227 scopus 로고    scopus 로고
    • Clinical significance of statin pleiotropic effects: Hypotheses versus evidence
    • Davidson MH. Clinical significance of statin pleiotropic effects: Hypotheses versus evidence. Circulation 2005;111:2280-2281
    • (2005) Circulation , vol.111 , pp. 2280-2281
    • Davidson, M.H.1
  • 9
    • 0033587667 scopus 로고    scopus 로고
    • Long-term effects of pravastatin on plasma concentration of C-reactive protein
    • The Cholesterol and Recurrent Events (CARE) Investigators
    • Ridker PM, Rifai N, Pfeffer MA, et al. Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation 1999;100:230-235
    • (1999) Circulation , vol.100 , pp. 230-235
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3
  • 10
    • 0035963529 scopus 로고    scopus 로고
    • Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    • Ridker PM, Rifai N, Clearfield M, et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 2001;344:1959-1965
    • (2001) N Engl J Med , vol.344 , pp. 1959-1965
    • Ridker, P.M.1    Rifai, N.2    Clearfield, M.3
  • 11
    • 0043166521 scopus 로고    scopus 로고
    • Statins promote potent systemic antioxidant effects through specific inflammatory pathways
    • Shishehbor MH, Brennan ML, Aviles RJ, et al. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation 2003;108:426-431
    • (2003) Circulation , vol.108 , pp. 426-431
    • Shishehbor, M.H.1    Brennan, M.L.2    Aviles, R.J.3
  • 12
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U, La Fata V, Plutzky J, et al. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998;97:1129-1135
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3
  • 13
    • 0141430989 scopus 로고    scopus 로고
    • Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
    • Kleemann R, Princen HM, Emeis JJ, et al. Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin. Circulation 2003;108:1368-1374
    • (2003) Circulation , vol.108 , pp. 1368-1374
    • Kleemann, R.1    Princen, H.M.2    Emeis, J.J.3
  • 14
    • 67749115977 scopus 로고    scopus 로고
    • Update on statin-mediated anti-inflammatory activities in atherosclerosis
    • DOI 10.1007/s00281-009-0150-y
    • Montecucco F, Mach F. Update on statin-mediated anti-inflammatory activities in atherosclerosis. Semin Immunopathol 2009; DOI 10.1007/s00281-009- 0150-y
    • (2009) Semin Immunopathol
    • Montecucco, F.1    MacH, F.2
  • 15
    • 60849096661 scopus 로고    scopus 로고
    • The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: Evidence from clinical trials
    • Alsheikh-Ali AA, Karas RH. The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: Evidence from clinical trials. Curr Atheroscler Rep 2009;11:100-104
    • (2009) Curr Atheroscler Rep , vol.11 , pp. 100-104
    • Alsheikh-Ali, A.A.1    Karas, R.H.2
  • 16
    • 34247267133 scopus 로고    scopus 로고
    • Safety of aggressive lipid management
    • Davidson MH, Robinson JG. Safety of aggressive lipid management. J Am Coll Cardiol 2007;49:1753-1762
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1753-1762
    • Davidson, M.H.1    Robinson, J.G.2
  • 17
    • 10744221008 scopus 로고    scopus 로고
    • Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    • Altmann SW, Davis HR Jr, Zhu LJ, et al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004;303:1201-1204
    • (2004) Science , vol.303 , pp. 1201-1204
    • Altmann, S.W.1    Davis Jr., H.R.2    Zhu, L.J.3
  • 18
    • 66149156588 scopus 로고    scopus 로고
    • Statin and ezetimibe combination therapy in cardiovascular disease
    • Dembowski E, Davidson MH. Statin and ezetimibe combination therapy in cardiovascular disease. Curr Opin Endocrinol Diabetes Obes 2009;16:183-188
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 183-188
    • Dembowski, E.1    Davidson, M.H.2
  • 19
    • 41649107358 scopus 로고    scopus 로고
    • Simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Kastelein JJ, Akdim F, Stroes ES, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008;358:1431-1443
    • (2008) N Engl J Med , vol.358 , pp. 1431-1443
    • Kastelein, J.J.1    Akdim, F.2    Stroes, E.S.3
  • 20
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008;359:1343-1356
    • (2008) N Engl J Med , vol.359 , pp. 1343-1356
    • Rossebø, A.B.1    Pedersen, T.R.2    Boman, K.3
  • 21
    • 2342574933 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: A randomized, double-blind, placebo-controlled trial
    • Goldberg AC, Sapre A, Liu J, et al. Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: A randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004;79:620-629
    • (2004) Mayo Clin Proc , vol.79 , pp. 620-629
    • Goldberg, A.C.1    Sapre, A.2    Liu, J.3
  • 22
    • 0037132598 scopus 로고    scopus 로고
    • Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia
    • Davidson MH, McGarry T, Bettis R, et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-2134
    • (2002) J Am Coll Cardiol , vol.40 , pp. 2125-2134
    • Davidson, M.H.1    McGarry, T.2    Bettis, R.3
  • 23
    • 70350370453 scopus 로고    scopus 로고
    • Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men
    • [Epub ahead of print]
    • Sudhop T, Reber M, Tribble D, et al. Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men. J Lipid Res 2009. [Epub ahead of print]
    • (2009) J Lipid Res
    • Sudhop, T.1    Reber, M.2    Tribble, D.3
  • 25
    • 2342428971 scopus 로고    scopus 로고
    • Toward a role for statins in immunomodulation
    • Mach F. Toward a role for statins in immunomodulation. Mol Interv 2002;2:478-480
    • (2002) Mol Interv , vol.2 , pp. 478-480
    • MacH, F.1
  • 26
    • 0035138445 scopus 로고    scopus 로고
    • Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia
    • Musial J, Undas A, Gajewski P, et al. Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia. Int J Cardiol 2001;77:247-253
    • (2001) Int J Cardiol , vol.77 , pp. 247-253
    • Musial, J.1    Undas, A.2    Gajewski, P.3
  • 27
    • 0034730781 scopus 로고    scopus 로고
    • Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells
    • Hernández-Perera O, Pérez-Sala D, Soria E, et al. Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res 2000;87:616-622
    • (2000) Circ Res , vol.87 , pp. 616-622
    • Hernández-Perera, O.1    Pérez-Sala, D.2    Soria, E.3
  • 28
    • 34547951311 scopus 로고    scopus 로고
    • High dosage of simvastatin reduces TNF-alpha-induced apoptosis of endothelial progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro
    • Henrich D, Seebach C, Wilhelm K, et al. High dosage of simvastatin reduces TNF-alpha-induced apoptosis of endothelial progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro. J Surg Res 2007;142:13-19
    • (2007) J Surg Res , vol.142 , pp. 13-19
    • Henrich, D.1    Seebach, C.2    Wilhelm, K.3
  • 29
    • 54049113083 scopus 로고    scopus 로고
    • Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation
    • Spiel AO, Mayr FB, Leitner JM, et al. Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation. Thromb Res 2008;123:108-113
    • (2008) Thromb Res , vol.123 , pp. 108-113
    • Spiel, A.O.1    Mayr, F.B.2    Leitner, J.M.3
  • 30
    • 44849126759 scopus 로고    scopus 로고
    • Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products
    • Liang YJ, Shyu KG, Wang BW, et al. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. Cardiology 2008;110:182-190
    • (2008) Cardiology , vol.110 , pp. 182-190
    • Liang, Y.J.1    Shyu, K.G.2    Wang, B.W.3
  • 31
    • 49749111057 scopus 로고    scopus 로고
    • Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow
    • Eccles KA, Sowden H, Porter KE, et al. Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow. Atherosclerosis 2008;200:69-79
    • (2008) Atherosclerosis , vol.200 , pp. 69-79
    • Eccles, K.A.1    Sowden, H.2    Porter, K.E.3
  • 32
    • 58149314288 scopus 로고    scopus 로고
    • Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose-response effect dependent on endothelial nitric oxide synthase
    • Chen H, Ren JY, Xing Y, et al. Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose-response effect dependent on endothelial nitric oxide synthase. Int J Cardiol 2009;131:313-320
    • (2009) Int J Cardiol , vol.131 , pp. 313-320
    • Chen, H.1    Ren, J.Y.2    Xing, Y.3
  • 33
    • 3843150632 scopus 로고    scopus 로고
    • Aortic eNOS expression and phosphorylation in Apo-E knockout mice: Differing effects of rapamycin and simvastatin
    • Naoum JJ, Zhang S, Woodside KJ, et al. Aortic eNOS expression and phosphorylation in Apo-E knockout mice: Differing effects of rapamycin and simvastatin. Surgery 2004;136:323-328
    • (2004) Surgery , vol.136 , pp. 323-328
    • Naoum, J.J.1    Zhang, S.2    Woodside, K.J.3
  • 34
    • 59049103155 scopus 로고    scopus 로고
    • Evidence for statin pleiotropy in humans: Differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation
    • Liu PY. Liu YW, Lin LJ, et al. Evidence for statin pleiotropy in humans: Differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circulation 2009;119:131-138
    • (2009) Circulation , vol.119 , pp. 131-138
    • Liu, P.Y.1    Liu, Y.W.2    Lin, L.J.3
  • 35
    • 33746473678 scopus 로고    scopus 로고
    • Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
    • Veillard NR, Braunersreuther V, Arnaud C, et al. Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 2006;188:51-58
    • (2006) Atherosclerosis , vol.188 , pp. 51-58
    • Veillard, N.R.1    Braunersreuther, V.2    Arnaud, C.3
  • 36
    • 15444368304 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo
    • Han KH, Ryu J, Hong KH, et al. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation 2005;111:1439-1447
    • (2005) Circulation , vol.111 , pp. 1439-1447
    • Han, K.H.1    Ryu, J.2    Hong, K.H.3
  • 37
    • 61349091828 scopus 로고    scopus 로고
    • Statins inhibit C-reactive protein-induced chemokine secretion ICAM-1 upregulation and chemotaxis in adherent human monocytes
    • Montecucco F, Burger F, Pelli G, et al. Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes. Rheumatology (Oxford) 2009;48:233-242
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 233-242
    • Montecucco, F.1    Burger, F.2    Pelli, G.3
  • 38
    • 0030913270 scopus 로고    scopus 로고
    • Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity
    • Day AP, Bellavia S, Jones OT, et al. Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity. Ann Clin Biochem 1997;34:269-275
    • (1997) Ann Clin Biochem , vol.34 , pp. 269-275
    • Day, A.P.1    Bellavia, S.2    Jones, O.T.3
  • 39
    • 0033779741 scopus 로고    scopus 로고
    • The influence of treatment of hypercholesterolemic patients with simvastatin on plasma chemotactic activity and adherence of neutrophils
    • Deskur-Smielecka E, Wykretowicz A, Banaszak A, et al. The influence of treatment of hypercholesterolemic patients with simvastatin on plasma chemotactic activity and adherence of neutrophils. Int J Cardiol 2000;75:85-90
    • (2000) Int J Cardiol , vol.75 , pp. 85-90
    • Deskur-Smielecka, E.1    Wykretowicz, A.2    Banaszak, A.3
  • 40
    • 0031830852 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors pravastatin and simvastatin inhibit human B-lymphocyte activation
    • Rudich SM, Mongini PK, Perez RV, et al. HMG-CoA reductase inhibitors pravastatin and simvastatin inhibit human B-lymphocyte activation. Transplant Proc 1998;30:992-995
    • (1998) Transplant Proc , vol.30 , pp. 992-995
    • Rudich, S.M.1    Mongini, P.K.2    Perez, R.V.3
  • 41
    • 16344370063 scopus 로고    scopus 로고
    • Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases
    • Ghittoni R, Patrussi L, Pirozzi K, et al. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J 2005;19:605-607
    • (2005) FASEB J , vol.19 , pp. 605-607
    • Ghittoni, R.1    Patrussi, L.2    Pirozzi, K.3
  • 42
    • 34547588531 scopus 로고    scopus 로고
    • Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue
    • Evans J, Powell JT, Schwalbe E, et al. Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg 2007;34:302-303
    • (2007) Eur J Vasc Endovasc Surg , vol.34 , pp. 302-303
    • Evans, J.1    Powell, J.T.2    Schwalbe, E.3
  • 43
    • 34247347733 scopus 로고    scopus 로고
    • Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation
    • Ferri N, Colombo G, Ferrandi C, et al. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol 2007;27:1043-1049
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1043-1049
    • Ferri, N.1    Colombo, G.2    Ferrandi, C.3
  • 44
    • 33645104706 scopus 로고    scopus 로고
    • Effects of simvastatin withdrawal on serum matrix metalloproteinases in hypercholesterolaemic patients
    • Huang CY, Wu TC, Lin WT, et al. Effects of simvastatin withdrawal on serum matrix metalloproteinases in hypercholesterolaemic patients. Eur J Clin Invest 2006;36:76-84
    • (2006) Eur J Clin Invest , vol.36 , pp. 76-84
    • Huang, C.Y.1    Wu, T.C.2    Lin, W.T.3
  • 45
    • 0037625637 scopus 로고    scopus 로고
    • Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages
    • Luan Z, Chase AJ, Newby AC. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol 2003;23:769-775
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 769-775
    • Luan, Z.1    Chase, A.J.2    Newby, A.C.3
  • 46
    • 33846273797 scopus 로고    scopus 로고
    • Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: The PIOSTAT Study
    • Hanefeld M, Marx N, Pfützner A, et al. Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: The PIOSTAT Study. J Am Coll Cardiol 2007;49:290-297
    • (2007) J Am Coll Cardiol , vol.49 , pp. 290-297
    • Hanefeld, M.1    Marx, N.2    Pfützner, A.3
  • 47
    • 20144379879 scopus 로고    scopus 로고
    • Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: New evidence for direct antiinflammatory effects of statins
    • Arnaud C, Burger F, Steffens S, et al. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arterioscler Thromb Vasc Biol 2005;25:1231-1236
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1231-1236
    • Arnaud, C.1    Burger, F.2    Steffens, S.3
  • 48
    • 34249875675 scopus 로고    scopus 로고
    • Comparison of effects of ezetimibe/ simvastatin versus simvastatin versus atorvastatin in reducing C-reactive protein and low-density lipoprotein cholesterol levels
    • Pearson T, Ballantyne C, Sisk C, et al. Comparison of effects of ezetimibe/ simvastatin versus simvastatin versus atorvastatin in reducing C-reactive protein and low-density lipoprotein cholesterol levels. Am J Cardiol 2007;99:1706-1713
    • (2007) Am J Cardiol , vol.99 , pp. 1706-1713
    • Pearson, T.1    Ballantyne, C.2    Sisk, C.3
  • 49
    • 0034776367 scopus 로고    scopus 로고
    • Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function
    • van Heek M, Farley C, Compton DS, et al. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br J Pharmacol 2001;134:409-417
    • (2001) Br J Pharmacol , vol.134 , pp. 409-417
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3
  • 50
    • 1442335817 scopus 로고    scopus 로고
    • Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia
    • Salen G, von Bergmann K, Lütjohann D, et al. Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. Circulation 2004;109:966-971
    • (2004) Circulation , vol.109 , pp. 966-971
    • Salen, G.1    Von Bergmann, K.2    Lütjohann, D.3
  • 51
    • 0034003105 scopus 로고    scopus 로고
    • Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
    • van Heek M, Farley C, Compton DS, et al. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br J Pharmacol 2000;129:1748-1754
    • (2000) Br J Pharmacol , vol.129 , pp. 1748-1754
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3
  • 53
    • 19544371758 scopus 로고    scopus 로고
    • Ezetimibe: A review of its metabolism, pharmacokinetics and drug interactions
    • Kosoglou T, Statkevich P, Johnson-Levonas AO, et al. Ezetimibe: A review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet 2005;44:467-494
    • (2005) Clin Pharmacokinet , vol.44 , pp. 467-494
    • Kosoglou, T.1    Statkevich, P.2    Johnson-Levonas, A.O.3
  • 54
    • 0034765624 scopus 로고    scopus 로고
    • The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs
    • Davis HR Jr, Pula KK, Alton KB, et al. The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs. Metabolism 2001;50:1234-1241
    • (2001) Metabolism , vol.50 , pp. 1234-1241
    • Davis Jr., H.R.1    Pula, K.K.2    Alton, K.B.3
  • 55
    • 34547950892 scopus 로고    scopus 로고
    • Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis
    • Mäki-Petäjä KM, Booth AD, Hall FC, et al. Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. J Am Coll Cardiol 2007;50:852-858
    • (2007) J Am Coll Cardiol , vol.50 , pp. 852-858
    • Mäki-Petäjä, K.M.1    Booth, A.D.2    Hall, F.C.3
  • 56
    • 58749090559 scopus 로고    scopus 로고
    • Pooled analyses of effects on C-reactive protein and low density lipoprotein cholesterol in placebo-controlled trials of ezetimibe monotherapy or ezetimibe added to baseline statin therapy
    • Pearson TA, Ballantyne CM, Veltri E, et al. Pooled analyses of effects on C-reactive protein and low density lipoprotein cholesterol in placebo-controlled trials of ezetimibe monotherapy or ezetimibe added to baseline statin therapy. Am J Cardiol 2009;103:369-374
    • (2009) Am J Cardiol , vol.103 , pp. 369-374
    • Pearson, T.A.1    Ballantyne, C.M.2    Veltri, E.3
  • 57
    • 57649213900 scopus 로고    scopus 로고
    • Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice
    • Kuhlencordt PJ, Padmapriya P, Rützel S, et al. Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice. Atherosclerosis 2009;202:48-57
    • (2009) Atherosclerosis , vol.202 , pp. 48-57
    • Kuhlencordt, P.J.1    Padmapriya, P.2    Rützel, S.3
  • 58
    • 68749102069 scopus 로고    scopus 로고
    • Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect
    • doi:10.1111/j.1476-5381.2008.00091.x
    • Gomez-Garre D, Munoz-Pacheco P, Gonzalez-Rubio M, et al. Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect. Br J Pharmacol 2009; doi:10.1111/j.1476-5381.2008.00091.x
    • (2009) Br J Pharmacol
    • Gomez-Garre, D.1    Munoz-Pacheco, P.2    Gonzalez-Rubio, M.3
  • 59
    • 33947424291 scopus 로고    scopus 로고
    • Total and low-density lipoprotein cholesterol responses to ezetimibe in clinical practice
    • Capps N. Total and low-density lipoprotein cholesterol responses to ezetimibe in clinical practice. Int J Clin Pract 2006;60:867-869
    • (2006) Int J Clin Pract , vol.60 , pp. 867-869
    • Capps, N.1
  • 60
    • 34249005579 scopus 로고    scopus 로고
    • Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia
    • Kalogirou M, Tsimihodimos V, Gazi I, et al. Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia. Curr Med Res Opin 2007;23:1169-1176
    • (2007) Curr Med Res Opin , vol.23 , pp. 1169-1176
    • Kalogirou, M.1    Tsimihodimos, V.2    Gazi, I.3
  • 61
    • 37449028932 scopus 로고    scopus 로고
    • Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: An exploratory analysis of archived samples using two commercially available techniques
    • Ose L, Reyes R, Johnson-Levonas AO, et al. Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: An exploratory analysis of archived samples using two commercially available techniques. Clin Ther 2007;29:2419-2432
    • (2007) Clin Ther , vol.29 , pp. 2419-2432
    • Ose, L.1    Reyes, R.2    Johnson-Levonas, A.O.3
  • 62
    • 59449101190 scopus 로고    scopus 로고
    • The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia
    • Nakou ES, Filippatos TD, Kiortsis DN, et al. The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia. Expert Opin Pharmacother 2008;9:3151-863.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 3151-3863
    • Nakou, E.S.1    Filippatos, T.D.2    Kiortsis, D.N.3
  • 63
    • 43849104295 scopus 로고    scopus 로고
    • Effects of fenofibrate and ezetimibe, both as monotherapy and in coadministration, on cholesterol mass within lipoprotein subfractions and low-density lipoprotein peak particle size in patients with mixed hyperlipidemia
    • Tribble DL, Farnier M, Macdonell G, et al. Effects of fenofibrate and ezetimibe, both as monotherapy and in coadministration, on cholesterol mass within lipoprotein subfractions and low-density lipoprotein peak particle size in patients with mixed hyperlipidemia. Metabolism 2008;57:796-801
    • (2008) Metabolism , vol.57 , pp. 796-801
    • Tribble, D.L.1    Farnier, M.2    MacDonell, G.3
  • 64
    • 69349101542 scopus 로고    scopus 로고
    • Effect of ezetimibe/simvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia
    • doi:10.1111/j.1463-1326.2009.01061.x
    • Tomassini JE, Mazzone T, Goldberg RB, et al. Effect of ezetimibe/simvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia. Diabetes Obes Metab 2009; doi:10.1111/j.1463-1326.2009.01061.x
    • (2009) Diabetes Obes Metab
    • Tomassini, J.E.1    Mazzone, T.2    Goldberg, R.B.3
  • 65
    • 18244390229 scopus 로고    scopus 로고
    • A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The ezetimibe add-on to statin for effectiveness (EASE) trial
    • Pearson TA, Denke MA, McBride PE, et al. A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The ezetimibe add-on to statin for effectiveness (EASE) trial. Mayo Clin Proc 2005;80:587-595
    • (2005) Mayo Clin Proc , vol.80 , pp. 587-595
    • Pearson, T.A.1    Denke, M.A.2    McBride, P.E.3
  • 66
    • 17844410923 scopus 로고    scopus 로고
    • Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) study
    • Ballantyne CM, Abate N, Yuan Z, et al. Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) study. Am Heart J 2005;149:464-473
    • (2005) Am Heart J , vol.149 , pp. 464-473
    • Ballantyne, C.M.1    Abate, N.2    Yuan, Z.3
  • 67
    • 0037132598 scopus 로고    scopus 로고
    • Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia
    • Davidson MH, McGarry T, Bettis R, et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-2134
    • (2002) J Am Coll Cardiol , vol.40 , pp. 2125-2134
    • Davidson, M.H.1    McGarry, T.2    Bettis, R.3
  • 68
    • 33845296148 scopus 로고    scopus 로고
    • Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: The VYTAL study
    • Goldberg RB, Guyton JR, Mazzone T, et al. Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: The VYTAL study. Mayo Clin Proc 2006;81:1579-1588
    • (2006) Mayo Clin Proc , vol.81 , pp. 1579-1588
    • Goldberg, R.B.1    Guyton, J.R.2    Mazzone, T.3
  • 69
    • 62549118503 scopus 로고    scopus 로고
    • Lipid-altering efficacy of ezetimibe/ simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study
    • Farnier M, Averna M, Missault L, et al. Lipid-altering efficacy of ezetimibe/ simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study. Int J Clin Pract 2009;63:547-559
    • (2009) Int J Clin Pract , vol.63 , pp. 547-559
    • Farnier, M.1    Averna, M.2    Missault, L.3
  • 70
    • 57449084685 scopus 로고    scopus 로고
    • Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: More clarity or confusion?
    • Stein EA. Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: more clarity or confusion? J Am Coll Cardiol 2008;52:2206-2209
    • (2008) J Am Coll Cardiol , vol.52 , pp. 2206-2209
    • Stein, E.A.1
  • 71
    • 57449105069 scopus 로고    scopus 로고
    • Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial
    • Fleg JL, Mete M, Howard BV, et al. Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial. J Am Coll Cardiol 2008;52:2198-2205
    • (2008) J Am Coll Cardiol , vol.52 , pp. 2198-2205
    • Fleg, J.L.1    Mete, M.2    Howard, B.V.3
  • 72
    • 67650475384 scopus 로고    scopus 로고
    • The Vytorin on Carotid Intima-Media Thickness and Overall Arterial Rigidity (VYCTOR) Study
    • Meaney A, Ceballos G, Asbun J, et al. The Vytorin on Carotid Intima-Media Thickness and Overall Arterial Rigidity (VYCTOR) Study. J Clin Pharmacol 2009;49:838-847
    • (2009) J Clin Pharmacol , vol.49 , pp. 838-847
    • Meaney, A.1    Ceballos, G.2    Asbun, J.3
  • 73
    • 0021846720 scopus 로고
    • Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia
    • Sugrue DD, Trayner I, Thompson GR, et al. Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia. Br Heart J 1985;53:265-268
    • (1985) Br Heart J , vol.53 , pp. 265-268
    • Sugrue, D.D.1    Trayner, I.2    Thompson, G.R.3
  • 74
    • 40449111044 scopus 로고    scopus 로고
    • Lipid-altering efficacy of ezetimibe/ simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: The INFORCE study
    • Reckless JP, Henry P, Pomykaj T, et al. Lipid-altering efficacy of ezetimibe/ simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: The INFORCE study. Int J Clin Pract 2008;62:539-554
    • (2008) Int J Clin Pract , vol.62 , pp. 539-554
    • Reckless, J.P.1    Henry, P.2    Pomykaj, T.3
  • 75
    • 34247530360 scopus 로고    scopus 로고
    • Co-administration of ezetimibe and simvastatin in acute myocardial infarction
    • Chenot F, Montant PF, Marcovitch O, et al. Co-administration of ezetimibe and simvastatin in acute myocardial infarction. Eur J Clin Invest 2007;37:357-363
    • (2007) Eur J Clin Invest , vol.37 , pp. 357-363
    • Chenot, F.1    Montant, P.F.2    Marcovitch, O.3
  • 76
    • 0037407617 scopus 로고    scopus 로고
    • Study of Heart and Renal Protection (SHARP)
    • Baigent C, Landry M. Study of Heart and Renal Protection (SHARP). Kidney Int 2003;63(Suppl 84):S207-10
    • (2003) Kidney Int , vol.63 , Issue.SUPPL. 84
    • Baigent, C.1    Landry, M.2
  • 77
    • 50949102416 scopus 로고    scopus 로고
    • Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    • Cannon CP, Giugliano RP, Blazing MA, et al. Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. Am Heart J 2008;156:826-832
    • (2008) Am Heart J , vol.156 , pp. 826-832
    • Cannon, C.P.1    Giugliano, R.P.2    Blazing, M.A.3
  • 78
    • 70449485117 scopus 로고    scopus 로고
    • Impact of severity of aortic valve stenosis on effect of intensive lipid lowering therapy. Insights from the SEAS study
    • Gerdts E, Rossebo AB, Pedersen TR, et al. Impact of severity of aortic valve stenosis on effect of intensive lipid lowering therapy. Insights from the SEAS study. J Am Coll Cardiol 2009;53(10 Suppl A):A415
    • (2009) J Am Coll Cardiol , vol.53 , Issue.10 SUPPL. A
    • Gerdts, E.1    Rossebo, A.B.2    Pedersen, T.R.3
  • 79
    • 34547950892 scopus 로고    scopus 로고
    • Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis
    • Mäki-Petäjä KM, Booth AD, Hall FC, et al. Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. J Am Coll Cardiol 2007;50:852-858
    • (2007) J Am Coll Cardiol , vol.50 , pp. 852-858
    • Mäki-Petäjä, K.M.1    Booth, A.D.2    Hall, F.C.3
  • 80
    • 61649093065 scopus 로고    scopus 로고
    • Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment
    • Shirinsky IV, Zheltova OI, Solovyova NY, et al. Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment. Scand J Rheumatol 2009;38:23-27
    • (2009) Scand J Rheumatol , vol.38 , pp. 23-27
    • Shirinsky, I.V.1    Zheltova, O.I.2    Solovyova, N.Y.3
  • 81
    • 19944433437 scopus 로고    scopus 로고
    • Simvastatin improves endothelial function in patients with rheumatoid arthritis
    • Hermann F, Forster A, Chenevard R, et al. Simvastatin improves endothelial function in patients with rheumatoid arthritis. J Am Coll Cardiol 2005;45:461-464
    • (2005) J Am Coll Cardiol , vol.45 , pp. 461-464
    • Hermann, F.1    Forster, A.2    Chenevard, R.3
  • 82
    • 56449107482 scopus 로고    scopus 로고
    • Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy
    • Westerweel PE, Visseren FL, Hajer GR, et al. Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy. Eur Heart J 2008;29:2808-2817
    • (2008) Eur Heart J , vol.29 , pp. 2808-2817
    • Westerweel, P.E.1    Visseren, F.L.2    Hajer, G.R.3
  • 83
    • 57649176432 scopus 로고    scopus 로고
    • The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients
    • Hajer GR, Dallinga-Thie GM, van Vark-van der Zee LC, et al. The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients. Atherosclerosis 2009;202:216-224
    • (2009) Atherosclerosis , vol.202 , pp. 216-224
    • Hajer, G.R.1    Dallinga-Thie, G.M.2    Van Vark-Van Der Zee, L.C.3
  • 84
    • 56149091842 scopus 로고    scopus 로고
    • The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: A randomized double-blind crossover trial
    • Olijhoek JK, Hajer GR, van der Graaf Y, et al. The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: A randomized double-blind crossover trial. J Cardiovasc Pharmacol 2008;52:145-150
    • (2008) J Cardiovasc Pharmacol , vol.52 , pp. 145-150
    • Olijhoek, J.K.1    Hajer, G.R.2    Van Der Graaf, Y.3
  • 85
    • 33845876333 scopus 로고    scopus 로고
    • Risks associated with statin therapy: A systematic overview of randomized clinical trials
    • Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: A systematic overview of randomized clinical trials. Circulation 2006;114:2788-2797
    • (2006) Circulation , vol.114 , pp. 2788-2797
    • Kashani, A.1    Phillips, C.O.2    Foody, J.M.3
  • 86
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law M, Rudnicka AR. Statin safety: A systematic review. Am J Cardiol 2006;97:52C-60C
    • (2006) Am J Cardiol , vol.97
    • Law, M.1    Rudnicka, A.R.2
  • 87
    • 65749097599 scopus 로고    scopus 로고
    • Effects of Simvastatin 40mg Daily on Muscle and Liver Adverse Effects in A 5-year Randomized Placebo-controlled Trial in 20,536 High-risk People
    • MRC/BHF Heart Protection Study Collaborative Group. Effects of simvastatin 40mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people. BMC Clin Pharmacol 2009;9:6
    • (2009) BMC Clin Pharmacol , vol.9 , pp. 6
  • 88
    • 33751096467 scopus 로고    scopus 로고
    • SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
    • Pasanen MK, Neuvonen M, Neuvonen PJ, et al. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics 2006;16:873-879
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 873-879
    • Pasanen, M.K.1    Neuvonen, M.2    Neuvonen, P.J.3
  • 89
    • 34250890634 scopus 로고    scopus 로고
    • Phytosterols as anticancer compounds
    • Bradford PG, Awad AB. Phytosterols as anticancer compounds. Mol Nutr Food Res 2007;51:161-170
    • (2007) Mol Nutr Food Res , vol.51 , pp. 161-170
    • Bradford, P.G.1    Awad, A.B.2
  • 90
    • 59149086732 scopus 로고    scopus 로고
    • After the failure of ENHANCEd cholesterol lowering in familial hypercholesterolemia,SEAS of problems with ezetimibe
    • Mascitelli L, Ravnskov U, Pezzetta F, et al. After the failure of ENHANCEd cholesterol lowering in familial hypercholesterolemia, SEAS of problems with ezetimibe. Angiology 2009;60:127-128
    • (2009) Angiology , vol.60 , pp. 127-128
    • Mascitelli, L.1    Ravnskov, U.2    Pezzetta, F.3
  • 91
    • 52649138998 scopus 로고    scopus 로고
    • Analyses of cancer data from three ezetimibe trials
    • Peto R, Emberson J, Landray M, et al. Analyses of cancer data from three ezetimibe trials. N Engl J Med 2008;359:1357-1366
    • (2008) N Engl J Med , vol.359 , pp. 1357-1366
    • Peto, R.1    Emberson, J.2    Landray, M.3
  • 92
    • 64249120001 scopus 로고    scopus 로고
    • Ezetimibe monotherapy for cholesterol lowering in 2,722 people: Systematic review and meta-analysis of randomized controlled trials
    • Pandor A. Ara R.M. Tumur I. et al. Ezetimibe monotherapy for cholesterol lowering in 2,722 people: Systematic review and meta-analysis of randomized controlled trials J Intern Med 2009 265 568-8093.
    • (2009) J Intern Med , vol.265 , pp. 568-8093
    • Pandor, A.1    Ara, R.M.2    Tumur, I.3
  • 93
    • 38649095993 scopus 로고    scopus 로고
    • Screening statins for possible carcinogenic risk: Up to 9 years of follow-up of 361,859 recipients
    • Pandor A, Ara RM, Tumur I, et al. Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials. J Intern Med 2009;265:568-8093. Friedman GD, Flick ED, Udaltsova N, et al. Screening statins for possible carcinogenic risk: up to 9 years of follow-up of 361,859 recipients. Pharmacoepidemiol Drug Saf 2008;17:27-36
    • (2008) Pharmacoepidemiol Drug Saf , vol.17 , pp. 27-36
    • Friedman, G.D.1    Flick, E.D.2    Udaltsova, N.3
  • 94
    • 61349115459 scopus 로고    scopus 로고
    • An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach
    • Halleck M, Davis HR, Kirschmeier P, et al. An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach. Toxicology 2009;258:116-130
    • (2009) Toxicology , vol.258 , pp. 116-130
    • Halleck, M.1    Davis, H.R.2    Kirschmeier, P.3
  • 95
    • 62549086930 scopus 로고    scopus 로고
    • Ezetimibe is an inhibitor of tumor angiogenesis
    • Solomon KR, Pelton K, Boucher K, et al. Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol 2009;174:1017-1026
    • (2009) Am J Pathol , vol.174 , pp. 1017-1026
    • Solomon, K.R.1    Pelton, K.2    Boucher, K.3
  • 96
    • 67649401873 scopus 로고    scopus 로고
    • Long-term safety and tolerability of ezetimibe coadministered with simvastatin in hypercholesterolemic patients: A randomized, 12-month double-blind extension study
    • Strony J, Yang B, Hanson ME, et al. Long-term safety and tolerability of ezetimibe coadministered with simvastatin in hypercholesterolemic patients: A randomized, 12-month double-blind extension study. Curr Med Res Opin 2008;24:3149-3157
    • (2008) Curr Med Res Opin , vol.24 , pp. 3149-3157
    • Strony, J.1    Yang, B.2    Hanson, M.E.3
  • 97
    • 53449088738 scopus 로고    scopus 로고
    • Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia
    • van der Graaf A, Cuffie-Jackson C, Vissers MN, et al. Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia. J Am Coll Cardiol 2008;52:1421-1429
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1421-1429
    • Van Der Graaf, A.1    Cuffie-Jackson, C.2    Vissers, M.N.3
  • 98
    • 58349089823 scopus 로고    scopus 로고
    • Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: Results from two open-label extension studies in hypercholesterolemic patients
    • Strony J, Hoffman R, Hanson M, et al. Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: Results from two open-label extension studies in hypercholesterolemic patients. Clin Ther 2008;30:2280-2297
    • (2008) Clin Ther , vol.30 , pp. 2280-2297
    • Strony, J.1    Hoffman, R.2    Hanson, M.3
  • 99
    • 0037395141 scopus 로고    scopus 로고
    • Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia
    • Knopp RH, Gitter H, Truitt T, et al. Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur Heart J 2003;24:729-741
    • (2003) Eur Heart J , vol.24 , pp. 729-741
    • Knopp, R.H.1    Gitter, H.2    Truitt, T.3
  • 100
    • 0037111924 scopus 로고    scopus 로고
    • Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia
    • Dujovne CA, Ettinger MP, McNeer JF, et al. Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol 2002;90:1092-1097
    • (2002) Am J Cardiol , vol.90 , pp. 1092-1097
    • Dujovne, C.A.1    Ettinger, M.P.2    McNeer, J.F.3
  • 101
    • 31344444438 scopus 로고    scopus 로고
    • Striated muscle safety of ezetimibe/simvastatin (Vytorin)
    • Davidson MH, Maccubbin D, Stepanavage M, et al. Striated muscle safety of ezetimibe/simvastatin (Vytorin). Am J Cardiol 2006;97:223-228
    • (2006) Am J Cardiol , vol.97 , pp. 223-228
    • Davidson, M.H.1    MacCubbin, D.2    Stepanavage, M.3
  • 102
    • 0037387192 scopus 로고    scopus 로고
    • Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatement with minimum side effects in 51,321 Japanese hypercholesterolemic patients
    • Matsuzawa Y, Kita T, Mabuchi H, et al. Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatement with minimum side effects in 51,321 Japanese hypercholesterolemic patients. Circ J 2003;67:287-294
    • (2003) Circ J , vol.67 , pp. 287-294
    • Matsuzawa, Y.1    Kita, T.2    Mabuchi, H.3
  • 103
    • 4544243333 scopus 로고    scopus 로고
    • Early intesive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: Phase Z of the A to Z trial
    • de Lemos JA, Blazing MA, Wiviott SD, et al. Early intesive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: Phase Z of the A to Z trial. JAMA 2004;292:1307-1316
    • (2004) JAMA , vol.292 , pp. 1307-1316
    • De Lemos, J.A.1    Blazing, M.A.2    Wiviott, S.D.3
  • 104
    • 0024990522 scopus 로고
    • Pharmacology and mechanism of action of the new HMG-CoA reductase inhibitors
    • Sirtori CR. Pharmacology and mechanism of action of the new HMG-CoA reductase inhibitors. Pharmacol Res 1990;22:555-563
    • (1990) Pharmacol Res , vol.22 , pp. 555-563
    • Sirtori, C.R.1
  • 105
    • 19844378287 scopus 로고    scopus 로고
    • Adverse events with concomitant amiodarone and statin therapy
    • Alsheikh-Ali AA, Karas RH. Adverse events with concomitant amiodarone and statin therapy. Prev Cardiol 2005;8:95-97
    • (2005) Prev Cardiol , vol.8 , pp. 95-97
    • Alsheikh-Ali, A.A.1    Karas, R.H.2
  • 106
    • 11344285421 scopus 로고    scopus 로고
    • Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia
    • DOI 10.2165/00002512-200421150-00005
    • Lipka L, Sager P, Strony J, et al. Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia. Drugs Aging 2004;21:1025-1032 (Pubitemid 40075727)
    • (2004) Drugs and Aging , vol.21 , Issue.15 , pp. 1025-1032
    • Lipka, L.1    Sager, P.2    Strony, J.3    Yang, B.4    Suresh, R.5    Veltri, E.6
  • 107
    • 62349126043 scopus 로고    scopus 로고
    • Ezetimibe, and the combination of ezetimibe/ simvastatin, and risk of cancer: A post-marketing analysis
    • Alsheikh-Ali AA, Karas RH. Ezetimibe, and the combination of ezetimibe/ simvastatin, and risk of cancer: A post-marketing analysis. J Clin Lipidol 2009;3:138-142
    • (2009) J Clin Lipidol , vol.3 , pp. 138-142
    • Alsheikh-Ali, A.A.1    Karas, R.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.