-
1
-
-
70049110201
-
Interventions in the management of serum lipids for preventing stroke recurrence
-
Manktelow BN, Potter JF. Interventions in the management of serum lipids for preventing stroke recurrence. Cochrane Database Syst Rev 2009;(3): CD002091
-
(2009)
Cochrane Database Syst Rev
, Issue.3
-
-
Manktelow, B.N.1
Potter, J.F.2
-
2
-
-
0342981862
-
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
-
Cholesterol and Recurrent Events Trial investigators
-
Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996;335:1001-1009
-
(1996)
N Engl J Med
, vol.335
, pp. 1001-1009
-
-
Sacks, F.M.1
Pfeffer, M.A.2
Moye, L.A.3
-
3
-
-
0027987849
-
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S)
-
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S). Lancet 1994;344:1383-1389
-
(1994)
Lancet
, vol.344
, pp. 1383-1389
-
-
-
4
-
-
0037031061
-
MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
-
Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002;360:7-22
-
(2002)
Lancet
, vol.360
, pp. 7-22
-
-
-
5
-
-
0032487931
-
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
-
The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
-
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med 1998;339:1349-1357
-
(1998)
N Engl J Med
, vol.339
, pp. 1349-1357
-
-
-
6
-
-
0028883828
-
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
-
West of Scotland Coronary Prevention Study Group
-
Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995;333:1301-1307
-
(1995)
N Engl J Med
, vol.333
, pp. 1301-1307
-
-
Shepherd, J.1
Cobbe, S.M.2
Ford, I.3
-
7
-
-
27644544308
-
Pleiotropic effects of statins: Benefit beyond cholesterol reduction? A meta-regression analysis
-
Robinson JG, Smith B, Maheshwari N, et al. Pleiotropic effects of statins: Benefit beyond cholesterol reduction? A meta-regression analysis. J AmColl Cardiol 2005;46:1855-1862
-
(2005)
J AmColl Cardiol
, vol.46
, pp. 1855-1862
-
-
Robinson, J.G.1
Smith, B.2
Maheshwari, N.3
-
8
-
-
18444374227
-
Clinical significance of statin pleiotropic effects: Hypotheses versus evidence
-
Davidson MH. Clinical significance of statin pleiotropic effects: Hypotheses versus evidence. Circulation 2005;111:2280-2281
-
(2005)
Circulation
, vol.111
, pp. 2280-2281
-
-
Davidson, M.H.1
-
9
-
-
0033587667
-
Long-term effects of pravastatin on plasma concentration of C-reactive protein
-
The Cholesterol and Recurrent Events (CARE) Investigators
-
Ridker PM, Rifai N, Pfeffer MA, et al. Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation 1999;100:230-235
-
(1999)
Circulation
, vol.100
, pp. 230-235
-
-
Ridker, P.M.1
Rifai, N.2
Pfeffer, M.A.3
-
10
-
-
0035963529
-
Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
-
Ridker PM, Rifai N, Clearfield M, et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 2001;344:1959-1965
-
(2001)
N Engl J Med
, vol.344
, pp. 1959-1965
-
-
Ridker, P.M.1
Rifai, N.2
Clearfield, M.3
-
11
-
-
0043166521
-
Statins promote potent systemic antioxidant effects through specific inflammatory pathways
-
Shishehbor MH, Brennan ML, Aviles RJ, et al. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation 2003;108:426-431
-
(2003)
Circulation
, vol.108
, pp. 426-431
-
-
Shishehbor, M.H.1
Brennan, M.L.2
Aviles, R.J.3
-
12
-
-
0032584177
-
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
-
Laufs U, La Fata V, Plutzky J, et al. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998;97:1129-1135
-
(1998)
Circulation
, vol.97
, pp. 1129-1135
-
-
Laufs, U.1
La Fata, V.2
Plutzky, J.3
-
13
-
-
0141430989
-
Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
-
Kleemann R, Princen HM, Emeis JJ, et al. Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin. Circulation 2003;108:1368-1374
-
(2003)
Circulation
, vol.108
, pp. 1368-1374
-
-
Kleemann, R.1
Princen, H.M.2
Emeis, J.J.3
-
14
-
-
67749115977
-
Update on statin-mediated anti-inflammatory activities in atherosclerosis
-
DOI 10.1007/s00281-009-0150-y
-
Montecucco F, Mach F. Update on statin-mediated anti-inflammatory activities in atherosclerosis. Semin Immunopathol 2009; DOI 10.1007/s00281-009- 0150-y
-
(2009)
Semin Immunopathol
-
-
Montecucco, F.1
MacH, F.2
-
15
-
-
60849096661
-
The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: Evidence from clinical trials
-
Alsheikh-Ali AA, Karas RH. The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: Evidence from clinical trials. Curr Atheroscler Rep 2009;11:100-104
-
(2009)
Curr Atheroscler Rep
, vol.11
, pp. 100-104
-
-
Alsheikh-Ali, A.A.1
Karas, R.H.2
-
17
-
-
10744221008
-
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
-
Altmann SW, Davis HR Jr, Zhu LJ, et al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004;303:1201-1204
-
(2004)
Science
, vol.303
, pp. 1201-1204
-
-
Altmann, S.W.1
Davis Jr., H.R.2
Zhu, L.J.3
-
18
-
-
66149156588
-
Statin and ezetimibe combination therapy in cardiovascular disease
-
Dembowski E, Davidson MH. Statin and ezetimibe combination therapy in cardiovascular disease. Curr Opin Endocrinol Diabetes Obes 2009;16:183-188
-
(2009)
Curr Opin Endocrinol Diabetes Obes
, vol.16
, pp. 183-188
-
-
Dembowski, E.1
Davidson, M.H.2
-
19
-
-
41649107358
-
Simvastatin with or without ezetimibe in familial hypercholesterolemia
-
Kastelein JJ, Akdim F, Stroes ES, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008;358:1431-1443
-
(2008)
N Engl J Med
, vol.358
, pp. 1431-1443
-
-
Kastelein, J.J.1
Akdim, F.2
Stroes, E.S.3
-
20
-
-
52649120889
-
Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
-
Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008;359:1343-1356
-
(2008)
N Engl J Med
, vol.359
, pp. 1343-1356
-
-
Rossebø, A.B.1
Pedersen, T.R.2
Boman, K.3
-
21
-
-
2342574933
-
Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: A randomized, double-blind, placebo-controlled trial
-
Goldberg AC, Sapre A, Liu J, et al. Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: A randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004;79:620-629
-
(2004)
Mayo Clin Proc
, vol.79
, pp. 620-629
-
-
Goldberg, A.C.1
Sapre, A.2
Liu, J.3
-
22
-
-
0037132598
-
Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia
-
Davidson MH, McGarry T, Bettis R, et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-2134
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 2125-2134
-
-
Davidson, M.H.1
McGarry, T.2
Bettis, R.3
-
23
-
-
70350370453
-
Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men
-
[Epub ahead of print]
-
Sudhop T, Reber M, Tribble D, et al. Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men. J Lipid Res 2009. [Epub ahead of print]
-
(2009)
J Lipid Res
-
-
Sudhop, T.1
Reber, M.2
Tribble, D.3
-
25
-
-
2342428971
-
Toward a role for statins in immunomodulation
-
Mach F. Toward a role for statins in immunomodulation. Mol Interv 2002;2:478-480
-
(2002)
Mol Interv
, vol.2
, pp. 478-480
-
-
MacH, F.1
-
26
-
-
0035138445
-
Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia
-
Musial J, Undas A, Gajewski P, et al. Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia. Int J Cardiol 2001;77:247-253
-
(2001)
Int J Cardiol
, vol.77
, pp. 247-253
-
-
Musial, J.1
Undas, A.2
Gajewski, P.3
-
27
-
-
0034730781
-
Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells
-
Hernández-Perera O, Pérez-Sala D, Soria E, et al. Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res 2000;87:616-622
-
(2000)
Circ Res
, vol.87
, pp. 616-622
-
-
Hernández-Perera, O.1
Pérez-Sala, D.2
Soria, E.3
-
28
-
-
34547951311
-
High dosage of simvastatin reduces TNF-alpha-induced apoptosis of endothelial progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro
-
Henrich D, Seebach C, Wilhelm K, et al. High dosage of simvastatin reduces TNF-alpha-induced apoptosis of endothelial progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro. J Surg Res 2007;142:13-19
-
(2007)
J Surg Res
, vol.142
, pp. 13-19
-
-
Henrich, D.1
Seebach, C.2
Wilhelm, K.3
-
29
-
-
54049113083
-
Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation
-
Spiel AO, Mayr FB, Leitner JM, et al. Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation. Thromb Res 2008;123:108-113
-
(2008)
Thromb Res
, vol.123
, pp. 108-113
-
-
Spiel, A.O.1
Mayr, F.B.2
Leitner, J.M.3
-
30
-
-
44849126759
-
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products
-
Liang YJ, Shyu KG, Wang BW, et al. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. Cardiology 2008;110:182-190
-
(2008)
Cardiology
, vol.110
, pp. 182-190
-
-
Liang, Y.J.1
Shyu, K.G.2
Wang, B.W.3
-
31
-
-
49749111057
-
Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow
-
Eccles KA, Sowden H, Porter KE, et al. Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow. Atherosclerosis 2008;200:69-79
-
(2008)
Atherosclerosis
, vol.200
, pp. 69-79
-
-
Eccles, K.A.1
Sowden, H.2
Porter, K.E.3
-
32
-
-
58149314288
-
Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose-response effect dependent on endothelial nitric oxide synthase
-
Chen H, Ren JY, Xing Y, et al. Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose-response effect dependent on endothelial nitric oxide synthase. Int J Cardiol 2009;131:313-320
-
(2009)
Int J Cardiol
, vol.131
, pp. 313-320
-
-
Chen, H.1
Ren, J.Y.2
Xing, Y.3
-
33
-
-
3843150632
-
Aortic eNOS expression and phosphorylation in Apo-E knockout mice: Differing effects of rapamycin and simvastatin
-
Naoum JJ, Zhang S, Woodside KJ, et al. Aortic eNOS expression and phosphorylation in Apo-E knockout mice: Differing effects of rapamycin and simvastatin. Surgery 2004;136:323-328
-
(2004)
Surgery
, vol.136
, pp. 323-328
-
-
Naoum, J.J.1
Zhang, S.2
Woodside, K.J.3
-
34
-
-
59049103155
-
Evidence for statin pleiotropy in humans: Differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation
-
Liu PY. Liu YW, Lin LJ, et al. Evidence for statin pleiotropy in humans: Differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circulation 2009;119:131-138
-
(2009)
Circulation
, vol.119
, pp. 131-138
-
-
Liu, P.Y.1
Liu, Y.W.2
Lin, L.J.3
-
35
-
-
33746473678
-
Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
-
Veillard NR, Braunersreuther V, Arnaud C, et al. Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 2006;188:51-58
-
(2006)
Atherosclerosis
, vol.188
, pp. 51-58
-
-
Veillard, N.R.1
Braunersreuther, V.2
Arnaud, C.3
-
36
-
-
15444368304
-
HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo
-
Han KH, Ryu J, Hong KH, et al. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation 2005;111:1439-1447
-
(2005)
Circulation
, vol.111
, pp. 1439-1447
-
-
Han, K.H.1
Ryu, J.2
Hong, K.H.3
-
37
-
-
61349091828
-
Statins inhibit C-reactive protein-induced chemokine secretion ICAM-1 upregulation and chemotaxis in adherent human monocytes
-
Montecucco F, Burger F, Pelli G, et al. Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes. Rheumatology (Oxford) 2009;48:233-242
-
(2009)
Rheumatology (Oxford)
, vol.48
, pp. 233-242
-
-
Montecucco, F.1
Burger, F.2
Pelli, G.3
-
38
-
-
0030913270
-
Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity
-
Day AP, Bellavia S, Jones OT, et al. Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity. Ann Clin Biochem 1997;34:269-275
-
(1997)
Ann Clin Biochem
, vol.34
, pp. 269-275
-
-
Day, A.P.1
Bellavia, S.2
Jones, O.T.3
-
39
-
-
0033779741
-
The influence of treatment of hypercholesterolemic patients with simvastatin on plasma chemotactic activity and adherence of neutrophils
-
Deskur-Smielecka E, Wykretowicz A, Banaszak A, et al. The influence of treatment of hypercholesterolemic patients with simvastatin on plasma chemotactic activity and adherence of neutrophils. Int J Cardiol 2000;75:85-90
-
(2000)
Int J Cardiol
, vol.75
, pp. 85-90
-
-
Deskur-Smielecka, E.1
Wykretowicz, A.2
Banaszak, A.3
-
40
-
-
0031830852
-
HMG-CoA reductase inhibitors pravastatin and simvastatin inhibit human B-lymphocyte activation
-
Rudich SM, Mongini PK, Perez RV, et al. HMG-CoA reductase inhibitors pravastatin and simvastatin inhibit human B-lymphocyte activation. Transplant Proc 1998;30:992-995
-
(1998)
Transplant Proc
, vol.30
, pp. 992-995
-
-
Rudich, S.M.1
Mongini, P.K.2
Perez, R.V.3
-
41
-
-
16344370063
-
Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases
-
Ghittoni R, Patrussi L, Pirozzi K, et al. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J 2005;19:605-607
-
(2005)
FASEB J
, vol.19
, pp. 605-607
-
-
Ghittoni, R.1
Patrussi, L.2
Pirozzi, K.3
-
42
-
-
34547588531
-
Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue
-
Evans J, Powell JT, Schwalbe E, et al. Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg 2007;34:302-303
-
(2007)
Eur J Vasc Endovasc Surg
, vol.34
, pp. 302-303
-
-
Evans, J.1
Powell, J.T.2
Schwalbe, E.3
-
43
-
-
34247347733
-
Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation
-
Ferri N, Colombo G, Ferrandi C, et al. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol 2007;27:1043-1049
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 1043-1049
-
-
Ferri, N.1
Colombo, G.2
Ferrandi, C.3
-
44
-
-
33645104706
-
Effects of simvastatin withdrawal on serum matrix metalloproteinases in hypercholesterolaemic patients
-
Huang CY, Wu TC, Lin WT, et al. Effects of simvastatin withdrawal on serum matrix metalloproteinases in hypercholesterolaemic patients. Eur J Clin Invest 2006;36:76-84
-
(2006)
Eur J Clin Invest
, vol.36
, pp. 76-84
-
-
Huang, C.Y.1
Wu, T.C.2
Lin, W.T.3
-
45
-
-
0037625637
-
Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages
-
Luan Z, Chase AJ, Newby AC. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol 2003;23:769-775
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 769-775
-
-
Luan, Z.1
Chase, A.J.2
Newby, A.C.3
-
46
-
-
33846273797
-
Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: The PIOSTAT Study
-
Hanefeld M, Marx N, Pfützner A, et al. Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: The PIOSTAT Study. J Am Coll Cardiol 2007;49:290-297
-
(2007)
J Am Coll Cardiol
, vol.49
, pp. 290-297
-
-
Hanefeld, M.1
Marx, N.2
Pfützner, A.3
-
47
-
-
20144379879
-
Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: New evidence for direct antiinflammatory effects of statins
-
Arnaud C, Burger F, Steffens S, et al. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arterioscler Thromb Vasc Biol 2005;25:1231-1236
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1231-1236
-
-
Arnaud, C.1
Burger, F.2
Steffens, S.3
-
48
-
-
34249875675
-
Comparison of effects of ezetimibe/ simvastatin versus simvastatin versus atorvastatin in reducing C-reactive protein and low-density lipoprotein cholesterol levels
-
Pearson T, Ballantyne C, Sisk C, et al. Comparison of effects of ezetimibe/ simvastatin versus simvastatin versus atorvastatin in reducing C-reactive protein and low-density lipoprotein cholesterol levels. Am J Cardiol 2007;99:1706-1713
-
(2007)
Am J Cardiol
, vol.99
, pp. 1706-1713
-
-
Pearson, T.1
Ballantyne, C.2
Sisk, C.3
-
49
-
-
0034776367
-
Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function
-
van Heek M, Farley C, Compton DS, et al. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br J Pharmacol 2001;134:409-417
-
(2001)
Br J Pharmacol
, vol.134
, pp. 409-417
-
-
Van Heek, M.1
Farley, C.2
Compton, D.S.3
-
50
-
-
1442335817
-
Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia
-
Salen G, von Bergmann K, Lütjohann D, et al. Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. Circulation 2004;109:966-971
-
(2004)
Circulation
, vol.109
, pp. 966-971
-
-
Salen, G.1
Von Bergmann, K.2
Lütjohann, D.3
-
51
-
-
0034003105
-
Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
-
van Heek M, Farley C, Compton DS, et al. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br J Pharmacol 2000;129:1748-1754
-
(2000)
Br J Pharmacol
, vol.129
, pp. 1748-1754
-
-
Van Heek, M.1
Farley, C.2
Compton, D.S.3
-
52
-
-
18344380806
-
Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects
-
DOI 10.1124/dmd.30.4.430
-
Patrick JE, Kosoglou T, Stauber KL, et al. Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects. Drug Metab Dispos 2002;30:430-437 (Pubitemid 34263828)
-
(2002)
Drug Metabolism and Disposition
, vol.30
, Issue.4
, pp. 430-437
-
-
Patrick, J.E.1
Kosoglou, T.2
Stauber, K.L.3
Alton, K.B.4
Maxwell, S.E.5
Zhu, Y.6
Statkevich, P.7
Iannucci, R.8
Chowdhury, S.9
Affrime, M.10
Cayen, M.N.11
-
53
-
-
19544371758
-
Ezetimibe: A review of its metabolism, pharmacokinetics and drug interactions
-
Kosoglou T, Statkevich P, Johnson-Levonas AO, et al. Ezetimibe: A review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet 2005;44:467-494
-
(2005)
Clin Pharmacokinet
, vol.44
, pp. 467-494
-
-
Kosoglou, T.1
Statkevich, P.2
Johnson-Levonas, A.O.3
-
54
-
-
0034765624
-
The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs
-
Davis HR Jr, Pula KK, Alton KB, et al. The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs. Metabolism 2001;50:1234-1241
-
(2001)
Metabolism
, vol.50
, pp. 1234-1241
-
-
Davis Jr., H.R.1
Pula, K.K.2
Alton, K.B.3
-
55
-
-
34547950892
-
Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis
-
Mäki-Petäjä KM, Booth AD, Hall FC, et al. Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. J Am Coll Cardiol 2007;50:852-858
-
(2007)
J Am Coll Cardiol
, vol.50
, pp. 852-858
-
-
Mäki-Petäjä, K.M.1
Booth, A.D.2
Hall, F.C.3
-
56
-
-
58749090559
-
Pooled analyses of effects on C-reactive protein and low density lipoprotein cholesterol in placebo-controlled trials of ezetimibe monotherapy or ezetimibe added to baseline statin therapy
-
Pearson TA, Ballantyne CM, Veltri E, et al. Pooled analyses of effects on C-reactive protein and low density lipoprotein cholesterol in placebo-controlled trials of ezetimibe monotherapy or ezetimibe added to baseline statin therapy. Am J Cardiol 2009;103:369-374
-
(2009)
Am J Cardiol
, vol.103
, pp. 369-374
-
-
Pearson, T.A.1
Ballantyne, C.M.2
Veltri, E.3
-
57
-
-
57649213900
-
Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice
-
Kuhlencordt PJ, Padmapriya P, Rützel S, et al. Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice. Atherosclerosis 2009;202:48-57
-
(2009)
Atherosclerosis
, vol.202
, pp. 48-57
-
-
Kuhlencordt, P.J.1
Padmapriya, P.2
Rützel, S.3
-
58
-
-
68749102069
-
Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect
-
doi:10.1111/j.1476-5381.2008.00091.x
-
Gomez-Garre D, Munoz-Pacheco P, Gonzalez-Rubio M, et al. Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect. Br J Pharmacol 2009; doi:10.1111/j.1476-5381.2008.00091.x
-
(2009)
Br J Pharmacol
-
-
Gomez-Garre, D.1
Munoz-Pacheco, P.2
Gonzalez-Rubio, M.3
-
59
-
-
33947424291
-
Total and low-density lipoprotein cholesterol responses to ezetimibe in clinical practice
-
Capps N. Total and low-density lipoprotein cholesterol responses to ezetimibe in clinical practice. Int J Clin Pract 2006;60:867-869
-
(2006)
Int J Clin Pract
, vol.60
, pp. 867-869
-
-
Capps, N.1
-
60
-
-
34249005579
-
Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia
-
Kalogirou M, Tsimihodimos V, Gazi I, et al. Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia. Curr Med Res Opin 2007;23:1169-1176
-
(2007)
Curr Med Res Opin
, vol.23
, pp. 1169-1176
-
-
Kalogirou, M.1
Tsimihodimos, V.2
Gazi, I.3
-
61
-
-
37449028932
-
Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: An exploratory analysis of archived samples using two commercially available techniques
-
Ose L, Reyes R, Johnson-Levonas AO, et al. Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: An exploratory analysis of archived samples using two commercially available techniques. Clin Ther 2007;29:2419-2432
-
(2007)
Clin Ther
, vol.29
, pp. 2419-2432
-
-
Ose, L.1
Reyes, R.2
Johnson-Levonas, A.O.3
-
62
-
-
59449101190
-
The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia
-
Nakou ES, Filippatos TD, Kiortsis DN, et al. The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia. Expert Opin Pharmacother 2008;9:3151-863.
-
(2008)
Expert Opin Pharmacother
, vol.9
, pp. 3151-3863
-
-
Nakou, E.S.1
Filippatos, T.D.2
Kiortsis, D.N.3
-
63
-
-
43849104295
-
Effects of fenofibrate and ezetimibe, both as monotherapy and in coadministration, on cholesterol mass within lipoprotein subfractions and low-density lipoprotein peak particle size in patients with mixed hyperlipidemia
-
Tribble DL, Farnier M, Macdonell G, et al. Effects of fenofibrate and ezetimibe, both as monotherapy and in coadministration, on cholesterol mass within lipoprotein subfractions and low-density lipoprotein peak particle size in patients with mixed hyperlipidemia. Metabolism 2008;57:796-801
-
(2008)
Metabolism
, vol.57
, pp. 796-801
-
-
Tribble, D.L.1
Farnier, M.2
MacDonell, G.3
-
64
-
-
69349101542
-
Effect of ezetimibe/simvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia
-
doi:10.1111/j.1463-1326.2009.01061.x
-
Tomassini JE, Mazzone T, Goldberg RB, et al. Effect of ezetimibe/simvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia. Diabetes Obes Metab 2009; doi:10.1111/j.1463-1326.2009.01061.x
-
(2009)
Diabetes Obes Metab
-
-
Tomassini, J.E.1
Mazzone, T.2
Goldberg, R.B.3
-
65
-
-
18244390229
-
A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The ezetimibe add-on to statin for effectiveness (EASE) trial
-
Pearson TA, Denke MA, McBride PE, et al. A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The ezetimibe add-on to statin for effectiveness (EASE) trial. Mayo Clin Proc 2005;80:587-595
-
(2005)
Mayo Clin Proc
, vol.80
, pp. 587-595
-
-
Pearson, T.A.1
Denke, M.A.2
McBride, P.E.3
-
66
-
-
17844410923
-
Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) study
-
Ballantyne CM, Abate N, Yuan Z, et al. Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) study. Am Heart J 2005;149:464-473
-
(2005)
Am Heart J
, vol.149
, pp. 464-473
-
-
Ballantyne, C.M.1
Abate, N.2
Yuan, Z.3
-
67
-
-
0037132598
-
Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia
-
Davidson MH, McGarry T, Bettis R, et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-2134
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 2125-2134
-
-
Davidson, M.H.1
McGarry, T.2
Bettis, R.3
-
68
-
-
33845296148
-
Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: The VYTAL study
-
Goldberg RB, Guyton JR, Mazzone T, et al. Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: The VYTAL study. Mayo Clin Proc 2006;81:1579-1588
-
(2006)
Mayo Clin Proc
, vol.81
, pp. 1579-1588
-
-
Goldberg, R.B.1
Guyton, J.R.2
Mazzone, T.3
-
69
-
-
62549118503
-
Lipid-altering efficacy of ezetimibe/ simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study
-
Farnier M, Averna M, Missault L, et al. Lipid-altering efficacy of ezetimibe/ simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study. Int J Clin Pract 2009;63:547-559
-
(2009)
Int J Clin Pract
, vol.63
, pp. 547-559
-
-
Farnier, M.1
Averna, M.2
Missault, L.3
-
70
-
-
57449084685
-
Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: More clarity or confusion?
-
Stein EA. Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: more clarity or confusion? J Am Coll Cardiol 2008;52:2206-2209
-
(2008)
J Am Coll Cardiol
, vol.52
, pp. 2206-2209
-
-
Stein, E.A.1
-
71
-
-
57449105069
-
Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial
-
Fleg JL, Mete M, Howard BV, et al. Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial. J Am Coll Cardiol 2008;52:2198-2205
-
(2008)
J Am Coll Cardiol
, vol.52
, pp. 2198-2205
-
-
Fleg, J.L.1
Mete, M.2
Howard, B.V.3
-
72
-
-
67650475384
-
The Vytorin on Carotid Intima-Media Thickness and Overall Arterial Rigidity (VYCTOR) Study
-
Meaney A, Ceballos G, Asbun J, et al. The Vytorin on Carotid Intima-Media Thickness and Overall Arterial Rigidity (VYCTOR) Study. J Clin Pharmacol 2009;49:838-847
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 838-847
-
-
Meaney, A.1
Ceballos, G.2
Asbun, J.3
-
73
-
-
0021846720
-
Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia
-
Sugrue DD, Trayner I, Thompson GR, et al. Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia. Br Heart J 1985;53:265-268
-
(1985)
Br Heart J
, vol.53
, pp. 265-268
-
-
Sugrue, D.D.1
Trayner, I.2
Thompson, G.R.3
-
74
-
-
40449111044
-
Lipid-altering efficacy of ezetimibe/ simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: The INFORCE study
-
Reckless JP, Henry P, Pomykaj T, et al. Lipid-altering efficacy of ezetimibe/ simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: The INFORCE study. Int J Clin Pract 2008;62:539-554
-
(2008)
Int J Clin Pract
, vol.62
, pp. 539-554
-
-
Reckless, J.P.1
Henry, P.2
Pomykaj, T.3
-
75
-
-
34247530360
-
Co-administration of ezetimibe and simvastatin in acute myocardial infarction
-
Chenot F, Montant PF, Marcovitch O, et al. Co-administration of ezetimibe and simvastatin in acute myocardial infarction. Eur J Clin Invest 2007;37:357-363
-
(2007)
Eur J Clin Invest
, vol.37
, pp. 357-363
-
-
Chenot, F.1
Montant, P.F.2
Marcovitch, O.3
-
76
-
-
0037407617
-
-
Study of Heart and Renal Protection (SHARP)
-
Baigent C, Landry M. Study of Heart and Renal Protection (SHARP). Kidney Int 2003;63(Suppl 84):S207-10
-
(2003)
Kidney Int
, vol.63
, Issue.SUPPL. 84
-
-
Baigent, C.1
Landry, M.2
-
77
-
-
50949102416
-
Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
-
Cannon CP, Giugliano RP, Blazing MA, et al. Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. Am Heart J 2008;156:826-832
-
(2008)
Am Heart J
, vol.156
, pp. 826-832
-
-
Cannon, C.P.1
Giugliano, R.P.2
Blazing, M.A.3
-
78
-
-
70449485117
-
Impact of severity of aortic valve stenosis on effect of intensive lipid lowering therapy. Insights from the SEAS study
-
Gerdts E, Rossebo AB, Pedersen TR, et al. Impact of severity of aortic valve stenosis on effect of intensive lipid lowering therapy. Insights from the SEAS study. J Am Coll Cardiol 2009;53(10 Suppl A):A415
-
(2009)
J Am Coll Cardiol
, vol.53
, Issue.10 SUPPL. A
-
-
Gerdts, E.1
Rossebo, A.B.2
Pedersen, T.R.3
-
79
-
-
34547950892
-
Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis
-
Mäki-Petäjä KM, Booth AD, Hall FC, et al. Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. J Am Coll Cardiol 2007;50:852-858
-
(2007)
J Am Coll Cardiol
, vol.50
, pp. 852-858
-
-
Mäki-Petäjä, K.M.1
Booth, A.D.2
Hall, F.C.3
-
80
-
-
61649093065
-
Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment
-
Shirinsky IV, Zheltova OI, Solovyova NY, et al. Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment. Scand J Rheumatol 2009;38:23-27
-
(2009)
Scand J Rheumatol
, vol.38
, pp. 23-27
-
-
Shirinsky, I.V.1
Zheltova, O.I.2
Solovyova, N.Y.3
-
81
-
-
19944433437
-
Simvastatin improves endothelial function in patients with rheumatoid arthritis
-
Hermann F, Forster A, Chenevard R, et al. Simvastatin improves endothelial function in patients with rheumatoid arthritis. J Am Coll Cardiol 2005;45:461-464
-
(2005)
J Am Coll Cardiol
, vol.45
, pp. 461-464
-
-
Hermann, F.1
Forster, A.2
Chenevard, R.3
-
82
-
-
56449107482
-
Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy
-
Westerweel PE, Visseren FL, Hajer GR, et al. Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy. Eur Heart J 2008;29:2808-2817
-
(2008)
Eur Heart J
, vol.29
, pp. 2808-2817
-
-
Westerweel, P.E.1
Visseren, F.L.2
Hajer, G.R.3
-
83
-
-
57649176432
-
The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients
-
Hajer GR, Dallinga-Thie GM, van Vark-van der Zee LC, et al. The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients. Atherosclerosis 2009;202:216-224
-
(2009)
Atherosclerosis
, vol.202
, pp. 216-224
-
-
Hajer, G.R.1
Dallinga-Thie, G.M.2
Van Vark-Van Der Zee, L.C.3
-
84
-
-
56149091842
-
The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: A randomized double-blind crossover trial
-
Olijhoek JK, Hajer GR, van der Graaf Y, et al. The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: A randomized double-blind crossover trial. J Cardiovasc Pharmacol 2008;52:145-150
-
(2008)
J Cardiovasc Pharmacol
, vol.52
, pp. 145-150
-
-
Olijhoek, J.K.1
Hajer, G.R.2
Van Der Graaf, Y.3
-
85
-
-
33845876333
-
Risks associated with statin therapy: A systematic overview of randomized clinical trials
-
Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: A systematic overview of randomized clinical trials. Circulation 2006;114:2788-2797
-
(2006)
Circulation
, vol.114
, pp. 2788-2797
-
-
Kashani, A.1
Phillips, C.O.2
Foody, J.M.3
-
86
-
-
33645881669
-
Statin safety: A systematic review
-
Law M, Rudnicka AR. Statin safety: A systematic review. Am J Cardiol 2006;97:52C-60C
-
(2006)
Am J Cardiol
, vol.97
-
-
Law, M.1
Rudnicka, A.R.2
-
87
-
-
65749097599
-
Effects of Simvastatin 40mg Daily on Muscle and Liver Adverse Effects in A 5-year Randomized Placebo-controlled Trial in 20,536 High-risk People
-
MRC/BHF Heart Protection Study Collaborative Group. Effects of simvastatin 40mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people. BMC Clin Pharmacol 2009;9:6
-
(2009)
BMC Clin Pharmacol
, vol.9
, pp. 6
-
-
-
88
-
-
33751096467
-
SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
-
Pasanen MK, Neuvonen M, Neuvonen PJ, et al. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics 2006;16:873-879
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 873-879
-
-
Pasanen, M.K.1
Neuvonen, M.2
Neuvonen, P.J.3
-
89
-
-
34250890634
-
Phytosterols as anticancer compounds
-
Bradford PG, Awad AB. Phytosterols as anticancer compounds. Mol Nutr Food Res 2007;51:161-170
-
(2007)
Mol Nutr Food Res
, vol.51
, pp. 161-170
-
-
Bradford, P.G.1
Awad, A.B.2
-
90
-
-
59149086732
-
After the failure of ENHANCEd cholesterol lowering in familial hypercholesterolemia,SEAS of problems with ezetimibe
-
Mascitelli L, Ravnskov U, Pezzetta F, et al. After the failure of ENHANCEd cholesterol lowering in familial hypercholesterolemia, SEAS of problems with ezetimibe. Angiology 2009;60:127-128
-
(2009)
Angiology
, vol.60
, pp. 127-128
-
-
Mascitelli, L.1
Ravnskov, U.2
Pezzetta, F.3
-
91
-
-
52649138998
-
Analyses of cancer data from three ezetimibe trials
-
Peto R, Emberson J, Landray M, et al. Analyses of cancer data from three ezetimibe trials. N Engl J Med 2008;359:1357-1366
-
(2008)
N Engl J Med
, vol.359
, pp. 1357-1366
-
-
Peto, R.1
Emberson, J.2
Landray, M.3
-
92
-
-
64249120001
-
Ezetimibe monotherapy for cholesterol lowering in 2,722 people: Systematic review and meta-analysis of randomized controlled trials
-
Pandor A. Ara R.M. Tumur I. et al. Ezetimibe monotherapy for cholesterol lowering in 2,722 people: Systematic review and meta-analysis of randomized controlled trials J Intern Med 2009 265 568-8093.
-
(2009)
J Intern Med
, vol.265
, pp. 568-8093
-
-
Pandor, A.1
Ara, R.M.2
Tumur, I.3
-
93
-
-
38649095993
-
Screening statins for possible carcinogenic risk: Up to 9 years of follow-up of 361,859 recipients
-
Pandor A, Ara RM, Tumur I, et al. Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials. J Intern Med 2009;265:568-8093. Friedman GD, Flick ED, Udaltsova N, et al. Screening statins for possible carcinogenic risk: up to 9 years of follow-up of 361,859 recipients. Pharmacoepidemiol Drug Saf 2008;17:27-36
-
(2008)
Pharmacoepidemiol Drug Saf
, vol.17
, pp. 27-36
-
-
Friedman, G.D.1
Flick, E.D.2
Udaltsova, N.3
-
94
-
-
61349115459
-
An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach
-
Halleck M, Davis HR, Kirschmeier P, et al. An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach. Toxicology 2009;258:116-130
-
(2009)
Toxicology
, vol.258
, pp. 116-130
-
-
Halleck, M.1
Davis, H.R.2
Kirschmeier, P.3
-
95
-
-
62549086930
-
Ezetimibe is an inhibitor of tumor angiogenesis
-
Solomon KR, Pelton K, Boucher K, et al. Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol 2009;174:1017-1026
-
(2009)
Am J Pathol
, vol.174
, pp. 1017-1026
-
-
Solomon, K.R.1
Pelton, K.2
Boucher, K.3
-
96
-
-
67649401873
-
Long-term safety and tolerability of ezetimibe coadministered with simvastatin in hypercholesterolemic patients: A randomized, 12-month double-blind extension study
-
Strony J, Yang B, Hanson ME, et al. Long-term safety and tolerability of ezetimibe coadministered with simvastatin in hypercholesterolemic patients: A randomized, 12-month double-blind extension study. Curr Med Res Opin 2008;24:3149-3157
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 3149-3157
-
-
Strony, J.1
Yang, B.2
Hanson, M.E.3
-
97
-
-
53449088738
-
Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia
-
van der Graaf A, Cuffie-Jackson C, Vissers MN, et al. Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia. J Am Coll Cardiol 2008;52:1421-1429
-
(2008)
J Am Coll Cardiol
, vol.52
, pp. 1421-1429
-
-
Van Der Graaf, A.1
Cuffie-Jackson, C.2
Vissers, M.N.3
-
98
-
-
58349089823
-
Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: Results from two open-label extension studies in hypercholesterolemic patients
-
Strony J, Hoffman R, Hanson M, et al. Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: Results from two open-label extension studies in hypercholesterolemic patients. Clin Ther 2008;30:2280-2297
-
(2008)
Clin Ther
, vol.30
, pp. 2280-2297
-
-
Strony, J.1
Hoffman, R.2
Hanson, M.3
-
99
-
-
0037395141
-
Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia
-
Knopp RH, Gitter H, Truitt T, et al. Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur Heart J 2003;24:729-741
-
(2003)
Eur Heart J
, vol.24
, pp. 729-741
-
-
Knopp, R.H.1
Gitter, H.2
Truitt, T.3
-
100
-
-
0037111924
-
Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia
-
Dujovne CA, Ettinger MP, McNeer JF, et al. Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol 2002;90:1092-1097
-
(2002)
Am J Cardiol
, vol.90
, pp. 1092-1097
-
-
Dujovne, C.A.1
Ettinger, M.P.2
McNeer, J.F.3
-
101
-
-
31344444438
-
Striated muscle safety of ezetimibe/simvastatin (Vytorin)
-
Davidson MH, Maccubbin D, Stepanavage M, et al. Striated muscle safety of ezetimibe/simvastatin (Vytorin). Am J Cardiol 2006;97:223-228
-
(2006)
Am J Cardiol
, vol.97
, pp. 223-228
-
-
Davidson, M.H.1
MacCubbin, D.2
Stepanavage, M.3
-
102
-
-
0037387192
-
Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatement with minimum side effects in 51,321 Japanese hypercholesterolemic patients
-
Matsuzawa Y, Kita T, Mabuchi H, et al. Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatement with minimum side effects in 51,321 Japanese hypercholesterolemic patients. Circ J 2003;67:287-294
-
(2003)
Circ J
, vol.67
, pp. 287-294
-
-
Matsuzawa, Y.1
Kita, T.2
Mabuchi, H.3
-
103
-
-
4544243333
-
Early intesive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: Phase Z of the A to Z trial
-
de Lemos JA, Blazing MA, Wiviott SD, et al. Early intesive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: Phase Z of the A to Z trial. JAMA 2004;292:1307-1316
-
(2004)
JAMA
, vol.292
, pp. 1307-1316
-
-
De Lemos, J.A.1
Blazing, M.A.2
Wiviott, S.D.3
-
104
-
-
0024990522
-
Pharmacology and mechanism of action of the new HMG-CoA reductase inhibitors
-
Sirtori CR. Pharmacology and mechanism of action of the new HMG-CoA reductase inhibitors. Pharmacol Res 1990;22:555-563
-
(1990)
Pharmacol Res
, vol.22
, pp. 555-563
-
-
Sirtori, C.R.1
-
105
-
-
19844378287
-
Adverse events with concomitant amiodarone and statin therapy
-
Alsheikh-Ali AA, Karas RH. Adverse events with concomitant amiodarone and statin therapy. Prev Cardiol 2005;8:95-97
-
(2005)
Prev Cardiol
, vol.8
, pp. 95-97
-
-
Alsheikh-Ali, A.A.1
Karas, R.H.2
-
106
-
-
11344285421
-
Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia
-
DOI 10.2165/00002512-200421150-00005
-
Lipka L, Sager P, Strony J, et al. Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia. Drugs Aging 2004;21:1025-1032 (Pubitemid 40075727)
-
(2004)
Drugs and Aging
, vol.21
, Issue.15
, pp. 1025-1032
-
-
Lipka, L.1
Sager, P.2
Strony, J.3
Yang, B.4
Suresh, R.5
Veltri, E.6
-
107
-
-
62349126043
-
Ezetimibe, and the combination of ezetimibe/ simvastatin, and risk of cancer: A post-marketing analysis
-
Alsheikh-Ali AA, Karas RH. Ezetimibe, and the combination of ezetimibe/ simvastatin, and risk of cancer: A post-marketing analysis. J Clin Lipidol 2009;3:138-142
-
(2009)
J Clin Lipidol
, vol.3
, pp. 138-142
-
-
Alsheikh-Ali, A.A.1
Karas, R.H.2
|