Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity

Annals of Clinical Biochemistry

Volumn 34, Issue 3, 1997, Pages 269-275

  Day, A P ^a   Bellavia, S ^a   Jones, O T G ^b   Stansbie, D ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

HMGCoA reductase inhibitors; Hypercholesterolaemia; Hyperlipidaemia

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; CHOLESTEROL ESTER; CHOLESTEROL OLEATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE LIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD SAMPLING; CELL MEMBRANE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; MALE; MEMBRANE FLUIDITY; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0030913270     PISSN: 00045632     EISSN: None     Source Type: Journal    
DOI: 10.1177/000456329703400308     Document Type: Article

References (33)

1. Lange Y. Membrane Cholesterol. In: Scanu AM, Spector AA, eds. Biochemistry and Biology of Plasma Lipoproteins. New York: Marcel Dekker Inc, 1986: 179-99
2. Shinitzky M. Membrane fluidity and cellular functions. In: Shinitzky M, ed. Physiology of Membrane Fluidity, Vol 1. Boca Raton: CRC Press, 1984: 1-51
3. Dowd A, Thomas TH, Wilkinson R. Erythrocyte sodium-lithium countertransport activity (SLC) is related to membrane fluidity in hyperlipidaemia. Clin Sci 1992; 83: 1P
4. Lutton C. Dietary cholesterol, membrane cholesterol and cholesterol synthesis. Biochimie 1991; 73: 1327-34
5. Davis RA. Lipoprotein structure and secretion. In: Vance DE, Vance J, eds. Biochemistry of Lipids, Lipoproteins and Membranes. Amsterdam: Elsevier Science, 1991. 403-26
6. Shaper AG, Pocock SR, Walker M, Cohen NM, Wale CJ, Thomson AG. British Regional Heart Study: Cardiovascular risk factors in middle aged men in 24 towns. BMJ 1982; 283: 179-86
7. Bharaj HS, Norman RI, Bing RF. Red cell structure and function in familial hypercholesterolaemia. Clin Sci 1993; 85: 18P
8. 2+ -ATPase) activity in primary combined hyperlipidaemia. Clin Sci 1993; 85: 18P
9. Muzulu SI, Bing RF, Norman RI. Human erythrocyte membrane fluidity and calcium pump activity in primary combined hyperlipidaemia. Clin Sci 1995; 88: 307-10
10. Muzulu SI, Patel HR, Norman RI, Bing RF. Effect of lowering serum cholesterol on erythrocyte membrane fluidity. Clin Sci 1993; 85: 18P
11. Babior BM. Oxygen-dependent microbial killing by phagocytes. N Engl J Med 1978; 298: 659-68 and 721-5
12. Nishizuka Y. The molecular hetrogeneity of protein kinase C and its implications for cellular regulation. Nature 1988; 334: 661-5
13. Baggiolini M, Boulay F, Badwey JA, Curnutte JT. Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst. FASEB J 1993; 7: 1004-10
14. Jones OTG. The regulation of superoxide production by the NADPH oxidase of neutrophils and other mammalian cells. Bioessays 1994; 16: 919-23
15. Nauseef WM, Vlopp BD, McCormick S, Leidal KG, Clark RA. Assembly of the neutrophil respiratory burst oxidase. J Biol Chem 1991; 266: 5911-7
16. + channel. Biochem J 1987; 246: 325-9
17. Kusner DJ, Aucott JN, Fanceschi D, Sarasua MM, Spagnuolo PJ, King CH. Protease priming of neutrophil superoxide production. J Biol Chem 1991; 266: 16465-71
18. Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20: 470-5
19. English D, Andersen BR. Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradient ficoll-hypaque. J Immunol 1974; 5: 249
20. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest 1968; 21(suppl 97): 77-89
21. Mayo LA, Curnutte JT. Kinetic microtitre assay for superoxide production by neutrophils and other phagocytic cells. Meth Enzymol 1990; 186: 567-75
22. Vercaemst R, Union A, Rosseneu M. Separation and quantitation of free cholesterol and cholesterol esters in a macrophage line by high performance liquid chromatography. J Chromatogr 1989; 494: 43-52
23. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383-9
24. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, Macfarlane PW, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. N Engl J Med 1995; 333: 1301-6
25. Todd PA, Goa KL. Simvastatin, a review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs 1990; 40: 583-607
26. Bloch K. Cholesterol: evolution of structure and function. In: Vance DE, Vance J, eds. Biochemistry of Lipids, Lipoproteins and Membranes. Amsterdam: Elsevier Science, 1991: 363-81
27. Cooper RA, Arner EC, Wiley JS, Shattil SJ. Modification of red cell membrane structure by cholesterol-rich lipid dispersions. J Clin Invest 1975; 55: 115-26
28. Weder AB, Serr C, Torretti BA, Bassett DR, Zweifler AJ. Effects of lovastatin treatment on red blood cell and platelet cation transport. Hypertension 1991; 17: 203-9
29. Glomset JA, Gelb MH, Farnsworth CC. Prenyl proteins in eukaryotic cells: a new type of membrane anchor. Trends Biochein Sci 1990; 15: 139-42
30. Bokoch G, Prossnitz V. Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. J Clin Invest 1992; 89: 402-8
31. Rine J, Kim S-H. A role for isoprenoid lipids in the localization and function of an oncoprotein. New Biol 1990; 2: 219-26
32. Lunec J. Free radicals: their involvement in disease processes. Ann Clin Biochem 1990; 27: 173-82
33. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet 1994; 344: 793-5