Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia

Journal of the American College of Cardiology

Volumn 52, Issue 17, 2008, Pages 1421-1429

  van der Graaf, Anouk ^a   Cuffie Jackson, Cynthia ^b   Vissers, Maud N ^a   Trip, Mieke D ^a   Gagné, Claude ^c   Shi, Genming ^b   Veltri, Enrico ^b   Avis, Hans J ^a   Kastelein, John J P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MERCK RESEARCH LABORATORIES   (United States)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

efficacy; ezetimibe; heterozygous familial hypercholesterolemia; pediatric; safety; simvastatin

Indexed keywords

EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SIMVASTATIN;

ABDOMINAL PAIN; ACNE; ADOLESCENT; ARTICLE; BODY HEIGHT; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HEADACHE; HUMAN; INFLUENZA; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; MYALGIA; NAUSEA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; RISK ASSESSMENT; SIDE EFFECT; SINUSITIS; SORE THROAT; TREATMENT DURATION; VOMITING; WEIGHT CHANGE;

ADOLESCENT; ANTICHOLESTEREMIC AGENTS; AZETIDINES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; MALE; SIMVASTATIN; TIME FACTORS; TREATMENT OUTCOME;

EID: 53449088738     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.09.002     Document Type: Article

References (13)

1. Tonstad S., Joakimsen O., Stensland-Bugge E., et al. Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arterioscler Thromb Vasc Biol 16 (1996) 984-991
2. Aggoun Y., Bonnet D., Sidi D., et al. Arterial mechanical changes in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 20 (2000) 2070-2075
3. de Jongh S., Lilien M.R., Bakker H.D., Hutten B.A., Kastelein J.J., and Stroes E.S. Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. Atherosclerosis 163 (2002) 193-197
4. McCrindle B.W., Urbina E.M., Dennison B.A., et al. Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. Circulation 115 (2007) 1948-1967
5. American Academy of Pediatrics Committee on Nutrition. Cholesterol in childhood. Pediatrics 101 (1998) 141-147
6. Kavey R.-E.W., Allada V., Daniels S.R., et al. Cardiovascular risk reduction in high-risk pediatric patients. Circulation 114 (2006) 2710-2738
7. NCEP Expert Panel on Blood Cholesterol Levels in Children and Adolescents. National Cholesterol Education Program (NCEP): highlights of the report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 89 (1992) 495-501
8. de Jongh S., Ose L., Szamosi T., et al. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin. Circulation 106 (2002) 2231-2237
9. Wiegman A., Hutten B.A., de Groot E., et al. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial. JAMA 292 (2004) 331-337
10. Avis H.J., Vissers M.N., Stein E.A., et al. A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 27 (2007) 1803-1810
11. Rodenburg J., Vissers M.N., Wiegman A., et al. Statin treatment in children with familial hypercholesterolemia: the younger, the better. Circulation 116 (2007) 664-668
12. Zetia (ezetimibe) (2007), Merck/Schering-Plough Pharmaceuticals, North Wales, PA [prescribing information]. June
13. Davidson M.H., McCarry T., Bettis R., et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 40 (2002) 2125-2134