메뉴 건너뛰기




Volumn 52, Issue 2, 2008, Pages 145-150

The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: A randomized double-blind crossover trial

Author keywords

Endothelial function; Ezetimibe; Metabolic syndrome; Postprandial lipid profiles; Statins

Indexed keywords

APOLIPOPROTEIN B; EZETIMIBE; INSULIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; TRIACYLGLYCEROL; AZETIDINE DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT;

EID: 56149091842     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31817ffe76     Document Type: Article
Times cited : (43)

References (31)
  • 1
    • 11144355354 scopus 로고    scopus 로고
    • Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    • Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495-1504.
    • (2004) N Engl J Med , vol.350 , pp. 1495-1504
    • Cannon, C.P.1    Braunwald, E.2    McCabe, C.H.3
  • 2
    • 0037132598 scopus 로고    scopus 로고
    • Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia
    • Davidson MH, McGarry T, Bettis R, et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol. 2002;40:2125-2134.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 2125-2134
    • Davidson, M.H.1    McGarry, T.2    Bettis, R.3
  • 3
    • 0029121091 scopus 로고
    • Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication
    • Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet. 1995;346:467-471.
    • (1995) Lancet , vol.346 , pp. 467-471
    • Stroes, E.S.1    Koomans, H.A.2    de Bruin, T.W.3    Rabelink, T.J.4
  • 4
    • 0032555170 scopus 로고    scopus 로고
    • Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: A randomized, placebo-controlled, double-blind study
    • John S, Schlaich M, Langenfeld M, et al. Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: a randomized, placebo-controlled, double-blind study. Circulation. 1998; 98:211-216.
    • (1998) Circulation , vol.98 , pp. 211-216
    • John, S.1    Schlaich, M.2    Langenfeld, M.3
  • 5
    • 0037015288 scopus 로고    scopus 로고
    • Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: Effects of short-and long-term simvastatin treatment
    • Ceriello A, Taboga C, Tonutti L, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short-and long-term simvastatin treatment. Circulation. 2002;106:1211-1218.
    • (2002) Circulation , vol.106 , pp. 1211-1218
    • Ceriello, A.1    Taboga, C.2    Tonutti, L.3
  • 6
    • 17944401657 scopus 로고    scopus 로고
    • Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
    • Evans M, Anderson RA, Graham J, et al. Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus. Circulation. 2000;101:1773-1779.
    • (2000) Circulation , vol.101 , pp. 1773-1779
    • Evans, M.1    Anderson, R.A.2    Graham, J.3
  • 7
    • 0031877652 scopus 로고    scopus 로고
    • The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta
    • Grieve DJ, Avella MA, Elliott J, et al. The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis. 1998;139:273-281.
    • (1998) Atherosclerosis , vol.139 , pp. 273-281
    • Grieve, D.J.1    Avella, M.A.2    Elliott, J.3
  • 8
    • 0032581015 scopus 로고    scopus 로고
    • Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries
    • Kugiyama K, Doi H, Motoyama T, et al. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation. 1998;97:2519-2526.
    • (1998) Circulation , vol.97 , pp. 2519-2526
    • Kugiyama, K.1    Doi, H.2    Motoyama, T.3
  • 9
    • 0347355494 scopus 로고    scopus 로고
    • The close relationship between postprandial remnant metabolism and insulin resistance
    • Funada J, Sekiya M, Otani T, et al. The close relationship between postprandial remnant metabolism and insulin resistance. Atherosclerosis. 2004;172:151-154.
    • (2004) Atherosclerosis , vol.172 , pp. 151-154
    • Funada, J.1    Sekiya, M.2    Otani, T.3
  • 10
    • 1242295275 scopus 로고    scopus 로고
    • Early alterations in the postprandial VLDL1 apoB-100 and apoB-48 metabolism in men with strong heredity for type 2 diabetes
    • Johanson EH, Jansson PA, Gustafson B, et al. Early alterations in the postprandial VLDL1 apoB-100 and apoB-48 metabolism in men with strong heredity for type 2 diabetes. J Intern Med. 2004;255:273-279.
    • (2004) J Intern Med , vol.255 , pp. 273-279
    • Johanson, E.H.1    Jansson, P.A.2    Gustafson, B.3
  • 11
    • 0033536205 scopus 로고    scopus 로고
    • Vascular reactivity
    • Baron AD. Vascular reactivity. Am J Cardiol. 1999;84:25-27.
    • (1999) Am J Cardiol , vol.84 , pp. 25-27
    • Baron, A.D.1
  • 12
    • 0037900056 scopus 로고    scopus 로고
    • Pathophysiological implications of insulin resistance on vascular endothelial function
    • Wheatcroft SB, Williams IL, Shah AM, et al. Pathophysiological implications of insulin resistance on vascular endothelial function. Diabet Med. 2003;20:255-268.
    • (2003) Diabet Med , vol.20 , pp. 255-268
    • Wheatcroft, S.B.1    Williams, I.L.2    Shah, A.M.3
  • 13
    • 0345737202 scopus 로고    scopus 로고
    • Low adipocyte-derived plasma protein adiponectin concentrations are associated with the metabolic syndrome and small dense low-density lipoprotein particles: Atherosclerosis and insulin resistance study
    • Hulthe J, Hulten LM, Fagerberg B. Low adipocyte-derived plasma protein adiponectin concentrations are associated with the metabolic syndrome and small dense low-density lipoprotein particles: atherosclerosis and insulin resistance study. Metabolism. 2003;52:1612-1614.
    • (2003) Metabolism , vol.52 , pp. 1612-1614
    • Hulthe, J.1    Hulten, L.M.2    Fagerberg, B.3
  • 14
    • 1442327754 scopus 로고    scopus 로고
    • Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation
    • Tan KC, Xu A, Chow WS, et al. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab. 2004;89:765-769.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 765-769
    • Tan, K.C.1    Xu, A.2    Chow, W.S.3
  • 15
    • 0035897696 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
    • Executive Summary of The Third Report of The National Cholesterol Education Program NCEP
    • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 16
    • 33646173076 scopus 로고    scopus 로고
    • Effect of 80 mg/day simvastatin therapy on cardiovascular outcomes in adults with versus without metabolic syndrome
    • Kamalesh M, Rao R, Sawada S, et al. Effect of 80 mg/day simvastatin therapy on cardiovascular outcomes in adults with versus without metabolic syndrome. Am J Cardiol. 2006;97:1487-1489.
    • (2006) Am J Cardiol , vol.97 , pp. 1487-1489
    • Kamalesh, M.1    Rao, R.2    Sawada, S.3
  • 17
    • 33644687456 scopus 로고    scopus 로고
    • Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes
    • Martens FM, Visseren FL, de Koning EJ, et al. Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes. J Cardiovac Pharmacol. 2005;46:773-778.
    • (2005) J Cardiovac Pharmacol , vol.46 , pp. 773-778
    • Martens, F.M.1    Visseren, F.L.2    de Koning, E.J.3
  • 18
    • 0037342036 scopus 로고    scopus 로고
    • Induction of postprandial inflammatory response in adult onset growth hormone deficiency is related to plasma remnant-like particle-cholesterol concentration
    • Twickler TB, Dallinga-Thie GM, Visseren FL, et al. Induction of postprandial inflammatory response in adult onset growth hormone deficiency is related to plasma remnant-like particle-cholesterol concentration. J Clin Endocrinol Metab. 2003;88:1228-1233.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1228-1233
    • Twickler, T.B.1    Dallinga-Thie, G.M.2    Visseren, F.L.3
  • 20
    • 19544371758 scopus 로고    scopus 로고
    • Ezetimibe: A review of its metabolism, pharmacokinetics and drug interactions
    • Kosoglou T, Statkevich P, Johnson-Levonas AO, et al. Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44:467-494.
    • (2005) Clin Pharmacokinet , vol.44 , pp. 467-494
    • Kosoglou, T.1    Statkevich, P.2    Johnson-Levonas, A.O.3
  • 21
    • 10744221008 scopus 로고    scopus 로고
    • Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption
    • Altmann SW, Davis HR, Jr., Zhu LJ, et al. Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption. Science. 2004;303:1201- 1204.
    • (2004) Science , vol.303 , pp. 1201-1204
    • Altmann, S.W.1    Davis Jr., H.R.2    Zhu, L.J.3
  • 22
    • 33646442215 scopus 로고    scopus 로고
    • Effect of ezetimibe on the in vivo kinetics of ApoB-48 and ApoB-100 in men with primary hypercholesterolemia
    • Tremblay AJ, Lamarche B, Cohn JS, et al. Effect of ezetimibe on the in vivo kinetics of ApoB-48 and ApoB-100 in men with primary hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2006;26:1101-1106.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1101-1106
    • Tremblay, A.J.1    Lamarche, B.2    Cohn, J.S.3
  • 23
    • 34147127812 scopus 로고    scopus 로고
    • High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia
    • de Graaf J, van der Vleuten GM, ter Avest E, et al. High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia. J Clin Endocrinol Metab. 2007;92:1269-1275.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1269-1275
    • de Graaf, J.1    van der Vleuten, G.M.2    ter Avest, E.3
  • 24
    • 14944370951 scopus 로고    scopus 로고
    • Effects of ezetimibe coadministered with simvastatin on C-reactive protein in a large cohort of hypercholes- terolemic patients
    • Sager PT, Capece R, Lipka L, et al. Effects of ezetimibe coadministered with simvastatin on C-reactive protein in a large cohort of hypercholes- terolemic patients. Atherosclerosis. 2005;179:361-367.
    • (2005) Atherosclerosis , vol.179 , pp. 361-367
    • Sager, P.T.1    Capece, R.2    Lipka, L.3
  • 25
    • 0026642471 scopus 로고
    • C-reactive protein levels as a direct indicator of interleukin-6 levels in humans in vivo
    • Bataille R, Klein B. C-reactive protein levels as a direct indicator of interleukin-6 levels in humans in vivo. Arthritis Rheum. 1992;35:982-984.
    • (1992) Arthritis Rheum , vol.35 , pp. 982-984
    • Bataille, R.1    Klein, B.2
  • 26
    • 33745171041 scopus 로고    scopus 로고
    • Effect of atorvastatin (10 mg/day) on glucose metabolism in patients with the metabolic syndrome
    • Huptas S, Geiss HC, Otto C, et al. Effect of atorvastatin (10 mg/day) on glucose metabolism in patients with the metabolic syndrome. Am J Cardiol. 2006;98:66-69.
    • (2006) Am J Cardiol , vol.98 , pp. 66-69
    • Huptas, S.1    Geiss, H.C.2    Otto, C.3
  • 27
    • 0033818023 scopus 로고    scopus 로고
    • The metabolic syndrome, LDL particle size, and atherosclerosis: The Atherosclerosis and Insulin Resistance (AIR) study
    • Hulthe J, Bokemark L, Wikstrand J, et al. The metabolic syndrome, LDL particle size, and atherosclerosis: the Atherosclerosis and Insulin Resistance (AIR) study. Arterioscler Thromb Vasc Biol. 2000;20:2140-2147.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2140-2147
    • Hulthe, J.1    Bokemark, L.2    Wikstrand, J.3
  • 28
    • 20844463066 scopus 로고    scopus 로고
    • Simvastatin versus ezetimibe: Pleiotropic and lipid-lowering effects on endothelial function in humans
    • Landmesser U, Bahlmann F, Mueller M, et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation. 2005;111:2356-2363.
    • (2005) Circulation , vol.111 , pp. 2356-2363
    • Landmesser, U.1    Bahlmann, F.2    Mueller, M.3
  • 29
    • 33646740966 scopus 로고    scopus 로고
    • Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: Clinical evidence for 'pleiotropic' functions of statin therapy
    • Fichtlscherer S, Schmidt-Lucke C, Bojunga S, et al. Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for 'pleiotropic' functions of statin therapy. Eur Heart J. 2006;27:1182-1190.
    • (2006) Eur Heart J , vol.27 , pp. 1182-1190
    • Fichtlscherer, S.1    Schmidt-Lucke, C.2    Bojunga, S.3
  • 30
    • 2942683360 scopus 로고    scopus 로고
    • Lipoprotein remnants and endothelial dysfunction in the postprandial phase
    • Maggi FM, Raselli S, Grigore L, et al. Lipoprotein remnants and endothelial dysfunction in the postprandial phase. J Clin Endocrinol Metab. 2004;89:2946-2950.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2946-2950
    • Maggi, F.M.1    Raselli, S.2    Grigore, L.3
  • 31
    • 26044473080 scopus 로고    scopus 로고
    • Endothelial function in the forearm circulation of patients with the metabolic syndrome-effect of different lipid-lowering regimens
    • Bulut D, Hanefeld C, Bulut-Streich N, et al. Endothelial function in the forearm circulation of patients with the metabolic syndrome-effect of different lipid-lowering regimens. Cardiology. 2005;104:176-180.
    • (2005) Cardiology , vol.104 , pp. 176-180
    • Bulut, D.1    Hanefeld, C.2    Bulut-Streich, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.