Efficacy of drugs in regional anesthesia: A review

European Journal of Pain Supplements

Volumn 3, Issue 2, 2009, Pages 41-48

  Allegri, Massimo ^a   Delazzo, Marco G ^a   Grossi, Paolo ^b   Borghi, Battista ^c  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Adjuvants; Local anesthetics; Opioids; Regional anesthesia

Indexed keywords

ADRENALIN; BUPIVACAINE; CHLOROPROCAINE; CLONIDINE; DEXMEDETOMIDINE; FENTANYL; KETAMINE; LEVOBUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; MIDAZOLAM; MORPHINE; NEOSTIGMINE; OPIATE; ROPIVACAINE; SUFENTANIL; TRAMADOL;

ADD ON THERAPY; ADJUVANT THERAPY; ANALGESIA; ARTICLE; BRADYCARDIA; CARDIOTOXICITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; GLIOSIS; HEART ARREST; HEART ARRHYTHMIA; HUMAN; HYPOTENSION; LOW DRUG DOSE; NAUSEA AND VOMITING; NEUROTOXICITY; NONHUMAN; PAIN; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PRURITUS; REGIONAL ANESTHESIA; RESPIRATION DEPRESSION; RISK ASSESSMENT; SEDATION; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; SURGICAL TECHNIQUE; UNSPECIFIED SIDE EFFECT; URINE RETENTION; VOMITING;

EID: 70350770961     PISSN: 17543207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eujps.2009.08.004     Document Type: Article

References (141)

1. Bailey P.L., Sperry R.J., Johnson G.K., Eldredge S.J., East K.A., East T.D., et al. Respiratory effects of clonidine alone and combined with morphine, in humans. Anaesthesiology 74 1 (1991) 43-48
2. Bazin J.E., Massoni C., Bruelle P., Fenies V., Groslier D., and Schoeffler P. The addition of opioids to local anaesthetics in brachial plexus block: the comparative effects of morphine, buprenorphine and sufentanil. Anaesthesia 52 9 (1997) 858-862
3. Benhamou D., Ghosh C., and Mercier F.J. A randomized sequential allocation study to determine the minimum effective analgesic concentration of levobupivacaine and ropivacaine in patients receiving epidural analgesia for labor. Anaesthesiology 99 (2003) 1383-1386
4. Bernard J.M., and Macaire P. Dose-range effects of clonidine added to lidocaine for brachial plexus block. Anaesthesiology 87 (1997) 277-284
5. Bernards C.M., Shen D.D., Sterling E.S., Adkins J.E., Risler L., Phillips B., et al. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 1): differences among opioids. Anaesthesiology 99 (2003) 455-465
6. Bernards C.M., Shen D.D., Sterling E.S., Adkins J.E., Risler L., Phillips B., et al. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2): effect of epinephrine. Anaesthesiology 99 (2003) 466-472
7. Borghi B., Stagni F., Bugamelli S., Paini M.B., Nepoti M.L., Montebugnoli M., et al. Unilateral spinal block for outpatient knee arthroscopy: a dose-finding study. J Clin Anaesth 15 (2003) 351-356
8. Borghi B., Facchini F., Agnoletti V., Adduci A., Lambertini A., Marini E., et al. Pain relief and motor function during continuous interscalene analgesia after open shoulder surgery: a prospective, randomized, double-blind comparison between levobupivacaine 0.25%, and ropivacaine 0.25% or 0.4%. Eur J Anaesthesiol 23 12 (2006) 1005-1009
9. Bouaziz H., Paqueron X., Bur M.L., Merle M., Laxenaire M.C., and Benhamou D. No enhancement of sensory and motor blockade by neostigmine added to mepivacaine axillary plexus block. Anaesthesiology 91 (1999) 78-83
10. Bouaziz H., Kinirons B.P., Macalou D., Heck M., Dap F., Benhamou D., et al. Sufentanil does not prolong the duration of analgesia in a mepivacaine brachial plexus block: a dose response study. Anaesth Analg 90 2 (2000) 383-387
11. Breschan C., Jost R., Krumpholz R., Schaumberger F., Stettner H., Marhofer P., et al. A prospective study comparing the analgesic efficacy of levobupivacaine, ropivacaine and bupivacaine in pediatric patients undergoing caudal blockade. Paediatr Anaesth 15 4 (2005) 301.6
12. Brown W.U., Bell G.C., Lurie A.O., Weiss B., Scanlon J.W., and Alper M.H. Newborn blood levels of lidocaine and mepivacaine in the first postnatal day following maternal epidural anesthesia. Anaesthesiology 42 6 (1975) 698-707
13. Brummett C.M., Norat M.A., Palmisano J.M., and Lydic R. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. Anaesthesiology 109 3 (2008) 502-511
14. Buckenmaier III C.C., Nielsen K.C., Pietrobon R., Klein S.M., Martin A.H., Greengrass R.A., et al. Small-dose intrathecal lidocaine versus ropivacaine for anorectal surgery in an ambulatory setting. Anaesth Analg 95 5 (2002) 1253-1257
15. Buckenmaier C.C., and Bleckner L.L. Anesthetic agents for advanced regional anesthesia. A north American perspective. Drugs 65 6 (2005) 745-759
16. Camorcia M., Capogna G., and Columb M.O. Minimum local analgesic doses of ropivacaine, levobupivacaine, and bupivacaine for intrathecal labor analgesia. Anaesthesiology 102 3 (2005) 646-650
17. Capdevila X., Ponrouch M., and Choquet O. Continuous peripheral nerve blocks in clinical practice. Curr Opin Anaesthesiol 21 5 (2008) 619-623
18. Capogna G., Camorcia M., and Columb M.O. Minimum analgesic doses of fentanyl and sufentanil for epidural analgesia in the first stage of labor. Anaesth Analg 96 4 (2003) 1178-1182
19. Casati A., Fanelli G., Borghi B., and Torri G. Ropivacaine or 2% mepivacaine for lower limb peripheral nerve blocks: study group on orthopedic anesthesia of the Italian Society of anesthesia, analgesia and intensive care. Anaesthesiology 90 (1999) 1047-1052
20. Casati A., Fanelli G., Magistris L., Beccaria P., Berti M., and Torri G. Minimum local anesthetic volume blocking the femoral nerve in 50% of cases: a double-blinded comparison between 0.5% ropivacaine and 0.5% bupivacaine. Anaesth Analg 92 (2001) 205-208
21. Casati A., Borghi B., Fanelli G., Cerchierini E., Santorsola R., Sassoli V., et al. A double-blinded, randomized comparison of either 0.5% levobupivacaine or 0.5% ropivacaine for sciatic nerve block. Anaesth Analg 94 (2002) 987-990
22. Casati A., Borghi B., Fanelli G., Montone N., Rotini R., Fraschini G., et al. Interscalene brachial plexus anesthesia and analgesia for open shoulder surgery: a randomized, double-blinded comparison between levobupivacaine and ropivacaine. Anaesth Analg 96 (2003) 253-259
23. Casati A., Fanelli G., Danelli G., Berti M., Ghisi D., Brivio M., et al. Spinal anesthesia with lidocaine or preservative-free 2-chlorprocaine for outpatient knee arthroscopy: a prospective, randomized, double-blind comparison. Anaesth Analg 104 4 (2007) 959-964
24. Cline E., Franz D., Polley R.D., Maye J., Burkard J., and Pellegrini J. Analgesia and effectiveness of levobupivacaine compared with ropivacaine in patients undergoing an axillary brachial plexus block. AANA J 72 5 (2004) 339-345
25. Corman S.L., and Skledar S.J. Use of lipid emulsion to reverse local anesthetic-induced toxicity. Ann Pharmacother 41 11 (2007) 1873-1877
26. Cuvillon P., Nouvellon E., Ripart J., Boyer J.C., Dehour L., Mahamat A., et al. A comparison of the pharmacodynamics and pharmacokinetics of bupivacaine, ropivacaine (with epinephrine) and their equal volume mixtures with lidocaine used for femoral and sciatic nerve blocks: a double-blind randomized study. Anaesth Analg 108 2 (2009) 641-649
27. D'Angelo R., and James R.L. Is ropivacaine less potent than bupivacaine?. Anaesthesiology 90 4 (1999) 941-943
28. Dahl J.B., Jeppesen I.S., Jørgensen H., Wetterslev J., and Møiniche S. Intraoperative and postoperative analgesic efficacy and adverse effects of intrathecal opioids in patients undergoing cesarean section with spinal anesthesia: a qualitative and quantitative systematic review of randomized controlled trials. Anaesthesiology 91 6 (1999) 1919-1927
29. Dalens B. Some current controversies in pediatric regional anesthesia. Curr Opin Anaesthesiol 19 3 (2006) 301-308
30. Danelli G., Fanelli G., Berti M., Cornini A., Lacava L., Nuzzi M., et al. Spinal ropivacaine or bupivacaine for cesarean delivery: a prospective, randomized, double-blind comparison. Reg Anaesth Pain Med 29 3 (2004) 221-226
31. Danelli G., Nuzzi M., Salcuni P.F., Caberti L., Berti M., Rossini E., et al. Does clonidine 50 microg improve cervical plexus block obtained with ropivacaine 150 mg for carotid endarterectomy? A randomized, double-blinded study. J Clin Anaesth 18 8 (2006) 585-588
32. De Negri P., Ivani G., Tirri T., Modano P., Reato C., Eksborg S., et al. A comparison of epidural bupivacaine, levobupivacaine, and ropivacaine on postoperative analgesia and motor blockade. Anaesth Analg 99 1 (2004) 45-48
33. Dobrydnjov I., Axelsson K., Gupta A., Lundin A., Holmström B., and Granath B. Improved analgesia with clonidine when added to local anesthetics during combined spinal-epidural anesthesia for hip arthroplasty: a double blind, randomized and placebo-controlled study. Acta Anaesthesiol Scand 49 4 (2005) 538-545
34. Eisenach J.C., Shafer S.L., Bucklin B.A., Jackson C., and Kallio A. Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep. Anaesthesiology 80 6 (1994) 1349-1359
35. Eisenach J.C., De Kock M., and Klimscha W. Alpha(2)-adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984-1995). Anaesthesiology 85 3 (1996) 665-674
36. Eisenach J.C. Muscarinic-mediated analgesia. Life Sci 64 6-7 (1999) 549-554
37. Faccenda K.A., and Finucane B.T. Complications of regional anesthesia Incidence and prevention. Drug Saf 24 6 (2001) 413-442
38. Fanelli G., Casati A., Magistris L., Berti M., Albertin A., Scarioni M., et al. Fentanyl does not improve the nerve block characteristics of axillary brachial plexus anesthesia performed with ropivacaine. Acta Anaesthesiol Scand 45 5 (2001) 590-594
39. Fisher B., Zornow M.H., Yaksh T.L., and Peterson B.M. Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur J Pharmacol 192 2 (1991) 221-225
40. Flory N., Van-Gessel E., Donald F., Hoffmeyer P., and Gamulin Z. Does the addition of morphine to brachial plexus block improve analgesia after shoulder surgery?. Br J Anaesth 75 1 (1995) 23-26
41. Foster R.H., and Markham A. Levobupivacaine: a review of its pharmacology and use as a local anesthetic. Drugs 18 5 (2000) 551-579
42. Freise H., Meissner A., Lauer S., Ellger B., Radke R., Bruewer M., et al. Thoracic epidural analgesia with low concentration of bupivacaine induces thoracic and lumbar sympathetic block: a randomized, double-blind clinical trial. Anaesthesiology 109 6 (2008) 1107-1112
43. Frikha N., Ellachtar M., Mebazaa M.S., and Ben Ammar M.S. Combined spinal-epidural analgesia in labor - comparison of sufentanil vs tramadol. Middle East J Anaesthesiol 19 1 (2007) 87-96
44. Ganesh A., Adzick N.S., Foster T., and Cucchiaro G. Efficacy of addition of fentanyl to epidural bupivacaine on postoperative analgesia after thoracotomy for lung resection in infants. Anaesthesiology 109 5 (2008) 890-894
45. Graf B.M. The cardiotoxicity of local anesthetics: the place of ropivacaine. Curr Top Med Chem 1 3 (2001) 207-214
46. Gurun M.S., Leinbach R., Moore L., Lee C.S., Owen M.D., and Eisenach J.C. Studies on the safety of glucose and paraben-containing neostigmine for intrathecal administration. Anesth Analg 85 2 (1997) 317-323
47. Hall J.E., Uhrich T.D., and Ebert T.J. Sedative, analgesic and cognitive effects of clonidine infusions in humans. Br J Anaesth 86 (2001) 5-11
48. Ho K.M., and Ismail H. Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis. Anaesth Intensive Care 36 3 (2008) 365-373
49. Ilfeld B.M., Morey T.E., and Enneking F.K. Continuous infraclavicular perineural infusion with clonidine and ropivacaine compared with ropivacaine alone: a randomized, double-blinded, controlled study. Anaesth Analg 97 (2003) 706-712
50. Ilfeld B.M., Morey T.E., Thannikary L.J., Wright T.W., and Enneking F.K. Clonidine added to a continuous interscalene ropivacaine perineural infusion to improve postoperative analgesia: a randomized, double-blind, controlled study. Anaesth Analg 100 4 (2005) 1172-1178
51. Ilfeld B.M., Loland V.J., Gerancher J.C., Wadhwa A.N., Renehan E.M., Sessler D.I., et al., PAINfRE Investigators. The effects of varying local anesthetic concentration and volume on continuous popliteal sciatic nerve blocks: a dual-center, randomized, controlled study. Anaesth Analg 107 2 (2008) 701-707
52. Ilfeld B.M., Le L.T., Ramjohn J., Loland V.J., Wadhwa A.N., Gerancher J.C., et al., PAINfRETM Investigators. The effects of local anesthetic concentration and dose on continuous infraclavicular nerve blocks: a multicenter, randomized, observer-masked, controlled study. Anaesth Analg 108 1 (2009) 345-350
53. Iohom G., Machmachi A., Diarra D.P., Khatouf M., Boileau S., Dap F., et al. The effects of clonidine added to mepivacaine for paronychia surgery under axillary brachial plexus block. Anaesth Analg 100 4 (2005) 1179-1183
54. Jarbo K., Batra Y.K., and Panda N.B. Brachial plexus block with midazolam and bupivacaine improves analgesia. Can J Anaesth 52 8 (2005) 822-826
55. Johnson M.E., Saenz J.A., and Da Silva A.D. Effect of local anesthetic on neuronal cytoplasmatic calciun and plasma membrane lysis (necrosis) in a cell culture model. Anaesthesiology 97 (2002) 1466-1476
56. Kaabachi O., Ouezini R., Koubaa W., Ghrab B., Zargouni A., and Ben Abdelaziz A. Tramadol as an adjuvant to lidocaine for axillary brachial plexus block. Anaesth Analg 108 1 (2009) 367-370
57. Kanazi G.E., Aouad M.T., Jabbour-Khoury S.I., Al Jazzar M.D., Alameddine M.M., Al-Yaman R., et al. Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. Acta Anaesthesiol Scand 50 2 (2006) 222-227
58. Kapral S., Gollmann G., Waltl B., Likar R., Sladen R.N., Weinstabl C., et al. Tramadol added to mepivacaine prolongs the duration of an axillary brachial plexus blockade. Anaesth Analg 88 4 (1999) 853-856
59. Kardash K., Schools A., and Concepcion M. Effects of brachial plexus fentanyl on supraclavicular block. A randomized, double-blind study. Reg Anaesth 20 4 (1995) 311-315
60. Kathirvel S., Sadhasivam S., Saxena A., Kannan T.R., and Ganjoo P. Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia. Anaesthesia 55 (2000) 899-904
61. Kaya F.N., Sahin S., Owen M.D., and Eisenach J.C. Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery. Anesthesiology 100 (2004) 381-385
62. Kesimci E., Izdes S., Gozdemir M., and Kanbak O. Tramadol does not prolong the effect of ropivacaine 7.5 mg/ml for axillary brachial plexus block. Acta Anaesthesiol Scand 51 6 (2007) 736-741
63. Khaw K.S., Ngan Kee W.D., Wong M., Ng F., and Lee A. Spinal ropivacaine for cesarean delivery: a comparison of hyperbaric and plain solutions. Anaesth Analg 94 3 (2002) 680-685
64. Kito K., Kato H., Shibata M., Adachi T., Nakao S., and Mori K. The effect of varied doses of epinephrine on duration of lidocaine spinal anesthesia in the thoracic and lumbosacral dermatomes. Anaesth Analg 86 (1998) 1018-1022
65. Klein S.M., Greengrass R.A., Steele S.M., D'Ercole F.J., Speer K.P., Gleason D.H., et al. A comparison of 0.5% bupivacaine, 0.5% ropivacaine, and 0.75% ropivacaine for interscalene brachial plexus block. Anaesth Analg 87 (1998) 1316-1319
66. Kozody R., Palahniuk R.J., Wade J.G., Cumming M.O., and Pucci W.R. The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow. Can Anaesth Soc J 31 5 (1984) 503-508
67. Kohno T., Wakai A., Ataka T., Ikoma M., Yamakura T., and Baba H. Actions of midazolam on excitatory transmission in dorsal horn neurons of adult rat spinal cord. Anaesthesiology 104 2 (2006) 338-343
68. Konakci S., Adanir T., Yilmaz G., and Rezanko T. The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route. Eur J Anaesthesiol 25 5 (2008) 403-409
69. Kopacz D.J. Spinal 2-chloroprocaine: minimum effective dose. Reg Anaesth Pain Med 30 1 (2005) 36-42
70. Korhonen A.M. Use of spinal anaesthesia in day surgery. Curr Opin Anaesthesiol 19 6 (2006) 612-616
71. Kotake Y., Matsumoto M., Morisaki H., and Takeda J. The effectiveness of continuous epidural infusion of low-dose fentanyl and mepivacaine in perioperative analgesia and hemodynamic control in mastectomy patients. J Clin Anaesth 16 2 (2004) 88-91
72. Lacassie H.J., and Columb M.O. The relative motor blocking potencies of bupivacaine and levobupivacaine in labor. Anaesth Analg 97 5 (2003) 1509-1513
73. Landau R., Schiffer E., Morales M., Savoldelli G., and Kern C. The dose-sparing effect of clonidine added to ropivacaine for labor epidural analgesia. Anaesth Analg 95 (2002) 728-734
74. Lauretti G.R., Hood D.D., Eisenach J.C., and Pfeifer B.L. A multi-center study of intrathecal neostigmine for analgesia following vaginal hysterectomy. Anaesthesiology 89 4 (1998) 913-918
75. Le Guen H., Roy D., Branger B., and Ecoffey C. Comparison of fentanyl and sufentanil in combination with bupivacaine for patient-controlled epidural analgesia during labor. J Clin Anaesth 13 2 (2001) 98-102
76. Lee I.O., Kim W.K., Kong M.H., Lee M.K., Kim N.S., Choi Y.S., et al. No enhancement of sensory and motor blockade by ketamine added to ropivacaine interscalene brachial plexus blockade. Acta Anaesthesiol Scand 46 (2002) 821-826
77. Leone S., Di Cianni S., Casati A., and Fanelli G. Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed 79 2 (2008) 92-105
78. Lilker S., Rofaeel A., Balki M., and Carvalho J.C. Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia. J Clin Anaesth 21 2 (2009) 108-112
79. Liu S., Chiu A.A., Carpenter R.L., Mulroy M.F., Allen H.W., Neal J.M., et al. Fentanyl prolongs lidocaine spinal anesthesia without prolonging recovery. Anaesth Analg 80 (1995) 730-734
80. Luck J.F., Fettes P.D., and Wildsmith J.A. Spinal anaesthesia for elective surgery: a comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine. Br J Anaesth 101 5 (2008) 705-710
81. Mantouvalou M., Ralli S., Arnaoutoglou H., Tziris G., and Papadopoulos G. Spinal anesthesia: comparison of plain ropivacaine, bupivacaine and levobupivacaine for lower abdominal surgery. Acta Anaesthesiol Belg 59 2 (2008) 65-71
82. Mather L.E., Huang Y.F., Veering B., and Pryor M.E. Systemic and regional pharmacokinetics of levobupivacaine and bupivacaine enantiomers in sheep. Anaesth Analg 86 4 (1998) 805-811
83. McCoy E.P., and Wilson C.M. A comparison of lignocaine with prilocaine in axillary brachial plexus anaesthesia. Anaesthesia 46 (1991) 309-311
84. Mizogami M., Tsuchiya H., Ueno T., Kashimata M., and Takakura K. Stereospecific interaction of bupivacaine enantiomers with lipid membranes. Reg Anaesth Pain Med 33 4 (2008) 304-311
85. Morros Viñoles C., Pérez Cuenca M.D., Castillo Monsegur J., and Cedo Valloba F. Addition of fentanyl to mepivacaine in axillary brachial plexus block. Effects on the anesthetic and postoperative analgesic quality. Rev Esp Anaesthsiol Reanim 38 2 (1991) 87-89
86. Nafisi S. Effects of epidural lidocaine analgesia on labor and delivery: a randomized, prospective, controlled trial. BMC Anaesthesiol 18 6 (2006) 15
87. Nair G.S., Abrishami A., Lermitte J., and Chung F. Systematic review of spinal anaesthesia using bupivacaine for ambulatory knee arthroscopy. Br J Anaesth 102 3 (2009) 307-315
88. Nakamura T., Popitz-Bergez F., Birknes J., and Stritchartz G.R. The critical role of concentration for lidocaine block of peripheral nerve in vivo. Anaesthesiology 99 (2003) 1189-1197
89. Nassogne M.C., Evard P., and Coutoy P.J. Selective direct toxicity of cocaine on fetal mouse neurons: teratogenic implications of neurite and apoptotic neuronal loss. Ann NY Acad Sci 846 (1998) 61-68
90. Neal J.M., Gerancher J.C., Hebl J.R., Ilfeld B.M., McCartney C.J., Franco C.D., et al. Upper extremity regional anesthesia. Essentials of our current understanding, 2008. Reg Anaesth Pain Med 34 2 (2009) 134-170
91. Nelson T. Bupivacaine-associated cardiac arrest. Reg Anaesth Pain Med 33 5 (2008) 504-555
92. Nelson K.E., Rauch T., Terebuh V., and D'Angelo R. A comparison of intrathecal fentanyl and sufentanil for labor analgesia. Anaesthesiology 96 5 (2002) 1070-1073
93. Niemi G. Advantages and disadvantages of adrenaline in regional anesthesia. Best Pract Res Clin Anaesthesiol 19 2 (2005) 229-245
94. Niemi G., and Breivik H. Epinephrine markedly improves thoracic epidural analgesia produced by a small-dose infusion of ropivacaine, fentanyl, and epinephrine after major surgery: a randomized, double-blinded crossover study with and without epinephrine. Anaesth Analg 94 6 (2002) 1598-1605
95. Ohmura S., Kawada M., Ohta T., Yamamoto K., and Kobayashi T. Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats. Anaesth Analg 93 (2001) 743-778
96. Partridge B.L. The effects of local anesthetics and epinephrine on rat sciatic nerve blood flow. Anaesthesiology 75 2 (1991) 243-250
97. Perez-Castro R., Patel S., Garavito-Aguilar Z.V., Rosenberg A., Recio-Pinto E., Zhang J., et al. Cytotoxicity of local anesthetics in human neuronal cells. Anaesth Analg 108 3 (2009) 997-1007
98. Piangatelli C., De Angelis C., Pecora L., Recanatini F., Cerchiara P., and Testasecca D. Levobupivacaine and ropivacaine in the infraclavicular brachial plexus block. Minerva Anaesthesiol 72 4 (2006) 217-221
99. Polley L.S., Columb M.O., Naughton N.N., Wagner D.S., Dorantes D.M., and van de Ven C.J. Effect of intravenous versus epidural fentanyl on the minimum local analgesic concentration of bupivacaine in labor. Anaesthesiology 93 (2000) 122-128
100. Polley L.S., Columb M.O., Naughton N.N., Wagner D.S., and van de Ven C.J. Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes. Anaesthesiology 90 4 (1999) 944-950
101. Qian X.W., Chen X.Z., and Li D.B. Low-dose ropivacaine-sufentanil spinal anaesthesia for caesarean delivery: a randomised trial. Int J Obstet Anaesth 17 4 (2008) 309-314
102. Rathmell J.P., Lair T.R., and Nauman B. The role of intrathecal drugs in the treatment of acute pain. Anaesth Analg 101 5 Suppl. (2005) S30-S43
103. Reuben S.S., and Reuben J.P. Brachial plexus anesthesia with verapamil and/or morphine. Anaesth Analg 91 2 (2000) 379-383
104. Rigg J.R., Jamrozik K., Myles P.S., Silbert B.S., Peyton P.J., Parsons R.W., et al., MASTER. Anaesthesia trial study group. Epidural anaesthesia and analgesia and outcome of major surgery: a randomized trial. Lancet 359 9314 (2002) 1276-1282
105. Rochette A., Raux O., Troncin R., Dadure C., Verdier R., and Capdevila X. Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study. Anaesth Analg 98 (2004) 56-59
106. Roelants F., Rizzo M., and Lavand'homme P.M. The effect of epidural neostigmine combined with ropivacaine and sufentanil on neuraxial analgesia during labor. Anaesth Analg 96 4 (2003) 1161-1166
107. Roelants F., and Lavand'homme P.M. Epidural neostigmine combined with sufentanil provides balanced and selective analgesia in early labor. Anaesthesiology 101 2 (2004) 439-444
108. Salgado P.F., Sabbag A.T., Silva P.C., Brienze S.L., Dalto H.P., Módolo N.S., et al. Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia. Rev Assoc Med Bras 54 2 (2008) 110-115
109. Sanli S., Yegin A., Kayacan N., Yilmaz M., Coskunfirat N., and Karsli B. Effects of hyperbaric spinal ropivacaine for caesarean section: with or without fentanyl. Eur J Anaesthesiol 22 6 (2005) 457-461
110. Schewe J.C., Komusin A., Zinserling J., Nadstawek J., Hoeft A., and Hering R. Effects of spinal anaesthesia versus epidural anaesthesia for caesarean section on postoperative analgesic consumption and postoperative pain. Eur J Anaesthesiol 26 1 (2009) 52-59
111. Schug S.A., Saunders D., Kurowski I., and Paech M.J. Neuraxial drug administration. A review of treatment options or anaesthesia and analgesia. CNS Drugs 20 11 (2006) 917-933
112. Shapiro A., Zohar E., Zaslansky R., Hoppenstein D., Shabat S., and Fredman B. The frequency and timing of respiratory depression in 1524 postoperative patients treated with systemic or neuraxial morphine. J Clin Anaesth 17 7 (2005) 537-542
113. Simon M.J., Veering B.T., Stienstra R., van Kleef J.W., and Burm A.G.L. Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration. Br J Anaesth 93 4 (2004) 512-520
114. Simon M.J., Veering B.T., Vletter A.A., Stienstra R., van Kleef J.W., and Burm A.G. The effect of age on the systemic absorption and systemic disposition of ropivacaine after epidural administration. Anaesth Analg 102 1 (2006) 276-282
115. Simpson D., Curran M.P., Oldfield V., and Keating G.M. Ropivacaine: a review of its use in regional anesthesia and acute pain management. Drugs 65 18 (2005) 2675-2717
116. Sinnott C.J., Cogswell III L.P., Johnson A., and Strichartz G.R. On the mechanism by which epinephrine potentiates lidocaine's peripheral nerve block. Anaesthesiology 98 1 (2003) 181-188
117. Stewart J., Kellett N., and Castro D. The central nervous system and cardiovascular effects of levobupivacaine and ropivacaine in healthy volunteers. Anaesth Analg 97 2 (2003) 412-416
118. Subramaniam K., Subramaniam B., and Steinbrook R.A. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. Anaesth Analg 99 2 (2004) 482-495
119. Suzuki T., Mizutani H., Ishikawa K., Miyake E., Saeki S., and Ogawa S. Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block. Br J Anaesth 99 5 (2007) 721-725
120. Suzuki M., Sugimoto K., and Shimada Y. Ropivacaine produces sensory blockade in the lumbar sacral region more frequently than mepivacaine in lower thoracic epidural anesthesia. J Anaesth 18 4 (2004) 250-256
121. Taboada Muñiz M., Rodríguez J., Bermúdez M., Valiño C., Blanco N., Amor M., et al. Low volume and high concentration of local anesthetic is more efficacious than high volume and low concentration in Labat's sciatic nerve block: a prospective, randomized comparison. Anaesth Analg 107 6 (2008) 2085-2088
122. Tagariello V., Caporuscio A., and De Tommaso O. Mepivacaine: update on an evergreen local anesthetic. Minerva Anaesthesiol 67 (2001) 5-8
123. Takenami T., Yagishita S., Nara Y., and Hoka S. Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model. Reg Anaesth Pain Med 29 5 (2004) 446-453
124. Topcu I., Luleci N., Tekin S., Kefi A., and Erincler T. Effectiveness of clonidine and fentanyl addition to bupivacaine in postoperative patient controlled epidural analgesia. Anasthesiol Intensivmed Notfallmed Schmerzther 40 9 (2005) 521-525
125. Tucker A.P., Mezzatesta J., Nadeson R., and Goodchild C.S. Intrathecal midazolam II: combination with intrathecal fentanyl for labor pain. Anaesth Analg 98 6 (2004) 1521-1527
126. Unlugenc H., Ozalevli M., Gunes Y., Olguner S., Evrüke C., Ozcengiz D., et al. A double-blind comparison of intrathecal S(+) ketamine and fentanyl combined with bupivacaine 0.5% for Caesarean delivery. Eur J Anaesthesiol 23 12 (2006) 1018-1024
127. Vaghadia H., McLeod D.H., Mitchell G.W., Merrick P.M., and Chilvers C.R. Small dose hypobaric lidocaine-fentanyl spinal anaesthesia for short duration outpatient laparoscopy: a randomized comparison with conventional dose hyperbaric lidocaine. Anaesth Analg 84 (1997) 59-64
128. Vallejo M.C., and Ramanathan S. Plasma lidocaine concentrations are higher in twin compared to singleton newborns following epidural anesthesia for Cesarean delivery. Can J Anaesth 49 7 (2002) 701-705
129. Vercauteren M.P., Geernaert K., Hoffmann V.L., Dohmen D., and Adriaensen H.A. Postoperative intrathecal patient-controlled analgesia with bupivacaine, sufentanyl or a mixture of both. Anaesthesia 53 (1998) 1022-1027
130. Vetter T.R., Carvallo D., Johnson J.L., Mazurek M.S., and Presson Jr. R.G. A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation. Anaesth Analg 104 6 (2007) 1356-1363
131. Vranken J.H., Troost D., Wegener J.T., Kruis M.R., and van der Vegt M.H. Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain. Pain 117 1-2 (2005) 231-235
132. Vranken J.H., Troost D., de Haan P., Pennings F.A., van der Vegt M.H., Dijkgraaf M.G., et al. Severe toxic damage to the rabbit spinal cord after intrathecal administration of preservative-free S(+)-ketamine. Anaesthesiology 105 4 (2006) 813-818 Oct
133. Walker S.M., Goudas L.C., Cousins M.J., and Carr D.B. Combination spinal analgesic chemotherapy: a systematic review. Anaesth Analg 95 3 (2002) 674-715
134. Whiteside J.B., and Wildsmith J.A. Developments in local anaesthetic drugs. Br J Anaesth 87 1 (2001) 27-35
135. YaDeau J.T., Liguori G.A., and Zayas V.M. The incidence of transient neurologic symptoms after spinal anesthesia with mepivacaine. Anaesth Analg 101 3 (2005) 661-665
136. Yaksh T.L., and Allen J.W. The use of intrathecal midazolam in humans: a case study of process. Anaesth Analg 98 6 (2004) 1536-1545
137. Yaksh T.L., Tozier N., Horais K.A., Malkmus S., Rathbun M., Lafranco L., et al. Toxicology profile of N-methyl-d-aspartate antagonists delivered by intrathecal infusion in the canine model. Anaesthesiology 108 5 (2008) 938-949
138. Yoos J.R., and Kopacz D.J. Spinal 2-chloroprocaine: a comparison with small-dose bupivacaine in volunteers. Anaesth Analg 100 2 (2005) 566-572
139. Zink W., and Graf B.M. The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine. Curr Opin Anaesthesiol 21 5 (2008) 645-650
140. Zaric D., Christiansen C., Pace N.L., and Punjasawadwong Y. Transient neurologic symptoms after spinal anesthesia with lidocaine versus other local anesthetics: a systematic review of randomized, controlled trials. Anaesth Analg 100 6 (2005) 1811-1816
141. Zaric D., Christiansen C., Pace N.L., and Punjasawadwong Y. Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics. Cochrane Database Syst Rev 4 (2005) CD003006