Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (Part 1): Differences among opioids

Anesthesiology

Volumn 99, Issue 2, 2003, Pages 455-465

  Bernards, Christopher M ^a   Shen, Danny D ^a,b   Sterling, Emily S ^b   Adkins, Jason E ^b   Risler, Linda ^b   Phillips, Brian ^b   Ummenhofer, Wolfgang ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; ANESTHETIC AGENT; FENTANYL; MORPHINE; MORPHINE SULFATE; OPIATE; SUFENTANIL;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCULATION; CENTRAL VEIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; EPIDURAL ANESTHESIA; EPIDURAL SPACE; FEMALE; HYDROPHOBICITY; LUMBAR SPINE; MALE; MEAN RESIDENCE TIME; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; VEIN BLOOD FLOW;

EID: 0042845903     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200308000-00029     Document Type: Article

References (15)

1. Mather LE, Tucker GT, Murphy TM, Stanton-Hicks DA, Bonica JJ: The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia: II. Pharmacokinetics. Br J Anaesth 1976; 48:989-94
2. Scott DB, Jebson PJ, Braid DP, Ortengren B, Frisch P: Factors affecting plasma levels of lignocaine and prilocaine. Br J Anaesth 1972; 44:1040-9
3. Tucker GT, Mather LE: Pharmacology of local anaesthetic agents: Pharmacokinetics of local anaesthetic agents. Br J Anaesth 1975; 47(suppl):213-24
4. Ummenhofer WC, Arends RH, Shen DD, Bernards CM: Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. ANESTHESIOLOGY 2000; 92:739-53
5. Bernards CM, Kopacz DJ: Effect of epinephrine on lidocaine clearance in vivo: A microdialysis study in humans. ANESTHESIOLOGY 1999; 91:962-8
6. Powers KM, Schimmel C, Glenny RW, Bernards CM: Cerebral blood flow determinations using fluorescent microspheres: Variations on the sedimentation method validated. J Neurosci Methods 1999;87:159-65
7. Coda BA, Brown MC, Schaffer R, Donaldson G, Jacobson R, Hautman B, Shen DD: Pharmacology of epidural fentanyl, alfentanil, and sufentanil in volunteers. ANESTHESIOLOGY. 1994;81:1149-61
8. Bernards CM, Hill HF: Morphine and alfentanil permeability through the spinal dura, arachnoid, and pia mater of dogs and monkeys. ANESTHESIOLOGY 1990; 73:1214-9
9. Mather LE: Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet 1983; 8:422-46
10. Coda BA, Brown MC, Schaffer RL, Donaldson G, Shen DD: A pharmacokinetic approach to resolving spinal and systemic contributions to epidural alfentanil analgesia and side-effects. Pain 1995; 62:329-37
11. Coda BA, Brown MC, Risler L, Syrjala K, Shen DD: Equivalent analgesia and side effects during epidural and pharmacokinetically tailored intravenous infusion with matching plasma alfentanil concentration. ANESTHESIOLOGY 1999; 90:98-108
12. Glass PS, Estok P, Ginsberg B, Goldberg JS, Sladen RN: Use of patient-controlled analgesia to compare the efficacy of epidural to intravenous fentanyl administration. Anesth Analg 1992; 74:345-51
13. Guinard JP, Mavrocordatos P, Chiolero R, Carpenter RL: A randomized comparison of intravenous versus lumbar and thoracic epidural fentanyl for analgesia after thoracotomy. ANESTHESIOLOGY 1992: 77:1108-15
14. Miguel R, Barlow I, Morrell M, Scharf J, Sanusi D, Fu E: A prospective, randomized, double-blind comparison of epidural and intravenous sufentanil infusions. ANESTHESIOLOGY 1994; 81:346-52; discussion 25A-26A
15. Loper KA, Ready LB, Downey M, Sandler AN, Nessly M, Rapp S, Badner N: Epidural and intravenous fentanyl infusions are clinically equivalent after knee surgery. Anesth Analg 1990; 70:72-5