LY294002 and rapamycin co-operate to inhibit T-cell proliferation

British Journal of Pharmacology

Volumn 144, Issue 6, 2005, Pages 791-800

  Breslin, Elaine M ^a   White, Paul C ^a   Shore, Angharad M ^a   Clement, Mathew ^a   Brennan, Paul ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cyclin D2; Immunosuppression; Interleukin 2 (IL 2); LY294002; Phosphatidylinositol 3 kinase (PI3K); Rapamycin; T cell proliferation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIBODY; CD28 ANTIGEN; CELL CYCLE PROTEIN; CYCLIN D; CYCLIN D2; CYCLIN D3; CYTOKINE; INTERLEUKIN 2; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RAPAMYCIN; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MAMMAL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; DRUG INTERACTIONS; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTE ACTIVATION; MORPHOLINES; SIROLIMUS; T-LYMPHOCYTES; THYMIDINE;

EID: 17144370268     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706061     Document Type: Article

References (35)

1. ABRAHAM, R.T. & WIEDERRECHT, G.J. (1996). Immunopharmacology of rapamycin. Annu. Rev. Immunol., 14, 483-510.
2. APPLEMAN, L.J., BEREZOVSKAYA, A., GRASS, I. & BOUSSIOTIS, V.A. (2000). CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression. J. Immunol., 164, 144-151.
3. APPLEMAN, L.J., VAN PUIJENBROEK, A.A., SHU, K.M., NADLER, L.M. & BOUSSIOTIS, V.A. (2002). CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J. Immunol., 168, 2729-2736.
4. BARBET, N.C., SCHNEIDER, U., HELLIWELL, S.B., STANSFIELD, I., TUITE, M.F. & HALL, M.N. (1996). TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell, 7, 25-42.
5. BEADLING, C., GUSCHIN, D., WITTHUHN, B.A., ZIEMIECKI, A., IHLE, J.N., KERR, I.M. & CANTRELL, D.A. (1994). Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J., 13, 5605-5615.
6. BOONEN, G.J., VAN DIJK, A.M., VERDONCK, L.F., VAN LIER, R.A., RIJKSEN, G. & MEDEMA, R.H. (1999). CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kipl expression in human peripheral T lymphocytes. Eur. J. Immunol., 29, 789-798.
7. BRENNAN, P., BABBAGE, J.W., BURGERING, B.M., GRONER, B., REIF, K. & CANTRELL, D.A. (1997). Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity, 7, 679-689.
8. BRENNAN, P., BABBAGE, J.W., THOMAS, G. & CANTRELL, D. (1999). p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol. Cell. Biol., 19, 4729-4738.
9. BURGERING, B.M. & KOPS, G.J. (2002). Cell cycle and death control: long live Forkheads. Trends Biochem. Sci., 27, 352-360.
10. CRESPO, J.L., POWERS, T., FOWLER, B. & HALL, M.N. (2002). The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. U.S.A., 99, 6784-6789.
11. FRAUWIRTH, K.A., RILEY, J.L., HARRIS, M.H., PARRY, R.V., RATHMELL, J.C., PLAS, D.R., ELSTROM, R.L., JUNE, C.H. & THOMPSON, C.B. (2002). The CD28 signaling pathway regulates glucose metabolism. Immunity, 16, 769-777.
12. HAERYFAR, S.M. & HOSKIN, D.W. (2001). Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes. Int. Immunopharmacol., 1, 689-698.
13. HASHEMOLHOSSEINI, S., NAGAMINE, Y., MORLEY, S.J., DESRIVIERES, S., MERCEP, L. & FERRARI, S. (1998). Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J. Biol. Chem., 273, 14424-14429.
14. HORI, T., UCHIYAMA, T., TSUDO, M., UMADOME, H., OHNO, H., FUKUHARA, S., KITA, K. & UCHINO, H. (1987). Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus. Blood, 70, 1069-1072.
15. HSUEH, Y.P., LIANG, H.E., NG, S.Y. & LAI, M.Z. (1997). CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes. J. Immunol., 158, 85-93.
16. KAHAN, B.D. (2003). Individuality, the barrier to optimal immunosuppression. Nat. Rev. Immunol., 3, 831-838.
17. KIM, D.H., SARBASSOV, D.D., ALI, S.M., KING, J.E., LATEK, R.R., ERDJUMENT-BROMAGE, H., TEMPST, P. & SABATINI, D.M. (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell, 110, 163-175.
18. KOPS, G.J., MEDEMA, R.H., GLASSFORD, J., ESSERS, M.A., DIJKERS, P.P., COFFER, P.J., LAM, E.W. & BURGERING, B.M. (2002). Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol., 22, 2025-2036.
19. KURTS, C., KOSAKA, H., CARBONE, F.R., MILLER, J.F. & HEATH, W.R. (1997). Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J. Exp. Med., 186, 239-245.
20. LALI, F.V., CRAWLEY, J., MCCULLOCH, D.A. & FOXWELL, B.M. (2004). A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation. J. Immunol., 111, 3527-3534.
21. LEONARD, W.J. (2001). Cytokines and immunodeficiency diseases. Nat. Rev. Immunol., 1, 200-208.
22. LUO, Y., MARX, S.O., KIYOKAWA, H., KOFF, A., MASSAGUE, J. & MARKS, A.R. (1996). Rapamycin resistance tied to defective regulation of p27Kipl. Mol. Cell. Biol., 16, 6744-6751.
23. MEDEMA, R.H., KOPS, G.J., BOS, J.L. & BURGERING, B.M. (2000). AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kipl. Nature, 404, 782-787.
24. MEHL, A.M., FLOETTMANN, J.E., JONES, M., BRENNAN, P. & ROWE, M. (2001). Characterization of intercellular adhesion molecule-1 regulation by Epstein-Barr virus-encoded latent membrane protein-1 identifies pathways that cooperate with nuclear factor kappa B to activate transcription. J. Biol. Chem., 276, 984-992.
25. NELSON, B.H. & WILLERFORD, D.M. (1998). Biology of the interleukin-2 receptor. Adv. Immunol., 70, 1-81.
26. NOURSE, J., FIRPO, E., FLANAGAN, W.M., COATS, S., POLYAK, K., LEE, M.H., MASSAGUE, J., CRABTREE, G.R. & ROBERTS, J.M. (1994). Interleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin. Nature, 372, 570-573.
27. OEHEN, S. & BRDUSCHA-RIEM, K. (1999). Naive cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: a pitfall for T cell memory studies? Eur. J. Immunol., 29, 608-614.
28. OKKENHAUG, K., BILANCIO, A., FARJOT, G., PRIDDLE, H., SANCHO, S., PESKETT, E., PEARCE, W., MEEK, S.E., SALPEKAR, A., WATERFIELD, M.D., SMITH, A.J. & VANHAESEBROECK, B. (2002). Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science, 297, 1031-1034.
29. SADHU, C., DICK, K., TINO, W.T. & STAUNTON, D.E. (2003a). Selective role of PI3K delta in neutrophil inflammatory responses. Biochem. Biophys. Res. Commun., 308, 764-769.
30. SADHU, C., MASINOVSKY, B., DICK, K., SOWELL, C.G. & STAUNTON, D.E. (2003b). Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol., 170, 2647-2654.
31. SHERR, C.J. (1996). Cancer cell cycles. Science, 274, 1672-1677.
32. STAHL, M., DIJKERS, P.F., KOPS, G.J., LENS, S.M., COFFER, P.J., BURGERING, B.M. & MEDEMA, R.H. (2002). The forkhead transcription factor FoxO regulates transcription of p27Kipl and Bim in response to IL-2. J. Immunol., 168, 5024-5031.
33. VLAHOS, C.J., MATTER, W.F., HUI, K.Y. & BROWN, R.F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl- 4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269, 5241-5248.
34. WARD, S.G. & CANTRELL, D.A. (2001). Phosphoinositide 3-kinases in T lymphocyte activation. Curr. Opin. Immunol., 13, 332-338.
35. YUSUF, I. & FRUMAN, D.A. (2003). Regulation of quiescence in lymphocytes. Trends Immunol, 24, 380-386.