The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults

International Journal of Geriatric Psychiatry

Volumn 24, Issue 10, 2009, Pages 1127-1133

  Potter, G G ^a   Taylor, W D ^a   McQuoid, D R ^a   Steffens, D C ^a   Welsh Bohmer, K A ^a,b   Krishnan, K R R ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Joseph and Kathleen Bryan Alzheimer's Disease Research Center   (United States)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Aging; Catechol 0 Methyltransferase; Cognition; Geriatric depression; Neuropsychology

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

AGED; ARTICLE; BEHAVIOR GENETICS; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC TRANSMISSION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; PREFRONTAL CORTEX;

AGED; AGING; CATECHOL O-METHYLTRANSFERASE; COGNITION; DEPRESSIVE DISORDER; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC;

EID: 70350702915     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2235     Document Type: Article

References (48)

1. Airaksinen E, Larsson M, Lundberg I, Forsell Y. 2004. Cognitive functions in depressive disorders: evidence from a population-based study. Psychol Med 34: 83-91. (Pubitemid 38139443)
2. Arnsten AF, Li BM. 2005. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry 57: 1377-1384.
3. Backman L, Nyberg L, Lindenberger U, Li SC, Farde L. 2006. The correlative triad among aging, dopamine, and cognition: current status and future prospects. Neurosci Biobehav Rev 30: 791-807. (Pubitemid 44389711)
4. Barnett JH, Jones PB, Robbins TW, Muller U. 2007. Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 12: 502-509. (Pubitemid 46656086)
5. Baumeister AA, Francis JL. 2002. Historical development of the dopamine hypothesis of schizophrenia. J Hist Neurosci 11: 265-277.
6. Beats BC, Sahakian BJ, Levy R. 1996. Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med 26: 591-603. (Pubitemid 26142501)
7. Benton AL, Hamsher KD, Varney NR, Spreen O. 1983. Contributions to Neuropsychological Assessment: A Clinical Manual. Oxford University Press: New York.
8. Bierman EJ, Comijs HC, Jonker C, Beekman AT. 2005. Effects of anxiety versus depression on cognition in later life. Am J Geriatr Psychiatry 13: 686-693. (Pubitemid 41197239)
9. Boone K, Lesser B, Miller B, et al. 1995. Cognitive functioning in a geriatric depressed population: relationship of presence and severity of depression to neuropsychological scores. Neuropsychology 9: 390-398.
10. Boone KB, Lesser I, Miller B, et al. 1994. Cognitive functioning in a mildly to moderately depressed geriatric sample: relationship to chronological age. J Neuropsychiatry Clin Neurosci 6: 267-272. (Pubitemid 24239744)
11. Bruder GE, Keilp JG, Xu H, et al. 2005. Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry 58: 901-907. (Pubitemid 41790719)
12. Channon S, Baker JE, Robertson MM. 1993. Effects of structure and clustering on recall and recognition memory in clinical depression. J Abnorm Psychol 102: 323-326. (Pubitemid 23185914)
13. Chen J, Lipska BK, Halim N, et al. 2004. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75: 807-821. (Pubitemid 39390488)
14. Cohen J. 1988. Statistical Power Analysis for the Behavioral Sciences, 2nd edn. Lawrence Erlbaum Associates, Inc.: Hillsdale, NJ.
15. Cusin C, Serretti A, Lattuada E, et al. 2002. Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders. Am J Med Genet 114: 380-390. (Pubitemid 34525235)
16. de Frias CM, Annerbrink K, Westberg L, et al. 2004. COMT gene polymorphism is associated with declarative memory in adulthood and old age. Behav Genet 34: 533-539. (Pubitemid 39178766)
17. Deary IJ, Wright AF, Harris SE, et al. 2004. Searching for genetic influences on normal cognitive ageing. Trends Cogn Sci 8: 178-184.
18. Egan MF, Goldberg TE, Kolachana BS, et al. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98: 6917-6922.
19. Elderkin-Thompson V, Kumar A, Bilker W, et al. 2003. Neuropsychological deficits among patients with late-onset minor and major depression. Arch Clin Neuropsychology 28: 529-549. (Pubitemid 36593200)
20. Folstein M, Folstein S, Fanjiang G. 2001. Mini-Mental State Examination: Clinical Guide and User's Guide. Psychological Assessment Resources: Lutz, FL.
21. Frisch A, Postilnick D, Rockah R, et al. 1999. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 4: 389-392. (Pubitemid 29440581)
22. Goldberg TE, Egan MF, Gscheidle T, et al. 2003. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60: 889-896. (Pubitemid 37122307)
23. Harris SE, Wright AF, Hayward C, et al. 2005. The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds. Neurosci Lett 385: 1-6. (Pubitemid 40909972)
24. Klimek V, Schenck JE, Han H, et al. 2002. Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study. Biol Psychiatry 52: 740-748.
25. Kunugi H, Vallada HP, Hoda F, et al. 1997. No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene. Biol Psychiatry 42: 282-285. (Pubitemid 27325816)
26. Lachman HM, Papolos DF, Saito T, et al. 1996. Human catechol-O- methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6: 243-250. (Pubitemid 26226317)
27. Malhotra AK, Kestler LJ, Mazzanti C, et al. 2002. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159: 652-654. (Pubitemid 34274949)
28. Massat I, Souery D, Del-Favero J, et al. 2005. Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry 10: 598-605. (Pubitemid 40897044)
29. Millan MJ, Lejeune F, Gobert A. 2000. Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents. J Psychopharmacol 14: 114-138. (Pubitemid 30389486)
30. Montgomery SA, Asberg M. 1979. A new depression scale designed to be sensitive to change. Br J Psychiatry 134: 382-389. (Pubitemid 9136500)
31. Murphy CF, Alexopoulos GS. 2006. Attention network dysfunction and treatment response of geriatric depression. J Clin Exp Neuropsychol 28: 96-100.
32. O'Hara R, Miller E, Liao CP, et al. 2006. COMT genotype, gender and cognition in community-dwelling, older adults. Neurosci Lett 409: 205-209. (Pubitemid 44648567)
33. Phillips ML, Drevets WC, Rauch SL, Lane R. 2003. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry 54: 504-514. (Pubitemid 37289437)
34. Reitan RM. 1992. Trail Making Test: Manual for Administration and Scoring. Reitan Neuropsychological Laboratory: Tuscon, AZ.
35. Rimmler J, McDowell JG, Slotterback BD, et al. 1998. Development of a data coordinating center (DCC): Data quality control for complex disease studies. Am J Hum Genet (Suppl 62): A240.
36. Robins LN, Helzer JE, Croughan J, Ratcliff KS. 1981. National Institute of Mental Health diagnostic interview schedule. Arch Gen Psychiatry 38: 381-389.
37. Rosa A, Peralta V, Cuesta MJ, et al. 2004. New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis. Am J Psychiatry 161: 1110-1112. (Pubitemid 38735999)
38. Russ MJ, Lachman HM, Kashdan T, et al. 2000. Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide. Psychiatry Res 93: 73-78. (Pubitemid 30123136)
39. Savitz J, Solms M, Ramesar R. 2006. The molecular genetics of cognition: dopamine, COMT and BDNF. Genes Brain Behav 5: 311-328. (Pubitemid 43794814)
40. Smith A. 1982. Symbol Digit Modalities Test - Manual. Western Psychological Services: Los Angeles, CA.
41. Starr JM, Fox H, Harris SE, et al. 2007. COMT genotype and cognitive ability: a longitudinal aging study. Neurosci Lett 421: 57-61. (Pubitemid 46899332)
42. Stefanis NC, van Os J, Avramopoulos D, et al. 2005. Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance. Am J Psychiatry 162: 1752-1754. (Pubitemid 41318251)
43. Steffens DC, McQuoid DR, Krishnan KRR. 2002. The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach. Psychopharmacol Bull 36: 58-68.
44. Steffens DC, Welsh-Bohmer KA, Burke JR, et al. 2004. Methodology and preliminary results from the Neurocognitive Outcomes of Depression in the Elderly Study. J Geriatr Psychiatry Neurol 17: 202-211. (Pubitemid 40515139)
45. Taylor WD, Zuchner S, Payne ME, et al. 2007. The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. Psychiatry Res 155: 173-177. (Pubitemid 46874917)
46. Wechsler D. 1987. Wechsler Memory Scale - Revised Manual. Psychological Corporation: San Antonio, TX.
47. Weinberger DR, Egan MF, Bertolino A, et al. 2001. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 50: 825-844.
48. Zachary RA. 1991. Shipley Institute of Living Scale - Revised Manual. Western Psychological Services: Los Angeles, CA.