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Volumn 158, Issue 3, 2009, Pages 300-307

Alpha versus beta: Are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?

Author keywords

Alpha galactosylceramide; Beta glucosylceramide; CD1d; Gaucher disease; Glycosphingolipids; NKT cells

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; GLUCOSYLCERAMIDASE; GLYCOSPHINGOLIPID; LIGAND;

EID: 70350585024     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.04030.x     Document Type: Article
Times cited : (19)

References (100)
  • 1
    • 10044286529 scopus 로고    scopus 로고
    • Going both ways: Immune regulation via CD1d-dependent NKT cells
    • Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 2004 114 : 1379 1388.
    • (2004) J Clin Invest , vol.114 , pp. 1379-1388
    • Godfrey, D.I.1    Kronenberg, M.2
  • 2
    • 34250849637 scopus 로고    scopus 로고
    • Control points in NKT-cell development
    • Godfrey DI, Berzins SP. Control points in NKT-cell development. Nat Rev Immunol 2007 7 : 505 518.
    • (2007) Nat Rev Immunol , vol.7 , pp. 505-518
    • Godfrey, D.I.1    Berzins, S.P.2
  • 4
    • 33847625852 scopus 로고    scopus 로고
    • On the road: Progress in finding the unique pathway of invariant NKT cell differentiation
    • Kronenberg M, Engel I. On the road: progress in finding the unique pathway of invariant NKT cell differentiation. Curr Opin Immunol 2007 19 : 186 193.
    • (2007) Curr Opin Immunol , vol.19 , pp. 186-193
    • Kronenberg, M.1    Engel, I.2
  • 6
    • 34748925204 scopus 로고    scopus 로고
    • A closer look at CD1d molecules: New horizons in studying NKT cells
    • Stronge VS, Salio M, Jones EY, Cerundolo V. A closer look at CD1d molecules: new horizons in studying NKT cells. Trends Immunol 2007 28 : 455 462.
    • (2007) Trends Immunol , vol.28 , pp. 455-462
    • Stronge, V.S.1    Salio, M.2    Jones, E.Y.3    Cerundolo, V.4
  • 8
    • 20444461870 scopus 로고    scopus 로고
    • Adoptive transfer of NK 1·1+ lymphocytes in immune-mediated colitis: A pro-inflammatory or a tolerizing subgroup of cells?
    • Menachem Y, Trop S, Kolker O et al. Adoptive transfer of NK 1·1+ lymphocytes in immune-mediated colitis: a pro-inflammatory or a tolerizing subgroup of cells? Microbes Infect 2005 7 : 825 835.
    • (2005) Microbes Infect , vol.7 , pp. 825-835
    • Menachem, Y.1    Trop, S.2    Kolker, O.3
  • 9
    • 0038155134 scopus 로고    scopus 로고
    • NKT and CD8 lymphocytes mediate suppression of hepatocellular carcinoma growth via tumor antigen-pulsed dendritic cells
    • Shibolet O, Alper R, Zlotogarov L et al. NKT and CD8 lymphocytes mediate suppression of hepatocellular carcinoma growth via tumor antigen-pulsed dendritic cells. Int J Cancer 2003 106 : 236 243.
    • (2003) Int J Cancer , vol.106 , pp. 236-243
    • Shibolet, O.1    Alper, R.2    Zlotogarov, L.3
  • 10
    • 1842735264 scopus 로고    scopus 로고
    • The role of intrahepatic CD8+ T cell trapping and NK1·1+ cells in liver-mediated immune regulation
    • Shibolet O, Alper R, Zolotarov L et al. The role of intrahepatic CD8+ T cell trapping and NK1·1+ cells in liver-mediated immune regulation. Clin Immunol 2004 111 : 82 92.
    • (2004) Clin Immunol , vol.111 , pp. 82-92
    • Shibolet, O.1    Alper, R.2    Zolotarov, L.3
  • 12
    • 0141958207 scopus 로고    scopus 로고
    • Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells
    • Crowe NY, Uldrich AP, Kyparissoudis K et al. Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol 2003 171 : 4020 4027.
    • (2003) J Immunol , vol.171 , pp. 4020-4027
    • Crowe, N.Y.1    Uldrich, A.P.2    Kyparissoudis, K.3
  • 13
    • 33745838249 scopus 로고    scopus 로고
    • CD1d ligands: The good, the bad, and the ugly
    • Brutkiewicz RR. CD1d ligands: the good, the bad, and the ugly. J Immunol 2006 177 : 769 775.
    • (2006) J Immunol , vol.177 , pp. 769-775
    • Brutkiewicz, R.R.1
  • 15
    • 34247577500 scopus 로고    scopus 로고
    • NKT cells: T lymphocytes with innate effector functions
    • Van Kaer L. NKT cells: T lymphocytes with innate effector functions. Curr Opin Immunol 2007 19 : 354 364.
    • (2007) Curr Opin Immunol , vol.19 , pp. 354-364
    • Van Kaer, L.1
  • 16
    • 2542448243 scopus 로고    scopus 로고
    • CD1: Antigen presentation and T cell function
    • Brigl M, Brenner MB. CD1: antigen presentation and T cell function. Annu Rev Immunol 2004 22 : 817 890.
    • (2004) Annu Rev Immunol , vol.22 , pp. 817-890
    • Brigl, M.1    Brenner, M.B.2
  • 17
    • 0035999811 scopus 로고    scopus 로고
    • Lipid presentation by CD1: The short and the long lipid story
    • Bendelac A, Teyton L, Savage PB. Lipid presentation by CD1: the short and the long lipid story. Nat Immunol 2002 3 : 421 422.
    • (2002) Nat Immunol , vol.3 , pp. 421-422
    • Bendelac, A.1    Teyton, L.2    Savage, P.B.3
  • 19
    • 21144462780 scopus 로고    scopus 로고
    • The SrtA sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestine
    • Lalioui L, Pellegrini E, Dramsi S et al. The SrtA sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestine. Infect Immun 2005 73 : 3342 3350.
    • (2005) Infect Immun , vol.73 , pp. 3342-3350
    • Lalioui, L.1    Pellegrini, E.2    Dramsi, S.3
  • 20
    • 33645074941 scopus 로고    scopus 로고
    • Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors
    • Gadola SD, Koch M, Marles-Wright J et al. Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. J Exp Med 2006 203 : 699 710.
    • (2006) J Exp Med , vol.203 , pp. 699-710
    • Gadola, S.D.1    Koch, M.2    Marles-Wright, J.3
  • 22
    • 45449103839 scopus 로고    scopus 로고
    • CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system
    • Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L. CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol 2008 20 : 358 368.
    • (2008) Curr Opin Immunol , vol.20 , pp. 358-368
    • Matsuda, J.L.1    Mallevaey, T.2    Scott-Browne, J.3    Gapin, L.4
  • 23
    • 34250203551 scopus 로고    scopus 로고
    • Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals
    • Rothenberg EV. Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals. Immunity 2007 26 : 690 702.
    • (2007) Immunity , vol.26 , pp. 690-702
    • Rothenberg, E.V.1
  • 25
    • 35748963515 scopus 로고    scopus 로고
    • Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity
    • Fujii S, Shimizu K, Hemmi H, Steinman RM. Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity. Immunol Rev 2007 220 : 183 198.
    • (2007) Immunol Rev , vol.220 , pp. 183-198
    • Fujii, S.1    Shimizu, K.2    Hemmi, H.3    Steinman, R.M.4
  • 26
    • 0038047128 scopus 로고    scopus 로고
    • Dendritic cells, T cell tolerance and therapy of adverse immune reactions
    • Morel PA, Feili-Hariri M, Coates PT, Thomson AW. Dendritic cells, T cell tolerance and therapy of adverse immune reactions. Clin Exp Immunol 2003 133 : 1 10.
    • (2003) Clin Exp Immunol , vol.133 , pp. 1-10
    • Morel, P.A.1    Feili-Hariri, M.2    Coates, P.T.3    Thomson, A.W.4
  • 27
    • 33947545104 scopus 로고    scopus 로고
    • Alleviation of acute and chronic graft-versus-host disease in a murine model is associated with glucocerebroside-enhanced natural killer T lymphocyte plasticity
    • Ilan Y, Ohana M, Pappo O et al. Alleviation of acute and chronic graft-versus-host disease in a murine model is associated with glucocerebroside-enhanced natural killer T lymphocyte plasticity. Transplantation 2007 83 : 458 467.
    • (2007) Transplantation , vol.83 , pp. 458-467
    • Ilan, Y.1    Ohana, M.2    Pappo, O.3
  • 28
    • 0036751122 scopus 로고    scopus 로고
    • Lineage plasticity and commitment in T-cell development
    • Rothenberg EV, Dionne CJ. Lineage plasticity and commitment in T-cell development. Immunol Rev 2002 187 : 96 115.
    • (2002) Immunol Rev , vol.187 , pp. 96-115
    • Rothenberg, E.V.1    Dionne, C.J.2
  • 29
    • 46749126493 scopus 로고    scopus 로고
    • Modulation of intracellular machinery by beta-glycolipids is associated with alteration of NKT lipid rafts and amelioration of concanavalin-induced hepatitis
    • Lalazar G, Ben Ya'acov A, Lador A et al. Modulation of intracellular machinery by beta-glycolipids is associated with alteration of NKT lipid rafts and amelioration of concanavalin-induced hepatitis. Mol Immunol 2008 45 : 3517 3525.
    • (2008) Mol Immunol , vol.45 , pp. 3517-3525
    • Lalazar, G.1    Ben Ya'Acov, A.2    Lador, A.3
  • 30
    • 0026681578 scopus 로고
    • Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: Role of vesicular traffic
    • Lencer WI, Delp C, Neutra MR, Madara JL. Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic. J. Cell Biol 1992 117 : 1197 1209.
    • (1992) J. Cell Biol , vol.117 , pp. 1197-1209
    • Lencer, W.I.1    Delp, C.2    Neutra, M.R.3    Madara, J.L.4
  • 31
    • 44849083151 scopus 로고    scopus 로고
    • NKT cells in tumor immunity: Opposing subsets define a new immunoregulatory axis
    • Berzofsky JA, Terabe M. NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis. J Immunol 2008 180 : 3627 3635.
    • (2008) J Immunol , vol.180 , pp. 3627-3635
    • Berzofsky, J.A.1    Terabe, M.2
  • 33
    • 80055116110 scopus 로고    scopus 로고
    • Interview: Glycolipid antigen presentation by CD1d and the therapeutic potential of NKT cell activation
    • Kronenberg M. Interview: glycolipid antigen presentation by CD1d and the therapeutic potential of NKT cell activation. J Vis Exp 2007 635.
    • (2007) J Vis Exp , pp. 635
    • Kronenberg, M.1
  • 35
    • 39649087352 scopus 로고    scopus 로고
    • Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis
    • Tsuji M, Suzuki K, Kinoshita K, Fagarasan S. Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis. Semin Immunol 2008 20 : 59 66.
    • (2008) Semin Immunol , vol.20 , pp. 59-66
    • Tsuji, M.1    Suzuki, K.2    Kinoshita, K.3    Fagarasan, S.4
  • 36
    • 20844463676 scopus 로고    scopus 로고
    • Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells
    • Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR. Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol 2005 35 : 1692 1701.
    • (2005) Eur J Immunol , vol.35 , pp. 1692-1701
    • Sriram, V.1    Du, W.2    Gervay-Hague, J.3    Brutkiewicz, R.R.4
  • 37
    • 11244304412 scopus 로고    scopus 로고
    • Alpha-galactosylceramide therapy for autoimmune diseases: Prospects and obstacles
    • Van Kaer L. Alpha-galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat Rev Immunol 2005 5 : 31 42.
    • (2005) Nat Rev Immunol , vol.5 , pp. 31-42
    • Van Kaer, L.1
  • 38
    • 23644432847 scopus 로고    scopus 로고
    • Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases
    • Miyake S, Yamamura T. Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases. Curr Drug Targets Immune Endocr Metabol Disord 2005 5 : 315 322.
    • (2005) Curr Drug Targets Immune Endocr Metabol Disord , vol.5 , pp. 315-322
    • Miyake, S.1    Yamamura, T.2
  • 39
    • 3042591658 scopus 로고    scopus 로고
    • NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease
    • Yamamura T, Miyamoto K, Illes Z, Pal E, Araki M, Miyake S. NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease. Curr Top Med Chem 2004 4 : 561 567.
    • (2004) Curr Top Med Chem , vol.4 , pp. 561-567
    • Yamamura, T.1    Miyamoto, K.2    Illes, Z.3    Pal, E.4    Araki, M.5    Miyake, S.6
  • 40
    • 62749198174 scopus 로고    scopus 로고
    • Natural killer T cells and autoimmune disease
    • Wu L, Van Kaer L. Natural killer T cells and autoimmune disease. Curr Mol Med 2009 9 : 4 14.
    • (2009) Curr Mol Med , vol.9 , pp. 4-14
    • Wu, L.1    Van Kaer, L.2
  • 41
    • 0033939943 scopus 로고    scopus 로고
    • Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide
    • Osman Y, Kawamura T, Naito T et al. Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur J Immunol 2000 30 : 1919 1928.
    • (2000) Eur J Immunol , vol.30 , pp. 1919-1928
    • Osman, Y.1    Kawamura, T.2    Naito, T.3
  • 42
    • 1842814985 scopus 로고    scopus 로고
    • The 2003 ASBMB-Avanti Award in Lipids address: Applications of novel synthetic lipids to biological problems
    • Bittman R. The 2003 ASBMB-Avanti Award in Lipids address: applications of novel synthetic lipids to biological problems. Chem Phys Lipids 2004 129 : 111 131.
    • (2004) Chem Phys Lipids , vol.129 , pp. 111-131
    • Bittman, R.1
  • 43
    • 20044387608 scopus 로고    scopus 로고
    • Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides
    • Yu KO, Im JS, Molano A et al. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides. Proc Natl Acad Sci USA 2005 102 : 3383 3388.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3383-3388
    • Yu, K.O.1    Im, J.S.2    Molano, A.3
  • 44
    • 12944255911 scopus 로고    scopus 로고
    • Alpha-galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria
    • Gonzalez-Aseguinolaza G, de Oliveira C, Tomaska M et al. Alpha-galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria. Proc Natl Acad Sci USA 2000 97 : 8461 8466.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8461-8466
    • Gonzalez-Aseguinolaza, G.1    De Oliveira, C.2    Tomaska, M.3
  • 45
    • 0037018103 scopus 로고    scopus 로고
    • Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines
    • Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC et al. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med 2002 195 : 617 624.
    • (2002) J Exp Med , vol.195 , pp. 617-624
    • Gonzalez-Aseguinolaza, G.1    Van Kaer, L.2    Bergmann, C.C.3
  • 46
    • 34547512326 scopus 로고    scopus 로고
    • Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
    • Chang YJ, Huang JR, Tsai YC et al. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids. Proc Natl Acad Sci USA 2007 104 : 10299 10304.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10299-10304
    • Chang, Y.J.1    Huang, J.R.2    Tsai, Y.C.3
  • 47
    • 0141446179 scopus 로고    scopus 로고
    • Role of CD1d-restricted NKT cells in microbial immunity
    • Skold M, Behar SM. Role of CD1d-restricted NKT cells in microbial immunity. Infect Immun 2003 71 : 5447 5455.
    • (2003) Infect Immun , vol.71 , pp. 5447-5455
    • Skold, M.1    Behar, S.M.2
  • 49
    • 23944448650 scopus 로고    scopus 로고
    • Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    • Zajonc DM, Cantu C 3rd., Mattner J et al. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol 2005 6 : 810 818.
    • (2005) Nat Immunol , vol.6 , pp. 810-818
    • Zajonc, D.M.1    Cantu III, C.2    Mattner, J.3
  • 50
    • 0038519517 scopus 로고    scopus 로고
    • Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences
    • Stanic AK, Park JJ, Joyce S. Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences. Immunology 2003 109 : 171 184.
    • (2003) Immunology , vol.109 , pp. 171-184
    • Stanic, A.K.1    Park, J.J.2    Joyce, S.3
  • 51
    • 34249103661 scopus 로고    scopus 로고
    • The unique role of natural killer T cells in the response to microorganisms
    • Tupin E, Kinjo Y, Kronenberg M. The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol 2007 5 : 405 417.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 405-417
    • Tupin, E.1    Kinjo, Y.2    Kronenberg, M.3
  • 52
    • 33744974779 scopus 로고    scopus 로고
    • Locus of Pseudomonas aeruginosa encodes a protein secretion apparatus
    • Mougous JD, Cuff ME, Raunser S et al. Locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 2006 312 : 1526 1530.
    • (2006) Science , vol.312 , pp. 1526-1530
    • Mougous, J.D.1    Cuff, M.E.2    Raunser, S.3
  • 54
    • 34247592222 scopus 로고    scopus 로고
    • Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency
    • Porubsky S, Speak AO, Luckow B, Cerundolo V, Platt FM, Grone HJ. Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci USA 2007 104 : 5977 5982.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5977-5982
    • Porubsky, S.1    Speak, A.O.2    Luckow, B.3    Cerundolo, V.4    Platt, F.M.5    Grone, H.J.6
  • 56
    • 29444439664 scopus 로고    scopus 로고
    • Valpha14i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes
    • Kinjo Y, Kronenberg M. Valpha14i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes. J Clin Immunol 2005 25 : 522 533.
    • (2005) J Clin Immunol , vol.25 , pp. 522-533
    • Kinjo, Y.1    Kronenberg, M.2
  • 57
    • 20144389877 scopus 로고    scopus 로고
    • Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    • Mattner J, Debord KL, Ismail N et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 2005 434 : 525 529.
    • (2005) Nature , vol.434 , pp. 525-529
    • Mattner, J.1    Debord, K.L.2    Ismail, N.3
  • 58
    • 0037080344 scopus 로고    scopus 로고
    • Lipid protein interactions: The assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum
    • De Silva AD, Park JJ, Matsuki N et al. Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. J Immunol 2002 168 : 723 733.
    • (2002) J Immunol , vol.168 , pp. 723-733
    • De Silva, A.D.1    Park, J.J.2    Matsuki, N.3
  • 59
    • 23244459501 scopus 로고    scopus 로고
    • Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: A molecular basis for NKT cell activation
    • Giabbai B, Sidobre S, Crispin MD et al. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol 2005 175 : 977 984.
    • (2005) J Immunol , vol.175 , pp. 977-984
    • Giabbai, B.1    Sidobre, S.2    Crispin, M.D.3
  • 60
    • 33845346790 scopus 로고    scopus 로고
    • Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids
    • Goni FM, Alonso A. Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids. Biochim Biophys Acta 2006 1758 : 1902 1921.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1902-1921
    • Goni, F.M.1    Alonso, A.2
  • 63
    • 0027489663 scopus 로고
    • Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to epithelial cells in vitro
    • Apter FM, Lencer WI, Finkelstein RA, Mekalanos JJ, Neutra MR. Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to epithelial cells in vitro. Infect Immun 1993 61 : 5271 5278.
    • (1993) Infect Immun , vol.61 , pp. 5271-5278
    • Apter, F.M.1    Lencer, W.I.2    Finkelstein, R.A.3    Mekalanos, J.J.4    Neutra, M.R.5
  • 64
    • 27444445562 scopus 로고    scopus 로고
    • Glucocerebroside induces altered anti hepatitis C immunity in patients with Gaucher's disease
    • Margalit MZL, Hemed N, Elstein D, Zimran A, Ilan Y. Glucocerebroside induces altered anti hepatitis C immunity in patients with Gaucher's disease. Hepatology 2003 38 (Suppl. 1 490A.
    • (2003) Hepatology , vol.38 , Issue.1 SUPPL
    • Margalit, M.Z.L.1    Hemed, N.2    Elstein, D.3    Zimran, A.4    Ilan, Y.5
  • 65
    • 70350611381 scopus 로고    scopus 로고
    • Impact of glycosphingolipid accumulation on the immunological phenotype: Gaucher disease as a model
    • Abstract S3-8
    • Baleria A. Impact of glycosphingolipid accumulation on the immunological phenotype: Gaucher disease as a model. 5th Interantional CD1d NKT meeting 2009. Abstract S3-8.
    • 5th Interantional CD1d NKT Meeting 2009
    • Baleria, A.1
  • 66
    • 27444432804 scopus 로고    scopus 로고
    • Glucocerebroside treatment ameliorates ConA hepatitis by inhibition of NKT lymphocytes
    • Margalit M, Ghazala SA, Alper R et al. Glucocerebroside treatment ameliorates ConA hepatitis by inhibition of NKT lymphocytes. Am J Physiol Gastrointest Liver Physiol 2005 289 : G917 25.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289 , pp. 917-25
    • Margalit, M.1    Ghazala, S.A.2    Alper, R.3
  • 67
    • 1642454720 scopus 로고    scopus 로고
    • Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides
    • Ortaldo JR, Young HA, Winkler-Pickett RT, Bere EW Jr., Murphy WJ, Wiltrout RH. Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides. J Immunol 2004 172 : 943 953.
    • (2004) J Immunol , vol.172 , pp. 943-953
    • Ortaldo, J.R.1    Young, H.A.2    Winkler-Pickett, R.T.3    Bere, Jr.E.W.4    Murphy, W.J.5    Wiltrout, R.H.6
  • 68
    • 0037452710 scopus 로고    scopus 로고
    • Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency
    • Stanic AK, De Silva AD, Park JJ et al. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc Natl Acad Sci USA 2003 100 : 1849 1854.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1849-1854
    • Stanic, A.K.1    De Silva, A.D.2    Park, J.J.3
  • 69
    • 70349746923 scopus 로고    scopus 로고
    • Glucocerebroside: An evolutionary advantage for patients with Gaucher disease and a new immunomodulatory agent
    • Ilan Y, Elstein D, Zimran A. Glucocerebroside: an evolutionary advantage for patients with Gaucher disease and a new immunomodulatory agent. Immunol Cell Biol 2009.
    • (2009) Immunol Cell Biol
    • Ilan, Y.1    Elstein, D.2    Zimran, A.3
  • 70
    • 33846008441 scopus 로고    scopus 로고
    • Beta-glucosylceramide: A novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders
    • Zigmond E, Preston S, Pappo O et al. Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders. Gut 2007 56 : 82 9.
    • (2007) Gut , vol.56 , pp. 82-9
    • Zigmond, E.1    Preston, S.2    Pappo, O.3
  • 71
    • 34548590364 scopus 로고    scopus 로고
    • Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution
    • Safadi R, Zigmond E, Pappo O, Shalev Z, Ilan Y. Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution. Int Immunol 2007 19 : 1021 1029.
    • (2007) Int Immunol , vol.19 , pp. 1021-1029
    • Safadi, R.1    Zigmond, E.2    Pappo, O.3    Shalev, Z.4    Ilan, Y.5
  • 72
    • 33748517193 scopus 로고    scopus 로고
    • Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: Failure of humoral and cellular immune response
    • Rosenau J, Hooman N, Rifai K et al. Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: failure of humoral and cellular immune response. Transpl Int 2006 19 : 828 833.
    • (2006) Transpl Int , vol.19 , pp. 828-833
    • Rosenau, J.1    Hooman, N.2    Rifai, K.3
  • 73
    • 33749003142 scopus 로고    scopus 로고
    • Glucocerebroside ameliorates the metabolic syndrome in OB/OB mice
    • Margalit M, Shalev Z, Pappo O et al. Glucocerebroside ameliorates the metabolic syndrome in OB/OB mice. J Pharmacol Exp Ther 2006 319 : 105 110.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 105-110
    • Margalit, M.1    Shalev, Z.2    Pappo, O.3
  • 74
    • 58249116770 scopus 로고    scopus 로고
    • Beta}-Glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat
    • Zigmond E, Zangen SW, Pappo O et al. beta}-Glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat. Am J Physiol Endocrinol Metab 2009 296 : E72 8.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. 72-8
    • Zigmond, E.1    Zangen, S.W.2    Pappo, O.3
  • 75
    • 70349751324 scopus 로고    scopus 로고
    • Amelioration of hepatic steatosis and insulin resistance in psammomys obesus by a combination of beta-glycolipids is associated with STAT 1 and 4 expression
    • Tayer-Shiffman O ZE, Pappo O, Sklair-Levy M et al. Amelioration of hepatic steatosis and insulin resistance in psammomys obesus by a combination of beta-glycolipids is associated with STAT 1 and 4 expression. Hepatology 2006 44 (Suppl. 1 71A.
    • (2006) Hepatology , vol.44 , Issue.1 SUPPL
    • Ze, T.O.1    Pappo, O.2    Sklair-Levy, M.3
  • 76
    • 42749088766 scopus 로고    scopus 로고
    • Beta-glycoglycosphingolipid-induced augmentation of the anti-HBV immune response is associated with altered CD8 and NKT lymphocyte distribution: A novel adjuvant for HBV vaccination
    • Mizrahi M, Lalazar G, Ben Ya'acov A et al. Beta-glycoglycosphingolipid- induced augmentation of the anti-HBV immune response is associated with altered CD8 and NKT lymphocyte distribution: a novel adjuvant for HBV vaccination. Vaccine 2008 26 : 2589 2595.
    • (2008) Vaccine , vol.26 , pp. 2589-2595
    • Mizrahi, M.1    Lalazar, G.2    Ben Ya'Acov, A.3
  • 77
    • 35348828497 scopus 로고    scopus 로고
    • Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells
    • Onoe K, Yanagawa Y, Minami K, Iijima N, Iwabuchi K. Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells. Immunol Res 2007 38 : 319 332.
    • (2007) Immunol Res , vol.38 , pp. 319-332
    • Onoe, K.1    Yanagawa, Y.2    Minami, K.3    Iijima, N.4    Iwabuchi, K.5
  • 78
    • 35848941934 scopus 로고    scopus 로고
    • Understanding the behavior of invariant NKT cells in autoimmune diseases
    • Yamamura T, Sakuishi K, Illes Z, Miyake S. Understanding the behavior of invariant NKT cells in autoimmune diseases. J Neuroimmunol 2007 191 : 8 15.
    • (2007) J Neuroimmunol , vol.191 , pp. 8-15
    • Yamamura, T.1    Sakuishi, K.2    Illes, Z.3    Miyake, S.4
  • 79
    • 45849094310 scopus 로고    scopus 로고
    • Alleviation of ConA immune mediated hepatitis via glycolipids: The role of beta versus alpha configuration in determining NKT lymphocyte distribution and the TH1/TH2 paradigm
    • Lalazar G PS, Lador A, Pappo O, Zolotarov L, Ilan Y. Alleviation of ConA immune mediated hepatitis via glycolipids: the role of beta versus alpha configuration in determining NKT lymphocyte distribution and the TH1/TH2 paradigm. J Hepatol 2006 44 : S237.
    • (2006) J Hepatol , vol.44 , pp. 237
    • Ps, L.G.1    Lador, A.2    Pappo, O.3    Zolotarov, L.4    Ilan, Y.5
  • 81
    • 2442459084 scopus 로고    scopus 로고
    • Plasma membrane rafts and chaperones in cytokine/STAT signaling
    • Sehgal PB. Plasma membrane rafts and chaperones in cytokine/STAT signaling. Acta Biochim Pol 2003 50 : 583 594.
    • (2003) Acta Biochim Pol , vol.50 , pp. 583-594
    • Sehgal, P.B.1
  • 82
    • 27144528203 scopus 로고    scopus 로고
    • The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung
    • Wieland CW, Florquin S, Maris NA et al. The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung. J Immunol 2005 175 : 6042 6049.
    • (2005) J Immunol , vol.175 , pp. 6042-6049
    • Wieland, C.W.1    Florquin, S.2    Maris, N.A.3
  • 83
    • 1642481152 scopus 로고    scopus 로고
    • New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases
    • Butters TD, Dwek RA, Platt FM. New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases. Adv Exp Med Biol 2003 535 : 219 226.
    • (2003) Adv Exp Med Biol , vol.535 , pp. 219-226
    • Butters, T.D.1    Dwek, R.A.2    Platt, F.M.3
  • 84
    • 58149394044 scopus 로고    scopus 로고
    • Enzyme replacement therapy for Gaucher disease
    • Charrow J. Enzyme replacement therapy for Gaucher disease. Expert Opin Biol Ther 2009 9 : 121 131.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 121-131
    • Charrow, J.1
  • 85
    • 45849102732 scopus 로고    scopus 로고
    • Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring
    • Cox TM, Aerts JM, Belmatoug N et al. Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring. J Inherit Metab Dis 2008 31 : 319 336.
    • (2008) J Inherit Metab Dis , vol.31 , pp. 319-336
    • Cox, T.M.1    Aerts, J.M.2    Belmatoug, N.3
  • 86
    • 41049113128 scopus 로고    scopus 로고
    • Gaucher disease: Unmet treatment needs
    • Mehta A. Gaucher disease: unmet treatment needs. Acta Paediatr Suppl 2008 97 : 83 7.
    • (2008) Acta Paediatr Suppl , vol.97 , pp. 83-7
    • Mehta, A.1
  • 87
    • 4744370348 scopus 로고    scopus 로고
    • Therapeutic goals in the treatment of Gaucher disease
    • Pastores GM, Weinreb NJ, Aerts H et al. Therapeutic goals in the treatment of Gaucher disease. Semin Hematol 2004 41 : 4 14.
    • (2004) Semin Hematol , vol.41 , pp. 4-14
    • Pastores, G.M.1    Weinreb, N.J.2    Aerts, H.3
  • 88
    • 56749172489 scopus 로고    scopus 로고
    • Life expectancy in Gaucher disease type 1
    • Weinreb NJ, Deegan P, Kacena KA et al. Life expectancy in Gaucher disease type 1. Am J Hematol 2008 83 : 896 900.
    • (2008) Am J Hematol , vol.83 , pp. 896-900
    • Weinreb, N.J.1    Deegan, P.2    Kacena, K.A.3
  • 89
    • 0020014944 scopus 로고
    • The pathology of Gaucher disease
    • Lee RE. The pathology of Gaucher disease. Prog Clin Biol Res 1982 95 : 177 217.
    • (1982) Prog Clin Biol Res , vol.95 , pp. 177-217
    • Lee, R.E.1
  • 90
    • 64549098111 scopus 로고    scopus 로고
    • Enzyme replacement therapy for mild patients with Gaucher disease
    • Zimran A, Ilan Y, Elstein D. Enzyme replacement therapy for mild patients with Gaucher disease. Am J Hematol 2009 84 : 202 204.
    • (2009) Am J Hematol , vol.84 , pp. 202-204
    • Zimran, A.1    Ilan, Y.2    Elstein, D.3
  • 91
    • 41949110081 scopus 로고    scopus 로고
    • Overweight, insulin resistance and type II diabetes in type i Gaucher disease patients in relation to enzyme replacement therapy
    • Langeveld M, de Fost M, Aerts JM, Sauerwein HP, Hollak CE. Overweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy. Blood Cell Mol Dis 2008 40 : 428 432.
    • (2008) Blood Cell Mol Dis , vol.40 , pp. 428-432
    • Langeveld, M.1    De Fost, M.2    Aerts, J.M.3    Sauerwein, H.P.4    Hollak, C.E.5
  • 92
    • 35348971298 scopus 로고    scopus 로고
    • Treatment of non-alcoholic steatohepatitis by B-glucosylceramide: A phase I/II clinical study
    • Zigmond E, Papo O, Zangen S et al. Treatment of non-alcoholic steatohepatitis by B-glucosylceramide: a phase I/II clinical study. Hepatology 2006 44 : 180A.
    • (2006) Hepatology , vol.44
    • Zigmond, E.1    Papo, O.2    Zangen, S.3
  • 93
    • 65349134102 scopus 로고    scopus 로고
    • Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2
    • Lalazar G, Ben Ya'acov A, Livovsky DM et al. Beta-glycoglycosphingolipid- induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2. Am J Pathol 2009 174 : 1390 1399.
    • (2009) Am J Pathol , vol.174 , pp. 1390-1399
    • Lalazar, G.1    Ben Ya'Acov, A.2    Livovsky, D.M.3
  • 94
    • 0028944665 scopus 로고
    • Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    • Halder G, Callaerts P, Gehring WJ. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 1995 267 : 1788 1792.
    • (1995) Science , vol.267 , pp. 1788-1792
    • Halder, G.1    Callaerts, P.2    Gehring, W.J.3
  • 95
    • 53849114351 scopus 로고    scopus 로고
    • The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy- pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells
    • Bijl N, Scheij S, Houten S, Boot RG, Groen AK, Aerts JM. The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)- deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells. J Pharmacol Exp Ther 2008 326 : 849 855.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 849-855
    • Bijl, N.1    Scheij, S.2    Houten, S.3    Boot, R.G.4    Groen, A.K.5    Aerts, J.M.6
  • 96
    • 61949419193 scopus 로고    scopus 로고
    • Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice
    • Bijl N, van Roomen CP, Triantis V et al. Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice. Hepatology 2009 49 : 637 645.
    • (2009) Hepatology , vol.49 , pp. 637-645
    • Bijl, N.1    Van Roomen, C.P.2    Triantis, V.3
  • 97
    • 63349110943 scopus 로고    scopus 로고
    • Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation
    • van Eijk M, Aten J, Bijl N et al. Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PLoS One 2009 4 : e4723.
    • (2009) PLoS One , vol.4 , pp. 4723
    • Van Eijk, M.1    Aten, J.2    Bijl, N.3
  • 98
    • 34248228704 scopus 로고    scopus 로고
    • Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes
    • Zhao H, Przybylska M, Wu IH et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes 2007 56 : 1210 1218.
    • (2007) Diabetes , vol.56 , pp. 1210-1218
    • Zhao, H.1    Przybylska, M.2    Wu, I.H.3
  • 99
    • 0036479215 scopus 로고    scopus 로고
    • Ganglioside GM3 participates in the pathological conditions of insulin resistance
    • Tagami S, Inokuchi Ji J, Kabayama K et al. Ganglioside GM3 participates in the pathological conditions of insulin resistance. J Biol Chem 2002 277 : 3085 3092.
    • (2002) J Biol Chem , vol.277 , pp. 3085-3092
    • Tagami, S.1    Inokuchi Ji, J.2    Kabayama, K.3
  • 100
    • 53149151479 scopus 로고    scopus 로고
    • Beta}-Glycosphingolipids-mediated lipid raft alteration is associated with redistribution of NKT cells and increased intrahepatic CD8+ T lymphocyte trapping
    • Lalazar G, Ben Ya'acov A, Eliakim-Raz N et al. beta}-Glycosphingolipids- mediated lipid raft alteration is associated with redistribution of NKT cells and increased intrahepatic CD8+ T lymphocyte trapping. J Lipid Res 2008 49 : 1884 1893.
    • (2008) J Lipid Res , vol.49 , pp. 1884-1893
    • Lalazar, G.1    Ben Ya'Acov, A.2    Eliakim-Raz, N.3


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