메뉴 건너뛰기




Volumn 69, Issue 1, 2010, Pages 9-15

Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells

Author keywords

Intron; Mammalian cells; Post transcription; Transient gene expression; Untranslated region (UTR); WPRE

Indexed keywords

GAMMA INTERFERON; LUCIFERASE; MONOCLONAL ANTIBODY; TRASTUZUMAB;

EID: 70350574634     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2009.08.010     Document Type: Article
Times cited : (41)

References (41)
  • 1
    • 34147125994 scopus 로고    scopus 로고
    • Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives
    • Baldi L., Hacker D.L., Adam M., and Wurm F.M. Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives. Biotechnology Letters 29 (2007) 677-684
    • (2007) Biotechnology Letters , vol.29 , pp. 677-684
    • Baldi, L.1    Hacker, D.L.2    Adam, M.3    Wurm, F.M.4
  • 3
    • 33846049519 scopus 로고    scopus 로고
    • Limiting factors governing protein expression following polyethyleneimine-mediated gene transfer in HEK293-EBNA1 cells
    • Carpentier E., Paris S., Kamen A.A., and Durocher Y. Limiting factors governing protein expression following polyethyleneimine-mediated gene transfer in HEK293-EBNA1 cells. Journal of Biotechnology 128 (2007) 268-280
    • (2007) Journal of Biotechnology , vol.128 , pp. 268-280
    • Carpentier, E.1    Paris, S.2    Kamen, A.A.3    Durocher, Y.4
  • 4
    • 0033039916 scopus 로고    scopus 로고
    • Large-scale transient expression in mammalian cells for recombinant protein production
    • Wurm F., and Bernard A. Large-scale transient expression in mammalian cells for recombinant protein production. Current Opinion in Biotechnology 10 (1999) 156-159
    • (1999) Current Opinion in Biotechnology , vol.10 , pp. 156-159
    • Wurm, F.1    Bernard, A.2
  • 5
    • 50849109798 scopus 로고    scopus 로고
    • Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
    • Backliwal G., Hildinger M., Chenuet S., Wulhfard S., De Jesus M., and Wurm F.M. Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions. Nucleic Acids Research 36 (2008)
    • (2008) Nucleic Acids Research , vol.36
    • Backliwal, G.1    Hildinger, M.2    Chenuet, S.3    Wulhfard, S.4    De Jesus, M.5    Wurm, F.M.6
  • 6
    • 0037082158 scopus 로고    scopus 로고
    • High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells
    • Durocher Y., Perret S., and Kamen A. High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Research 30 (2002)
    • (2002) Nucleic Acids Research , vol.30
    • Durocher, Y.1    Perret, S.2    Kamen, A.3
  • 7
    • 5044221831 scopus 로고    scopus 로고
    • Reduction of adenovirus E1A mRNA by RNAi results in enhanced recombinant protein expression in transiently transfected HEK293 cells
    • Hacker D.L., Bertschinger M., Baldi L., and Wurm F.M. Reduction of adenovirus E1A mRNA by RNAi results in enhanced recombinant protein expression in transiently transfected HEK293 cells. Gene 341 (2004) 227-234
    • (2004) Gene , vol.341 , pp. 227-234
    • Hacker, D.L.1    Bertschinger, M.2    Baldi, L.3    Wurm, F.M.4
  • 8
    • 0033653716 scopus 로고    scopus 로고
    • Overview of vector design for mammalian gene expression
    • Kaufman R.J. Overview of vector design for mammalian gene expression. Molecular Biotechnology 16 (2000) 151-160
    • (2000) Molecular Biotechnology , vol.16 , pp. 151-160
    • Kaufman, R.J.1
  • 11
    • 0030823320 scopus 로고    scopus 로고
    • Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells
    • Kim C.H., Oh Y., and Lee T.H. Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells. Gene 199 (1997) 293-301
    • (1997) Gene , vol.199 , pp. 293-301
    • Kim, C.H.1    Oh, Y.2    Lee, T.H.3
  • 12
    • 0038489122 scopus 로고    scopus 로고
    • Optimization of transgene expression at the posttranscriptional level in neural cells: implications for gene therapy
    • Brun S., Faucon-Biguet N., and Mallet J. Optimization of transgene expression at the posttranscriptional level in neural cells: implications for gene therapy. Molecular Therapy 7 (2003) 782-789
    • (2003) Molecular Therapy , vol.7 , pp. 782-789
    • Brun, S.1    Faucon-Biguet, N.2    Mallet, J.3
  • 13
    • 33847340082 scopus 로고    scopus 로고
    • The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide
    • Knappskog S., Ravneberg H., Gjerdrum C., Trosse C., Stern B., and Pryme I.F. The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide. Journal of Biotechnology 128 (2007) 705-715
    • (2007) Journal of Biotechnology , vol.128 , pp. 705-715
    • Knappskog, S.1    Ravneberg, H.2    Gjerdrum, C.3    Trosse, C.4    Stern, B.5    Pryme, I.F.6
  • 15
    • 0033231184 scopus 로고    scopus 로고
    • Components of vectors for gene transfer and expression in mammalian cells
    • Makrides S.C. Components of vectors for gene transfer and expression in mammalian cells. Protein Expression and Purification 17 (1999) 183-202
    • (1999) Protein Expression and Purification , vol.17 , pp. 183-202
    • Makrides, S.C.1
  • 16
    • 15944427155 scopus 로고    scopus 로고
    • Alteration in the IL-2 signal peptide affects secretion of proteins in vitro and in vivo
    • Zhang L., Leng Q.X., and Mixson A.J. Alteration in the IL-2 signal peptide affects secretion of proteins in vitro and in vivo. Journal of Gene Medicine 7 (2005) 354-365
    • (2005) Journal of Gene Medicine , vol.7 , pp. 354-365
    • Zhang, L.1    Leng, Q.X.2    Mixson, A.J.3
  • 17
    • 0033059981 scopus 로고    scopus 로고
    • Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis
    • Zhao J., Hyman L., and Moore C. Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Microbiology and Molecular Biology Reviews 63 (1999) 405-445
    • (1999) Microbiology and Molecular Biology Reviews , vol.63 , pp. 405-445
    • Zhao, J.1    Hyman, L.2    Moore, C.3
  • 18
    • 31444451310 scopus 로고    scopus 로고
    • A transient expression vector for recombinant protein production in Chinese hamster ovary cells
    • Liao M.M.L., and Sunstrom N.A. A transient expression vector for recombinant protein production in Chinese hamster ovary cells. Journal of Chemical Technology and Biotechnology 81 (2006) 82-88
    • (2006) Journal of Chemical Technology and Biotechnology , vol.81 , pp. 82-88
    • Liao, M.M.L.1    Sunstrom, N.A.2
  • 20
    • 0031869662 scopus 로고    scopus 로고
    • Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia
    • Stein I., Itin A., Einat P., Skaliter R., Grossman Z., and Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Molecular and Cellular Biology 18 (1998) 3112-3119
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 3112-3119
    • Stein, I.1    Itin, A.2    Einat, P.3    Skaliter, R.4    Grossman, Z.5    Keshet, E.6
  • 24
    • 0025866787 scopus 로고
    • Effect of intron A from human cytomegalovirus (Towne) immediately-early gene on heterologous expression in mammalian cells
    • Chapman B.S.T., Thayer R.M., Vincent K.A., and Haigwood N.L. Effect of intron A from human cytomegalovirus (Towne) immediately-early gene on heterologous expression in mammalian cells. Nucleic Acids Research 19 (1991) 3979-3986
    • (1991) Nucleic Acids Research , vol.19 , pp. 3979-3986
    • Chapman, B.S.T.1    Thayer, R.M.2    Vincent, K.A.3    Haigwood, N.L.4
  • 25
    • 0032406411 scopus 로고    scopus 로고
    • Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene
    • Simari R.D., Yang Z.Y., Ling X., Stephan D., Perkins N.D., Nabel G.J., and Nabel E.G. Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene. Molecular Medicine 4 (1998) 700-706
    • (1998) Molecular Medicine , vol.4 , pp. 700-706
    • Simari, R.D.1    Yang, Z.Y.2    Ling, X.3    Stephan, D.4    Perkins, N.D.5    Nabel, G.J.6    Nabel, E.G.7
  • 28
    • 0031950572 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element
    • Donello J.E., Loeb J.E., and Hope T.J. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. Journal of Virology 72 (1998) 5085-5092
    • (1998) Journal of Virology , vol.72 , pp. 5085-5092
    • Donello, J.E.1    Loeb, J.E.2    Hope, T.J.3
  • 30
    • 0034322479 scopus 로고    scopus 로고
    • Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors
    • Schambach A., Wodrich H., Hildinger M., Bohne J., Krausslich H.G., and Baum C. Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors. Molecular Therapy 2 (2000) 435-445
    • (2000) Molecular Therapy , vol.2 , pp. 435-445
    • Schambach, A.1    Wodrich, H.2    Hildinger, M.3    Bohne, J.4    Krausslich, H.G.5    Baum, C.6
  • 31
    • 0038699545 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors
    • Xu Z.L., Mizuguchi H., Mayumi T., and Hayakawa T. Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors. Biochimica Et Biophysica Acta-General Subjects 1621 (2003) 266-271
    • (2003) Biochimica Et Biophysica Acta-General Subjects , vol.1621 , pp. 266-271
    • Xu, Z.L.1    Mizuguchi, H.2    Mayumi, T.3    Hayakawa, T.4
  • 32
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R., Donello J.E., Trono D., and Hope T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. Journal of Virology 73 (1999) 2886-2892
    • (1999) Journal of Virology , vol.73 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4
  • 33
    • 33646051851 scopus 로고    scopus 로고
    • WPRE-mediated enhancement of gene expression is promoter and cell line specific
    • Klein R., Ruttkowski B., Knapp E., Salmons B., Gunzburg W.H., and Hohenadl C. WPRE-mediated enhancement of gene expression is promoter and cell line specific. Gene 372 (2006) 153-161
    • (2006) Gene , vol.372 , pp. 153-161
    • Klein, R.1    Ruttkowski, B.2    Knapp, E.3    Salmons, B.4    Gunzburg, W.H.5    Hohenadl, C.6
  • 34
    • 25144441095 scopus 로고    scopus 로고
    • Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors
    • Hlavaty J., Schittmayer M., Stracke A., Jandl G., Knapp E., Felber B.K., Salmons B., Gunzburg W.H., and Renner M. Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors. Virology 341 (2005) 1-11
    • (2005) Virology , vol.341 , pp. 1-11
    • Hlavaty, J.1    Schittmayer, M.2    Stracke, A.3    Jandl, G.4    Knapp, E.5    Felber, B.K.6    Salmons, B.7    Gunzburg, W.H.8    Renner, M.9
  • 35
    • 3042790053 scopus 로고    scopus 로고
    • Increased in vitro and in vivo transgene expression levels mediated through cis-acting elements
    • Johansen J., Tornoe J., Moller A., and Johansen T.E. Increased in vitro and in vivo transgene expression levels mediated through cis-acting elements. Journal of Gene Medicine 5 (2003) 1080-1089
    • (2003) Journal of Gene Medicine , vol.5 , pp. 1080-1089
    • Johansen, J.1    Tornoe, J.2    Moller, A.3    Johansen, T.E.4
  • 36
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
    • Molina M.A., Codony-Servat J., Albanell J., Rojo F., Arribas J., and Baselga J. Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. Cancer Research 61 (2001) 4744-4749
    • (2001) Cancer Research , vol.61 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3    Rojo, F.4    Arribas, J.5    Baselga, J.6
  • 37
    • 60549116306 scopus 로고    scopus 로고
    • Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells
    • Yang Y.S., Mariati, and Ho S.C.L. Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells. Biotechnology and Bioengineering 102 (2009) 1152-1160
    • (2009) Biotechnology and Bioengineering , vol.102 , pp. 1152-1160
    • Yang, Y.S.1    Mariati2    Ho, S.C.L.3
  • 38
    • 0033038265 scopus 로고    scopus 로고
    • Genetic optimization of recombinant glycoprotein production by mammalian cells
    • Fussenegger M., Bailey J.E., Hauser H., and Mueller P.P. Genetic optimization of recombinant glycoprotein production by mammalian cells. Trends in Biotechnology 17 (1999) 35-42
    • (1999) Trends in Biotechnology , vol.17 , pp. 35-42
    • Fussenegger, M.1    Bailey, J.E.2    Hauser, H.3    Mueller, P.P.4
  • 39
    • 35748974497 scopus 로고    scopus 로고
    • Cell-specific effects of human cytomegalovirus unique region on recombinant protein expression
    • Lee J., Lau J., Chong G., and Chao S.H. Cell-specific effects of human cytomegalovirus unique region on recombinant protein expression. Biotechnology Letters 29 (2007) 1797-1802
    • (2007) Biotechnology Letters , vol.29 , pp. 1797-1802
    • Lee, J.1    Lau, J.2    Chong, G.3    Chao, S.H.4
  • 41
    • 0033066691 scopus 로고    scopus 로고
    • Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences
    • Li X.Y., Eastman E.M., Schwartz R.J., and Draghia-Akli R. Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences. Nature Biotechnology 17 (1999) 241-245
    • (1999) Nature Biotechnology , vol.17 , pp. 241-245
    • Li, X.Y.1    Eastman, E.M.2    Schwartz, R.J.3    Draghia-Akli, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.