-
1
-
-
34147125994
-
Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives
-
Baldi L., Hacker D.L., Adam M., and Wurm F.M. Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives. Biotechnology Letters 29 (2007) 677-684
-
(2007)
Biotechnology Letters
, vol.29
, pp. 677-684
-
-
Baldi, L.1
Hacker, D.L.2
Adam, M.3
Wurm, F.M.4
-
2
-
-
13544257263
-
Transient gene expression in suspension HEK-293 cells: application to large-scale protein production
-
Baldi L., Muller N., Picasso S., Jacquet R., Girard P., Thanh H.P., Derow E., and Wurm F.M. Transient gene expression in suspension HEK-293 cells: application to large-scale protein production. Biotechnology Progress 21 (2005) 148-153
-
(2005)
Biotechnology Progress
, vol.21
, pp. 148-153
-
-
Baldi, L.1
Muller, N.2
Picasso, S.3
Jacquet, R.4
Girard, P.5
Thanh, H.P.6
Derow, E.7
Wurm, F.M.8
-
3
-
-
33846049519
-
Limiting factors governing protein expression following polyethyleneimine-mediated gene transfer in HEK293-EBNA1 cells
-
Carpentier E., Paris S., Kamen A.A., and Durocher Y. Limiting factors governing protein expression following polyethyleneimine-mediated gene transfer in HEK293-EBNA1 cells. Journal of Biotechnology 128 (2007) 268-280
-
(2007)
Journal of Biotechnology
, vol.128
, pp. 268-280
-
-
Carpentier, E.1
Paris, S.2
Kamen, A.A.3
Durocher, Y.4
-
4
-
-
0033039916
-
Large-scale transient expression in mammalian cells for recombinant protein production
-
Wurm F., and Bernard A. Large-scale transient expression in mammalian cells for recombinant protein production. Current Opinion in Biotechnology 10 (1999) 156-159
-
(1999)
Current Opinion in Biotechnology
, vol.10
, pp. 156-159
-
-
Wurm, F.1
Bernard, A.2
-
5
-
-
50849109798
-
Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
-
Backliwal G., Hildinger M., Chenuet S., Wulhfard S., De Jesus M., and Wurm F.M. Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions. Nucleic Acids Research 36 (2008)
-
(2008)
Nucleic Acids Research
, vol.36
-
-
Backliwal, G.1
Hildinger, M.2
Chenuet, S.3
Wulhfard, S.4
De Jesus, M.5
Wurm, F.M.6
-
6
-
-
0037082158
-
High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells
-
Durocher Y., Perret S., and Kamen A. High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Research 30 (2002)
-
(2002)
Nucleic Acids Research
, vol.30
-
-
Durocher, Y.1
Perret, S.2
Kamen, A.3
-
7
-
-
5044221831
-
Reduction of adenovirus E1A mRNA by RNAi results in enhanced recombinant protein expression in transiently transfected HEK293 cells
-
Hacker D.L., Bertschinger M., Baldi L., and Wurm F.M. Reduction of adenovirus E1A mRNA by RNAi results in enhanced recombinant protein expression in transiently transfected HEK293 cells. Gene 341 (2004) 227-234
-
(2004)
Gene
, vol.341
, pp. 227-234
-
-
Hacker, D.L.1
Bertschinger, M.2
Baldi, L.3
Wurm, F.M.4
-
8
-
-
0033653716
-
Overview of vector design for mammalian gene expression
-
Kaufman R.J. Overview of vector design for mammalian gene expression. Molecular Biotechnology 16 (2000) 151-160
-
(2000)
Molecular Biotechnology
, vol.16
, pp. 151-160
-
-
Kaufman, R.J.1
-
9
-
-
0037279411
-
Engineering mRNA translation initiation to enhance transient gene expression in Chinese hamster ovary cells
-
Underhill M.F., Coley C., Birch J.R., Findlay A., Kallmeier R., Proud C.G., and James D.C. Engineering mRNA translation initiation to enhance transient gene expression in Chinese hamster ovary cells. Biotechnology Progress 19 (2003) 121-129
-
(2003)
Biotechnology Progress
, vol.19
, pp. 121-129
-
-
Underhill, M.F.1
Coley, C.2
Birch, J.R.3
Findlay, A.4
Kallmeier, R.5
Proud, C.G.6
James, D.C.7
-
11
-
-
0030823320
-
Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells
-
Kim C.H., Oh Y., and Lee T.H. Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells. Gene 199 (1997) 293-301
-
(1997)
Gene
, vol.199
, pp. 293-301
-
-
Kim, C.H.1
Oh, Y.2
Lee, T.H.3
-
12
-
-
0038489122
-
Optimization of transgene expression at the posttranscriptional level in neural cells: implications for gene therapy
-
Brun S., Faucon-Biguet N., and Mallet J. Optimization of transgene expression at the posttranscriptional level in neural cells: implications for gene therapy. Molecular Therapy 7 (2003) 782-789
-
(2003)
Molecular Therapy
, vol.7
, pp. 782-789
-
-
Brun, S.1
Faucon-Biguet, N.2
Mallet, J.3
-
13
-
-
33847340082
-
The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide
-
Knappskog S., Ravneberg H., Gjerdrum C., Trosse C., Stern B., and Pryme I.F. The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide. Journal of Biotechnology 128 (2007) 705-715
-
(2007)
Journal of Biotechnology
, vol.128
, pp. 705-715
-
-
Knappskog, S.1
Ravneberg, H.2
Gjerdrum, C.3
Trosse, C.4
Stern, B.5
Pryme, I.F.6
-
15
-
-
0033231184
-
Components of vectors for gene transfer and expression in mammalian cells
-
Makrides S.C. Components of vectors for gene transfer and expression in mammalian cells. Protein Expression and Purification 17 (1999) 183-202
-
(1999)
Protein Expression and Purification
, vol.17
, pp. 183-202
-
-
Makrides, S.C.1
-
16
-
-
15944427155
-
Alteration in the IL-2 signal peptide affects secretion of proteins in vitro and in vivo
-
Zhang L., Leng Q.X., and Mixson A.J. Alteration in the IL-2 signal peptide affects secretion of proteins in vitro and in vivo. Journal of Gene Medicine 7 (2005) 354-365
-
(2005)
Journal of Gene Medicine
, vol.7
, pp. 354-365
-
-
Zhang, L.1
Leng, Q.X.2
Mixson, A.J.3
-
17
-
-
0033059981
-
Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis
-
Zhao J., Hyman L., and Moore C. Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Microbiology and Molecular Biology Reviews 63 (1999) 405-445
-
(1999)
Microbiology and Molecular Biology Reviews
, vol.63
, pp. 405-445
-
-
Zhao, J.1
Hyman, L.2
Moore, C.3
-
18
-
-
31444451310
-
A transient expression vector for recombinant protein production in Chinese hamster ovary cells
-
Liao M.M.L., and Sunstrom N.A. A transient expression vector for recombinant protein production in Chinese hamster ovary cells. Journal of Chemical Technology and Biotechnology 81 (2006) 82-88
-
(2006)
Journal of Chemical Technology and Biotechnology
, vol.81
, pp. 82-88
-
-
Liao, M.M.L.1
Sunstrom, N.A.2
-
19
-
-
0034741797
-
An element within the 5′ untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation
-
Vivinus S., Baulande S., van Zanten M., Campbell F., Topley P., Ellis J.H., Dessen P., and Coste H. An element within the 5′ untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation. European Journal of Biochemistry 268 (2001) 1908-1917
-
(2001)
European Journal of Biochemistry
, vol.268
, pp. 1908-1917
-
-
Vivinus, S.1
Baulande, S.2
van Zanten, M.3
Campbell, F.4
Topley, P.5
Ellis, J.H.6
Dessen, P.7
Coste, H.8
-
20
-
-
0031869662
-
Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia
-
Stein I., Itin A., Einat P., Skaliter R., Grossman Z., and Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Molecular and Cellular Biology 18 (1998) 3112-3119
-
(1998)
Molecular and Cellular Biology
, vol.18
, pp. 3112-3119
-
-
Stein, I.1
Itin, A.2
Einat, P.3
Skaliter, R.4
Grossman, Z.5
Keshet, E.6
-
22
-
-
0031888264
-
Inducible overexpression of a toxic protein by an adenovirus vector with a tetracycline-regulatable expression cassette
-
Massie B., Couture F., Lamoureux L., Mosser D.D., Guilbault C., Jolicoeur P., Belanger F., and Langelier Y. Inducible overexpression of a toxic protein by an adenovirus vector with a tetracycline-regulatable expression cassette. Journal of Virology 72 (1998) 2289-2296
-
(1998)
Journal of Virology
, vol.72
, pp. 2289-2296
-
-
Massie, B.1
Couture, F.2
Lamoureux, L.3
Mosser, D.D.4
Guilbault, C.5
Jolicoeur, P.6
Belanger, F.7
Langelier, Y.8
-
23
-
-
6544275270
-
New adenovirus vectors for protein production and gene transfer
-
Massie B., Mosser D.D., Koutroumanis M., Vitte-Mony I., Lamoureux L., Couture F., Paquet L., Guilbault C., Dionne J., Chahla D., et al. New adenovirus vectors for protein production and gene transfer. Cytotechnology 28 (1998) 53-64
-
(1998)
Cytotechnology
, vol.28
, pp. 53-64
-
-
Massie, B.1
Mosser, D.D.2
Koutroumanis, M.3
Vitte-Mony, I.4
Lamoureux, L.5
Couture, F.6
Paquet, L.7
Guilbault, C.8
Dionne, J.9
Chahla, D.10
-
24
-
-
0025866787
-
Effect of intron A from human cytomegalovirus (Towne) immediately-early gene on heterologous expression in mammalian cells
-
Chapman B.S.T., Thayer R.M., Vincent K.A., and Haigwood N.L. Effect of intron A from human cytomegalovirus (Towne) immediately-early gene on heterologous expression in mammalian cells. Nucleic Acids Research 19 (1991) 3979-3986
-
(1991)
Nucleic Acids Research
, vol.19
, pp. 3979-3986
-
-
Chapman, B.S.T.1
Thayer, R.M.2
Vincent, K.A.3
Haigwood, N.L.4
-
25
-
-
0032406411
-
Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene
-
Simari R.D., Yang Z.Y., Ling X., Stephan D., Perkins N.D., Nabel G.J., and Nabel E.G. Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene. Molecular Medicine 4 (1998) 700-706
-
(1998)
Molecular Medicine
, vol.4
, pp. 700-706
-
-
Simari, R.D.1
Yang, Z.Y.2
Ling, X.3
Stephan, D.4
Perkins, N.D.5
Nabel, G.J.6
Nabel, E.G.7
-
26
-
-
28844456641
-
High levels of protein expression using different mammalian CMV promoters in several cell lines
-
Xia W., Bringmann P., McClary J., Jones P.P., Manzana W., Zhu Y., Wang S.J., Liu Y., Harvey S., Madlansacay M.R., et al. High levels of protein expression using different mammalian CMV promoters in several cell lines. Protein Expression and Purification 45 (2006) 115-124
-
(2006)
Protein Expression and Purification
, vol.45
, pp. 115-124
-
-
Xia, W.1
Bringmann, P.2
McClary, J.3
Jones, P.P.4
Manzana, W.5
Zhu, Y.6
Wang, S.J.7
Liu, Y.8
Harvey, S.9
Madlansacay, M.R.10
-
27
-
-
0037123721
-
Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector
-
Xu Z.L., Mizuguchi H., Ishii-Watabe A., Uchida E., Mayumi T., and Hayakawa T. Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector. Journal of Controlled Release 81 (2002) 155-163
-
(2002)
Journal of Controlled Release
, vol.81
, pp. 155-163
-
-
Xu, Z.L.1
Mizuguchi, H.2
Ishii-Watabe, A.3
Uchida, E.4
Mayumi, T.5
Hayakawa, T.6
-
28
-
-
0031950572
-
Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element
-
Donello J.E., Loeb J.E., and Hope T.J. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. Journal of Virology 72 (1998) 5085-5092
-
(1998)
Journal of Virology
, vol.72
, pp. 5085-5092
-
-
Donello, J.E.1
Loeb, J.E.2
Hope, T.J.3
-
29
-
-
34447255471
-
Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells
-
Mahonen A.J., Airenne K.J., Purola S., Peltomaa E., Kaikkonen M.U., Riekkinen M.S., Heikura T., Kinnunen K., Roschier M.M., and Wirth T. Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells. Journal of Biotechnology 131 (2007) 1-8
-
(2007)
Journal of Biotechnology
, vol.131
, pp. 1-8
-
-
Mahonen, A.J.1
Airenne, K.J.2
Purola, S.3
Peltomaa, E.4
Kaikkonen, M.U.5
Riekkinen, M.S.6
Heikura, T.7
Kinnunen, K.8
Roschier, M.M.9
Wirth, T.10
-
30
-
-
0034322479
-
Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors
-
Schambach A., Wodrich H., Hildinger M., Bohne J., Krausslich H.G., and Baum C. Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors. Molecular Therapy 2 (2000) 435-445
-
(2000)
Molecular Therapy
, vol.2
, pp. 435-445
-
-
Schambach, A.1
Wodrich, H.2
Hildinger, M.3
Bohne, J.4
Krausslich, H.G.5
Baum, C.6
-
31
-
-
0038699545
-
Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors
-
Xu Z.L., Mizuguchi H., Mayumi T., and Hayakawa T. Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors. Biochimica Et Biophysica Acta-General Subjects 1621 (2003) 266-271
-
(2003)
Biochimica Et Biophysica Acta-General Subjects
, vol.1621
, pp. 266-271
-
-
Xu, Z.L.1
Mizuguchi, H.2
Mayumi, T.3
Hayakawa, T.4
-
32
-
-
0032978712
-
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
-
Zufferey R., Donello J.E., Trono D., and Hope T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. Journal of Virology 73 (1999) 2886-2892
-
(1999)
Journal of Virology
, vol.73
, pp. 2886-2892
-
-
Zufferey, R.1
Donello, J.E.2
Trono, D.3
Hope, T.J.4
-
33
-
-
33646051851
-
WPRE-mediated enhancement of gene expression is promoter and cell line specific
-
Klein R., Ruttkowski B., Knapp E., Salmons B., Gunzburg W.H., and Hohenadl C. WPRE-mediated enhancement of gene expression is promoter and cell line specific. Gene 372 (2006) 153-161
-
(2006)
Gene
, vol.372
, pp. 153-161
-
-
Klein, R.1
Ruttkowski, B.2
Knapp, E.3
Salmons, B.4
Gunzburg, W.H.5
Hohenadl, C.6
-
34
-
-
25144441095
-
Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors
-
Hlavaty J., Schittmayer M., Stracke A., Jandl G., Knapp E., Felber B.K., Salmons B., Gunzburg W.H., and Renner M. Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors. Virology 341 (2005) 1-11
-
(2005)
Virology
, vol.341
, pp. 1-11
-
-
Hlavaty, J.1
Schittmayer, M.2
Stracke, A.3
Jandl, G.4
Knapp, E.5
Felber, B.K.6
Salmons, B.7
Gunzburg, W.H.8
Renner, M.9
-
35
-
-
3042790053
-
Increased in vitro and in vivo transgene expression levels mediated through cis-acting elements
-
Johansen J., Tornoe J., Moller A., and Johansen T.E. Increased in vitro and in vivo transgene expression levels mediated through cis-acting elements. Journal of Gene Medicine 5 (2003) 1080-1089
-
(2003)
Journal of Gene Medicine
, vol.5
, pp. 1080-1089
-
-
Johansen, J.1
Tornoe, J.2
Moller, A.3
Johansen, T.E.4
-
36
-
-
0035874981
-
Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
-
Molina M.A., Codony-Servat J., Albanell J., Rojo F., Arribas J., and Baselga J. Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. Cancer Research 61 (2001) 4744-4749
-
(2001)
Cancer Research
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
37
-
-
60549116306
-
Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells
-
Yang Y.S., Mariati, and Ho S.C.L. Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells. Biotechnology and Bioengineering 102 (2009) 1152-1160
-
(2009)
Biotechnology and Bioengineering
, vol.102
, pp. 1152-1160
-
-
Yang, Y.S.1
Mariati2
Ho, S.C.L.3
-
39
-
-
35748974497
-
Cell-specific effects of human cytomegalovirus unique region on recombinant protein expression
-
Lee J., Lau J., Chong G., and Chao S.H. Cell-specific effects of human cytomegalovirus unique region on recombinant protein expression. Biotechnology Letters 29 (2007) 1797-1802
-
(2007)
Biotechnology Letters
, vol.29
, pp. 1797-1802
-
-
Lee, J.1
Lau, J.2
Chong, G.3
Chao, S.H.4
-
41
-
-
0033066691
-
Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences
-
Li X.Y., Eastman E.M., Schwartz R.J., and Draghia-Akli R. Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences. Nature Biotechnology 17 (1999) 241-245
-
(1999)
Nature Biotechnology
, vol.17
, pp. 241-245
-
-
Li, X.Y.1
Eastman, E.M.2
Schwartz, R.J.3
Draghia-Akli, R.4
|