Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells

Gene

Volumn 199, Issue 1-2, 1997, Pages 293-301

  Kim, Chang H ^a   Oh, Younghoon ^a   Lee, Tae H ^b  

^a LG Chemical Ltd   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

GC content; High frequency codons; Promoter; Signal leader sequence

Indexed keywords

MESSENGER RNA; RECOMBINANT ERYTHROPOIETIN; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CHO CELL; CODON USAGE; CONTROLLED STUDY; DNA FLANKING REGION; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; HYBRID; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CHO CELLS; CODON; CRICETINAE; DNA, RECOMBINANT; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; GENES; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROMOTER REGIONS (GENETICS); PROTEIN SORTING SIGNALS; RNA, MESSENGER; SPECIES SPECIFICITY;

EID: 0030823320     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00384-3     Document Type: Article

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