Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF

Bioorganic Chemistry

Volumn 37, Issue 6, 2009, Pages 217-222

  Sova, Matej ^a   Kovač, Andreja ^a   Turk, Samo ^a   Hrast, Martina ^a   Blanot, Didier ^b   Gobec, Stanislav ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b IBBMC   (France)

Author keywords

Antibacterial agents; Enzyme inhibitors; Hydroxyethylamines; Mur ligases

Indexed keywords

1 (4 METHOXYPHENYLSULFONAMIDO) 3 MORPHOLINOPROPAN 2 YL DIHYDROGEN PHOSPHATE; ANTIINFECTIVE AGENT; HYDROXYETHYLAMINE; HYDROXYL GROUP; MURC PROTEIN; MURD PROTEIN; MURE PROTEIN; MURF PROTEIN; PEPTIDOGLYCAN; PHOSPHATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; IC 50; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BINDING SITES; CELL WALL; COMPUTER SIMULATION; ENZYME INHIBITORS; ESCHERICHIA COLI; ETHYLAMINES; PEPTIDE SYNTHASES; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

BACTERIA (MICROORGANISMS);

EID: 70350569372     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2009.09.001     Document Type: Article

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