Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme

Journal of Medicinal Chemistry

Volumn 51, Issue 23, 2008, Pages 7486-7494

  Humljan, Jan ^a   Kotnik, Miha ^a   Contreras Martel, Carlos ^b   Blanot, Didier ^c   Urleb, Uroš ^a   Dessen, Andréa ^b   Šolmajer, Tom ^a   Gobec, Stanislav ^d  

^a Lek dd   (Slovenia)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID DERIVATIVE; LIGASE; NAPHTHALENE N SULFONYLGLUTAMIC ACID DERIVATIVE; PEPTIDOGLYCAN; PROTEIN MURD; PROTEIN MURD INHIBITOR; UDP N ACETYLMURAMOYLALANINE:GLUTAMATE LIGASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SYNTHESIS; ESCHERICHIA COLI; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; GLUTAMIC ACID; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; PEPTIDE SYNTHASES; PEPTIDOGLYCAN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57349132464     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800762u     Document Type: Article

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