메뉴 건너뛰기




Volumn 69, Issue 16, 2009, Pages 2279-2302

Pemetrexed: A review of its use in the management of advanced non-squamous non-small cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CARBOPLATIN; CISPLATIN; CYANOCOBALAMIN; DOCETAXEL; ERLOTINIB; FOLIC ACID; GEMCITABINE; IBUPROFEN; OXALIPLATIN; PEMETREXED; PLACEBO;

EID: 70350521064     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11202640-000000000-00000     Document Type: Review
Times cited : (34)

References (78)
  • 1
    • 66549109768 scopus 로고    scopus 로고
    • Non-small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • D'Addario G, Felip E. Non-small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2009; 20 Suppl. 4: iv68-70
    • (2009) Ann Oncol , vol.0 , Issue.SUPPL. 4
    • D'Addario, G.1    Felip, E.2
  • 2
    • 0013401756 scopus 로고    scopus 로고
    • National Cancer Institute [online] [Accessed 2009 Jul 9]
    • National Cancer Institute. Surveillance epidemiology and end results (SEER) stat fact sheets [online]. Available from URL: http://seer.cancer.gov/ statfacts/html/lungb.html [Accessed 2009 Jul 9]
    • Surveillance Epidemiology and End Results (SEER) Stat Fact Sheets
  • 3
    • 65349124698 scopus 로고    scopus 로고
    • Current treatments for ad-vanced stage non-small cell lung cancer
    • Stinchcombe TE, Socinski MA. Current treatments for ad-vanced stage non-small cell lung cancer. Proc Am Thorac Soc 2009; 6 (2): 233-241
    • (2009) Proc Am Thorac Soc , vol.6 , Issue.2 , pp. 233-241
    • Stinchcombe, T.E.1    Socinski, M.A.2
  • 4
    • 84866260466 scopus 로고    scopus 로고
    • Eli Lilly and Company [Accessed 2009 May 21]
    • Eli Lilly and Company. About lung cancer [online]. Avail-able from URL: http://www.gemzar.com/pat/pat110- types-of-nsclc.jsp [Accessed 2009 May 21]
    • About Lung Cancer [Online]
  • 5
    • 64049115311 scopus 로고    scopus 로고
    • The differential efficacy of pemetrexed according to NSCLC histology: A review of two phase III studies
    • Mar
    • Scagliotti G, Hanna N, Fossella F, et al. The differential efficacy of pemetrexed according to NSCLC histology: a review of two phase III studies. Oncologist 2009 Mar; 14 (3): 253-263
    • (2009) Oncologist , vol.14 , Issue.3 , pp. 253-263
    • Scagliotti, G.1    Hanna, N.2    Fossella, F.3
  • 6
    • 34848849097 scopus 로고    scopus 로고
    • Diagnosis and management of lung cancer: Executive summary
    • Alberts WM. Diagnosis and management of lung cancer: executive summary. Chest 2007; 132 Suppl.: 1-19
    • (2007) Chest , vol.132 , Issue.SUPPL. , pp. 1-19
    • Alberts, W.M.1
  • 7
    • 27144543198 scopus 로고    scopus 로고
    • National Institute for Clinical Excellence [online] [Accessed 2009 Jul 22]
    • National Institute for Clinical Excellence. The diagnosis and treatment of lung cancer: methods, evidence & guidance [online]. Available from URL: http://www.nice.org.uk/ nicemedia/pdf/cg024fullguideline.pdf [Accessed 2009 Jul 22]
    • The Diagnosis and Treatment of Lung Cancer: Methods, Evidence & Guidance
  • 9
    • 70350499887 scopus 로고    scopus 로고
    • European Medicines Agency [online] [Accessed 2009 Apr 27] Eli Lilly and Company. ALIMTA (pemetrexed disodium) injection, powder, lyophillized, for solution for intravenous use: US prescribing information [online]. Available from URL: http://pi.lilly.com/us/alimta-pi.pdf [Accessed 2009 Jul 20]
    • European Medicines Agency. ALIMTA 100mg powder for concentrate for solution for infusion: summary of product characteristics [online]. Available from URL: http://www. emea.europa.eu/humandocs/PDFs/EPAR/alimta/H-564-PI-en.pdf [Accessed 2009 Apr 27] 10. Eli Lilly and Company. ALIMTA (pemetrexed disodium) injection, powder, lyophillized, for solution for intravenous use: US prescribing information [online]. Available from URL: http://pi.lilly.com/us/ alimta-pi.pdf [Accessed 2009 Jul 20]
    • ALIMTA 100mg Powder for Concentrate for Solution for Infusion: Summary of Product Characteristics , vol.10
  • 11
    • 30644459850 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients
    • Latz JE, Chaudhary A, Ghosh A, et al. Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients. Cancer Chemother Pharmacol 2006; 57: 401-411
    • (2006) Cancer Chemother Pharmacol , vol.57 , pp. 401-411
    • Latz, J.E.1    Chaudhary, A.2    Ghosh, A.3
  • 12
    • 13244257128 scopus 로고    scopus 로고
    • Pemetrexed: A review of its use in malignant pleural mesothelioma and non-small-cell lung cancer
    • Robinson DM, Keating GM, Wagstaff AJ. Pemetrexed: a review of its use in malignant pleural mesothelioma and non-small-cell lung cancer. Am J Cancer 2004; 3 (6): 387-399
    • (2004) Am J Cancer , vol.3 , Issue.6 , pp. 387-399
    • Robinson, D.M.1    Keating, G.M.2    Wagstaff, A.J.3
  • 14
    • 33847364471 scopus 로고    scopus 로고
    • Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications
    • Feb
    • Chattopadhyay S, Moran RG, Goldman ID. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Mol Cancer Ther 2007 Feb; 6 (2): 404-417
    • (2007) Mol Cancer Ther , vol.6 , Issue.2 , pp. 404-417
    • Chattopadhyay, S.1    Moran, R.G.2    Goldman, I.D.3
  • 15
    • 0030891198 scopus 로고    scopus 로고
    • LY231514 a pyrrolo [23-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Mar 15
    • Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo [2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997 Mar 15; 57 (6): 1116-1123
    • (1997) Cancer Res , vol.57 , Issue.6 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 16
    • 67650456927 scopus 로고    scopus 로고
    • Therapeutics by cytotoxic metabolite accumulation: Pemetrexed causes ZMP accumulation, AMPK activation and mammalian target or rapamycin inhibition
    • Racanelli AC, Rothbart SB, Heyer CL, et al. Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation and mammalian target or rapamycin inhibition. Cancer Res 2009; 69 (13): 5467-5474
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5467-5474
    • Racanelli, A.C.1    Rothbart, S.B.2    Heyer, C.L.3
  • 17
    • 33751244559 scopus 로고    scopus 로고
    • Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
    • Qiu A, Jansen M, Sakaris A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006; 127: 917-928
    • (2006) Cell , vol.127 , pp. 917-928
    • Qiu, A.1    Jansen, M.2    Sakaris, A.3
  • 18
    • 50549085728 scopus 로고    scopus 로고
    • The proton-coupled folate transporter: Impact on pemetrexed transport and on anti-folates activities compared with the reduced folate carrier
    • Zhao R, Qiu A, Tsai E, et al. The proton-coupled folate transporter: impact on pemetrexed transport and on anti-folates activities compared with the reduced folate carrier. Mol Pharm 2008; 74 (3): 854-862
    • (2008) Mol Pharm , vol.74 , Issue.3 , pp. 854-862
    • Zhao, R.1    Qiu, A.2    Tsai, E.3
  • 19
    • 0029157160 scopus 로고
    • Substrate spe-cificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs
    • Aug
    • Habeck LL, Mendelsohn LG, Shih C, et al. Substrate spe-cificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. Mol Pharmacol 1995 Aug; 48 (2): 326-333
    • (1995) Mol Pharmacol , vol.48 , Issue.2 , pp. 326-333
    • Habeck, L.L.1    Mendelsohn, L.G.2    Shih, C.3
  • 20
    • 0032990562 scopus 로고    scopus 로고
    • Activity of the multitargeted antifolate LY231514 in the human tumor cloning assay
    • Britten CD, Izbicka E, Hilsenbeck S, et al. Activity of the multitargeted antifolate LY231514 in the human tumor cloning assay. Cancer Chemother Pharmacol 1999; 44 (2): 105-110
    • (1999) Cancer Chemother Pharmacol , vol.44 , Issue.2 , pp. 105-110
    • Britten, C.D.1    Izbicka, E.2    Hilsenbeck, S.3
  • 21
    • 0031024897 scopus 로고    scopus 로고
    • Cell cycle effects of antifolate antimetabolites; Implications for cytotoxicity and cytostasis
    • Tonkinson JL, Marder P, Andis SL, et al. Cell cycle effects of antifolate antimetabolites; implications for cytotoxicity and cytostasis. Cancer Chemother Pharmacol 1997; 39: 521-531
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 521-531
    • Tonkinson, J.L.1    Marder, P.2    Andis, S.L.3
  • 22
    • 0033179374 scopus 로고    scopus 로고
    • Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcita-bine in HT29 colon carcinoma
    • Aug
    • Tonkinson JL, Worzalla JF, Teng C-H, et al. Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcita-bine in HT29 colon carcinoma. Cancer Res 1999 Aug; 59: 3671-3676
    • (1999) Cancer Res , vol.59 , pp. 3671-3676
    • Tonkinson, J.L.1    Worzalla, J.F.2    Teng, C.-H.3
  • 23
    • 0034060265 scopus 로고    scopus 로고
    • Treatment regimens in-cluding the multitargeted antifolate LY231514 in human tumor xenografts
    • Mar
    • Teicher BA, Chen V, Shih C, et al. Treatment regimens in-cluding the multitargeted antifolate LY231514 in human tumor xenografts. Clin Can Res 2000 Mar; 6: 1016-1023
    • (2000) Clin Can Res , vol.6 , pp. 1016-1023
    • Teicher, B.A.1    Chen, V.2    Shih, C.3
  • 24
    • 34250637524 scopus 로고    scopus 로고
    • Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells
    • Jun 1
    • Li T, Ling YH, Goldman ID, et al. Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clin Cancer Res 2007 Jun 1; 13 (11): 3413-3422
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3413-3422
    • Li, T.1    Ling, Y.H.2    Goldman, I.D.3
  • 25
    • 41149096042 scopus 로고    scopus 로고
    • Molecular me-chanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
    • Apr
    • Giovannetti E, Lemos C, Tekle C, et al. Molecular me-chanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Mol Pharmacol 2008 Apr; 73 (4): 1290-1300
    • (2008) Mol Pharmacol , vol.73 , Issue.4 , pp. 1290-1300
    • Giovannetti, E.1    Lemos, C.2    Tekle, C.3
  • 26
    • 0344393780 scopus 로고    scopus 로고
    • Resistance to antifolates
    • Zhao R, Goldman ID. Resistance to antifolates. Oncogene 2003; 22: 7431-7457
    • (2003) Oncogene , vol.22 , pp. 7431-7457
    • Zhao, R.1    Goldman, I.D.2
  • 27
    • 0037039451 scopus 로고    scopus 로고
    • Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors
    • Andreassi JL, Moran RG. Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors. Biochemistry (Mosc) 2002; 41 (1): 226-235
    • (2002) Biochemistry (Mosc) , vol.41 , Issue.1 , pp. 226-235
    • Andreassi, J.L.1    Moran, R.G.2
  • 28
    • 33644975527 scopus 로고    scopus 로고
    • The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
    • Chattopadhyay S, Zhao R, Krupenko SA, et al. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 2006; 5 (2): 438-449
    • (2006) Mol Cancer Ther , vol.5 , Issue.2 , pp. 438-449
    • Chattopadhyay, S.1    Zhao, R.2    Krupenko, S.A.3
  • 29
    • 70350514766 scopus 로고    scopus 로고
    • The safety and pharmacokinetics (PK) of pemetrexed (PEM) in patients with third-space fluid (TSF) [abstract no 2555]
    • Dickgreber NJ, Diaz Padilla I, Paz-Ares LG, et al. The safety and pharmacokinetics (PK) of pemetrexed (PEM) in patients with third-space fluid (TSF) [abstract no. 2555]. J Clin Oncol 2008; 26 (15 Suppl.)
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Dickgreber, N.J.1    Diaz Padilla, I.2    Paz-Ares, L.G.3
  • 30
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Jul 20
    • Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008 Jul 20; 26 (21): 3543-3551
    • (2008) J Clin Oncol , vol.26 , Issue.21 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3
  • 31
    • 43049141175 scopus 로고    scopus 로고
    • A randomized phase III trial comparing standard and high-dose pemetrexed as second-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer
    • Cullen MH, Zatloukal P, Sorenson S, et al. A randomized phase III trial comparing standard and high-dose pemetrexed as second-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer. Ann Oncol 2008; 19: 939-945
    • (2008) Ann Oncol , vol.19 , pp. 939-945
    • Cullen, M.H.1    Zatloukal, P.2    Sorenson, S.3
  • 32
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • May 1
    • Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004 May 1; 22 (9): 1589-1597
    • (2004) J Clin Oncol , vol.22 , Issue.9 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 33
    • 85100463659 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study
    • In press
    • Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet. In press
    • Lancet
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 34
    • 0034029995 scopus 로고    scopus 로고
    • Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, pemetrexed disodium, ALIMTA) and cisplatin: A multicenter phase II trial
    • Manegold C, Gatzemeier U, von Pawel J, et al. Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, pemetrexed disodium, ALIMTA) and cisplatin: a multicenter phase II trial. Ann Oncol 2000; 11: 435-440
    • (2000) Ann Oncol , vol.11 , pp. 435-440
    • Manegold, C.1    Gatzemeier, U.2    Von Pawel, J.3
  • 35
    • 0035423962 scopus 로고    scopus 로고
    • Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced non-small cell lung carcinoma
    • Shepherd FA, Dancey J, Arnold A, et al. Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced non-small cell lung carcinoma. Cancer 2001; 92 (3): 595-600
    • (2001) Cancer , vol.92 , Issue.3 , pp. 595-600
    • Shepherd, F.A.1    Dancey, J.2    Arnold, A.3
  • 36
    • 0037352426 scopus 로고    scopus 로고
    • ALIMTA® ( pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: A phase II study
    • Smit EF, Mattson K, von Pawel J, et al. ALIMTA® (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: a phase II study. Ann Oncol 2003; 14: 455-460
    • (2003) Ann Oncol , vol.14 , pp. 455-460
    • Smit, E.F.1    Mattson, K.2    Von Pawel, J.3
  • 37
    • 70350517172 scopus 로고    scopus 로고
    • US FDA. Center for Drug Evaluation and Research. Application number: 21-677 medical review [online] [Accessed 2009 Jul 10]
    • US FDA. Center for Drug Evaluation and Research. Application number: 21-677 medical review [online]. Available from URL: http://www.accessdata.fda. gov/ drugsatfda-docs/nda/2004/021677s000-Alimta-MedR.pdf [Accessed 2009 Jul 10]
  • 39
    • 42549116071 scopus 로고    scopus 로고
    • Is pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non-small cell lung cancer (NSCLC)
    • [abstract no P2-328] Aug
    • Peterson P, Park K, Fossella F, et al. Is pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non-small cell lung cancer (NSCLC) [abstract no. P2-328]. J Thor Oncol 2007 Aug; 2 (8 Suppl. 4): S851
    • (2007) J Thor Oncol , vol.2 , Issue.8 SUPPL. 4
    • Peterson, P.1    Park, K.2    Fossella, F.3
  • 40
    • 64049102994 scopus 로고    scopus 로고
    • Resource utilization by non-small cell lung cancer histology: Results from the randomized, phase III trial of pemetrexed/ cisplatin versus gemcitabine/cisplatin [abstract no 8097]
    • Pimentel FL, von Pawel J, Martins RG, et al. Resource utilization by non-small cell lung cancer histology: results from the randomized, phase III trial of pemetrexed/ cisplatin versus gemcitabine/cisplatin [abstract no. 8097]. J Clin Oncol 2008; 26 (15 (Suppl.)
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Pimentel, F.L.1    Von Pawel, J.2    Martins, R.G.3
  • 41
    • 70350489872 scopus 로고    scopus 로고
    • The impor-tance of histology when evaluating the cost-effectiveness of pemetrexed plus cisplatin as first-line therapy for advanced non-small cell lung cancer [abstract no e17533]
    • Muehlenbein CE, Klein RW, Liepa AM, et al. The impor-tance of histology when evaluating the cost-effectiveness of pemetrexed plus cisplatin as first-line therapy for advanced non-small cell lung cancer [abstract no. e17533]. J Clin Oncol 2009; 27 Suppl.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Muehlenbein, C.E.1    Klein, R.W.2    Liepa, A.M.3
  • 43
    • 70350520890 scopus 로고    scopus 로고
    • Scottish Medicines Consortium [online] [Accessed 2009 Jul 21]
    • Scottish Medicines Consortium. Pemetrexed, 100 mg, 500 mg powder for concentrate for solution for infusion (Alimta®) [online]. Available from URL: http://www. scottishmedicines.org.uk/smc/files/pemetrexed%20Alimta% 20FINAL%20January%202009%20for%20website.pdf% 2016.02.09.pdf [Accessed 2009 Jul 21]
    • Pemetrexed 100 Mg 500 Mg Powder for Concentrate for Solution for Infusion (Alimta®)
  • 44
    • 13244255008 scopus 로고    scopus 로고
    • Redu-cing health care burden for the treatment of toxicity associated with pemetrexed or docetaxel in patients with advanced non-small cell lung cancer who previously received chemotherapy: Application to the UK setting [abstract no 769]
    • Bushill-Matthews L, Jackson D, Aristides M, et al. Redu-cing health care burden for the treatment of toxicity associated with pemetrexed or docetaxel in patients with advanced non-small cell lung cancer who previously received chemotherapy: application to the UK setting [abstract no. 769]. Eur J Cancer 2003; 1 (5 Suppl.): S231
    • (2003) Eur J Cancer , vol.1 , Issue.5 SUPPL. S231
    • Bushill-Matthews, L.1    Jackson, D.2    Aristides, M.3
  • 45
    • 17044396619 scopus 로고    scopus 로고
    • Improved toxicity profile of pemetrexed vs docetaxel in previously treated non-small cell lung cancer patients translates to cost savings in Spain [abstract no. PCN30]
    • Oct Hamburg
    • Stynes G, Aristides M, Rosell R, et al. Improved toxicity profile of pemetrexed vs docetaxel in previously treated non-small cell lung cancer patients translates to cost savings in Spain [abstract no. PCN30]. International Society for Pharmacoeconomics and Outcomes Research European Congress; 2004 Oct 24-26; Hamburg
    • (2004) International Society for Pharmacoeconomics and Outcomes Research European Congress , pp. 24-26
    • Stynes, G.1    Aristides, M.2    Rosell, R.3
  • 46
    • 70350489871 scopus 로고    scopus 로고
    • Cost effectiveness of pemetrexed for previously treated advanced non-small cell lung cancer [abstract no 6084]
    • Pavlakis N, Mitchell PL, Stynes G, et al. Cost effectiveness of pemetrexed for previously treated advanced non-small cell lung cancer [abstract no. 6084]. J Clin Oncol 2005; 23 (16 Suppl.)
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Pavlakis, N.1    Mitchell, P.L.2    Stynes, G.3
  • 47
    • 70350514315 scopus 로고    scopus 로고
    • Patient preference and willingness-to-pay for pemetrexed versus docetaxel in the second-line treatment of advanced non-small cell lung cancer: A discrete choice conjoint analysis
    • [abstract no. PCN7] Mar 5-7 Shanghai
    • Brown A, Aristides M, Fitzgerald P, et al. Patient preference and willingness-to-pay for pemetrexed versus docetaxel in the second-line treatment of advanced non-small cell lung cancer: a discrete choice conjoint analysis [abstract no. PCN7]. International Society for Pharmacoeconomics and Outcomes Research 2nd Asia-Pacific Conference; 2006 Mar 5-7; Shanghai
    • (2006) International Society for Pharmacoeconomics and Outcomes Research 2nd Asia-Pacific Conference
    • Brown, A.1    Aristides, M.2    Fitzgerald, P.3
  • 48
    • 70350514311 scopus 로고    scopus 로고
    • To determine the cost-effectiveness of pemetrexed compared to current standards of care in 2nd-line advanced non-small cell lung cancer from the UK National Health Service perspective
    • [abstract no 6540]
    • Bhalla S, Hibbert C, Watkins J, et al. To determine the cost-effectiveness of pemetrexed compared to current standards of care in 2nd-line advanced non-small cell lung cancer from the UK National Health Service perspective [abstract no. 6540]. J Clin Oncol 2007; 25 (18 Suppl.): 332
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL. , pp. 332
    • Bhalla, S.1    Hibbert, C.2    Watkins, J.3
  • 50
    • 50849117805 scopus 로고    scopus 로고
    • Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)
    • Sep
    • Carlson JJ, Reyes C, Oestreicher N, et al. Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC). Lung Cancer 2008 Sep; 61 (3): 405-415
    • (2008) Lung Cancer , vol.61 , Issue.3 , pp. 405-415
    • Carlson, J.J.1    Reyes, C.2    Oestreicher, N.3
  • 51
    • 61749088474 scopus 로고    scopus 로고
    • Economics of treatment for non-small cell lung cancer
    • Chouaid C, Atsou K, Hejblum G, et al. Economics of treatment for non-small cell lung cancer. Pharmaco-economics 2009; 27 (2): 113-125
    • (2009) Pharmaco-economics , vol.27 , Issue.2 , pp. 113-125
    • Chouaid, C.1    Atsou, K.2    Hejblum, G.3
  • 52
    • 67349088399 scopus 로고    scopus 로고
    • Pemetrexed in first-line treatment of non-small cell lung cancer
    • Esteban E, Casillas M, Cassinello A. Pemetrexed in first-line treatment of non-small cell lung cancer. Cancer Treat Rev 2009; 35 (4): 364-373
    • (2009) Cancer Treat Rev , vol.35 , Issue.4 , pp. 364-373
    • Esteban, E.1    Casillas, M.2    Cassinello, A.3
  • 53
    • 84871351824 scopus 로고    scopus 로고
    • National Cancer Institute [online] [Accessed 2009 Jun 2]
    • National Cancer Institute. Non-small cell lung cancer treat-ment [online]. Available from URL: http://www.cancer. gov/cancertopics/pdq/treatment/ non-small-cell-lung/health professional [Accessed 2009 Jun 2]
    • Non-small Cell Lung Cancer Treat-ment
  • 54
    • 1342268525 scopus 로고    scopus 로고
    • American So-ciety of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update
    • Pfister DG, Johnson DH, Azzoli CG, et al. American So-ciety of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol 2004; 22 (2): 330-353
    • (2003) J Clin Oncol 2004 , vol.22 , Issue.2 , pp. 330-353
    • Pfister, D.G.1    Johnson, D.H.2    Azzoli, C.G.3
  • 56
    • 33751048956 scopus 로고    scopus 로고
    • Scottish Intercollegiate Guidelines Network [online] [Accessed 2009 Jul 22]
    • Scottish Intercollegiate Guidelines Network. Management of patients with lung cancer: quick reference guide [online]. Available from URL: http://www.sign.ac.uk/pdf/ qrg80.pdf [Accessed 2009 Jul 22]
    • Management of Patients with Lung Cancer: Quick Reference Guide
  • 58
    • 70350501899 scopus 로고    scopus 로고
    • Scottish Medicines Consortium [online] Aug 17]
    • Scottish Medicines Consortium. SMC accepts restricted use of pemetrexed (Alimta) in locally advanced or metastatic NSCLC (resubmission) [online]. Available from URL: http://www.nelm.nhs.uk/en/NeLM-Area/Evidence/Drug-Specific- Reviews/SMC-accepts-restricted-use-of-pemetrexed-Alimta-in-locally-advanced-or- metastatic-NSCLC-resubmission [Accessed 2009 Aug 17]
    • (2009) SMC Accepts Restricted Use of Pemetrexed (Alimta) in Locally Advanced or Metastatic NSCLC (Resubmission)
  • 59
    • 65649144266 scopus 로고    scopus 로고
    • Treatment paradigms for advanced stage non-small cell lung cancer in the era of multiple lines of therapy
    • Stinchcombe TE, Socinski MA. Treatment paradigms for advanced stage non-small cell lung cancer in the era of multiple lines of therapy. J Thorac Oncol 2009; 4 (2): 243-250
    • (2009) J Thorac Oncol , vol.4 , Issue.2 , pp. 243-250
    • Stinchcombe, T.E.1    Socinski, M.A.2
  • 60
    • 42049099094 scopus 로고    scopus 로고
    • Systemic chemotherapy for ad-vanced non-small cell lung cancer: Recent advances and future directions
    • Ramalingam S, Belani C. Systemic chemotherapy for ad-vanced non-small cell lung cancer: recent advances and future directions. Oncologist 2008; 13 Suppl. 1: 5-13
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 1 , pp. 5-13
    • Ramalingam, S.1    Belani, C.2
  • 61
    • 70350501902 scopus 로고    scopus 로고
    • National Cancer Institute [online] [Accessed 2009 Oct 7]
    • National Cancer Institute. New lung cancer treatment hope raises hopes and debates [online]. Available from URL: http://www.cancer.gov/ ncicancerbulletin/072809/page5 [Accessed 2009 Oct 7]
    • New Lung Cancer Treatment Hope Raises Hopes and Debates
  • 62
    • 33749587054 scopus 로고    scopus 로고
    • Squamous cell carci-noma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
    • Ceppi P, Volante M, Saviozzi S, et al. Squamous cell carci-noma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer 2006; 107 (7): 1589-1596
    • (2006) Cancer , vol.107 , Issue.7 , pp. 1589-1596
    • Ceppi, P.1    Volante, M.2    Saviozzi, S.3
  • 63
    • 17644363305 scopus 로고    scopus 로고
    • Novel agents in the treatment of non-small cell lung cancer: Implications for neoadjuvant chemotherapy?
    • Bergqvist M, Henriksson R, Brattstrom D. Novel agents in the treatment of non-small cell lung cancer: implications for neoadjuvant chemotherapy? In Vivo 2005; 19 (3): 523-533
    • (2005) In Vivo , vol.19 , Issue.3 , pp. 523-533
    • Bergqvist, M.1    Henriksson, R.2    Brattstrom, D.3
  • 65
    • 33846884823 scopus 로고    scopus 로고
    • Role of non-taxane-containing chemotherapy in advanced non-small cell lung cancer
    • Bergqvist M, Sorenson S, Brattstrom D, et al. Role of non-taxane-containing chemotherapy in advanced non-small cell lung cancer. Am J Cancer 2006; 5 (4): 223-244
    • (2006) Am J Cancer , vol.5 , Issue.4 , pp. 223-244
    • Bergqvist, M.1    Sorenson, S.2    Brattstrom, D.3
  • 66
    • 33745622428 scopus 로고    scopus 로고
    • Review of the pemetrexed and gemcitabine combination in patients with advanced-stage non-small cell lung cancer
    • Monnerat C, Le Chevalier T. Review of the pemetrexed and gemcitabine combination in patients with advanced-stage non-small cell lung cancer. Ann Oncol 2006; 17 Suppl. 5: v86-90
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 5
    • Monnerat, C.1    Le Chevalier, T.2
  • 67
    • 67649405034 scopus 로고    scopus 로고
    • PROCLAIM: A phase III study of pemetrexed, cisplatin, and radiation therapy followed by consolidation pemetrexed versus etoposide, cisplatin, and radiation therapy followed by consolidation cytotoxic chemotherapy of choice in locally advanced stage III non-small-cell lung cancer of other than predominantly squamous cell histology
    • Vokes EE, Senan S, Treat JA, et al. PROCLAIM: a phase III study of pemetrexed, cisplatin, and radiation therapy followed by consolidation pemetrexed versus etoposide, cisplatin, and radiation therapy followed by consolidation cytotoxic chemotherapy of choice in locally advanced stage III non-small-cell lung cancer of other than predominantly squamous cell histology. Clin Lung Cancer 2009;10(3): 193-198
    • (2009) Clin Lung Cancer , vol.10 , Issue.3 , pp. 193-198
    • Vokes, E.E.1    Senan, S.2    Treat, J.A.3
  • 70
    • 70349474058 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL)
    • [abstract no 8010]
    • De Boer R, Arrieta O, Gottfried FH, et al. Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): a randomized, double-blind phase III trial (ZEAL) [abstract no. 8010]. J Clin Oncol 2009; 27 (15 Suppl.)
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • De Boer, R.1    Arrieta, O.2    Gottfried, F.H.3
  • 72
    • 70349452141 scopus 로고    scopus 로고
    • Treatment rationale and study design for the PointBreak study: A randomized, open-label phase III study of pemetrexed/carboplatin/ bevacizumab followed by maintenance pemetrexed/ bevacizumab versus paclitaxel/carboplatin/ bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small cell lung cancer
    • Patel JD, Bonomi P, Socinksi MA, et al. Treatment rationale and study design for the PointBreak study: a randomized, open-label phase III study of pemetrexed/carboplatin/ bevacizumab followed by maintenance pemetrexed/ bevacizumab versus paclitaxel/carboplatin/bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small cell lung cancer. Clin Lung Cancer 2009; 10 (4): 252-256
    • (2009) Clin Lung Cancer , vol.10 , Issue.4 , pp. 252-256
    • Patel, J.D.1    Bonomi, P.2    Socinksi, M.A.3
  • 73
    • 42049107120 scopus 로고    scopus 로고
    • Considerations for second-line therapy of non-small cell lung cancer
    • Stinchcombe TE, Socinski MA. Considerations for second-line therapy of non-small cell lung cancer. Oncologist 2008; 13 Suppl. 1: 28-36
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 1 , pp. 28-36
    • Stinchcombe, T.E.1    Socinski, M.A.2
  • 75
    • 51349157516 scopus 로고    scopus 로고
    • Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer
    • Jul
    • Russo F, Bearz A, Pampaloni G, et al. Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer. BMC Cancer 2008 Jul; 8: 216
    • (2008) BMC Cancer , vol.8 , pp. 216
    • Russo, F.1    Bearz, A.2    Pampaloni, G.3
  • 77
    • 70350508912 scopus 로고    scopus 로고
    • Electronic Medicines Compendium [online] [Accessed 2009 Jul 28]
    • Electronic Medicines Compendium. Iressa 250 mg film-coated tablets [online]. Available from URL: http:// www.emc.medicines.org.uk/medicine/22104/ SPC/Iressa% 20250 mg%20film-coated%20tablets/#INDICATIONS [Accessed 2009 Jul 28]
    • Iressa 250 Mg Film-coated Tablets


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.