Cell cycle effects of antifolate antimetabolites: Implications for cytotoxicity and cytostasis

Cancer Chemotherapy and Pharmacology

Volumn 39, Issue 6, 1997, Pages 521-531

  Tonkinson, John L ^a   Marder, Philip ^a   Andis, Sherri L ^a   Schultz, Richard M ^a   Gossett, Lynn S ^a   Shih, Chuan ^a   Mendelsohn, Laurane G ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Antifolate; Cell cycle; GARFT; Thymidylate synthase

Indexed keywords

CYCLINE; DNA FRAGMENT; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; LOMETREXOL; N [5 [2 (2 AMINO 1,4,5,6,7,8 HEXAHYDRO 4 OXOPYRIDO[2,3 D]PYRIMIDIN 6 YL)ETHYL] 2 THENOYL]GLUTAMIC ACID; PEMETREXED; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; RALTITREXED; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CELL LINE; CELL RESPIRATION; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DNA CONTENT; DNA SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHATIC LEUKEMIA; PRIORITY JOURNAL;

ACYLTRANSFERASES; ANTIMETABOLITES, ANTINEOPLASTIC; CELL CYCLE; CELL LINE; CELL SURVIVAL; DNA FRAGMENTATION; FOLIC ACID ANTAGONISTS; GLUTAMATES; GUANINE; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; OXYGEN; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; TETRAHYDROFOLATES; THYMIDYLATE SYNTHASE;

EID: 0031024897     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050608     Document Type: Article

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