Systemic detection of doxycycline after local administration

Acta Odontologica Scandinavica

Volumn 67, Issue 5, 2009, Pages 289-296

  Kim, Ti Sun ^a   Lee, Sang Heon ^b   Eickholz, Peter ^d   Zimmer, Holger ^c   Kim, Chong Kwan ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Yonsei University College of Dentistry   (South Korea)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

Antibiotics; Controlled release; Local elivery; Pharmacokinetics; Systemic contamination

Indexed keywords

DOXYCYCLINE; IVOCLAR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SALIVA LEVEL; FEMALE; GINGIVITIS; HUMAN; MALE; PERIODONTITIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHRONIC PERIODONTITIS; DELAYED-ACTION PREPARATIONS; DENTAL PLAQUE INDEX; DOXYCYCLINE; DRUG CARRIERS; FEMALE; GELS; GINGIVAL CREVICULAR FLUID; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; POLYESTERS; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; SALIVA;

EID: 70350508417     PISSN: 00016357     EISSN: 15023850     Source Type: Journal    
DOI: 10.1080/00016350903001841     Document Type: Article

References (41)

1. Drisko CH. Non-surgical pocket therapy: pharmacotherapeutics. Ann Periodontol 1996;/1:/491-566.
2. Van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996;/10:/47-78.
3. Slots J, Rams TE. Antibiotics in periodontal therapy: advantages and disadvantages. J Clin Periodontol 1990;/17:/ 479-493
4. Goodson JM, Holborow D, Dunn RL, Hogan P, Dunham S. Monolithic tetracycline containing fibers for controlled delivery to periodontal pockets. J Periodontol 1983;/54:/ 575-579
5. Addy M, Fugit DR. A review: Topical drug use and delivery in the mouth. Clin Mat 1989;/4:/271-84.
6. Minabe M. Application of a local drug delivery system to periodontal therapy [1]. Development of collagen preparations with immobilized tetracycline. J Periodontol 1989;/60:/ 113-117
7. Unsal E, Akkaya M, Walsh TF. Influence of a single application of subgingival chlorhexidine gel or tetracycline paste on the clinical parameters of adult periodontitis patients. J Clin Periodontol 1994;/21:/351-5.
8. Tonetti M, Cugini MA, Goodson JM. Zero-order delivery with periodontal element of tetracycline-loaded ethylene vinyl acetate fibers. J Periodont Res 1990;/25:/243-9.
9. Lie T, Bruun G, Böe O. Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. J Periodontol 1998;/69:/819-27.
10. Greenstein G, Polson A. The role of local drug delivery in the management of periodontal disease: a comprehensive review. J Periodontol 1998;/69:/507-20.
11. Oosterwaal PJM, Mikx FHM, Renggli HH. Clearance of a topically applied fluorescein gel from periodontal pockets. J Clin Periodontol 1990;/17:/613-5.
12. Stoller NH, Johnson LR, Trapnell S, Harrold CQ, Garrett S. The pharmacokinetic profile of a biodegradable controlledrelease delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum. J Periodontol 1998;/69:/1085-91.
13. Eickholz P, Kim TS, Bürklin T, Schacher B, Renggli HH, Schaecken MT, et al. Non-surgical periodontal therapy with adjunctive topical doxycycline: a double-blind randomized controlled multicenter study. I. Study design and clinical results. J Clin Periodontol 2002;/29:/108-17.
14. Eickholz P, Kim TS, Schacher B, Reitmeir P, Bürklin T, Ratka-Krüger P. Subgingival topical doxycycline versus mechanical debridement for supportive periodontal therapy: a single blind randomized controlled two-center study. Am J Dent 2005;/18:/341-6.
15. Kim TS, Bürklin T, Schacher B, Ratka-Krüger P, Schaecken MT, Renggli HH, et al. Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva. J Periodontol 2002;/73:/1285-91.
16. Kim TS, Klimpel H, Fiehn W, Eickholz P. Comparison of the pharmacokinetic profiles of two locally administered doxycycline gels in crevicular fluid and saliva. J Clin Periodontol 2004;/31:/286-92.
17. Ratka-Krüger P, Schacher B, Bürklin T, Böddinghaus B, Holle R, Renggli HH, et al. Non-surgical periodontal therapy with adjunctive topical doxycycline: a doublemasked, randomized, controlled multicenter study. II. Microbiological results. J Periodontol 2005;/76:/66-74.
18. Löe H. The Gingival Index, the Plaque Index and the Retention Index system. J Periodontol 1967;/38:/610-6.
19. Hellden LB, Listgarten MA, Lindhe J. The effect of tetracycline and/or scaling on human periodontal disease. J Clin Periodontol 1979;/6:/222-30.
20. Joyston-Bechal S, Smales FC, Duckworth R. Effect of metronidazole on chronic periodontal disease in subjects using a topically applied chlorhexidine gel. J Clin Periodontol 1984;/11:/53-62.
21. Greenstein G. The role of local drug delivery in the treatment of chronic periodontitis. Things you should know. Dent Today 2004;/23:/110-5.
22. Pascale D, Gordon J, Lamster I, Mann P, Seiger M, Arndt W. Concentration of doxycycline in human gingival fluid. J Clin Periodontol 1986;/13:/841-4.
23. Saux MC, Mosser J, Pontagnier H, Leng B. Pharmacokinetic study of doxycycline polyphosphate [PPD], hydro chloride [CHD] and base [DB]. Eur J Drug Metab Pharmacokinet 1981;/6:/3-10.
24. Saivin S, Houin G. Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet 1988;/15:/355-66.
25. Schreiner A, Digranes A. Pharmacokinetics of lymecycline and doxycycline in serum and suction blister fluid. Chemotherapy 1985;/31:/261-5. (Pubitemid 15054530)
26. Malmborg AS. Bioavailability of doxycycline monohydrate. A comparison with equivalent doses of doxycycline hydrochloride. Chemotherapy 1984;/30:/76-80.
27. Macdonald H, Kelly RG, Allen ES, Noble JF, Kanegis LA. Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther 1973;/14:/852-61.
28. Whelton A, Blanco LJ, Carter GG. Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. Obstet Gynecol 1980;/55:/28-32.
29. Sakellari D, Goodson JM, Kolokotronis A, Konstantinidis A. Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J Clin Periodontol 2000;/27:/53-60.
30. Mombelli AW, van Winkelhoff A. The systemic use of antibiotics in periodontal therapy. In: Lang NP, Karring T, Lindhe J, editors. Proceedings of the 2nd European Workshop on Periodontology. Chemicals in Periodontics. London: Quintessence; 2001. p. 38-77.
31. Cargill K, Pyle B, Sauer R, McFeters G. Effects of culture conditions and biofilm formation on the iodine susceptibility of Legionella pneumophila. Can JMicrobiol 1992;/38:/423-8.
32. Anwar H, Strap J, Costerton J. Establishment of ageing biofilms: possible mechanism of bacterial resistance to antimicrobial therapy. Antimicrob Agents Chemother 1992;/ 36:/1347-51.
33. Brown M, Gilbet P. Sensitivity of biofilms to antimicrobial agents. J Appl Bacteriol 1993;/74 Suppl:/87-91.
34. Vorachit M, Lam K, Jayanetra P, Costerton J. Resistance of Pseudomonas pseudomallei growing on a biofilm on silastic discs to ceftazidime and co-trimoxazole. Antimicrob Agents Chemother 1993;/37:/2000-4.
35. Shaddox ML, Andia DC, Casati MZ. Changes following administration of locally delivered doxycycline in smokers: a 15-month follow-up. J Periodontol 2007;/78:/2143-9.
36. Sallum AW, Vaconcelos Alves R, Teixeira Damis LF, Roesler Bertonini PF, Nociti Junior FH, Sallum EA. Tetracycline gel as an adjunct to surgical root debridement. Am J Dent 2008;/ 21:/168-70.
37. Bosco JM, Lopes BM, Bosco AF, Spolidorio DM, Marcantonio RA. Local application of tetracycline solution with a microbrush: an alternative treatment for persistent periodontitis. Quintessence Int 2009;/40:/29-40.
38. Gupta R, Pandit N, Aggarwal S, Verma A. Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan-based chlorhexidine gels in the treatment of chronic periodontitis. J Contemp Dent Pract 2008;/9:/ 25-32.
39. Bogren A, Teles RP, Torresyap G, Haffajee AD, Socransky SS, Wennström JL. Locally delivered doxycycline during supportive periodontal therapy: a 3-year study. J Periodontol 2008;/79:/827-35.
40. Garrett S, Johnson L, Drisko CH. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol 1999;/70:/490-503.
41. Polson AM, Garrett S, Stoller NH. Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. 1. Study design, procedures, and management. J Periodontol 1997;/ 68:/110-8. (Pubitemid 27149464)