Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva

Journal of Periodontology

Volumn 73, Issue 11, 2002, Pages 1285-1291

  Kim, Ti Sun ^a   Bürklin, Thomas ^b   Schacher, Beate ^b   Ratka Krüger, Petra ^b   Schaecken, Matthijs T ^c   Renggli, Heinz H ^c   Fiehn, Walter ^a   Eickholz, Peter ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Biodegradation; Controlled clinical trials; Doxycycline therapeutic use; Drug delivery systems

Indexed keywords

ANTIBIOTIC AGENT; CHLORHEXIDINE; DOXYCYCLINE; METRONIDAZOLE; MINOCYCLINE; TETRACYCLINE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DEVICE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG RETENTION; DRUG SALIVA LEVEL; FEMALE; GASTROINTESTINAL TOXICITY; GEL; GINGIVITIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PERIODONTITIS; RADIATION DETECTION; STATISTICAL ANALYSIS; ULTRAVIOLET RADIATION;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DOXYCYCLINE; FEMALE; GELS; GINGIVAL CREVICULAR FLUID; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PERIODONTAL POCKET; SALIVA; STATISTICS, NONPARAMETRIC;

EID: 0036865534     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2002.73.11.1285     Document Type: Article

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