Comparison of the pharmacokinetic profiles of two locally administered doxycycline gels in crevicular fluid and saliva

Journal of Clinical Periodontology

Volumn 31, Issue 4, 2004, Pages 286-292

  Kim, Ti Sun ^a   Klimpel, Homa ^b   Fiehn, Walter ^b   Eickholz, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Controlled release device biodegradable; Doxycycline doxycycline free amine, pharmacokinetics; Topical antibiotic delivery systems biodegradable

Indexed keywords

ANTIBIOTIC AGENT; ATRIDOX; DOXYCYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DOXYCYCLINE HYCLATE; DRUG DERIVATIVE;

ADULT; AGED; ARTICLE; BODY FLUID; CLINICAL ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG FORMULATION; DRUG HALF LIFE; FEMALE; GEL; GINGIVITIS; HUMAN; MALE; RANDOMIZATION; SALIVA; TOPICAL TREATMENT; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DELAYED RELEASE FORMULATION; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MIDDLE AGED; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DOXYCYCLINE; FEMALE; FOLLOW-UP STUDIES; GELS; GINGIVAL CREVICULAR FLUID; HUMANS; MALE; MIDDLE AGED; PERIODONTITIS; SALIVA; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 2342571680     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0303-6979.2004.00494.x     Document Type: Article

References (27)

1. Addy, M. & Fugit, D. R. (1989) A review: topical drug use and delivery in the mouth. Clinical Materials 4, 271-284.
2. Anwar, H., Strap, J. & Costerton, J. (1992) Establishment of ageing biofilms: possible mechanism of bacterial resistance to antimicrobial therapy. Antimicrobial Agents Chemotherapy 36, 1347-1351.
3. Brown, M. & Gilbet, P. (1993) Sensitivity of biofilms to antimicrobial agents. Journal of Applied Bacteriology 74, 87-91.
4. Cargill, K., Pyle, B., Sauer, R. & McFeters, G. (1992) Effects of culture conditions and biofilm formation on the iodine susceptibility of Legionella pneumophila. Canadian Journal of Microbiology 38, 423-428.
5. Drisko, C. H. (1996) Non-surgical pocket therapy: pharmacotherapeutics. Annals of Periodontology 1, 491-566.
6. Eick, S., Seltmann, T. & Pfister, W. (2002) Antibiotika und parodontalpathogene Bakteriesspezies im Biofilm - eine In-vitro-Studie. Dtsch Zahnärztl Z 57, 289-294.
7. Eickholz, P., Kim, T. S., Bürklin, T., Schacher, B., Renggli, H. H., Schaecken, M. T., Holle, R., Kübler, A. & Ratka-Krüger, P. (2002) Non-surgical periodontal therapy with adjunctive topical doxycycline: a double blind randomized controlled multicenter study. I. Study design and clinical results. Journal of Clinical Periodontology 29, 108-117.
8. Garrett, S., Johnson, L., Drisko, C. H., Adams, D. F., Bandt, C., Beiswanger, B., Bogle, G., Donly, K., Hallmon, W. W., Hancock, E. B., Hanes, P., Hawley, C. E., Kiger, R., Killoy, W., Mellonig, J. T., Polson, A., Raab, F. J., Ryder, M., Stoller, N. H., Wang, H. L., Wolinsky, L. E., Evans, G. H., Harrold, C. Q., Arnold, R. M. & Southard, G. L. (1999) Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. Journal of Periodontology 70, 490-503.
9. Goodson, J. M., Holborow, D., Dunn, R. L., Hogan, P. & Dunham, S. (1983) Monolithic tetracycline containing fibers for controlled delivery to periodontal pockets. Journal of Periodontology 54, 575-579.
10. Greenstein, G. & Polson, A. (1998) The role of local drug delivery in the management of periodontal disease: a comprehensive review. Journal of Periodontology 69, 507-520.
11. Hellden, L. B., Listgarten, M. A. & Lindhe, J. (1979) The effect of tetracycline and/or scaling on human periodontal disease. Journal of Clinical Periodontology 6, 222-230.
12. Joyston-Bechal, S., Smales, F. C. & Duckworth, R. (1984) Effect of metronidazole on chronic periodontal disease in subjects using a topically applied chlorhexidine gel. Journal of Clinical Periodontology 11, 53-62.
13. Kim, T. S., Bürklin, T., Schacher, B., Ratka-Krüger, P., Schaecken, M. T., Renggli, H. H., Fiehn, W. & Eickholz, P. (2002) Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva. Journal of Periodontology 73, 1285-1291.
14. Lie, T., Bruun, G. & Böe, O. (1998) Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. Journal of Periodontology 69, 819-827.
15. Löe, H. (1967) The gingival index, the plaque index and the retention index system. Journal of Periodontology 38, 610-616.
16. Minabe, M. (1989) Application of a local drug delivery system to periodontal therapy. (1) Development of collagen preparations with immobilized tetracycline. Journal of Periodontology 60, 113-117.
17. Mombelli, A. W. & van Winkelhoff, A. (2001) The systemic use of antibiotics in periodontal therapy. In: Proceedings of the Second European Workshop on Periodontology. Chemicals in Periodontics, eds Lang, N. P., Karring, T. & Lindhe, J., pp. 38-77. Quintessence Books.
18. Oosterwaal, P. J. M., Mikx, F. H. M. & Renggli, H. H. (1990) Clearance of a topically applied fluorescein gel from periodontal pockets. Journal of Clinical Periodontology 17, 613-615.
19. Pascale, D., Gordon, J., Lamster, I., Mann, P., Seiger, M. & Arndt, W. (1986) Concentration of doxycycline in human gingival fluid. Journal of Clinical Periodontology 13, 841-844.
20. Polson, A. M., Garrett, S., Stoller, N. H., Bandt, C. L., Hanes, P. J., Killoy, W. J., Southard, G. L., Duke, S. P., Bogle, G. C., Drisko, C. H. & Friesen, L. R. (1997) Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. 1. Study design, procedures, and management. Journal of Periodontology 68, 110-118.
21. Slots, J. & Rams, T. E. (1990) Antibiotics in periodontal therapy: advantages and disadvantages. Journal of Clinical Periodontology 17, 479-493.
22. Stoller, N. H., Johnson, L. R., Trapnell, S., Harrold, C. Q. & Garrett, S. (1998) The pharmacokinetic profile of a biodegradable controlled-release delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum. Journal of Periodontology 69, 1085-1091.
23. Tonetti, M., Cugini, M. A. & Goodson, J. M. (1990) Zero-order delivery with periodontal element of tetracycline-loaded ethylene vinyl acetate fibers. Journal of Periodontal Research 25, 243-249.
24. Tonetti, M. (1997) The topical use of antibiotics in periodontal pockets. In: Proceedings of the Second European Workshop on Periodontology, eds. Lang, N. P., Karring, T. & Lindhe, J., pp. 78-109. Berlin, London, Chicago: Quintessence Books.
25. Unsal, E., Akkaya, M. & Walsh, T. F. (1994) Influence of a single application of subgingival chlorhexidine gel or tetracycline paste on the clinical paramters of adult periodontitis patients. Journal of Clinical Periodontology 21, 351-355.
26. VanWinkelhoff, A. J., Rams, T. E. & Slots, J. (1996) Systemic antibiotic therapy in periodontics. Periodontology 2000, 47-78.
27. Vorachit, M., Lam, K., Jayanetra, P. & Costerton, J. (1993) Resistance of Pseudomonas pseudomallei growing on a biofilm on silastic discs to ceftazidime and co-trimoxazole. Antimicrobial Agents Chemotherapy 37, 2000-2004.