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Volumn 69, Issue 5, 1998, Pages 507-520

The role of local drug delivery in the management of periodontal diseases: A comprehensive review

Author keywords

Comparative study; Drug delivery systems; Periodontal diseases drug therapy

Indexed keywords

CHLORHEXIDINE; DOXYCYCLINE; METRONIDAZOLE; MINOCYCLINE; TETRACYCLINE;

EID: 0031832620     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1998.69.5.507     Document Type: Review
Times cited : (212)

References (90)
  • 1
    • 0028457308 scopus 로고
    • Microbial and etiological agents of destructive periodontal diseases
    • Haffajee AD, Socransky SS. Microbial and etiological agents of destructive periodontal diseases. Periodontol 2000 1994;5:78-111
    • (1994) Periodontol 2000 , vol.5 , pp. 78-111
    • Haffajee, A.D.1    Socransky, S.S.2
  • 3
    • 0030280424 scopus 로고    scopus 로고
    • Non-surgical therapy: Pharmacotherapeutics
    • Drisko CH. Non-surgical therapy: Pharmacotherapeutics. Ann Periodontol 1996;1:491-518.
    • (1996) Ann Periodontol , vol.1 , pp. 491-518
    • Drisko, C.H.1
  • 4
    • 0021977325 scopus 로고
    • Controlled drug delivery: A new means of treatment of dental diseases
    • Goodson JM. Controlled drug delivery: A new means of treatment of dental diseases. Campend Cont Educ Dent 1985;6:27-36.
    • (1985) Campend Cont Educ Dent , vol.6 , pp. 27-36
    • Goodson, J.M.1
  • 5
    • 3042968342 scopus 로고
    • Controlled local drug delivery of antimicrobials in the treatment of periodontitis
    • Chicago: The American Academy of Periodontology
    • Killoy WJ. Controlled local drug delivery of antimicrobials in the treatment of periodontitis. In: Periodontol Disease Management. Chicago: The American Academy of Periodontology; 1994;221-236.
    • (1994) Periodontol Disease Management , pp. 221-236
    • Killoy, W.J.1
  • 6
    • 0030978752 scopus 로고    scopus 로고
    • Subgingival delivery of therapeutic agents in the treatment of periodontal diseases
    • Soskolne WA. Subgingival delivery of therapeutic agents in the treatment of periodontal diseases. Crit Rev Oral Biol Med 1997;8: 164-174.
    • (1997) Crit Rev Oral Biol Med , vol.8 , pp. 164-174
    • Soskolne, W.A.1
  • 7
    • 0030072475 scopus 로고    scopus 로고
    • Local delivery of antimicrobial agents in the periodontal pocket
    • Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000 1996;10:139-159.
    • (1996) Periodontol 2000 , vol.10 , pp. 139-159
    • Rams, T.E.1    Slots, J.2
  • 8
    • 7144258945 scopus 로고    scopus 로고
    • Single and repeated tetracycline fiber treatment vs periodontal maintenance
    • Abstr. 1136
    • Killoy WJ, Rapley JW, Drisko CL et al. Single and repeated tetracycline fiber treatment vs periodontal maintenance. J Dent Res 1996; 75(Spec. Issue):153 (Abstr. 1136).
    • (1996) J Dent Res , vol.75 , Issue.SPEC. ISSUE , pp. 153
    • Killoy, W.J.1    Rapley, J.W.2    Drisko, C.L.3
  • 9
    • 0030902904 scopus 로고    scopus 로고
    • The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis
    • Vandekerckhove BNA, Quirynen M, van Steenberghe D. The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis. J Periodontol 1997;68:353-361.
    • (1997) J Periodontol , vol.68 , pp. 353-361
    • Vandekerckhove, B.N.A.1    Quirynen, M.2    Van Steenberghe, D.3
  • 10
    • 0028457303 scopus 로고
    • Antimicrobial strategies for treatment of periodontal diseases
    • Goodson JM. Antimicrobial strategies for treatment of periodontal diseases. Periodontol 2000 1994;5:142-168.
    • (1994) Periodontol 2000 , vol.5 , pp. 142-168
    • Goodson, J.M.1
  • 11
    • 0025740975 scopus 로고
    • Multicenter evaluation of tetracycline fiber therapy: II. Clinical response
    • Goodson MA, Cugini RL, Kent GC, et al. Multicenter evaluation of tetracycline fiber therapy: II. Clinical response. J Periodont Res 1991;26:371-379.
    • (1991) J Periodont Res , vol.26 , pp. 371-379
    • Goodson, M.A.1    Cugini, R.L.2    Kent, G.C.3
  • 12
    • 0025911612 scopus 로고
    • Multicenter evaluation of tetracycline fiber therapy: III. Microbiological response
    • Goodson JM, Tanner A, McArdle S, Dix K, Watanabe SM. Multicenter evaluation of tetracycline fiber therapy: III. Microbiological response. J Periodont Res 1991;26:440-451.
    • (1991) J Periodont Res , vol.26 , pp. 440-451
    • Goodson, J.M.1    Tanner, A.2    McArdle, S.3    Dix, K.4    Watanabe, S.M.5
  • 13
    • 0022323081 scopus 로고
    • Clinical responses following periodontal treatment by local drug delivery
    • Goodson JM, Hogan P, Dunham S. Clinical responses following periodontal treatment by local drug delivery. J Periodontol 1985; 56:81-87.
    • (1985) J Periodontol , vol.56 , pp. 81-87
    • Goodson, J.M.1    Hogan, P.2    Dunham, S.3
  • 14
    • 0025106013 scopus 로고
    • Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers
    • Tonetti M, Cugini MA, Goodson JM. Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers. J Periodont Res 1990;25:243-249.
    • (1990) J Periodont Res , vol.25 , pp. 243-249
    • Tonetti, M.1    Cugini, M.A.2    Goodson, J.M.3
  • 15
    • 0018746073 scopus 로고
    • Local tetracycline delivery using hollow fiber devices in periodontal therapy
    • Lindhe J, Heul L, Goodson JM, Socransky SS. Local tetracycline delivery using hollow fiber devices in periodontal therapy. J Clin Periodontol 1979;6:141-149.
    • (1979) J Clin Periodontol , vol.6 , pp. 141-149
    • Lindhe, J.1    Heul, L.2    Goodson, J.M.3    Socransky, S.S.4
  • 16
    • 0026026064 scopus 로고
    • A 4 quadrant comparative study of periodontal treatment using tetracycline containing drug delivery fibers and scaling
    • Heijl L, Dahlen G, Sundin Y, Wenander A, Goodson JM. A 4 quadrant comparative study of periodontal treatment using tetracycline containing drug delivery fibers and scaling. J Clin Periodontol 1991; 18:111-116.
    • (1991) J Clin Periodontol , vol.18 , pp. 111-116
    • Heijl, L.1    Dahlen, G.2    Sundin, Y.3    Wenander, A.4    Goodson, J.M.5
  • 17
    • 0027932951 scopus 로고
    • A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: Clinical results
    • Newman MG, Kornman KS, Doherty FM. A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: clinical results. J Periodontol 1994;65:685-691.
    • (1994) J Periodontol , vol.65 , pp. 685-691
    • Newman, M.G.1    Kornman, K.S.2    Doherty, F.M.3
  • 18
    • 0029087047 scopus 로고
    • Evaluation of periodontal treatments using controlled-release tetracycline fibers. Clinical response
    • Drisko C, Cobb C, Killoy R, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers. Clinical response. J Periodontol 1995;66:692-699.
    • (1995) J Periodontol , vol.66 , pp. 692-699
    • Drisko, C.1    Cobb, C.2    Killoy, R.3
  • 19
    • 0029143101 scopus 로고
    • Evaluation of periodontal treatments using controlled-release tetracycline fibers. Microbiologic response
    • Lowenguth R, Caton J, Chin I, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers. Microbiologic response. J Periodontol 1995;66:700-707.
    • (1995) J Periodontol , vol.66 , pp. 700-707
    • Lowenguth, R.1    Caton, J.2    Chin, I.3
  • 21
    • 0029092082 scopus 로고
    • Evaluation of periodontal treatments using controlled-release tetracycline fibers: Maintenance response
    • Michalowicz BS, Pihlstrom BL, Drisko CL, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers: Maintenance response. J Periodontol 1995;66:708-715.
    • (1995) J Periodontol , vol.66 , pp. 708-715
    • Michalowicz, B.S.1    Pihlstrom, B.L.2    Drisko, C.L.3
  • 22
    • 2442491631 scopus 로고    scopus 로고
    • Clinical and microbiological efficacy of tetracycline fiber therapy in relapsing periodontal sites during supportive periodontal therapy
    • Abstr. 1116
    • Sanz M, Serrano C, Garcia C, Echievarria C, O'Connor A. Clinical and microbiological efficacy of tetracycline fiber therapy in relapsing periodontal sites during supportive periodontal therapy. J Dent Res 1997;76(Spec. Issue):153 (Abstr. 1116).
    • (1997) J Dent Res , vol.76 , Issue.SPEC. ISSUE , pp. 153
    • Sanz, M.1    Serrano, C.2    Garcia, C.3    Echievarria, C.4    O'Connor, A.5
  • 23
    • 0344372042 scopus 로고    scopus 로고
    • Gingivalis (PG) and A. actinomycetemcomitans (Aa) be eradicated with local antimicrobial therapy?
    • Abstr. 1115
    • Mombelli A, Schmid B, Lang NP, Can P. gingivalis (PG) and A. actinomycetemcomitans (Aa) be eradicated with local antimicrobial therapy? J Dent Res 1997;76(Spec. Issue):153 (Abstr. 1115).
    • (1997) J Dent Res , vol.76 , Issue.SPEC. ISSUE , pp. 153
    • Mombelli, A.1    Schmid, B.2    Lang, N.P.3    Can, P.4
  • 24
    • 0026665504 scopus 로고
    • Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel
    • Stoltze K. Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. J Clin Periodontol 1992;19:698-701.
    • (1992) J Clin Periodontol , vol.19 , pp. 698-701
    • Stoltze, K.1
  • 25
    • 0026738519 scopus 로고
    • 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults
    • Klinge B, Attstrom R, Karring T, et al. 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. J Clin Periodontol 1992;19:708-714.
    • (1992) J Clin Periodontol , vol.19 , pp. 708-714
    • Klinge, B.1    Attstrom, R.2    Karring, T.3
  • 26
    • 0026940790 scopus 로고
    • Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis
    • Pedrazzoli V, Kilian M, Karring T, et al. Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. J Clin Periodontol 1992;19:715-722.
    • (1992) J Clin Periodontol , vol.19 , pp. 715-722
    • Pedrazzoli, V.1    Kilian, M.2    Karring, T.3
  • 27
    • 0026673649 scopus 로고
    • Clinical responses to subgingival application of a metronidazole 25% gel compared to the effects of subgingival scaling in adult periodontitis
    • Ainamo J, Lie T, Ellingsen BH, et al. Clinical responses to subgingival application of a metronidazole 25% gel compared to the effects of subgingival scaling in adult periodontitis. J Clin Periodontol 1992;19:723-729.
    • (1992) J Clin Periodontol , vol.19 , pp. 723-729
    • Ainamo, J.1    Lie, T.2    Ellingsen, B.H.3
  • 28
    • 0345234782 scopus 로고    scopus 로고
    • Metronidazole gel application as an adjunct to subgingival scaling
    • Abstr. 1129
    • Stelzel M, Flores-de-Jacoby L. Metronidazole gel application as an adjunct to subgingival scaling. J Dent Res 1996;75(Spec. Issue): 159(Abstr. 1129).
    • (1996) J Dent Res , vol.75 , Issue.SPEC. ISSUE , pp. 159
    • Stelzel, M.1    Flores-de-Jacoby, L.2
  • 29
    • 0344803890 scopus 로고    scopus 로고
    • Repeated local metronidazole application combined with scaling and root planing
    • Abstr. 1135
    • Riep B, Purucker P, Hopfenmuller W, Bernimoulin JR Repeated local metronidazole application combined with scaling and root planing. J Dent Res 1996;75(Spec. Issue):159(Abstr. 1135).
    • (1996) J Dent Res , vol.75 , Issue.SPEC. ISSUE , pp. 159
    • Riep, B.1    Purucker, P.2    Hopfenmuller, W.3    Bernimoulin, J.R.4
  • 30
    • 85038604623 scopus 로고    scopus 로고
    • 25% metronidazole gel as an adjunct to periodontal flap surgery
    • Abstr. 1109
    • Needleman IG, Collins AM, Smales FC. 25% metronidazole gel as an adjunct to periodontal flap surgery. J Dent Res 1997;76(Spec. Issue):152 (Abstr. 1109).
    • (1997) J Dent Res , vol.76 , Issue.SPEC. ISSUE , pp. 152
    • Needleman, I.G.1    Collins, A.M.2    Smales, F.C.3
  • 31
    • 7144251737 scopus 로고
    • Clinical effects of subgingival minocycline in periodontitis
    • Abstr. 1114
    • Jones A, Wood R, Newbold D, Manwell M, Kornman K. Clinical effects of subgingival minocycline in periodontitis. J Dent Res 1992; 71(Spec. Issue):245 (Abstr. 1114).
    • (1992) J Dent Res , vol.71 , Issue.SPEC. ISSUE , pp. 245
    • Jones, A.1    Wood, R.2    Newbold, D.3    Manwell, M.4    Kornman, K.5
  • 32
    • 0010186983 scopus 로고
    • Local delivery of minocin to periodontal lesions in a slow release polymer
    • Abstr. 1115
    • Braswell L, Offenbacher S, Fritz M, Van Dyke TE. Local delivery of minocin to periodontal lesions in a slow release polymer. J Dent Res 1992;71(Spec. Issue):245 (Abstr. 1115).
    • (1992) J Dent Res , vol.71 , Issue.SPEC. ISSUE , pp. 245
    • Braswell, L.1    Offenbacher, S.2    Fritz, M.3    Van Dyke, T.E.4
  • 33
    • 0027179321 scopus 로고
    • Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: A randomized, double-blind, vehicle controlled, multicenter study
    • van Steenberghe D, Bercy P, Kohl J, et al. Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: A randomized, double-blind, vehicle controlled, multicenter study. J Periodontol 1993;64;637-644.
    • (1993) J Periodontol , vol.64 , pp. 637-644
    • Van Steenberghe, D.1    Bercy, P.2    Kohl, J.3
  • 34
    • 0030203709 scopus 로고    scopus 로고
    • Evaluation of the long-term efficacy and safety of locally applied minocycline in adult periodontitis patients
    • Timmermans MF, van der Weijden GA, van Steenbergen TJM, et al. Evaluation of the long-term efficacy and safety of locally applied minocycline in adult periodontitis patients. J Clin Periodontol 1996; 23:707-716.
    • (1996) J Clin Periodontol , vol.23 , pp. 707-716
    • Timmermans, M.F.1    Van Der Weijden, G.A.2    Van Steenbergen, T.J.M.3
  • 35
    • 0031111651 scopus 로고    scopus 로고
    • A randomized, controlled trial of a 2% minocycline gel as an adjunct to non-surgical periodontal treatment, using a design with multiple matching criteria
    • Graca MA, Watts TLP, Wilson RF, Palmer RM. A randomized, controlled trial of a 2% minocycline gel as an adjunct to non-surgical periodontal treatment, using a design with multiple matching criteria. J Clin Periodontol 1997;24:249-253.
    • (1997) J Clin Periodontol , vol.24 , pp. 249-253
    • Graca, M.A.1    Watts, T.L.P.2    Wilson, R.F.3    Palmer, R.M.4
  • 36
    • 8244245754 scopus 로고    scopus 로고
    • Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results
    • Poison AM, Garrett S, Stoller N, et al. Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results. J Periodontol 1997;68:119-126.
    • (1997) J Periodontol , vol.68 , pp. 119-126
    • Poison, A.M.1    Garrett, S.2    Stoller, N.3
  • 37
    • 0006488709 scopus 로고    scopus 로고
    • Microbiota effects following sustained release subgingival delivery of doxycycline
    • Abstr. 1114
    • Borden LC, Walker CB, Stone C, et al. Microbiota effects following sustained release subgingival delivery of doxycycline. J Dent Res 1997;76(Spec. Issue):153 (Abstr. 1114).
    • (1997) J Dent Res , vol.76 , Issue.SPEC. ISSUE , pp. 153
    • Borden, L.C.1    Walker, C.B.2    Stone, C.3
  • 38
    • 0000099014 scopus 로고    scopus 로고
    • Two multicenter clinical trials of subgingival doxycycline in the treatment of periodontitis
    • Abstr. 1113
    • Garrett S, Adams D, Bandt C, et al. Two multicenter clinical trials of subgingival doxycycline in the treatment of periodontitis. J Dent Res 1997;76(Spec. Issue):153 (Abstr. 1113).
    • (1997) J Dent Res , vol.76 , Issue.SPEC. ISSUE , pp. 153
    • Garrett, S.1    Adams, D.2    Bandt, C.3
  • 39
    • 0025871380 scopus 로고
    • The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2-year clinical trial
    • Stabholz A, Soskolne WA, Friedman M, Sela MN. The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2-year clinical trial. J Periodontol 1991;62:429-433.
    • (1991) J Periodontol , vol.62 , pp. 429-433
    • Stabholz, A.1    Soskolne, W.A.2    Friedman, M.3    Sela, M.N.4
  • 40
    • 0031309647 scopus 로고    scopus 로고
    • Topical metronidazole application in recall patients. Long-term results
    • Stelzel M, Flores-de-Jacoby L. Topical metronidazole application in recall patients. Long-term results. J Clin Periodontol 1997;24:914-915.
    • (1997) J Clin Periodontol , vol.24 , pp. 914-915
    • Stelzel, M.1    Flores-de-Jacoby, L.2
  • 41
    • 85038604725 scopus 로고    scopus 로고
    • Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone
    • accepted for publication
    • Jeffcoat M, Bray KS, Cianico SG, et al. Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol, accepted for publication.
    • J Periodontol
    • Jeffcoat, M.1    Bray, K.S.2    Cianico, S.G.3
  • 42
    • 0031021027 scopus 로고    scopus 로고
    • Sustained local delivery of chlorhexidine in the treatment of periodontitis: A multicenter study
    • Soskolne WA, Heasman PA, Stabholz A, et al. Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multicenter study. J Periodontol 1997;68:32-38.
    • (1997) J Periodontol , vol.68 , pp. 32-38
    • Soskolne, W.A.1    Heasman, P.A.2    Stabholz, A.3
  • 43
    • 0026707926 scopus 로고
    • Systemic absorption of metronidazole after application of a metronidazole 25% dental gel
    • Stoltze K, Stellfeld M. Systemic absorption of metronidazole after application of a metronidazole 25% dental gel. J Clin Periodontol 1992;19:693-697.
    • (1992) J Clin Periodontol , vol.19 , pp. 693-697
    • Stoltze, K.1    Stellfeld, M.2
  • 44
    • 0020645262 scopus 로고
    • Antimicrobial susceptibilities of bacteria associated with periodontal diseases
    • Sutter VL, Jones MJ, Ghoneium ATM. Antimicrobial susceptibilities of bacteria associated with periodontal diseases. Antimicrob Agents Chemother 1983;23:483-486.
    • (1983) Antimicrob Agents Chemother , vol.23 , pp. 483-486
    • Sutter, V.L.1    Jones, M.J.2    Ghoneium, A.T.M.3
  • 45
    • 0028894070 scopus 로고
    • Detection and incidence of the tetracycline resistant determinant tet (m) in the microflora associated with adult periodontitis
    • Lacroix JM, Walker CB. Detection and incidence of the tetracycline resistant determinant tet (m) in the microflora associated with adult periodontitis. J Periodontol 1995;66:102-108.
    • (1995) J Periodontol , vol.66 , pp. 102-108
    • Lacroix, J.M.1    Walker, C.B.2
  • 46
    • 0029298384 scopus 로고
    • Tetracycline-resistant microorganisms recovered from patients with refractory disease
    • Olsvik B, Hansen BF, Tenover FC, Olsen I. Tetracycline-resistant microorganisms recovered from patients with refractory disease. J Clin Periodontol 1995;22:391-396.
    • (1995) J Clin Periodontol , vol.22 , pp. 391-396
    • Olsvik, B.1    Hansen, B.F.2    Tenover, F.C.3    Olsen, I.4
  • 47
    • 0029192230 scopus 로고
    • Tetracyclines in the management of periodontal diseases. A review
    • Seymour RA, Heasman PA. Tetracyclines in the management of periodontal diseases. A review. J Clin Periodontol 1995;22:22-35.
    • (1995) J Clin Periodontol , vol.22 , pp. 22-35
    • Seymour, R.A.1    Heasman, P.A.2
  • 48
    • 0026437738 scopus 로고
    • Tissue concentration and localization of tetracycline following site specific tetracycline fiber therapy
    • Ciancio SG, Cobb CM, Leung M. Tissue concentration and localization of tetracycline following site specific tetracycline fiber therapy. J Periodontol 1992;63:849-853.
    • (1992) J Periodontol , vol.63 , pp. 849-853
    • Ciancio, S.G.1    Cobb, C.M.2    Leung, M.3
  • 49
    • 0023967474 scopus 로고
    • Activity of metronidazole and its hydroxymetabolite against clinical isolates of Actinobacillus actinomycetemcomitans
    • Jousimies-Somer H, Asikainen S, Suomala P, Summanen P. Activity of metronidazole and its hydroxymetabolite against clinical isolates of Actinobacillus actinomycetemcomitans. Oral Microbial Immunol 1988;3:32-34.
    • (1988) Oral Microbial Immunol , vol.3 , pp. 32-34
    • Jousimies-Somer, H.1    Asikainen, S.2    Suomala, P.3    Summanen, P.4
  • 50
    • 0027401282 scopus 로고
    • The role of metronidazole in the treatment of periodontal diseases
    • Greenstein G. The role of metronidazole in the treatment of periodontal diseases. J Periodontol 1993;64:1-15.
    • (1993) J Periodontol , vol.64 , pp. 1-15
    • Greenstein, G.1
  • 51
    • 0022894713 scopus 로고
    • Chlorhexidine - An adjunct to periodontal therapy
    • Greenstein G, Berman C, Jaffin R. Chlorhexidine - An adjunct to periodontal therapy. J Periodontol 1986;57:370-377.
    • (1986) J Periodontol , vol.57 , pp. 370-377
    • Greenstein, G.1    Berman, C.2    Jaffin, R.3
  • 52
    • 0027537816 scopus 로고
    • Retention of antimicrobial activity by human root surfaces after in situ subgingival irrigation with tetracycline HCl or chlorhexidine
    • Stabholz A, Kettering J, Aprecio R, Zimmerman G, Baker PG, Wikesjö UME. Retention of antimicrobial activity by human root surfaces after in situ subgingival irrigation with tetracycline HCl or chlorhexidine. J Periodontol 1993;64:137-141.
    • (1993) J Periodontol , vol.64 , pp. 137-141
    • Stabholz, A.1    Kettering, J.2    Aprecio, R.3    Zimmerman, G.4    Baker, P.G.5    Wikesjö, U.M.E.6
  • 53
    • 0024806852 scopus 로고
    • Pharmacokinetic principles controlling efficacy of oral therapy
    • Goodson JM. Pharmacokinetic principles controlling efficacy of oral therapy. J Dent Res 1989;68:1625-1632.
    • (1989) J Dent Res , vol.68 , pp. 1625-1632
    • Goodson, J.M.1
  • 54
    • 0030256318 scopus 로고    scopus 로고
    • Full versus partial-mouth disinfection in the treatment of periodontal infections: A pilot study: long-term microbiological observations
    • Bollen CML, Vandekerckhove BNA, Papaioannou W, Van Eldere J, Quirynen M. Full versus partial-mouth disinfection in the treatment of periodontal infections: a pilot study: long-term microbiological observations. J Clin Periodontol 1996;23:960-970.
    • (1996) J Clin Periodontol , vol.23 , pp. 960-970
    • Bollen, C.M.L.1    Vandekerckhove, B.N.A.2    Papaioannou, W.3    Van Eldere, J.4    Quirynen, M.5
  • 55
    • 0028457303 scopus 로고
    • Antimicrobial strategies for treatment of periodontal diseases
    • Goodson JM. Antimicrobial strategies for treatment of periodontal diseases. Periodontol 2000 1994;5:142-168.
    • (1994) Periodontol 2000 , vol.5 , pp. 142-168
    • Goodson, J.M.1
  • 56
    • 0028401811 scopus 로고
    • Long-term effect of tetracycline fibers on recurrent lesions in periodontal maintenance patients
    • Corsair A. Long-term effect of tetracycline fibers on recurrent lesions in periodontal maintenance patients. Periodontol Clin Invest 1994;16:8-13.
    • (1994) Periodontol Clin Invest , vol.16 , pp. 8-13
    • Corsair, A.1
  • 57
    • 0028503138 scopus 로고
    • Tetracycline-loaded fibers as adjunctive treatment in periodontal disease
    • Kerry G. Tetracycline-loaded fibers as adjunctive treatment in periodontal disease. J Am Dent Assoc 1994;125:1199-1203.
    • (1994) J Am Dent Assoc , vol.125 , pp. 1199-1203
    • Kerry, G.1
  • 58
    • 0031087411 scopus 로고    scopus 로고
    • A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients
    • Noyan O, Yilmaz S, Kuru B, Kadir T, Acar O, Buget E. A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. J Clin Periodontol 1997;24: 158-165.
    • (1997) J Clin Periodontol , vol.24 , pp. 158-165
    • Noyan, O.1    Yilmaz, S.2    Kuru, B.3    Kadir, T.4    Acar, O.5    Buget, E.6
  • 59
    • 0027942833 scopus 로고
    • Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings
    • Sander L, Frandsen EVG, Arnbjerg D, Warrer K, Karring T. Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings. J Periodontol 1994;65: 914-920.
    • (1994) J Periodontol , vol.65 , pp. 914-920
    • Sander, L.1    Frandsen, E.V.G.2    Arnbjerg, D.3    Warrer, K.4    Karring, T.5
  • 60
    • 0028135073 scopus 로고
    • Metronidazole and guided tissue regeneration: Microbiological findings
    • Frandsen EVG, Sander L, Arnbjerg D, Theilade E. Metronidazole and guided tissue regeneration: Microbiological findings. J Periodontol 1994;65:921-928.
    • (1994) J Periodontol , vol.65 , pp. 921-928
    • Frandsen, E.V.G.1    Sander, L.2    Arnbjerg, D.3    Theilade, E.4
  • 61
    • 0029746640 scopus 로고    scopus 로고
    • Comparison of 3 periodontol local antibiotic therapies in persistent periodontal pockets
    • Radvar M, Pourtaghi N, Kinane DF. Comparison of 3 periodontol local antibiotic therapies in persistent periodontal pockets. J Periodontol 1996;67:860-865.
    • (1996) J Periodontol , vol.67 , pp. 860-865
    • Radvar, M.1    Pourtaghi, N.2    Kinane, D.F.3
  • 62
    • 0022634398 scopus 로고
    • The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis
    • Mandell R, Tripodi L, Savitt E, Goodson J, Socransky S. The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis. J Periodontol 1986;57:94-97.
    • (1986) J Periodontol , vol.57 , pp. 94-97
    • Mandell, R.1    Tripodi, L.2    Savitt, E.3    Goodson, J.4    Socransky, S.5
  • 63
    • 0005137170 scopus 로고
    • Effects of local delivery of tetracycline on the progression of juvenile periodontitis
    • Abstr. 451
    • Lowenguth R, Morad V, Gandini L, Tyrrell H, Proskin HM, Van Dyke T. Effects of local delivery of tetracycline on the progression of juvenile periodontitis. J Dent Res 1993;72(Spec. Issue):160 (Abstr. 451).
    • (1993) J Dent Res , vol.72 , Issue.SPEC. ISSUE , pp. 160
    • Lowenguth, R.1    Morad, V.2    Gandini, L.3    Tyrrell, H.4    Proskin, H.M.5    Van Dyke, T.6
  • 64
    • 0025286195 scopus 로고
    • Occurrence of Bacteroides gingivalis. Bacteroides intermedius and Actinobacillus actinomycetemcomitans in severe periodontitis in relation to age and treatment history
    • Rodenbury JP, van Winkelhoff AJ, Winkel EG, Goene RJ, Abbas F, de Graaff J. Occurrence of Bacteroides gingivalis. Bacteroides intermedius and Actinobacillus actinomycetemcomitans in severe periodontitis in relation to age and treatment history. J Clin Periodontol 1990;17:392-399.
    • (1990) J Clin Periodontol , vol.17 , pp. 392-399
    • Rodenbury, J.P.1    Van Winkelhoff, A.J.2    Winkel, E.G.3    Goene, R.J.4    Abbas, F.5    De Graaff, J.6
  • 66
    • 0026844142 scopus 로고
    • Antibiotic resistance of the subgingival microbiota following local tetracycline therapy
    • Goodson JM, Tanner A. Antibiotic resistance of the subgingival microbiota following local tetracycline therapy. Oral Microbiol Immunol 1992;7:113-117.
    • (1992) Oral Microbiol Immunol , vol.7 , pp. 113-117
    • Goodson, J.M.1    Tanner, A.2
  • 67
    • 0025976824 scopus 로고
    • Occurrence of doxycycline resistant bacteria in the oral cavity after local administration of doxycycline in patients with periodontal disease
    • Larsen T. Occurrence of doxycycline resistant bacteria in the oral cavity after local administration of doxycycline in patients with periodontal disease. Scand J Infect Dis 1991;23:89-95.
    • (1991) Scand J Infect Dis , vol.23 , pp. 89-95
    • Larsen, T.1
  • 68
    • 0029301491 scopus 로고
    • Bacterial resistance following subgingival and systemic administration of minocycline
    • Preus HR, Lassen J, Aass AM, Ciancio SG. Bacterial resistance following subgingival and systemic administration of minocycline. J Clin Periodontol 1995;22:380-384.
    • (1995) J Clin Periodontol , vol.22 , pp. 380-384
    • Preus, H.R.1    Lassen, J.2    Aass, A.M.3    Ciancio, S.G.4
  • 69
    • 0030072489 scopus 로고    scopus 로고
    • The acquisition of antibiotic resistance in the periodontal microflora
    • Walker C. The acquisition of antibiotic resistance in the periodontal microflora. Periodontol 2000 1996;10:79-88.
    • (1996) Periodontol 2000 , vol.10 , pp. 79-88
    • Walker, C.1
  • 70
    • 0031115496 scopus 로고    scopus 로고
    • Development of resistance to metronidazole and minocycline in vitro
    • Larsen T, Fiehn NE. Development of resistance to metronidazole and minocycline in vitro. J Clin Periodontol 1997;24:254-259.
    • (1997) J Clin Periodontol , vol.24 , pp. 254-259
    • Larsen, T.1    Fiehn, N.E.2
  • 71
    • 0344372050 scopus 로고
    • Efficacy of sustained release metronidazole discs in adult periodontitis
    • Abstr. 2053
    • Drisko CL, Bray KS, Hardman P, et al. Efficacy of sustained release metronidazole discs in adult periodontitis. J Dent Res 1993;72(Spec. Issue):360 (Abstr. 2053).
    • (1993) J Dent Res , vol.72 , Issue.SPEC. ISSUE , pp. 360
    • Drisko, C.L.1    Bray, K.S.2    Hardman, P.3
  • 72
    • 0038365843 scopus 로고
    • Radiographic and BANA test analysis of locally delivered metronidazole: A phase I/II clinical trial
    • Abstr. 1627
    • Paquette D, Ling S, Fiorellini J, Howell H, Weber H, Williams R. Radiographic and BANA test analysis of locally delivered metronidazole: a phase I/II clinical trial. J Dent Res 1994;73(Spec. Issue): 305 (Abstr. 1627).
    • (1994) J Dent Res , vol.73 , Issue.SPEC. ISSUE , pp. 305
    • Paquette, D.1    Ling, S.2    Fiorellini, J.3    Howell, H.4    Weber, H.5    Williams, R.6
  • 73
    • 0023407666 scopus 로고
    • Four modalities of periodontal treatment compared over 5 years
    • Ramfjord S, Caffesse R, Morrison E, et al. Four modalities of periodontal treatment compared over 5 years. J Clin Periodontol 1987; 14:445-452.
    • (1987) J Clin Periodontol , vol.14 , pp. 445-452
    • Ramfjord, S.1    Caffesse, R.2    Morrison, E.3
  • 74
    • 0019783952 scopus 로고
    • Four types of periodontal treatment compared over two years
    • Hill RW, Ramfjord S, Morrison EC, et al. Four types of periodontal treatment compared over two years. J Periodontol 1981;52:655-662.
    • (1981) J Periodontol , vol.52 , pp. 655-662
    • Hill, R.W.1    Ramfjord, S.2    Morrison, E.C.3
  • 75
    • 0026148910 scopus 로고
    • Short term effects of initial periodontal therapy (hygienic phase)
    • Hammerle CHF, Joss A, Lang NP. Short term effects of initial periodontal therapy (hygienic phase). J Clin Periodontol 1991;18:233-239.
    • (1991) J Clin Periodontol , vol.18 , pp. 233-239
    • Hammerle, C.H.F.1    Joss, A.2    Lang, N.P.3
  • 77
    • 0021397445 scopus 로고
    • Recolonization of a subgingival microbiota following scaling in deep pockets
    • Magnusson I, Lindhe J, Yoneyama T, Liljenberg B. Recolonization of a subgingival microbiota following scaling in deep pockets. J Clin Periodontol 1984;11:193-207.
    • (1984) J Clin Periodontol , vol.11 , pp. 193-207
    • Magnusson, I.1    Lindhe, J.2    Yoneyama, T.3    Liljenberg, B.4
  • 78
    • 0018756101 scopus 로고
    • Clinical improvement of gingival conditions following ultrasonic versus hand instrumentation of periodontal pockets
    • Torfason T, Kiger R, Selvig KA, Egelberg J. Clinical improvement of gingival conditions following ultrasonic versus hand instrumentation of periodontal pockets. J Clin Periodontol 1979;6:165-176.
    • (1979) J Clin Periodontol , vol.6 , pp. 165-176
    • Torfason, T.1    Kiger, R.2    Selvig, K.A.3    Egelberg, J.4
  • 79
    • 0018176964 scopus 로고
    • Effect of tetracycline and/or scaling on human periodontal disease
    • Listgarten MA, Lindhe J, Hellden LB. Effect of tetracycline and/or scaling on human periodontal disease. J Clin Periodontol 1978;5: 246-271.
    • (1978) J Clin Periodontol , vol.5 , pp. 246-271
    • Listgarten, M.A.1    Lindhe, J.2    Hellden, L.B.3
  • 80
    • 0026558491 scopus 로고
    • Metronidazole in periodontitis: Reduced need for surgery
    • Loesche WJ, Giordano JR, Hujoel P, et al. Metronidazole in periodontitis: Reduced need for surgery. J Clin Periodontol 1992;19:103-112.
    • (1992) J Clin Periodontol , vol.19 , pp. 103-112
    • Loesche, W.J.1    Giordano, J.R.2    Hujoel, P.3
  • 81
    • 0025878007 scopus 로고
    • Effects of metronidazole on periodontal treatment needs
    • Loesche WJ, Schmidt E, Smith A, et al. Effects of metronidazole on periodontal treatment needs. J Periodontol 1991;62:247-257.
    • (1991) J Periodontol , vol.62 , pp. 247-257
    • Loesche, W.J.1    Schmidt, E.2    Smith, A.3
  • 82
    • 0024442018 scopus 로고
    • Effects of nonsurgical periodontal therapy combined with adjunctive antibiotics in subjects with "refractory" periodontal disease (I). Clinical results
    • Magnusson I, Clark WB, Low SB, Maruniak J, Marks RG, Walker CB. Effects of nonsurgical periodontal therapy combined with adjunctive antibiotics in subjects with "refractory" periodontal disease (I). Clinical results. J Clin Periodontol 1989;16:647-653.
    • (1989) J Clin Periodontol , vol.16 , pp. 647-653
    • Magnusson, I.1    Clark, W.B.2    Low, S.B.3    Maruniak, J.4    Marks, R.G.5    Walker, C.B.6
  • 83
    • 0022297763 scopus 로고
    • Evaluation of clindamycin hydrochloride in refractory periodontitis: 12-month results
    • Gordon JM, Walker CB, Lamster I, et al. Evaluation of clindamycin hydrochloride in refractory periodontitis: 12-month results. J Periodontol 1985;56(Suppl.):75-80.
    • (1985) J Periodontol , vol.56 , Issue.SUPPL. , pp. 75-80
    • Gordon, J.M.1    Walker, C.B.2    Lamster, I.3
  • 84
    • 0027218232 scopus 로고
    • Failure of adjunctive minocycline-HCL to eliminate oral Actinobacillus actinomycetemcomitans
    • Miller HP, Lange DE, Muller RF. Failure of adjunctive minocycline-HCL to eliminate oral Actinobacillus actinomycetemcomitans. J Clin Periodontol 1993;20:498-504.
    • (1993) J Clin Periodontol , vol.20 , pp. 498-504
    • Miller, H.P.1    Lange, D.E.2    Muller, R.F.3
  • 85
    • 0024578563 scopus 로고
    • Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated with periodontitis
    • van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated with periodontitis. J Clin Periodontol 1989;16:128-131.
    • (1989) J Clin Periodontol , vol.16 , pp. 128-131
    • Van Winkelhoff, A.J.1    Rodenburg, J.P.2    Goene, R.J.3    Abbas, F.4    Winkel, E.G.5    De Graaff, J.6
  • 86
    • 0029882221 scopus 로고    scopus 로고
    • Susceptibility of oral bacterial biofilms to antimicrobial agents
    • Wilson M. Susceptibility of oral bacterial biofilms to antimicrobial agents. J Med Microbiol 1996;44:79-87.
    • (1996) J Med Microbiol , vol.44 , pp. 79-87
    • Wilson, M.1
  • 87
    • 0023501983 scopus 로고
    • In vitro susceptibilities of suspected periodontopathic anaerobes as determined by membrane transfer assay
    • Caufield PW, Allen DN, Childers NK. In vitro susceptibilities of suspected periodontopathic anaerobes as determined by membrane transfer assay. Antimicrob Agents Chemo 1987;31:1989-1993.
    • (1987) Antimicrob Agents Chemo , vol.31 , pp. 1989-1993
    • Caufield, P.W.1    Allen, D.N.2    Childers, N.K.3
  • 89
    • 0029793723 scopus 로고    scopus 로고
    • The impact of molecular medicine on health services
    • Jones R. The impact of molecular medicine on health services. Nature Med 1996;2:959-960.
    • (1996) Nature Med , vol.2 , pp. 959-960
    • Jones, R.1
  • 90
    • 0030731783 scopus 로고    scopus 로고
    • Tetracycllne fibers plus scaling and root planing versus scaling and root planing alone: Similar results after 5 years
    • Wilson TG, McGuire MK, Greenstein G, Nunn M. Tetracycllne fibers plus scaling and root planing versus scaling and root planing alone: Similar results after 5 years. J Periodontol 1997;68:1029-1032.
    • (1997) J Periodontol , vol.68 , pp. 1029-1032
    • Wilson, T.G.1    McGuire, M.K.2    Greenstein, G.3    Nunn, M.4


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