Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan-based chlorhexidine gels in the treatment of chronic periodontitis

Journal of Contemporary Dental Practice

Volumn 9, Issue 7, 2008, Pages 025-032

  Gupta, Rajan ^a   Pandit, Nymphea ^a   Aggarwal, Shweta ^a   Verma, Ashish ^a  

^a DAV (C) Dental College in Yamunanagar   (India)

Author keywords

Chlorhexidine gel; Doxycycline gel; Local drug delivery; Randomized clinical trial; Scaling and root planning; SRP

Indexed keywords

BACTERIAL POLYSACCHARIDE; CHLORHEXIDINE; DOXYCYCLINE; DOXYCYCLINE HYCLATE; DRUG CARRIER; DRUG DERIVATIVE; TOPICAL ANTIINFECTIVE AGENT; XANTHAN;

ADULT; AGED; ARTICLE; CHRONIC PERIODONTITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; GEL; HUMAN; MALE; MIDDLE AGED; PERIODONTICS; PREVENTIVE DENTISTRY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE;

ADULT; AGED; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; CHRONIC PERIODONTITIS; DENTAL PLAQUE INDEX; DENTAL SCALING; DOXYCYCLINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; GELS; HUMANS; MALE; MIDDLE AGED; PERIODONTAL INDEX; POLYSACCHARIDES, BACTERIAL; PROSPECTIVE STUDIES;

EID: 55849102097     PISSN: None     EISSN: 15263711     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Hancok EB, Newell DH. Antimicrobials in periodontal practice. Dent Clin North America; 1996; 38:719-731.
2. Goodson JM. Pharmacokinetic principles controlling efficacy of oral therapy. J Dent Res 1989; 68(spec issue):1625-1632.
3. Oosterwall PJ, Mikx FH, Renggli HH. Clearance of a topically applied flouroscien gel from periodontal pocket. J Clin Periodontol 1990; 17:613-615.
4. Kim TS, Klimpel H, Fiehn W. Comparison of the pharmacokinetic profiles of two locally administered doxycycline gels in crevicular fluid and saliva. J Clin Periodontol 2004; 31:286-292.
5. Greenstein G, Polson AM. The role of local drug delivery in the management of periodontal diseases: A comprehensive review. J Periodontol 1998; 69:507-520.
6. Martorelli de Lima AF, Cury CC. Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis. J Clin Periodontol 2004; 31:648-653.
7. Lauhio A, Sorsa T, Lindy O, Sumalainen K, Saari H, Golub LM, Konttinen YT. Anticollagenolytic potential of tetracycline in long term treatment of reactive arthritis. Arthritis Rheumatoid 1992; 35:195-198.
8. Sorsa T, Uitto VJ, Suomalainen K, Vauhkonen M, Lindy S. Comparison of interstitial collagenase from human gingival, sulcular fluid and polymorphonuclear leukocyte. J Periodontal Res 1998; 23:386-393.
9. Demirel K, Baer PN, McNamara TF. Topical application of doxycycline on periodontally involved root surfaces in vitro: Comparative analysis of substantivity on cementum and dentin. J Periodontol 1991; 62:312-316.
10. Rusu D, Benta A, Necker A. Non-surgical periodontal therapy using a novel chlorhexidine based xanthan gel; a split mout study. Int Poster J Dent Oral Med 2005; 7:286-291.
11. Wennstrom JL, Newman HN, MacNeill SR. Utilization of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-center trial of 2 treatment approaches. J Clin Periodontol 2001; 28:753-761.
12. Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964; 22:121-135.
13. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963; 21:533-551.
14. Eickholz P, Kim TS, Burklin T. Non-surgical periodontal therapy with adjunctive topical doxycycline: a double blind randomized controlled multicenter study. (1). Study design and clinical results. J Clin Periodontol 2002; 29:108-117.
15. Garrett S, Johnson L, Drisko CH. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol 1999; 70:490-503.
16. Killoy WJ, Polson AM. Controlled local delivery of antimicrobials in the treatment of periodontitis. Dent Clin North America 1998; 42:263-283.
17. Anwar H, Strap JI, .Costerton JW. Establishment of aging biofilms: possible mechanism of bacterial resistance to antibiotic therapy. Antimicrobial agents and chemotherapy 1992; 36:1347-1351.
18. Goodson JM, Cugini MA, Kent RL, Armitage GC, Cobb CM, Fine D, Fritz ME, Green E, Imoberdorf MJ, Killoy WJ, Mendieta C, Niederman R, Offenbacher S, Taggart E, Tonetti M. Multicentre evaluation of tetracycline fibre therapy: i experimental design, methods and baseline data. J Periodontal Res 1991; Jul;26(4)361-70.
19. Goodson JM, Cugini MA, Kent RL, Armitage GC, Cobb CM, Fine D, Fritz ME, Green E, Imoberdorf MJ, Killoy WJ, Mendieta C, Niederman R, Offenbacher S, Taggart E, Tonetti M. Multicentre evaluation of tetracycline fibre therapy: ii experimental design, methods and baseline data. J Periodontol Res 1991; 26(4):371-79.
20. Hujoel PP, DeRouen TA. Validity issues in split mouth trials. J Clin Periodontol 1992; Oct;19 (9 Pt 1):625-7.
21. Magnusson I, Marks RG, Clark, WB, Walker GB, Low SB, Mac Arthur WP. Clinical microbiological and immunological characteristics of subjects with refractory periodontitis. J Clin Periodontol 1991; 18:291-299.
22. Listgarten MA, Lindhe J, Hellden L. Effect of tetracycline and or scaling on human disease. J Clin Periodontol 1978; 5:246-271.
23. Knoll-Kohler E. Metronidazole dental gel as an alternative to scaling and root planning in the treatment of localized juvenile periodontitis and its efficacy period. Eur J Oral Sci.1999; 107:415-421.
24. Grossi SG, Skrepcinski FB, DeCaro T, Robertson DC, Ho AW, Dunford RG, Genco RJ. Treatment of periodontal in diabetic reduced glycated reduced hemoglobin. J Periodontol 1997; 68(8):713-719.
25. Mayfield L, Bratthall G, Attström R. Periodontal probe precision using 4 different periodontal probes. J Clin Periodontol. 1996 Feb;23(2):76-82.
26. Gibbs CH, Hirschfeld JW, Lee JG. Description and clinical evaluation of a new computerized periodontal probe. J Clin Periodontol 1998; 15:137-144.
27. Llambes F, Silvestre FJ. Effect of non-surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients. J Clin Periodontol 2005; 32:915-920.
28. Fowler EB, Breaut LG, Dryant JB. Site specific chlohexidine - a periodontal alternative. Gen Dent 2001; 49(1):84-88.
29. Offenbacher S. Periodontal diseases pathogenesis. Ann Periodontol. 1996 Nov;1(1):821-78.
30. Ryder MI, Pons B, Adams D. Effects of smoking on local delivery of controlled release doxycycline as compared to scaling and root planing. J Clin Periodontol 1999; 26:683-691.
31. Polson AM, Garrett S, Stoller NH. Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results. J Periodontol 1997; 68:119-126.