Subgingival topical doxycycline versus mechanical debridement for supportive periodontal therapy: A single blind randomized controlled two-center study

American Journal of Dentistry

Volumn 18, Issue 6, 2005, Pages 341-346

  Eickholz, Peter ^a,b   Kim, Ti Sun ^b   Schacher, Beate ^a   Reitmeir, Peter ^d   Bürklin, Thomas ^a,c   Ratka Krüger, Petra ^e  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c University Hospital of Johann Wolfgang Goethe University Frankfurt ^*

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEBRIDEMENT; EPIDEMIOLOGY; FEMALE; HUMAN; MALE; METHODOLOGY; MICROBIOLOGY; MULTICENTER STUDY; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTI-BACTERIAL AGENTS; DEBRIDEMENT; DOXYCYCLINE; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; MALE; PERIODONTITIS;

EID: 31744438502     PISSN: 08948275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Kaldahl WB, Kalkwarf KL, Kashinath D, Patil D, Molvar MP, Dyer JK. Long-term evaluation of periodontal therapy: I. Response to four therapeutic modalities. J Periodontol 1996; 67: 93-102.
2. American Academy of Periodontology. The role of controlled drug delivery for periodontitis. J Periodontol 2000; 71: 125-140.
3. Kinane DF, Radvar M. A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. J Periodontol 1999; 70: 1-7.
4. Meinberg TA, Barnes CM, Dunning DG, Reinhard RA. Comparison of conventional periodontal maintenance versus scaling and root planing with subgingival minocycline. J Periodontol 2002; 73: 167-172.
5. Stelzel M, Florès-de-Jacoby L. Topical metronidazole application in recall patients. Long-term results. J Clin Periodontol 1992; 24: 914-919.
6. Stelzel M, Florès-de-Jacoby L. Topical metronidazole application as an adjunct to scaring and root planing. J Clin Periodontol 2000; 27: 447-452.
7. Garrett S, Johnson L, Drisko CH, Adams DF, Brandt C, Beiswanger B, Bogle G, Donly K, Hallmon WW, Hancock EB, Hanes P, Hawley CE, Kiger R, Killoy W, Mellonig JT, Polson A, Raab FJ, Ryder M, Stoller NH, Wang H-L, Wolinsky LE, Evans GH, Harrold CQ, Arnold RM, Atack DF, Fitzgerald B, Hill M, Isaaks RL, Nasi HF, Newell DH, MacNeil RL, MacNeill S, Spolsky VW, Duke SP, Polson A, Southard, GL. Two multicenter studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol 1999; 70: 490-503.
8. Ainamo J, Lie T, Ellingsen BH, Hansen BF, Johansson L-Å, Karring T, Kisch J, Paunio K, Stotze K. Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult patients. J Clin Periodontol 1992; 19: 723-729.
9. Eickholz P, Kim T-S, Schacher B, Bürklin T, Renggli HH, Schaecken MT, Holle R, Kübler A, Ratka-Krüger P. Non-surgical periodontal therapy with adjunctive topical doxycycline: A double blind randomized controlled multicenter study. I. Study design and clinical results. J Clin Periodontol 2002; 29: 108-117.
10. Kim T-S, Bürklin T, Schacher B, Ratka-Krüger P, Schaecken MT, Renggli, HH, Fiehn W, Eickholz P. Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva. J Periodontol 2002; 73: 1285-1291.
11. O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol 1972; 43: 38.
12. Lang NP, Tonetti MS. Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT). Oral Health Prevent Dent 2003; 1: 7-16.
13. Löe H. The gingival index, the plaque index and the retention index system. J Periodontol 1967; 38: 610-616.
14. Cohen ME, Ralls SA. False positive rates in the determination of changes in probing depth related periodontal measurements. J Periodont Res 1988; 23: 161-165.
15. Goldstein H. Multilevel statistical models. London: Edward Arnold; 1995.
16. Stelzel M, Florès-de-Jacoby L. Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients. J Clin Periodontol 1996; 23: 24-29.
17. Pihlstrom BL. Overview of periodontal clinical trials utilizing anti infective or host modulating agents. Ann Periodontol 1997; 2: 153-165.
18. Antczak-Bouckoms AA, Tulloch JFC, Berkey CS. Split-mouth and cross-over designs in dental research. J Clin Periodontol 1990; 17: 446-453.
19. Hujoel PP, DeRouen TA. Validity issues in split-mouth trials. J Clin Periodontol 1992; 19: 625-627.
20. Jeffcoat M. What is clinical significance. J Clin Periodontol 2002; 29 (Supl): 30-32.
21. Rudhart A, Purucker P, Kage A, Hopfenmüller W, Bernimoulin J-P. Local metronidazole application in maintenance patients. Clinical and microbiological evaluation. J Periodontol 1998; 69: 1148-1154.