PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

Journal of Biomedical Materials Research - Part A

Volumn 91, Issue 3, 2009, Pages 719-729

  Soderquist, Ryan G ^a   Milligan, Erin D ^b   Sloane, Evan M ^b   Harrison, Jacqueline A ^b   Douvas, Klarika K ^a   Potter, Joseph M ^b   Hughes, Travis S ^b   Chavez, Raymond A ^c   Johnson, Kirk ^c   Watkins, Linda R ^b   Mahoney, Melissa J ^a  

^a University of Colorado at Boulder   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Avigen Inc   (United States)

Author keywords

Biological activity; Brain derived neurotrophic factor; Confocal microscopy; Intrathecal drug delivery; PEGylation

Indexed keywords

BIOLOGICAL ACTIVITIES; BIOLOGICAL ACTIVITY; BRAIN-DERIVED NEUROTROPHIC FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTORS; CEREBRO SPINAL FLUIDS; ENHANCED PENETRATION; HIGHER ORDER; IN-VITRO; IN-VIVO; INTRATHECAL; INTRATHECAL DRUG DELIVERY; PEGYLATION; REACTION CONDITIONS; SPINAL CORDS; SUBSTANTIAL REDUCTION; THERAPEUTIC PROTEIN;

BIOACTIVITY; BODY FLUIDS; CONFOCAL MICROSCOPY; DOSIMETRY; DRUG DELIVERY; MIXTURES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

BRAIN;

BRAIN DERIVED NEUROTROPHIC FACTOR; POLYETHYLENE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; DRUG DELIVERY SYSTEM; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PROTEIN STABILITY; RAT;

ALDEHYDES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DRUG DELIVERY SYSTEMS; ESTERS; INJECTIONS, SPINAL; MALE; MASS SPECTROMETRY; MICROSCOPY, CONFOCAL; NEURONS; PC12 CELLS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 70350346602     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32254     Document Type: Article

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