Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-β deposits

Journal of the American Chemical Society

Volumn 131, Issue 42, 2009, Pages 15257-15261

  Chongzhao, Ran ^a   Xiaoyin, Xu ^b   Raymond, Scott B ^a   Ferrara, Brian J ^a   Neal, Krista ^a   Bacskai, Brian J ^a   Medarova, Zdravka ^a   Moore, Anna ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; BLUE SHIFT; CLINICAL SYMPTOMS; CONTRAST AGENT; CURCUMIN; DATA POINTS; DRUG SCREENING; FLUORESCENCE INTENSITIES; HIGH AFFINITY; IN-VITRO; IN-VIVO; INTRAVENOUS INJECTIONS; LOG P-VALUE; NEAR INFRA RED; NEURONAL ATROPHY; NIR IMAGING; WEAK INTERACTIONS;

DEPOSITS; GLYCOPROTEINS; INFRARED DEVICES;

PROBES;

ALBUMIN; AMYLOID BETA PROTEIN; BORON DERIVATIVE; CONTRAST MEDIUM; CURCUMIN; CURCUMIN DERIVATIZED NEAR INFRARED PROBE 2; DIFLUOROBORON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MONITORING; MOUSE; NONHUMAN; QUANTUM YIELD; SENILE PLAQUE; SERUM; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; ANIMALS; BORON COMPOUNDS; CURCUMIN; FLUORINE COMPOUNDS; MICE; MOLECULAR PROBES; MOLECULAR STRUCTURE; SPECTROSCOPY, NEAR-INFRARED;

EID: 70350316758     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9047043     Document Type: Article

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