Osmolyte controlled fibrillation kinetics of insulin: New insight into fibrillation using the preferential exclusion principle

Biotechnology Progress

Volumn 25, Issue 5, 2009, Pages 1508-1514

  Nayak, Arpan ^a,c   Lee, Chuang Chung ^b   McRae, Gregory J ^b   Belfort, Georges ^a  

^a Rensselaer Polytechnic Institute   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

Amyloid; Osmolyte; Protein aggregation

Indexed keywords

AGGREGATION PROCESS; AMYLOID; AMYLOID FIBRIL; AMYLOID PROTEINS; EXCLUSION MODELS; EXCLUSION PRINCIPLE; FIBRIL FORMATION; FIBRIL GROWTH; FITTING PARAMETERS; HEAT OF SOLUTION; IN-VITRO; KINETIC RATES; LAG-TIME; LOW CONCENTRATIONS; MOLECULAR SURFACE AREA; NUCLEATION RATE; ORDERS OF MAGNITUDE; OSMOLYTE; OSMOLYTES; PENTAMERS; PROTEIN AGGREGATION; PROTEIN SURFACE; REACTION MODEL; REACTION PROCESS; SPEED-UPS; TETRAMERS; TIME-DEPENDENT;

AGGLOMERATION; GLUCOSE; GROWTH KINETICS; INSULIN; NUCLEATION; OLIGOMERS; REACTION KINETICS; SUGAR (SUCROSE); THERMOCHEMISTRY; UREA;

GLYCOPROTEINS;

AMYLOID; CARBOHYDRATE; INSULIN;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; HUMAN; KINETICS; METABOLISM; PROTEIN MULTIMERIZATION; TEMPERATURE;

AMYLOID; CARBOHYDRATES; COMPUTER SIMULATION; HUMANS; INSULIN; KINETICS; MODELS, CHEMICAL; PROTEIN MULTIMERIZATION; TEMPERATURE;

EID: 70350191425     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.255     Document Type: Article

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