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Volumn 37, Issue 5, 2009, Pages 1080-1084

Neural network dysfunction in bipolar depression: Clues from the efficacy of lamotrigine

Author keywords

Bipolar depression; Functional magnetic resonance imaging (fMRI); Gamma oscillation; Lamotrigine; Transcranial magnetic stimulation (TMS)

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; LAMOTRIGINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C;

EID: 70350168436     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0371080     Document Type: Conference Paper
Times cited : (19)

References (52)
  • 1
    • 25844452847 scopus 로고    scopus 로고
    • Mood stabilizers target cellular plasticity and resilience cascades: Implications for the development of novel therapeutics
    • Bachmann, R.F., Schloesser, R.J., Gould, T.D. and Manji, H.K. (2005) Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Mol. Neurobiol. 32, 173-202
    • (2005) Mol. Neurobiol , vol.32 , pp. 173-202
    • Bachmann, R.F.1    Schloesser, R.J.2    Gould, T.D.3    Manji, H.K.4
  • 2
    • 36549029252 scopus 로고    scopus 로고
    • Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder
    • Schloesser, R.J., Huang, J., Klein, P.S. and Manji, H.K. (2008) Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33, 110-133
    • (2008) Neuropsychopharmacology , vol.33 , pp. 110-133
    • Schloesser, R.J.1    Huang, J.2    Klein, P.S.3    Manji, H.K.4
  • 4
    • 0034981862 scopus 로고    scopus 로고
    • Bipolar disorder: Leads from the molecular and cellular mechanisms of action of mood stabilizers
    • Manji, H.K., Moore, G.J. and Chen, G. (2001) Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Br. J. Psychiatry Suppl. 41, s107-s119
    • (2001) Br. J. Psychiatry Suppl , vol.41
    • Manji, H.K.1    Moore, G.J.2    Chen, G.3
  • 5
    • 0141593927 scopus 로고    scopus 로고
    • Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders
    • Ketter, T.A., Manji, H.K. and Post, R.M. (2003) Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders. J. Clin. Psychopharmacol. 23, 484-495
    • (2003) J. Clin. Psychopharmacol , vol.23 , pp. 484-495
    • Ketter, T.A.1    Manji, H.K.2    Post, R.M.3
  • 6
    • 0031756758 scopus 로고    scopus 로고
    • Cellular and molecular actions of lamotrigine: Possible mechanisms of ef.cacy in bipolar disorder
    • Xie, X. and Hagan, R.M. (1998) Cellular and molecular actions of lamotrigine: possible mechanisms of ef.cacy in bipolar disorder. Neuropsychobiology 38, 119-130
    • (1998) Neuropsychobiology , vol.38 , pp. 119-130
    • Xie, X.1    Hagan, R.M.2
  • 7
    • 26944494494 scopus 로고    scopus 로고
    • The potential role of lamotrigine in schizophrenia
    • Large, C.H., Webster, E.L. and Goff, D.C. (2005) The potential role of lamotrigine in schizophrenia. Psychopharmacology 181, 415-436
    • (2005) Psychopharmacology , vol.181 , pp. 415-436
    • Large, C.H.1    Webster, E.L.2    Goff, D.C.3
  • 9
    • 33750006246 scopus 로고    scopus 로고
    • The use of antiepileptic drugs in bipolar disorders: A review based on evidence from controlled trials
    • Weisler, R.H., Cutler, A.J., Ballenger, J.C., Post, R.M. and Ketter, T.A. (2006) The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials. CNS Spectr. 11, 788-799
    • (2006) CNS Spectr , vol.11 , pp. 788-799
    • Weisler, R.H.1    Cutler, A.J.2    Ballenger, J.C.3    Post, R.M.4    Ketter, T.A.5
  • 10
    • 0033004838 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group
    • Calabrese, J.R., Bowden, C.L., Sachs, G.S., Ascher, J.A., Monaghan, E. and Rudd, G.D. (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J. Clin. Psychiatry 60, 79-88
    • (1999) J. Clin. Psychiatry , vol.60 , pp. 79-88
    • Calabrese, J.R.1    Bowden, C.L.2    Sachs, G.S.3    Ascher, J.A.4    Monaghan, E.5    Rudd, G.D.6
  • 11
    • 58149374246 scopus 로고    scopus 로고
    • Lamotrigine for treatment of bipolar depression: Independent meta-analysis and meta-regression of individual patient data from five randomised trials
    • Geddes, J.R., Calabrese, J.R. and Goodwin, G.M. (2009) Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials. Br. J. Psychiatry 194, 4-9
    • (2009) Br. J. Psychiatry , vol.194 , pp. 4-9
    • Geddes, J.R.1    Calabrese, J.R.2    Goodwin, G.M.3
  • 14
    • 0036096961 scopus 로고    scopus 로고
    • Lamotrigine update and its use in mood disorders
    • Hurley, S.C. (2002) Lamotrigine update and its use in mood disorders. Ann. Pharmacother. 36, 860-873
    • (2002) Ann. Pharmacother , vol.36 , pp. 860-873
    • Hurley, S.C.1
  • 15
    • 2342556422 scopus 로고    scopus 로고
    • Lamotrigine: A depression mood stabiliser
    • Herman, E. (2004) Lamotrigine: a depression mood stabiliser. Eur. Neuropsychopharmacol. 14 (Suppl. 2), S89-S93
    • (2004) Eur. Neuropsychopharmacol , vol.14 , Issue.SUPPL. 2
    • Herman, E.1
  • 16
    • 0036179509 scopus 로고    scopus 로고
    • Stabilization of mood from below versus above baseline in bipolar disorder: A new nomenclature
    • Ketter, T.A. and Calabrese, J.R. (2002) Stabilization of mood from below versus above baseline in bipolar disorder: a new nomenclature. J. Clin. Psychiatry 63, 146-151
    • (2002) J. Clin. Psychiatry , vol.63 , pp. 146-151
    • Ketter, T.A.1    Calabrese, J.R.2
  • 18
    • 0032915330 scopus 로고    scopus 로고
    • Cortical excitability in patients after loading doses of lamotrigine: A study with magnetic brain stimulation
    • Manganotti, P., Bongiovanni, L.G., Zanette, G., Turazzini, M. and Fiaschi, A. (1999) Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation. Epilepsia 40, 316-321
    • (1999) Epilepsia , vol.40 , pp. 316-321
    • Manganotti, P.1    Bongiovanni, L.G.2    Zanette, G.3    Turazzini, M.4    Fiaschi, A.5
  • 19
    • 0141755367 scopus 로고    scopus 로고
    • Relationship between lamotrigine oral dose, serum level and its inhibitory effect on CNS: Insights from transcranial magnetic stimulation
    • Tergau, F., Wischer, S., Somal, H.S., Nitsche, M.A., Mercer, A.J., Paulus, W. and Steinhoff, B.J. (2003) Relationship between lamotrigine oral dose, serum level and its inhibitory effect on CNS: insights from transcranial magnetic stimulation. Epilepsy Res. 56, 67-77
    • (2003) Epilepsy Res , vol.56 , pp. 67-77
    • Tergau, F.1    Wischer, S.2    Somal, H.S.3    Nitsche, M.A.4    Mercer, A.J.5    Paulus, W.6    Steinhoff, B.J.7
  • 20
    • 2942668428 scopus 로고    scopus 로고
    • Interleaved transcranial magnetic stimulation/functional MRI con.rms that lamotrigine inhibits cortical excitability in healthy young men
    • Li, X., Teneback, C.C., Nahas, Z., Kozel, F.A., Large, C., Cohn, J., Bohning, D.E. and George, M.S. (2004) Interleaved transcranial magnetic stimulation/functional MRI con.rms that lamotrigine inhibits cortical excitability in healthy young men. Neuropsychopharmacology 29, 1395-1407
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1395-1407
    • Li, X.1    Teneback, C.C.2    Nahas, Z.3    Kozel, F.A.4    Large, C.5    Cohn, J.6    Bohning, D.E.7    George, M.S.8
  • 22
    • 70350189765 scopus 로고    scopus 로고
    • Using motor and prefrontal cortex interleaved transcranial magnetic stimulation (TMS) BOLD fMRI to compare the mechanism of action of lamotrigine to valproic acid in normal volunteers
    • Hollywood, FL, U.S.A, P, Abstract
    • Li, X., George, M.S., Large, C.H., Ricci, R., Johnson, K., Anderson, B., Nahas, Z. and Bohning, D.E. (2006) Using motor and prefrontal cortex interleaved transcranial magnetic stimulation (TMS) BOLD fMRI to compare the mechanism of action of lamotrigine to valproic acid in normal volunteers, 45th American College of Neuropsychopharmacology Annual Meeting, Hollywood, FL, U.S.A., P.44 (Abstract)
    • (2006) 45th American College of Neuropsychopharmacology Annual Meeting , pp. 44
    • Li, X.1    George, M.S.2    Large, C.H.3    Ricci, R.4    Johnson, K.5    Anderson, B.6    Nahas, Z.7    Bohning, D.E.8
  • 23
    • 36749079919 scopus 로고    scopus 로고
    • Changes in brain activation during working memory and facial recognition tasks in patients with bipolar disorder with Lamotrigine monotherapy
    • Haldane, M., Jogia, J., Cobb, A., Kozuch, E., Kumari, V. and Frangou, S. (2007) Changes in brain activation during working memory and facial recognition tasks in patients with bipolar disorder with Lamotrigine monotherapy. Eur. Neuropsychopharmacol. 18, 48-54
    • (2007) Eur. Neuropsychopharmacol , vol.18 , pp. 48-54
    • Haldane, M.1    Jogia, J.2    Cobb, A.3    Kozuch, E.4    Kumari, V.5    Frangou, S.6
  • 24
    • 0002689598 scopus 로고    scopus 로고
    • A systematic review of the effects of lamotrigine on cognitive function and quality of life
    • Aldenkamp, A.P. and Baker, G. (2001) A systematic review of the effects of lamotrigine on cognitive function and quality of life. Epilepsy Behav. 2, 85-91
    • (2001) Epilepsy Behav , vol.2 , pp. 85-91
    • Aldenkamp, A.P.1    Baker, G.2
  • 25
    • 1242269790 scopus 로고    scopus 로고
    • Distinct differences in cortical reactivity of motor and prefrontal cortices to magnetic stimulation
    • Kahkonen, S., Wilenius, J., Komssi, S. and Ilmoniemi, R.J. (2004) Distinct differences in cortical reactivity of motor and prefrontal cortices to magnetic stimulation. Clin. Neurophysiol. 115, 583-588
    • (2004) Clin. Neurophysiol , vol.115 , pp. 583-588
    • Kahkonen, S.1    Wilenius, J.2    Komssi, S.3    Ilmoniemi, R.J.4
  • 26
    • 13444250064 scopus 로고    scopus 로고
    • Kainate receptors and rhythmic activity in neuronal networks: Hippocampal gamma oscillations as a tool
    • Fisahn, A. (2005) Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool. J. Physiol. 562, 65-72
    • (2005) J. Physiol , vol.562 , pp. 65-72
    • Fisahn, A.1
  • 27
    • 4744374361 scopus 로고    scopus 로고
    • Mechanisms underlying gamma (′40 Hz′) network oscillations in the hippocampus: A mini-review
    • Mann, E.O. and Paulsen, O. (2005) Mechanisms underlying gamma (′40 Hz′) network oscillations in the hippocampus: a mini-review. Prog. Biophys. Mol. Biol. 87, 67-76
    • (2005) Prog. Biophys. Mol. Biol , vol.87 , pp. 67-76
    • Mann, E.O.1    Paulsen, O.2
  • 28
  • 30
    • 0036909443 scopus 로고    scopus 로고
    • Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium
    • De Sarno, P., Li, X. and Jope, R.S. (2002) Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium. Neuropharmacology 43, 1158-1164
    • (2002) Neuropharmacology , vol.43 , pp. 1158-1164
    • De Sarno, P.1    Li, X.2    Jope, R.S.3
  • 32
    • 0033014180 scopus 로고    scopus 로고
    • The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3
    • Chen, G., Huang, L.D., Jiang, Y.M. and Manji, H.K. (1999) The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. J. Neurochem. 72, 1327-1330
    • (1999) J. Neurochem , vol.72 , pp. 1327-1330
    • Chen, G.1    Huang, L.D.2    Jiang, Y.M.3    Manji, H.K.4
  • 33
    • 5144226319 scopus 로고    scopus 로고
    • Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds
    • Werstuck, G.H., Kim, A.J., Brenstrum, T., Ohnmacht, S.A., Panna, E. and Capretta, A. (2004) Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. Bioorg. Med. Chem. Lett. 14, 5465-5467
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 5465-5467
    • Werstuck, G.H.1    Kim, A.J.2    Brenstrum, T.3    Ohnmacht, S.A.4    Panna, E.5    Capretta, A.6
  • 34
    • 33744987887 scopus 로고    scopus 로고
    • The common inositol-reversible effect of mood stabilizers on neurons does not involve GSK3 inhibition, myo-inositol-1-phosphate synthase or the sodium-dependent myo-inositol transporters
    • Di Daniel, E., Cheng, L., Maycox, P.R. and Mudge, A.W. (2006) The common inositol-reversible effect of mood stabilizers on neurons does not involve GSK3 inhibition, myo-inositol-1-phosphate synthase or the sodium-dependent myo-inositol transporters. Mol. Cell. Neurosci. 32, 27-36
    • (2006) Mol. Cell. Neurosci , vol.32 , pp. 27-36
    • Di Daniel, E.1    Cheng, L.2    Maycox, P.R.3    Mudge, A.W.4
  • 35
    • 0037118050 scopus 로고    scopus 로고
    • A common mechanism of action for three mood-stabilizing drugs
    • Williams, R.S., Cheng, L., Mudge, A.W. and Harwood, A.J. (2002) A common mechanism of action for three mood-stabilizing drugs. Nature 417, 292-295
    • (2002) Nature , vol.417 , pp. 292-295
    • Williams, R.S.1    Cheng, L.2    Mudge, A.W.3    Harwood, A.J.4
  • 36
    • 0034677804 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β facilitates staurosporine- and heat shock-induced apoptosis: Protection by lithium
    • Bijur, G.N., De Sarno, P. and Jope, R.S. (2000) Glycogen synthase kinase-3β facilitates staurosporine- and heat shock-induced apoptosis: protection by lithium. J. Biol. Chem. 275, 7583-7590
    • (2000) J. Biol. Chem , vol.275 , pp. 7583-7590
    • Bijur, G.N.1    De Sarno, P.2    Jope, R.S.3
  • 37
    • 0026567408 scopus 로고
    • Chronic lithium administration alters a prominent PKC substrate in rat hippocampus
    • Lenox, R.H., Watson, D.G., Patel, J. and Ellis, J. (1992) Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res. 570, 333-340
    • (1992) Brain Res , vol.570 , pp. 333-340
    • Lenox, R.H.1    Watson, D.G.2    Patel, J.3    Ellis, J.4
  • 38
    • 0030036555 scopus 로고    scopus 로고
    • Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: Potentiation by muscarinic receptor activation
    • Watson, D.G. and Lenox, R.H. (1996) Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: potentiation by muscarinic receptor activation. J. Neurochem. 67, 767-777
    • (1996) J. Neurochem , vol.67 , pp. 767-777
    • Watson, D.G.1    Lenox, R.H.2
  • 41
    • 0043240266 scopus 로고    scopus 로고
    • The role of the extracellular signal-regulated kinase signaling pathway in mood modulation
    • Einat, H., Yuan, P., Gould, T.D., Li, J., Du, J., Zhang, L., Manji, H.K. and Chen, G. (2003) The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J. Neurosci. 23, 7311-7316
    • (2003) J. Neurosci , vol.23 , pp. 7311-7316
    • Einat, H.1    Yuan, P.2    Gould, T.D.3    Li, J.4    Du, J.5    Zhang, L.6    Manji, H.K.7    Chen, G.8
  • 42
    • 0035943699 scopus 로고    scopus 로고
    • The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    • Yuan, P.X., Huang, L.D., Jiang, Y.M., Gutkind, J.S., Manji, H.K. and Chen, G. (2001) The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J. Biol. Chem. 276, 31674-31683
    • (2001) J. Biol. Chem , vol.276 , pp. 31674-31683
    • Yuan, P.X.1    Huang, L.D.2    Jiang, Y.M.3    Gutkind, J.S.4    Manji, H.K.5    Chen, G.6
  • 43
    • 13644254946 scopus 로고    scopus 로고
    • Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons
    • Di Daniel, E., Mudge, A.W. and Maycox, P.R. (2005) Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons. Bipolar Disord. 7, 33-41
    • (2005) Bipolar Disord , vol.7 , pp. 33-41
    • Di Daniel, E.1    Mudge, A.W.2    Maycox, P.R.3
  • 44
    • 28444477387 scopus 로고    scopus 로고
    • Plasma membrane phosphoinositide organization by protein electrostatics
    • McLaughlin, S. and Murray, D. (2005) Plasma membrane phosphoinositide organization by protein electrostatics. Nature 438, 605-611
    • (2005) Nature , vol.438 , pp. 605-611
    • McLaughlin, S.1    Murray, D.2
  • 45
    • 0024341795 scopus 로고
    • Neural and developmental actions of lithium: A unifying hypothesis
    • Berridge, M.J., Downes, C.P. and Hanley, M.R. (1989) Neural and developmental actions of lithium: a unifying hypothesis. Cell 59, 411-419
    • (1989) Cell , vol.59 , pp. 411-419
    • Berridge, M.J.1    Downes, C.P.2    Hanley, M.R.3
  • 46
    • 0019127799 scopus 로고
    • The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain
    • Hallcher, L.M. and Sherman, W.R. (1980) The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J. Biol. Chem. 255, 10896-10901
    • (1980) J. Biol. Chem , vol.255 , pp. 10896-10901
    • Hallcher, L.M.1    Sherman, W.R.2
  • 47
    • 34748850702 scopus 로고    scopus 로고
    • Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositol
    • McGrath, B.M., Greenshaw, A.J., McKay, R., Slupsky, C.M. and Silverstone, P.H. (2007) Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositol. Neuroreport 18, 1595-1598
    • (2007) Neuroreport , vol.18 , pp. 1595-1598
    • McGrath, B.M.1    Greenshaw, A.J.2    McKay, R.3    Slupsky, C.M.4    Silverstone, P.H.5
  • 48
    • 85009890734 scopus 로고    scopus 로고
    • Bipolar disorder: Involvement of signaling cascades and AMPA receptor trafficking at synapses
    • Du, J., Quiroz, J., Yuan, P., Zarate, C. and Manji, H.K. (2004) Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses. Neuron Glia Biol. 1, 231-243
    • (2004) Neuron Glia Biol , vol.1 , pp. 231-243
    • Du, J.1    Quiroz, J.2    Yuan, P.3    Zarate, C.4    Manji, H.K.5
  • 49
    • 33947213976 scopus 로고    scopus 로고
    • The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: Relationship to clinical effects in mood disorders
    • Du, J., Suzuki, K., Wei, Y., Wang, Y., Blumenthal, R., Chen, Z., Falke, C., Zarate, Jr, C.A. and Manji, H.K. (2007) The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders. Neuropsychopharmacology 32, 793-802
    • (2007) Neuropsychopharmacology , vol.32 , pp. 793-802
    • Du, J.1    Suzuki, K.2    Wei, Y.3    Wang, Y.4    Blumenthal, R.5    Chen, Z.6    Falke, C.7    Zarate Jr, C.A.8    Manji, H.K.9
  • 50
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: Role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • Maeng, S., Zarate, Jr, C.A., Du, J., Schloesser, R.J., McCammon, J., Chen, G. and Manji, H.K. (2008) Cellular mechanisms underlying the antidepressant effects of ketamine: role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol. Psychiatry 63, 349-352
    • (2008) Biol. Psychiatry , vol.63 , pp. 349-352
    • Maeng, S.1    Zarate Jr, C.A.2    Du, J.3    Schloesser, R.J.4    McCammon, J.5    Chen, G.6    Manji, H.K.7
  • 51
    • 27744578296 scopus 로고    scopus 로고
    • Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe
    • Tremblay, L.K., Naranjo, C.A., Graham, S.J., Herrmann, N., Mayberg, H.S., Hevenor, S. and Busto, U.E. (2005) Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch. Gen. Psychiatry 62, 1228-1236
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 1228-1236
    • Tremblay, L.K.1    Naranjo, C.A.2    Graham, S.J.3    Herrmann, N.4    Mayberg, H.S.5    Hevenor, S.6    Busto, U.E.7
  • 52
    • 36348963529 scopus 로고    scopus 로고
    • The effects of lamotrigine on alcohol seeking and relapse
    • Vengeliene, V., Heidbreder, C.A. and Spanagel, R. (2007) The effects of lamotrigine on alcohol seeking and relapse. Neuropharmacology 53, 951-957
    • (2007) Neuropharmacology , vol.53 , pp. 951-957
    • Vengeliene, V.1    Heidbreder, C.A.2    Spanagel, R.3


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