메뉴 건너뛰기




Volumn 106, Issue 40, 2009, Pages 17049-17054

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

Author keywords

cAMP dependent protein kinase; Macroautophagy; Stationary phase; Tor protein kinase

Indexed keywords

ATG1 PROTEIN; ATG13 PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; REGULATOR PROTEIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

EID: 70350128436     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903316106     Document Type: Article
Times cited : (245)

References (49)
  • 1
    • 0036569331 scopus 로고    scopus 로고
    • Yeast autophagosomes: De novo formation of a membrane structure
    • DOI 10.1016/S0962-8924(02)02278-X, PII S096289240202278X
    • Noda T, Suzuki K, Ohsumi Y (2002) Yeast autophagosomes: De novo formation of a membrane structure. Trends Cell Biol 12:231-235. (Pubitemid 34327616)
    • (2002) Trends in Cell Biology , vol.12 , Issue.5 , pp. 231-235
    • Noda, T.1    Suzuki, K.2    Ohsumi, Y.3
  • 2
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z, Klionsky DJ (2007) Autophagosome formation: Core machinery and adaptations. Nat Cell Biol 9:1102-1109. (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 3
    • 0025051251 scopus 로고
    • Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes
    • DOI 10.1083/jcb.111.3.941
    • Kopitz J, Kisen GO, Gordon PB, Bohley P, Seglen PO (1990) Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes. J Cell Biol 111:941-953. (Pubitemid 20263777)
    • (1990) Journal of Cell Biology , vol.111 , Issue.3 , pp. 941-953
    • Kopitz, J.1    Kisen, G.O.2    Gordon, P.B.3    Bohley, P.4    Seglen, P.O.5
  • 5
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • DOI 10.1016/S1534-5807(04)00099-1, PII S1534580704000991
    • Levine B, Klionsky DJ (2004) Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 6:463-477. (Pubitemid 38456176)
    • (2004) Developmental Cell , vol.6 , Issue.4 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 6
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • Klionsky DJ (2007) Autophagy: From phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8:931-937.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 931-937
    • Klionsky, D.J.1
  • 7
    • 0035503594 scopus 로고    scopus 로고
    • The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
    • DOI 10.1093/emboj/20.21.5971
    • Suzuki K, et al. (2001) The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 20:5971-5981. (Pubitemid 33049272)
    • (2001) EMBO Journal , vol.20 , Issue.21 , pp. 5971-5981
    • Suzuki, K.1    Kirisako, T.2    Kamada, Y.3    Mizushima, N.4    Noda, T.5    Ohsumi, Y.6
  • 9
    • 34250864795 scopus 로고    scopus 로고
    • Protein turnover via autophagy: Implications for metabolism
    • Mizushima N, Klionsky DJ (2007) Protein turnover via autophagy: Implications for metabolism. Annu Rev Nutr 27:19-40.
    • (2007) Annu Rev Nutr , vol.27 , pp. 19-40
    • Mizushima, N.1    Klionsky, D.J.2
  • 10
    • 10744225487 scopus 로고    scopus 로고
    • A unified nomenclature for yeast autophagy-related genes
    • Klionsky DJ, et al. (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5:539-545.
    • (2003) Dev Cell , vol.5 , pp. 539-545
    • Klionsky, D.J.1
  • 11
    • 33947383050 scopus 로고    scopus 로고
    • ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes
    • Meijer WH, van der Klei IJ, Veenhuis M, Kiel JA (2007) ATG genes involved in nonselective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3:106-116. (Pubitemid 46449098)
    • (2007) Autophagy , vol.3 , Issue.2 , pp. 106-116
    • Meijer, W.H.1    Van Der Klei, I.J.2    Veenhuis, M.3    Kiel, J.A.K.W.4
  • 12
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • DOI 10.1074/jbc.273.7.3963
    • Noda T, Ohsumi Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 273:3963-3966. (Pubitemid 28103257)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.7 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 13
    • 2442645050 scopus 로고    scopus 로고
    • The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae
    • DOI 10.1074/jbc.M400272200
    • Budovskaya YV, Stephan JS, Reggiori F, Klionsky DJ, Herman PK (2004) The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem 279:20663-20671. (Pubitemid 38656461)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.20 , pp. 20663-20671
    • Budovskaya, Y.V.1    Stephan, J.S.2    Reggiori, F.3    Klionsky, D.J.4    Herman, P.K.5
  • 15
    • 33645942074 scopus 로고    scopus 로고
    • The regulation of autophagy in eukaryotic cells: Do all roads pass through Atg1?
    • Stephan JS, Herman PK (2006) The regulation of autophagy in eukaryotic cells: Do all roads pass through Atg1? Autophagy 2:146-148.
    • (2006) Autophagy , vol.2 , pp. 146-148
    • Stephan, J.S.1    Herman, P.K.2
  • 16
    • 0037016752 scopus 로고    scopus 로고
    • Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de Novo vesicle formation
    • DOI 10.1074/jbc.M109134200
    • Kim J, Huang WP, Stromhaug PE, Klionsky DJ (2002) Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem 277:763-773. (Pubitemid 34952117)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.1 , pp. 763-773
    • Kim, J.1    Huang, W.-P.2    Stromhaug, P.E.3    Klionsky, D.J.4
  • 17
    • 34248139628 scopus 로고    scopus 로고
    • Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae
    • Suzuki K, OhsumiY(2007) Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 581:2156-2161.
    • (2007) FEBS Lett , vol.581 , pp. 2156-2161
    • Suzuki, K.1    Ohsumi, Y.2
  • 18
    • 34548482499 scopus 로고    scopus 로고
    • SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
    • DOI 10.1074/jbc.M703663200
    • Chan EY, Kir S, Tooze SA (2007) siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 282:25464-25474. (Pubitemid 47372826)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.35 , pp. 25464-25474
    • Chan, E.Y.W.1    Kir, S.2    Tooze, S.A.3
  • 21
    • 34948828483 scopus 로고    scopus 로고
    • Protein kinase a and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae
    • DOI 10.1091/mbc.E07-05-0485
    • Yorimitsu T, Zaman S, Broach JR, Klionsky DJ (2007) Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell 18:4180-4189. (Pubitemid 47519506)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.10 , pp. 4180-4189
    • Yorimitsu, T.1    Zaman, S.2    Broach, J.R.3    Klionsky, D.J.4
  • 22
    • 0024599698 scopus 로고
    • Dominant yeast and mammalian RAS mutants that interfere with the CDC25- Dependent activation of wild-type RAS in Saccharomyces cerevisiae
    • Powers S, O'Neill K, WiglerM(1989) Dominant yeast and mammalian RAS mutants that interfere with the CDC25- dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol Cell Biol 9:390-395.
    • (1989) Mol Cell Biol , vol.9 , pp. 390-395
    • Powers, S.1    O'Neill, K.2    Wigler, M.3
  • 25
    • 0025931525 scopus 로고
    • Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae
    • Mountain HA, Bystrom AS, Larsen JT, Korch C (1991) Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast 7:781-803.
    • (1991) Yeast , vol.7 , pp. 781-803
    • Mountain, H.A.1    Bystrom, A.S.2    Larsen, J.T.3    Korch, C.4
  • 26
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 28
    • 0032568055 scopus 로고    scopus 로고
    • Design of allele-specific inhibitors to probe protein kinase signaling
    • Bishop AC, et al. (1998) Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol 8:257-266.
    • (1998) Curr Biol , vol.8 , pp. 257-266
    • Bishop, A.C.1
  • 29
    • 0034699382 scopus 로고    scopus 로고
    • A chemical switch for inhibitor-sensitive alleles of any protein kinase
    • Bishop AC, et al. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407:395-401.
    • (2000) Nature , vol.407 , pp. 395-401
    • Bishop, A.C.1
  • 30
    • 0023658335 scopus 로고
    • Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
    • Toda T, Cameron S, Sass P, Zoller M, Wigler M (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50:277-287.
    • (1987) Cell , vol.50 , pp. 277-287
    • Toda, T.1    Cameron, S.2    Sass, P.3    Zoller, M.4    Wigler, M.5
  • 31
    • 0030919092 scopus 로고    scopus 로고
    • Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae
    • DOI 10.1016/S0378-1119(97)00031-0, PII S0378111997000310
    • Funakoshi T, Matsuura A, Noda T, Ohsumi Y (1997) Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene 192:207-213. (Pubitemid 27268244)
    • (1997) Gene , vol.192 , Issue.2 , pp. 207-213
    • Funakoshi, T.1    Matsuura, A.2    Noda, T.3    Ohsumi, Y.4
  • 32
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • Jung CH, et al. (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20:1992-2003.
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1
  • 33
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, et al. (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284:12297-12305.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1
  • 34
    • 58149473473 scopus 로고    scopus 로고
    • Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13- Independent mechanism
    • Chan EY, Longatti A, McKnight NC, Tooze SA (2009) Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13- independent mechanism. Mol Cell Biol 29:157-171.
    • (2009) Mol Cell Biol , vol.29 , pp. 157-171
    • Chan, E.Y.1    Longatti, A.2    McKnight, N.C.3    Tooze, S.A.4
  • 35
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1- Atg13-FIP200 complex required for autophagy
    • Hosokawa N, et al. (2009) Nutrient-dependent mTORC1 association with the ULK1- Atg13-FIP200 complex required for autophagy. Mol Biol Cell 20:1981-1991.
    • (2009) Mol Biol Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1
  • 36
    • 0026052920 scopus 로고
    • Substrate specificities for yeast and mammalian cAMPdependent protein kinases are similar but not identical
    • Denis CL, Kemp BE, Zoller MJ (1991) Substrate specificities for yeast and mammalian cAMPdependent protein kinases are similar but not identical. J Biol Chem 266:17932-17935.
    • (1991) J Biol Chem , vol.266 , pp. 17932-17935
    • Denis, C.L.1    Kemp, B.E.2    Zoller, M.J.3
  • 37
    • 3042760385 scopus 로고    scopus 로고
    • The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus
    • Chang YW, Howard SC, Herman PK (2004) The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus. Mol Cell 15:107-116.
    • (2004) Mol Cell , vol.15 , pp. 107-116
    • Chang, Y.W.1    Howard, S.C.2    Herman, P.K.3
  • 38
    • 33747859628 scopus 로고    scopus 로고
    • Using substrate-binding variants of the cAMP-dependent protein kinase to identify novel targets and a kinase domain important for substrate interactions in Saccharomyces cerevisiae
    • DOI 10.1534/genetics.106.059238
    • Deminoff SJ, Howard SC, Hester A, Warner S, Herman PK (2006) Using substrate-binding variants of the cAMP-dependent protein kinase to identify novel targets and a kinase domain important for substrate interactions in Saccharomyces cerevisiae. Genetics 173:1909-1917. (Pubitemid 44285672)
    • (2006) Genetics , vol.173 , Issue.4 , pp. 1909-1917
    • Deminoff, S.J.1    Howard, S.C.2    Hester, A.3    Warner, S.4    Herman, P.K.5
  • 39
    • 0021967321 scopus 로고
    • In yeast, RAS proteins are controlling elements of adenylate cyclase
    • Toda T, et al. (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40:27-36. (Pubitemid 15169303)
    • (1985) Cell , vol.40 , Issue.1 , pp. 27-36
    • Toda, T.1    Uno, I.2    Ishikawa, T.3
  • 42
    • 29644435706 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast
    • DOI 10.1074/jbc.R500016200
    • Nair U, Klionsky DJ (2005) Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem 280:41785-41788. (Pubitemid 43023145)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.51 , pp. 41785-41788
    • Nair, U.1    Klionsky, D.J.2
  • 43
    • 39449108917 scopus 로고    scopus 로고
    • The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae
    • DOI 10.1091/mbc.E07-08-0826
    • Cheong H, Nair U, Geng J, Klionsky DJ (2008) The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell 19:668-681. (Pubitemid 351272154)
    • (2008) Molecular Biology of the Cell , vol.19 , Issue.2 , pp. 668-681
    • Cheong, H.1    Nair, U.2    Geng, J.3    Klionsky, D.J.4
  • 44
    • 33846514235 scopus 로고    scopus 로고
    • Hierarchy of Atg proteins in pre-autophagosomal structure organization
    • DOI 10.1111/j.1365-2443.2007.01050.x
    • Suzuki K, Kubota Y, Sekito T, Ohsumi Y (2007) Hierarchy of Atg proteins in preautophagosomal structure organization. Genes Cells 12:209-218. (Pubitemid 46152659)
    • (2007) Genes to Cells , vol.12 , Issue.2 , pp. 209-218
    • Suzuki, K.1    Kubota, Y.2    Sekito, T.3    Ohsumi, Y.4
  • 45
    • 43149125546 scopus 로고    scopus 로고
    • Organization of the pre-autophagosomal structure responsible for autophagosome formation
    • Kawamata T, Kamada Y, Kabeya Y, Sekito T, Ohsumi Y (2008) Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell 19:2039-2050.
    • (2008) Mol Biol Cell , vol.19 , pp. 2039-2050
    • Kawamata, T.1    Kamada, Y.2    Kabeya, Y.3    Sekito, T.4    Ohsumi, Y.5
  • 47
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    • Chang YY, Neufeld TP (2009) An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 20:2004-2014.
    • (2009) Mol Biol Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 48
    • 56949093808 scopus 로고    scopus 로고
    • Nutrient signals driving cell growth
    • Dechant R, Peter M (2008) Nutrient signals driving cell growth. Curr Opin Cell Biol 20:678-687.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 678-687
    • Dechant, R.1    Peter, M.2
  • 49
    • 0029036915 scopus 로고
    • Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae
    • Noda T, Matsuura A,WadaY, Ohsumi Y (1995) Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 210:126-132.
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 126-132
    • Noda, T.1    Matsuura, A.2    Wada, Y.3    Ohsumi, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.