Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 670, Issue 1-2, 2009, Pages 15-23

  Xue, Lian ^a   Yu, Dong ^c   Furusawa, Yoshiya ^b   Okayasu, Ryuichi ^b   Tong, Jian ^a   Cao, Jianping ^a   Fan, Saijun ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

ATM; DNA repair; High linear energy transfer (LET); Homologous recombination repair (HRR); Non homologous end joining (NHEJ)

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; CARBON; CHLOROQUINE; DOUBLE STRANDED DNA; PROTEIN KINASE C; RAD51 PROTEIN; SERINE; THREONINE;

ARTICLE; AUTOPHOSPHORYLATION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL NUCLEUS; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENETIC REGULATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION EXPOSURE; RADIOSENSITIVITY; SKIN FIBROBLAST;

ATAXIA TELANGIECTASIA; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; LINEAR ENERGY TRANSFER; MODELS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RADIATION, IONIZING; RECOMBINATION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MAMMALIA;

EID: 70350102520     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.06.016     Document Type: Article

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