Staphylococcal multidrug efflux protein QacA

Journal of Molecular Microbiology and Biotechnology

Volumn 3, Issue 2, 2001, Pages 163-170

  Brown, M H ^a   Skurray, R A ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DIVALENT CATION; ETHIDIUM; HELIX LOOP HELIX PROTEIN; MONOVALENT CATION; QUATERNARY AMMONIUM DERIVATIVE; REPRESSOR PROTEIN; TRANS ACTING FACTOR;

AMINO TERMINAL SEQUENCE; ANTIBIOTIC RESISTANCE; BACTERIAL MEMBRANE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CONFERENCE PAPER; DNA HELIX; DRUG TRANSPORT; FLUORESCENCE ANALYSIS; HYDROPHOBICITY; MICHAELIS MENTEN KINETICS; MULTIDRUG RESISTANCE; NONHUMAN; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTON MOTIVE FORCE; REGULATORY MECHANISM; STAPHYLOCOCCUS AUREUS;

AMINES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CARRIER PROTEINS; CELL MEMBRANE; COLORING AGENTS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; QUATERNARY AMMONIUM COMPOUNDS; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 0035079976     PISSN: 14641801     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (43)

1. A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates
2. Residues important for the function of a multihelical DNA binding domain in the new transcription factor family to Cam and Tet repressors
3. Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters
4. In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity
5. Energetics and mechanism of drug transport mediated by the lactococcal multidrug transporter LmrP
6. Purification and ligand binding of EmrR, a regulator of a multidrug transporter
7. Multidrug resistance in enteric and other Gram-negative bacteria
8. + antiporter TetA(K) from Staphylococcus aureus
9. + antiporter TetA(K): Mutagenesis and functional analysis
10. Membrane transport proteins: Implications of sequence comparisons
11. Bacterial multidrug resistance is due to a single membrane protein which functions as a drug pump
12. QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA
13. Mechanisms underlying expression of Tn10 encoded tetracycline resistance
14. Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance
15. The cytoplasmic membrane is a primary target for the staphylocidal action of thrombin-induced platelet microbicidal protein
16. Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: Role of the qacA locus
17. Multidrug resistance to antiseptics and disinfectants in coagulase-negative staphylococci
18. Substrate specificity and energetics of antiseptic and disinfectant resistant in Staphylococcus aureus
19. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
20. The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain
21. QacA multidrug efflux pump from Staphylococcus aureus: Comparative analysis of resistance to diamidines, biguanidines and guanyldrazones
22. Bioenergetics of the staphylococcal multidrug export protein QacA: Identification of distinct binding sites for monovalent and divalent cations
23. Natural functions of bacterial multidrug transporters
24. Quinolone resistance mediated by norA: Physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome
25. Multiple antibiotic resistance and efflux
26. The major facilitator superfamily
27. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: Membrane topology and identification of residues involved in substrate specificity
28. Proton-dependent multidrug efflux systems
29. Characterization of the earliest known Staphylococcus aureus plasmids encoding multidrug efflux systems
30. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: Common ancestry with tetracycline-and sugar-transport proteins
31. Genome archeology leading to the characterization and classification of transport proteins
32. The major facilitator superfamily
33. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria
34. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate/nodulation/division efflux pump family
35. Cloning and expression of Staphylococcus aureus plasmid-mediated quaternary ammonium resistance in Escherichia coli
36. Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus
37. Inhibition of the multidrug resistance efflux pump
38. 1. Identification of base-pairs involved in Tet repressor recognition
39. Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt
40. In vitro resistance to platelet microbial protein correlates with endocarditis source among bacteremic staphylococcal and streptococcal isolates
41. Purification and in vitro activities of rabbit platelet microbial proteins
42. Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis
43. Structural basis of multidrug recognition by BmrR, a transcriptional activator of a multidrug transporter