Leptin and obesity

Minerva Medica

Volumn 100, Issue 3, 2009, Pages 229-236

  De Luis, D A ^a   Perez Castrillon J L ^a   Duenas A ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Adipokines; Cardiovascular diseases; Genetics; Leptin; Obesity; Risk factors

Indexed keywords

ARGININE; ASPARAGINE; CYTOKINE RECEPTOR; GLUTAMINE; GLYCOPROTEIN GP 130; LEPTIN; LEPTIN RECEPTOR; LYSINE;

AMINO ACID SUBSTITUTION; CHILD; CHROMOSOME 1P; CHROMOSOME 7; CODON; CONSANGUINITY; ENDOCRINE SYSTEM; EXON; FETOPLACENTAL UNIT; FOOD INTAKE; GENE; GENE LOCATION; GENE MAPPING; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IMMUNE SYSTEM; INTRON; LEP GENE; OBESITY; PARACRINE SIGNALING; PEDIGREE; PLACENTA FUNCTION; PROMOTER REGION; PROTEIN FAMILY; PUBERTY; REGULATORY MECHANISM; REPRODUCTION; REVIEW; TARGET ORGAN;

ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; LEPTIN; METABOLIC SYNDROME X; MICE; OBESITY; RECEPTORS, LEPTIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 70350069775     PISSN: 00264806     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin and resistin. Clin Chemistry 2004;50:1511-1525 (Pubitemid 39121218)
2. Matsuda M, Shimomura I, Sata M. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol CHem 2002;277:37487-37491
3. Kumada M, Kihara S, Sumitsuji S. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003;23:85-89 (Pubitemid 36091630)
4. Steppan CM, Bailey ST, Bhat S. The hormone resistin links obesity to diabetes. Nature 2001;409:307-312 (Pubitemid 32151228)
5. Matsuzawa Y. Adipocytokines: Emerging therapeutic targets. Current Atherosclerosis Reports 2005;7:58-62.
6. Shimomoura I, Hammer RE, Ikemoto S. Leptin reverses insulin resitance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999;401:73-76 (Pubitemid 29418444)
7. Fruhbeck G. A heliocentric view of leptin. Proc Nutr Soc 2001;60:301-318
8. Barr VA, Lane K, Taylor SI. Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem 1999;274:21416-21424 (Pubitemid 129519657)
9. Lammert A, Kiess W, Böttner A. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 2001;283:982-8. (Pubitemid 32924677)
10. Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001;276:6343-6349 (Pubitemid 37373493)
11. Margetic S, Gazzola C, Pegg GG. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26:1407-1433 (Pubitemid 36007818)
12. Parachinni V, Pedotti P, Taioli E. Genetics of leptin and obesity: A Huge Review. Am J of Epidemiolo 2005;162:101-114 (Pubitemid 41373535)
13. Lonnqvist F, Arner P, Nordfors L. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995;1:950-953
14. Ingalls Am, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 1950;41:317-318
15. Montague CT, Farooqi IS, Whitehead JP. Congenital leptin deficiency is associated with severe early onset obesity in humans, Nature 1997;387:903-908
16. Lucantoni R, Ponti E, Berselli M. The A19Gpolymorphism in the 5′untranslated region of the human obese gene does not affect leptin levels in severely obese patients. J Clin Endocrinol Metab 2000;85:3589-3591 (Pubitemid 30828558)
17. Oksanen L, Kainulainen K, Heiman M. Novel polymorphism of the human ob gene promoter in lean adn morbidly obese subjects. Int J Obes Relat Metab Disord 1997;21:489-494 (Pubitemid 27236968)
18. Echwald SM, Rasmussen SB, Sorense TI. Identfication of two novel missense mutations in the human OB gene. Int J Obes Relat Metab Dojisord 1997;21:321-326 (Pubitemid 27158312)
19. Schwartz MW, Seeley RJ, Campfield LA. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996;98:1101-1106
20. Mars M, van Rossum CT, de Graaf C. Leptin responsiveness to energy restriction: genetic variation in the leptin receptor gene. Obes Res 2004;12:442-444 (Pubitemid 41132522)
21. de Luis DA, Aller R, Izaola O, Conde R, Gonzalez M. Influence of lys656asn polymorphism of leptin receptor gene in leptin response and weight loss secondary to a lifestyle modification in obese patients. Arch Inter. Med 2006: 37:854-859
22. de Luis DA, Gonzalez Sagrado M. Aller R, Izaola O, Conde R. Influence of Lys 656Asn polymorphism of the leptin receptor gene on insulin resistance in nondiabetic obese patients. J of Diabetes and Its Complications 2008;22:199-204 (Pubitemid 351545844)
23. de Luis DA, Gonzalez sagrado M, Aller R, Izaola O, Conde R. Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.Diabetes Res Clin pract 2008:epudmed.
24. de Luis DA, Aller R, Izoala O, Gonzalez Sagrado M, Conde R. Influence of lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trial. Ann Nutr Metab 2008;52:209-214 (Pubitemid 351990891)
25. Ducy P, Amling M, Takeda S. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000;100:197-207. (Pubitemid 30064908)
26. Takeda S. Central control of bone remodeling. Biochem Biophys Res Commun 2005;328:697-699
27. Schlienger AR, Kraenzlin ME, Jic SS, Use of beta-blockers and risk of fractures. JAMA 2004:292:1326-1332
28. Ciccone M, Vettor R, Pannacciulli N. Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. Int J Obes Relat Metab Disord 2001;25:805-810 (Pubitemid 32601372)
29. Reilly MP, Iqbal N, Schutta M. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 2004;89:3872-3878 (Pubitemid 39071487)
30. Wolk R, Berger P, Lennon RJ. Plams leptin and prognosis in patients with estabished coronary atherosclerosis. J Am Coll Cardiol 2004;44:1819-1824
31. Somasundar P, Frakenberry KA, Skinner H. Prostate cancer cell proliferation is influenced by leptin. J Sur Res 2004:118:71-82. (Pubitemid 38490519)
32. Somasundar P, McFadden DW, Hileman SM. Leptin is a growth factor in cancer. J Surg Res 2004;116:337-349
33. Rose DP, Komninou D, Stephenson GD. Obesity, adipocytokines, ad insulin resistance in breast cancer. Obes Rev 2004;5:153-165 (Pubitemid 38998240)
34. Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 2001;166:5909-5916 (Pubitemid 32440714)
35. Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A. Leptin and its soluble receptor in plasma of patients suffering from remitting.relapsin multiple sclerosis (MS) in vitro effects of leptin of type-1 and type 2 cytokine secretion by peripheral blood mononuclear cells, t cells and monocytes of MS patients. J Autoimmun 2004;23:169-177 (Pubitemid 39485798)
36. Siegmund B, Sennello JA, Lehr HA, Batra A, Fedke Im Zeiz M. Development of intestinal inflammation in double IL.10 and leptin deficient mice. J Leukoc Biol 2004;76:782-786 (Pubitemid 39313713)
37. Tuzun A, Uygun A, Yesilova Z, Ozel AM, Erdil A, Yaman H. Leptin levels in the acute stage of ulcerative colitis, J Gastrienteril Hepatol 2004;19:429-432 (Pubitemid 38570194)
38. Sitaraman S, Liu X, Charrier L, gu LH, Ziegler TR, Gewirtz A. Colonic leptin:sorce of a novel proinflammatory cytokine involved in IBD. FASEB J 2004;18:696-698
39. Anders HJ, Rihl M, Heufelder A Loch O, Schattenkirchner M. Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism 1999;48:745-748
40. Speakman JR, Stubbs RJ, Mercer JG. Does body mass play a role in the regulation of food intake? Proc Nutr Soc 2002;61:473-487
41. Frayn KN, Karpe F, Fielding BA, Macdonald IA, Coppack SW. Integrative physiology of human adipose tissue. Int J Obes Relat Metab Disord 2003;27:875-88. (Pubitemid 36918608)
42. Gale SM, Castracane VD, Mantzoros CS, Energy homeostasis, obsity and eating disorders; recent advances in endocrinology. J Nutr 2004;134:295-298
43. Meier U, Gressner A. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin and resistin. Clinical Chemistry 2004;50:9:1511-1525 (Pubitemid 39121218)
44. Sandhofer A, Laimer M, Ebenbichler CF, Kaser S, Pailweber B, Pasch JR, Soluble leptin receptor nd soluble receptor bound fraction of leptin in the metabolic syndrome. Obes Res 2003;11:760-768 (Pubitemid 41151602)
45. de Luis DA, Aller R, Izaola O, Gonzalez sagrado M, Conde R, Bellido D. influence of insulin resistance and adipocytokines on elevated serum alanine aminotransferase in obese patients. Arch of Medical Research 2008:39:110-114
46. Aller R, de Luis DA, Fernadez L, Caller F, Velayos B, Olcoz JL, Izaola O, Gonzalez Sagrado M, Conde R, Gonzalez JM. Influence of insulin resistance and adipokines in the grade of steatosis of non-alcoholic fatty liver disease. Dig Dis Sci 2008;53:1088-1092
47. Otte C, Otte JM, Strodthoff D Bornstein SR, Folsch UR, Moning H, Expression of leptin and leptin receptors during development of liver fibrosis and cirrhosis. Exp Clin Endocrinol Diabetes 2004;112:10-17 (Pubitemid 38220427)
48. Shore SA, Schwartzmann IN, Mellema MS, Flynt L, Imrich A, Johnston R, Effect of letin on allergic airway responses in mce. J Allergy Clin Immunol 2005;115:103-109 (Pubitemid 40075428)
49. Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F, Leptin; does it have any role in childhood asthma ?J Allergy Clin Immunol 2004;114:254-259
50. Matsuzawa Y. Adipocytokines: emerging therapeutic targets. Current Atherosclerosis Reports 2005;7:58-62.
51. Oral EA, Sim HA, Ruiz E. Leptin replacement therapy for lipodystrophy. N Engl J of Med 2002;346:8:570-578
52. Licinio J, Caglayan S, Ozata M. Phenotipic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism and ehavior in leptin-deficient adults. Proc Nat Acad Sci USA 2004;101;4531-4536 (Pubitemid 38437445)
53. Welt CK, Chan JL, Bullen J. Recombinant human letin in women with hypothlamic amenorrhea. Ne Eng J Med 2004;351:987-997 (Pubitemid 39166262)
54. de Luis DA, Aller R, Izaola O, González Sagrado, Conde R, Perez Castrillon JL. Effects of lifestyle modification on adipocytokine levels in obese patients. Eur Rev Med Pharmacol Sci 2008;12:33-39
55. Okasaki T, Himeno E, Nanri H, Ogata H, Ikeda M. Efectsof mild aerobic exercise and a mild hypocaloric diet on plasma leptin in sedentary women. Clin exp Pharmacol 1999;26:415-420 (Pubitemid 29306958)
56. Xenachis C, Samojlik E, Raghuwanshi MP, Kirschner MA. Leptin, insulin and TNF-alpha in weight loss. J Endocrinol Invest 2001;24:865-870 (Pubitemid 34036716)
57. Bastard JP, Jardel C, Bruckert E. Elevated levels of interleukin-6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000;85:3338-3342 (Pubitemid 30944547)
58. Hotta K, Funahashi T, Arita Y. Plasma concentrations of a novel, adipose specific protein, adiponectin in tyoe 2 patients. Arterioscler Throm Vasc 2000;20:1595-1661 (Pubitemid 30353893)
59. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mulloly C, Jarema C, Porter S, Ovalle K. Efect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity Research 2003;11:1048-1052 (Pubitemid 41151581)
60. Piestrzeniewicz K, Luczak K, Komorowski J, Maciejewski M, Goch JH. The relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarctation. Cardiol J 2007;14:252-259 (Pubitemid 47249346)
61. Han CZ, Du LL, Jing JX, Zhao XW, Tian FG, Shi J, Tian BG, Liu XY, Zhang LJ. Associations among lipids, leptin, and leptin receptor gene gin223arg polymorphisms and breast cancer inc hina. Biol Trace Elem Res 2008;jul 31 epubmed.
62. Aydin S, Guzel SP, Kumru S, Aydin S, Akin O, Kavak E, Sahin I, Bozkurt M, Halifeoglu I. Serum leptin and ghrelin concentrations of maternal serum. Arterial and venous cord blood in healthy and preeclamptic pregnant women. J Physiol Biochem 2008;64:51-59 (Pubitemid 351997493)