Enhanced proliferation and activation of peripheral blood mononuclear cells in patients with psoriasis vulgaris mediated by streptococcal antigen with bacterial DNA

Journal of Investigative Dermatology

Volumn 129, Issue 11, 2009, Pages 2653-2660

  Cai, Yi Hua ^a   Lu, Zhi Yong ^a   Shi, Ruo Fei ^a   Xue, Feng ^a   Chen, Xiao Ying ^a   Pan, Meng ^a   Yuan, Wei Ru ^a   Xu, Han ^a   Li, Wei Ping ^a   Zheng, Jie ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIAL DNA; CD69 ANTIGEN; CD86 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; DEOXYRIBONUCLEASE I; GAMMA INTERFERON; STREPTOCOCCUS ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BACTERIUM CULTURE; BLOOD SAMPLING; CELL ISOLATION; CELL STIMULATION; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PSORIASIS VULGARIS; T LYMPHOCYTE ACTIVATION;

EID: 70350047051     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.153     Document Type: Article

References (35)

1. Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM (1999) Chlamydia infections and heart disease linked through antigenic mimicry. Science 283:1335-1339
2. Baker BS, Brown D, Porter W, Hardman C, Garioch JJ, Powles A et al. (1999) T lymphocytes reactive for group A streptococcal antigens in chronic plaque psoriatic lesions. Arch Dermatol Res 291:564-566
3. Baker BS, Powles AV, Malkani AK, Lewis H, Valdimarsson H, Fry L (1991) Altered cell-mediated immunity to group A haemolytic streptococcal antigens in chronic plaque psoriasis. Br J Dermatol 125:38-42
4. Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, Akira S et al. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 98:9237-9242
5. Bauer S, Wagner H (2002) Bacterial CpG-DNA licenses TLR9. Curr Top Microbiol Immunol 270:145-154
6. Bowcock AM, Krueger JG (2005) Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 5:699-711
7. Brown DW, Baker BS, Ovigne JM, Hardman C, Powles AV, Fry L (2000) Skin CD4+ T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic plaque psoriasis. J Invest Dermatol 114:576-580
8. Chatellier S, Kotb M (2000) Preferential stimulation of human lymphocytes by oligodeoxynucleotides that copy DNA CpG motifs present in virulent genes of group A streptococci. Eur J Immunol 30:993-1001
9. Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H et al. (2000) Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 95:999-1006
10. Diluvio L, Vollmer S, Besgen P, Ellwart JW, Chimenti S, Prinz JC (2006) Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris. J Immunol 176:7104-7111
11. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS (1997) Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389:978-981
12. Gaspari AA (2006) Innate and adaptive immunity and the pathophysiology of psoriasis. J Am Acad Dermatol 54:S67-80
13. Gilliet M, Lande R (2008) Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Curr Opin Immunol 20:401-407
14. Griffiths CE, Barker JN (2007) Pathogenesis and clinical features of psoriasis. Lancet 370:263-271
15. Gross WL, Packhauser U, Hahn G, Westphal E, Christophers E, Schlaak M (1977) Lymphocyte activation by streptococcal antigens in psoriasis. Br J Dermatol 97:529-536
16. Gudjonsson JE, Thorarinsson AM, Sigurgeirsson B, Kristinsson KG, Valdi-marsson H (2003) Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study. Br J Dermatol 149:530-534
17. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745
18. Ichikawa HT, Williams LP, Segal BM (2002) Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease. J Immunol 169:2781-2787
19. Krieg AM (2002) CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20:709-760
20. Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L et al. (2008) Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733-4741
21. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B et al. (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449:564-569
22. Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O et al. (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202:135-143
23. Oshikawa T, Okamoto M, Tano T, Sasai A, Kan S, Moriya Y et al. (2006) Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent. J Immunother (1997) 29:143-150
24. Pichyangkul S, Yongvanitchit K, Kum-arb U, Krieg AM, Heppner DG, Walsh DS (2001) Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides. J Immunol Methods 247:83-94
25. Pisetsky D, Drayton D, Wu ZQ (1999) Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus. J Rheumatol 26:1934-1938 (Pubitemid 30007060)
26. Prinz JC (2003) The role of T cells in psoriasis. J Eur Acad Dermatol Venereol 17:257-270
27. Prinz M, Garbe F, Schmidt H, Mildner A, Gutcher I, Wolter K et al. (2006) Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest 116:456-464
28. Schon MP, Boehncke WH (2005) Psoriasis. N Engl J Med 352:1899-1912
29. Sigmundsdottir H, Gudjonsson JE, Jonsdottir I, Ludviksson BR, Valdimarsson H (2001) The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease. Clin Exp Immunol 126:365-369
30. Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annu Rev Immunol 21:335-376
31. Torres-Alvarez B, Castanedo-Cazares JP, Fuentes-Ahumada C, Moncada B (2007) The effect of methotrexate on the expression of cell adhesion molecules and activation molecule CD69 in psoriasis. J Eur Acad Dermatol Venereol 21:334-339
32. Vollmer J, Weeratna R, Payette P, Jurk M, Schetter C, Laucht M et al. (2004) Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 34:251-262 (Pubitemid 38111541)
33. Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD et al. (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8:950-957
34. Yurci A, Guven K, Torun E, Gursoy S, Baskol M, Akgun H et al. (2007) Pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin treatment of chronic hepatitis C. Eur J Gastroenterol Hepatol 19:811-815
35. Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, Wu J et al. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445:648-651