Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2/M checkpoint

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 670, Issue 1-2, 2009, Pages 53-58

  Rodríguez, Pilar ^a   Barquinero, Joan Francesc ^a   Duran, Assumpta ^a   Caballín, María Rosa ^a   Ribas, Montserrat ^b   Barrios, Leonardo ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Biologia Vegetal i Ecologia ^*  (Spain)

Author keywords

Chromosome aberrations; G2 M checkpoint; Telomeres

Indexed keywords

CALYCULIN A; DEMECOLCINE; DNA;

ADULT; ARTICLE; BLOOD SAMPLING; CELL ACTIVITY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CENTROMERE; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOCHEMISTRY; DNA DAMAGE; DNA REPAIR; FLUORESCENCE IN SITU HYBRIDIZATION; GAMMA RADIATION; GENETIC SELECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; LYMPHOCYTE CULTURE; MALE; MITOSIS; PRIORITY JOURNAL; RADIATION EXPOSURE; TELOMERE;

ADULT; CELL CYCLE; CHROMOSOME ABERRATIONS; G2 PHASE; HUMANS; LYMPHOCYTES; MALE; MITOSIS; RADIATION, IONIZING; TELOMERE;

EID: 70350014887     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.07.003     Document Type: Article

References (48)

1. Iliakis G., Wang Y., Guan J., and Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22 (2003) 5834-5847
2. Mao Z., Bozzella M., Seluanov A., and Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7 (2008) 2902-2906
3. Weterings E., and Chen D.J. The endless tale of non-homologous end-joining. Cell Res. 18 (2008) 114-124
4. Shrivastav M., De Haro L.P., and Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18 (2008) 134-147
5. Maity A., McKenna W.G., Markiewicz D.A., Kunig A., and Muschel R.J. Alternate polyadenylation in rodent cells results in two differentially expressed cyclin B1 mRNAs. Biochem. Biophys. Res. Commun 202 (1994) 908-914
6. Bernhard E.J., Maity A., Muschel R.J., and McKenna W.G. Effects of ionizing radiation on cell cycle progression. A review. Radiat. Environ. Biophys. 34 (1995) 79-83
7. Iliakis G. Cell cycle regulation in irradiated and nonirradiated cells. Semin. Oncol. 24 (1997) 602-615
8. Zhou B.B., and Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 408 (2000) 433-439
9. Durante M., Furusawa Y., Majima H., Kawata T., and Gotoh E. Association between G2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes. Radiat. Res. 151 (1999) 670-676
10. Ritter S., Nasonova E., Gudowska-Nowak E., Scholz M., and Kraft G. High-LET-induced chromosome aberrations in V79 cells analysed in first and second post-irradiation metaphases. Int. J. Radiat. Biol. 76 (2000) 149-161
11. Wu H., George K., Willingham V., Kawata T., and Cucinotta F.A. Comparison of F ratios generated from interphase and metaphase chromosome damage induced by high doses of low- and high-LET radiation. Radiat. Res. 155 (2001) 57-62
12. Terzoudi G.I., Manola K.N., Pantelias G.E., and Iliakis G. Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells. Cancer Res. 65 (2005) 11292-11296
13. Cornforth M.N., and Bedford J.S. X-ray-induced breakage and rejoining of human interphase chromosomes. Science 222 (1983) 1141-1143
14. Gotoh E., Asakawa Y., and Kosaka H. Inhibition of protein serine/threonine phosphatase directly induces premature chromosome condensation in mammalian somatic cells. Biomed. Res. 16 (1995) 63-68
15. Coco-Martin J.M., and Begg A.C. Detection of radiation-induced chromosome aberrations using fluorescence in situ hybridization in drug-induced premature chromosome condensations of tumour cell lines with different radiosensitivities. Int. J. Radiat. Biol. 71 (1997) 265-273
16. Durante M., Furusawa Y., and Gotoh E. A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. Int. J. Radiat. Biol. 74 (1998) 457-462
17. Gotoh E., and Durante M. Chromosome condensation outside of mitosis: mechanisms and new tools. J. Cell Physiol. 209 (2006) 297-304
18. Febrer E., Mestres M., Caballín M.R., Barrios L., Ribas M., Gutiérrez-Enríquez S., Alonso C., Ramón y Cajal T., and Barquinero J.F. Mitotic delay in lymphocytes from BRCA1 heterozygotes unable to reduce the radiation-induced chromosomal damage. DNA Repair 7 (2008) 1907-1911
19. Boei J.J., Vermeulen S., Fomina J., and Natarajan A.T. Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric DNA probe. Int. J. Radiat. Biol. 73 (1998) 599-603
20. Fomina J., Darrroudi F., Boei J.J.W.A., and Natarajan A.T. Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. Int. J. Radiat. Biol. 76 (2000) 807-813
21. Fomina J., Darrroudi F., and Natarajan A.T. Accurate detection of true incomplete exchanges in human lymphocytes exposed to neutron radiation using chromosome painting in combination with a telomeric PNA probe. Int. J. Radiat. Biol. 77 (2001) 1175-1183
22. Mestres M., Caballín M.R., Schmid E., Stephan G., Sachs R., Barrios L., and Barquinero J.F. Analysis of alpha-particle induced chromosome aberrations in human lymphocytes, using pan-centromeric and pan-telomeric probes. Int. J. Radiat. Biol. 80 (2004) 737-744
23. Benkhaled L., Barrios L., Mestres M., Caballín M.R., Ribas M., and Barquinero J.F. Analysis of gamma-rays induced chromosome aberrations: a fingerprint evaluation with a combination of pan-centromeric and pan-telomeric probes. Int. J. Radiat. Biol. 82 (2006) 869-875
24. Benkhaled L., Xunclà M., Caballín M.R., Barrios L., and Barquinero J.F. Induction of complete and incomplete chromosome aberrations by bleomycin in human lymphocytes. Mutat. Res. 637 (2008) 134-141
25. Wu H., Durante M., Furusawa Y., George K., Kawata T., and Cucinotta F.A. Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions. Radiat. Res. 160 (2003) 418-424
26. IAEA. Cytogenetic Analysis for Radiation Dose Assessment, A Manual, Technical Reports Series no. 405 (Vienna: International Atomic Energy Agency), 2001.
27. Perry P., and Wolf S. New giemsa method for differential staining of sister chromatids. Nature 261 (1974) 156-158
28. Rodríguez P., Montoro A., Barquinero J.F., Caballín M.R., Villaescusa I., and Barrios L. Analysis of translocations in stable cells and their implications in retrospective biological dosimetry. Radiat. Res. 162 (2004) 31-38
29. Cornforth M.N. Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat. Res. 155 (2001) 643-659
30. Loucas B.D., and Cornforth M.N. Complex chromosome exchanges induced by gamma rays in human lymphocytes: an mFISH study. Radiat. Res. 155 (2001) 660-671
31. Lukas J., Lukas C., and Bartek J. Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair 3 (2004) 997-1007
32. Kovacs M.S., Evans J.W., Johnstone I.M., and Brown J.M. Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization. Radiat. Res. 137 (1994) 34-43
33. Durante M., George K., Wu H., and Yang T.C. Rejoining and misrejoining of radiation-induced chromatin breaks. I. Experiments with human lymphocytes. Radiat. Res. 145 (1996) 274-280
34. Borgmann K., and Dikomey E. Relationship between PCC fragments and cell killing studied in X-irradiated CHO, CHO-K1 cells and two radiosensitive mutants xrs1 and xrs5. Int. J. Radiat. Biol. 72 (1997) 667-674
35. Duran A., Barquinero J.F., Caballín M.R., Ribas M., and Barrios L. Persistence of radiation-induced chromosome aberrations in a long-term cell culture. Radiat. Res. 171 (2009) 425-437
36. Jeggo P.A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat. Res. 150 (1998) S80-91
37. Jackson S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23 (2002) 687-696
38. Rothkamm K., Krüger I., Thompson L.H., and Löbrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23 (2003) 5706-5715
39. Xu B., Kim S.T., Lim D.S., and Kastan M.B. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22 (2002) 1049-1059
40. Deckbar D., Birraux J., Krempler A., Tchouandong L., Beucher A., Walker S., Stiff T., Jeggo P., and Löbrich M. Chromosome breakage after G2 checkpoint release. J. Cell Biol. 176 (2007) 749-755
41. Löbrich M., and Jeggo P.A. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat. Rev. Cancer 7 (2007) 861-869
42. Boei J.J., Vermeulen S., and Natarajan A.T. Detection of chromosome aberrations by fluorescence in situ hybridization in the first three post-irradiation divisions. Mutat. Res. 349 (1996) 127-135
43. Hoffmann G.R., Sayer A.M., and Littlefield L.G. Higher frequency of chromosome aberrations in late-arising first-division metaphases than in early-arising metaphases after exposure of human lymphocytes to X-rays in G0. Int. J. Radiat. Biol. 78 (2002) 765-772
44. Anderson R.M., Marsden S.J., Wright E.G., Kadhim M.A., Goodhead D.T., and Griffin C.S. Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles. Int. J. Radiat. Biol. 76 (2000) 31-42
45. Ritter S., Nasonova E., Furusawa Y., and Ando K. Relationship between aberration yield and mitotic delay in human lymphocytes exposed to 200 MeV/u Fe-ions or X-rays. J. Radiat. Res. 43 (2002) S175-179
46. Lee R., Nasonova E., and Ritter S. Chromosome aberration yields and apoptosis in human lymphocytes irradiated with Fe-ions of differing LET. Adv. Space Res. 35 (2005) 268-275
47. Belloni P., Meschini R., Czene S., Harms-Ringdahl M., and Palitti F. Studies on radiation-induced apoptosis in G0 human lymphocytes. Int. J. Radiat. Biol. 81 (2005) 587-599
48. Bassi L., Carloni M., Meschini R., Fonti E., and Palitti F. X-irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin-dependent apoptosis. Int. J. Radiat. Biol. 79 (2003) 943-954