Chromosome aberration yields and apoptosis in human lymphocytes irradiated with Fe-ions of differing LET

Advances in Space Research

Volumn 35, Issue 2, 2005, Pages 268-275

  Lee, R ^a   Nasonova, E ^a,b   Ritter, S ^a  

^a GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH   (Germany)

^b JOINT INSTITUTE FOR NUCLEAR RESEARCH   (Russian Federation)

Author keywords

Apoptosis; Calyculin A induced premature chromosome condensation; Fe ions; High LET induced chromosome aberrations; Human lymphocytes; RBE

Indexed keywords

CELLS; CHROMOSOMES; HIGH ENERGY PHYSICS; HUMAN ENGINEERING; IRON; IRRADIATION; PROTONS;

APOPTOSIS; FE-IONS; HUMAN LYMPHOCYTES; RBE;

BIOLOGICAL RADIATION EFFECTS;

EID: 18844392091     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2004.11.020     Document Type: Article

References (31)

1. R.M. Anderson, S.J. Mardsen, and E.G. Wright Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET α-particles Int. J. Radiat. Biol. 76 2000 31 42
2. S. Bonassi, and W.W. Au Biomarkers in molecular epidemiology studies for health risk prediction Mutat. Res. 511 2002 73 86
3. M. Carloni, R. Meschini, and L. Ovidi PHA-induced cell proliferation rescues human peripheral blood lymphocytes from X-ray induced apoptosis Mutagenesis 16 2001 115 120
4. 60 Co gamma-rays and neon and helium ions on cycle duration and division probability of EMT 6 cells. A time-lapse cinematography study Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 39 1981 297 306
5. F.A. Cucinotta, W. Schimmerling, and J.W. Wilson Space radiation cancer risks and uncertainties for Mars missions Radiat. Res. 156 2001 682 688
6. S.B. Curtis, J.E. Nealy, and J.W. Wilson Risk cross sections and their application to risk estimation in the galactic cosmic-ray environment Radiat. Res. 141 1995 57 65
7. M. Durante, Y. Furusawa, and K. George Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles Radiat. Res. 149 1998 446 454
8. M. Durante, Y. Furusawa, and E. Gotoh A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry Int. J. Radiat. Biol. 74 1998 457 462
9. M. Durante, K. George, and H. Wu Karyotypes of human lymphocytes exposed to high-energy iron ions Radiat. Res. 158 2002 581 590
10. A.A. Edwards The use of chromosomal aberrations in human lymphocytes for biological dosimetry Radiat. Res. 148 Suppl. 1997 S39 44
11. K. George, H. Wu, and V. Willingham High- and low-LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase Int. J. Radiat. Biol. 77 2001 175 183
12. K. George, M. Durante, and V. Willingham Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes Radiat. Res. 160 2003 425 435
13. Th. Haberer, W. Becher, and D. Schardt Magnetic scanning system for heavy ion therapy Nucl. Inst. Meth. Phys. Res., Sec. A 330 1993 296 365
14. 0 Int. J. Radiat. Biol. 78 2002 765 772
15. A. Holgersson, A.R. Jernberg, and L.M. Persson Low and high LET radiation-induced apoptosis in M059J and M059K cells Int. J. Radiat. Biol. 79 2003 611 621
16. IAEA. Cytogenetic analysis for radiation dose assessment: a manual. Technical Reports Series No. 405. International Atomic Energy Agency, Vienna, 2001
17. J. Kiefer Radiation risk in manned space flights Mutat. Res. 430 1999 307 313
18. G. Kraft, H.W. Daues, and B. Fischer Irradiation chamber and sample changes for biological samples Nucl. Instr. Meth. 168 1980 175 179
19. A.E. Meijer, U.S. Kronquist, and R. Lewensohn RBE for the induction of apoptosis in human peripheral lymphocytes exposed in vitro to high LET radiation generated by accelerated nitrogen ions Int. J. Radiat. Biol. 73 1998 169 177
20. E. Nasonova, and S. Ritter Cytogenetic effects of densely ionising radiation in human lymphocytes: impact of cell cycle delays Cytogenet. Genome Res. 104 2004 216 220
21. -1 C ions Int. J. Radiat. Biol. 80 2004 621 634
22. H. Norppa Cytogenetic biomarkers IARC Sci. Publ. 157 2004 179 205
23. P. Perry, and S. Wolff New Giemsa method for the differential staining of sister chromatids Nature 251 1974 156 158
24. S. Ritter, E. Nasonova, and M. Scholz Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 keV/μm in G1 V79 cells Int. J. Radiat. Biol. 69 1996 155 166
25. S. Ritter, E. Nasonova, and Y. Furusawa Relationship between aberration yield and mitotic delay in human lymphocytes exposed to 200 MeV/u Fe-ions or X-rays J. Radiat. Res. 43 Suppl. 2002 S175 179
26. S. Ritter, E. Nasonova, and E. Gudowska-Novak Effect of LET on the yield and quality of chromosomal damage in metaphase cells: a time-course study Int. J. Radiat. Biol. 78 2002 191 202
27. W. Schimmerling, F.A. Cucinotta, and J.W. Wilson Radiation risk and human space exploration Adv. Space Res. 31 1 2003 27 34
28. M. Scholz, W. Kraft-Weyrather, and S. Ritter Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells Int. J. Radiat. Biol. 66 1994 59 75
29. M. Scholz, S. Ritter, and G. Kraft Analysis of chromosome damage based on the time course of aberrations Int. J. Radiat. Biol. 74 1998 325 331
30. M. Scholz Effects of ion radiation on cells and tissues Adv. Poly. Sci. 162 2003 95 155
31. Space Studies Board, National Research Council. Radiation hazards to crews of interplanetary missions. Biological Issues and Research Strategies. National Academy Press, Washington, DC, 1996