COMMD1 promotes pVHL and O2-independent proteolysis of HIF-1α via HSP90/70

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  van de Sluis, Bart ^a,b   Groot, Arjan J ^a   Vermeulen, Jeroen ^a   van der Wall, Elsken ^a   van Diest, Paul J ^a   Wijmenga, Cisca ^a,b   Klomp, Leo W ^a   Vooijs, Marc ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CHAPERONE; COPPER MUTABOLISM MURR1 DOMAIN CONTAINING 1 PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TANESPIMYCIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; 17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN; BENZOQUINONE DERIVATIVE; CARRIER PROTEIN; COMMD1 PROTEIN, HUMAN; MACROCYCLIC LACTAM; OXYGEN; PROTEASOME; UBIQUITIN;

ARTICLE; CONTROLLED STUDY; COPPER METABOLISM; DIMERIZATION; DNA BINDING; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; CELL LINE; GENE EXPRESSION REGULATION; HELA CELL; METABOLISM; TUMOR SUPPRESSOR GENE;

BENZOQUINONES; CARRIER PROTEINS; CELL LINE; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTAMS, MACROCYCLIC; OXYGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; UBIQUITIN; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 70350012306     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007332     Document Type: Article

References (35)

1. Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, et al. (2005) COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem 280: 22222-22232.
2. Maine GN, Burstein E (2007) COMMD proteins: COMMing to the scene. Cell Mol Life Sci 64: 1997-2005.
3. Maine GN, Mao X, Muller PA, Komarck CM, Klomp LW, et al. (2009) COMMD1 expression is controlled by critical residues that determine XIAP binding. Biochem J 417: 601-609.
4. Muller PA, van de Sluis B, Groot AJ, Verbeek D, Vonk WI, et al. (2009) Nuclear-cytosolic transport of COMMD1 regulates NF-kappaB and HIF-1 activity. Traffic.
5. Maine GN, Mao X, Komarck CM, Burstein E (2007) COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. Embo J 26: 436-447.
6. Klomp AE, van de Sluis B, Klomp LW, Wijmenga C (2003) The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. J Hepatol 39: 703-709.
7. van De Sluis B, Rothuizen J, Pearson PL, van Oost BA, Wijmenga C (2002) Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum Mol Genet 11: 165-173.
8. de Bie P, van de Sluis B, Burstein E, van de Berghe PV, Muller P, et al. (2007) Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B. Gastroenterology 133: 1316-1326.
9. Tao TY, Liu F, Klomp L, Wijmenga C, Gitlin JD (2003) The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein. J Biol Chem 278: 41593-41596.
10. Mao X, Gluck N, Li D, Maine GN, Li H, et al. (2009) GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev 23: 849-861.
11. van de Sluis B, Muller P, Duran K, Chen A, Groot AJ, et al. (2007) Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in commd1 null mice. Mol Cell Biol 27: 4142-4156.
12. Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007: cm8.
13. Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92: 5510-5514.
14. Wang GL, Semenza GL (1993) Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268: 21513-21518.
15. Bruick RK, McKnight SL (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340.
16. Ivan M, Kondo K, Yang H, Kim W, Valiando J, et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464-468.
17. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472.
18. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275.
19. Pugh CW, Tan CC, Jones RW, Ratcliffe PJ (1991) Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc Natl Acad Sci U S A 88: 10553-10557.
20. Liu YV, Semenza GL (2007) RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle 6: 656-659.
21. van de Sluis B, Groot AJ, Wijmenga C, Vooijs M, Klomp LW (2007) COMMD1: a novel protein involved in the proteolysis of proteins. Cell Cycle 6: 2091-2098.
22. Picard D (2002) Heat-shock protein 90, a chaperone for folding and regulation. Cell Mol Life Sci 59: 1640-1648.
23. Fath DM, Kong X, Liang D, Lin Z, Chou A, et al. (2006) Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J Biol Chem 281: 13612-13619.
24. Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, et al. (2002) Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 277: 29936-29944.
25. Kong X, Lin Z, Liang D, Fath D, Sang N, et al. (2006) Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol 26: 2019-2028.
26. Liu YV, Baek JH, Zhang H, Diez R, Cole RN, et al. (2007) RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25: 207-217.
27. Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, et al. (2002) Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res 62: 2478-2482.
28. Minet E, Mottet D, Michel G, Roland I, Raes M, et al. (1999) Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett 460: 251-256.
29. Kulka RG, Raboy B, Schuster R, Parag HA, Diamond G, et al. (1988) A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J Biol Chem 263: 15726-15731.
30. Zhou J, Schmid T, Frank R, Brune B (2004) PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem 279: 13506-13513.
31. Kong X, Alvarez-Castelao B, Lin Z, Castano JG, Caro J (2007) Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein. J Biol Chem 282: 15498-15505.
32. Cho S, Choi YJ, Kim JM, Jeong ST, Kim JH, et al. (2001) Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. FEBS Lett 498: 62-66.
33. Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, et al. (2003) Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97: 1573-1581.
34. Pouyssegur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443.
35. Semenza GL (2007) Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 12: 853-859.