Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages

Journal of Immunotoxicology

Volumn 6, Issue 2, 2009, Pages 84-93

  Lacour, Sandrine ^a,b   Antonios, Diane ^b   Gautier, Jean Charles ^a   Pallardy, Marc ^b  

^a SANOFI   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Acetaminophen; CYP450; Interleukin 1; Lipopolysaccharide; Macrophages; Mitogen activated protein kinase; Prostaglandin H synthase; Tumor necrosis factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BACTERIUM LIPOPOLYSACCHARIDE; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A11; FURAFYLLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PARACETAMOL; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; DRUG DERIVATIVE; FLAVONOID; IMIDAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROSTAGLANDIN SYNTHASE; PYRIDINE DERIVATIVE; THEOPHYLLINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY;

BACTERIA (MICROORGANISMS); MURINAE;

ACETAMINOPHEN; ANIMALS; ANTHRACENES; CELL LINE; CYTOCHROME P-450 CYP1A2; DRUG SYNERGISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; IMIDAZOLES; INDOMETHACIN; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE 1; MAP KINASE KINASE 4; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRIDINES; SIGNAL TRANSDUCTION; THEOPHYLLINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70350007331     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910902938250     Document Type: Article

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