-
1
-
-
0032188805
-
The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial. the Medical Research Council Adult and Children's Leukaemia Working Parties
-
Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998 92 : 2322 2333.
-
(1998)
Blood
, vol.92
, pp. 2322-2333
-
-
Grimwade, D.1
Walker, H.2
Oliver, F.3
-
2
-
-
33644798659
-
Molecular typing of adult acute myeloid leukaemia: Significance of translocations, tandem duplications, methylation, and selective gene expression profiling
-
Olesen LH, Aggerholm A, Andersen BL, Nyvold CG, Guldberg P, Norgaard JM, Hokland P. Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profiling. Br J Haematol 2005 131 : 457 467.
-
(2005)
Br J Haematol
, vol.131
, pp. 457-467
-
-
Olesen, L.H.1
Aggerholm, A.2
Andersen, B.L.3
Nyvold, C.G.4
Guldberg, P.5
Norgaard, J.M.6
Hokland, P.7
-
3
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, Sonoda Y, Fujimoto T, Misawa S. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996 10 : 1911 1918.
-
(1996)
Leukemia
, vol.10
, pp. 1911-1918
-
-
Nakao, M.1
Yokota, S.2
Iwai, T.3
Kaneko, H.4
Horiike, S.5
Kashima, K.6
Sonoda, Y.7
Fujimoto, T.8
Misawa, S.9
-
4
-
-
28444449081
-
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
-
Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli MF, Haferlach T, Hiddemann W, Falini B. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 2005 106 : 3733 3739.
-
(2005)
Blood
, vol.106
, pp. 3733-3739
-
-
Schnittger, S.1
Schoch, C.2
Kern, W.3
Mecucci, C.4
Tschulik, C.5
Martelli, M.F.6
Haferlach, T.7
Hiddemann, W.8
Falini, B.9
-
5
-
-
1442356729
-
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
-
Frohling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, Kreitmeier S, Tobis K, Dohner H, Dohner K. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol 2004 22 : 624 633.
-
(2004)
J Clin Oncol
, vol.22
, pp. 624-633
-
-
Frohling, S.1
Schlenk, R.F.2
Stolze, I.3
Bihlmayr, J.4
Benner, A.5
Kreitmeier, S.6
Tobis, K.7
Dohner, H.8
Dohner, K.9
-
6
-
-
42949142189
-
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
-
Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008 358 : 1909 1918.
-
(2008)
N Engl J Med
, vol.358
, pp. 1909-1918
-
-
Schlenk, R.F.1
Dohner, K.2
Krauter, J.3
-
7
-
-
47349131797
-
Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia
-
Grubach L, Juhl-Christensen C, Rethmeier A, Olesen LH, Aggerholm A, Hokland P, Ostergaard M. Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia. Eur J Haematol 2008 81 : 112 122.
-
(2008)
Eur J Haematol
, vol.81
, pp. 112-122
-
-
Grubach, L.1
Juhl-Christensen, C.2
Rethmeier, A.3
Olesen, L.H.4
Aggerholm, A.5
Hokland, P.6
Ostergaard, M.7
-
8
-
-
33846582947
-
The role of HOX genes in malignant myeloid disease
-
Eklund EA. The role of HOX genes in malignant myeloid disease. Curr Opin Hematol 2007 14 : 85 9.
-
(2007)
Curr Opin Hematol
, vol.14
, pp. 85-9
-
-
Eklund, E.A.1
-
9
-
-
0028079924
-
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells
-
Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A 1994 91 : 12223 12227.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 12223-12227
-
-
Sauvageau, G.1
Lansdorp, P.M.2
Eaves, C.J.3
Hogge, D.E.4
Dragowska, W.H.5
Reid, D.S.6
Largman, C.7
Lawrence, H.J.8
Humphries, R.K.9
-
10
-
-
0037732933
-
Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
-
Debernardi S, Lillington DM, Chaplin T, Tomlinson S, Amess J, Rohatiner A, Lister TA, Young BD. Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events. Genes Chromosomes Cancer 2003 37 : 149 158.
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 149-158
-
-
Debernardi, S.1
Lillington, D.M.2
Chaplin, T.3
Tomlinson, S.4
Amess, J.5
Rohatiner, A.6
Lister, T.A.7
Young, B.D.8
-
11
-
-
0029379593
-
The specificity of homeotic gene function
-
Mann RS. The specificity of homeotic gene function. BioEssays 1995 17 : 855 863.
-
(1995)
BioEssays
, vol.17
, pp. 855-863
-
-
Mann, R.S.1
-
12
-
-
0030848853
-
AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
-
Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol 1997 17 : 6448 6458.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6448-6458
-
-
Shen, W.F.1
Montgomery, J.C.2
Rozenfeld, S.3
Moskow, J.J.4
Lawrence, H.J.5
Buchberg, A.M.6
Largman, C.7
-
13
-
-
0032126633
-
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
-
Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998 17 : 3714 3725.
-
(1998)
EMBO J
, vol.17
, pp. 3714-3725
-
-
Kroon, E.1
Krosl, J.2
Thorsteinsdottir, U.3
Baban, S.4
Buchberg, A.M.5
Sauvageau, G.6
-
14
-
-
0034747741
-
Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia
-
Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G. Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol 2001 21 : 224 234.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 224-234
-
-
Thorsteinsdottir, U.1
Kroon, E.2
Jerome, L.3
Blasi, F.4
Sauvageau, G.5
-
15
-
-
0142153982
-
Profiling aberrant DNA methylation in hematologic neoplasms: A view from the tip of the iceberg
-
Esteller M. Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg. Clin Immunol 2003 109 : 80 8.
-
(2003)
Clin Immunol
, vol.109
, pp. 80-8
-
-
Esteller, M.1
-
16
-
-
33644878393
-
Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
-
Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P. Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 2006 76 : 23 32.
-
(2006)
Eur J Haematol
, vol.76
, pp. 23-32
-
-
Aggerholm, A.1
Holm, M.S.2
Guldberg, P.3
Olesen, L.H.4
Hokland, P.5
-
17
-
-
60849089645
-
Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
-
Jiang Y, Dunbar A, Gondek LP, Mohan S, Rataul M, O'Keefe C, Saunthararajah Y, Maciejewski JP. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 2009 113 : 1315 1325.
-
(2009)
Blood
, vol.113
, pp. 1315-1325
-
-
Jiang, Y.1
Dunbar, A.2
Gondek, L.P.3
Mohan, S.4
Rataul, M.5
O'Keefe, C.6
Saunthararajah, Y.7
MacIejewski, J.P.8
-
18
-
-
3142733632
-
MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias
-
Lasa A, Carnicer MJ, Aventin A, Estivill C, Brunet S, Sierra J, Nomdedeu JF. MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. Leukemia 2004 18 : 1231 1237.
-
(2004)
Leukemia
, vol.18
, pp. 1231-1237
-
-
Lasa, A.1
Carnicer, M.J.2
Aventin, A.3
Estivill, C.4
Brunet, S.5
Sierra, J.6
Nomdedeu, J.F.7
-
19
-
-
34548819044
-
Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis
-
Strathdee G, Holyoake TL, Sim A, et al. Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis. Clin Cancer Res 2007 13 : 5048 5055.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5048-5055
-
-
Strathdee, G.1
Holyoake, T.L.2
Sim, A.3
-
20
-
-
0032724360
-
Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript
-
Pallisgaard N, Clausen N, Schroder H, Hokland P. Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript. Genes Chromosomes Cancer 1999 26 : 355 365.
-
(1999)
Genes Chromosomes Cancer
, vol.26
, pp. 355-365
-
-
Pallisgaard, N.1
Clausen, N.2
Schroder, H.3
Hokland, P.4
-
21
-
-
1442323788
-
Bisulfite conversion of genomic DNA for methylation analysis: Protocol simplification with higher recovery applicable to limited samples and increased throughput
-
Boyd VL, Zon G. Bisulfite conversion of genomic DNA for methylation analysis: protocol simplification with higher recovery applicable to limited samples and increased throughput. Anal Biochem 2004 326 : 278 280.
-
(2004)
Anal Biochem
, vol.326
, pp. 278-280
-
-
Boyd, V.L.1
Zon, G.2
-
22
-
-
0038556900
-
Validation and clinical implication of a quantitative real-time PCR determination of MDR1 gene expression: Comparison with semi-quantitative PCR in 101 patients with acute myeloid leukemia
-
Olesen LH, Norgaard JM, Pallisgaard N, Bukh A, Hokland P. Validation and clinical implication of a quantitative real-time PCR determination of MDR1 gene expression: comparison with semi-quantitative PCR in 101 patients with acute myeloid leukemia. Eur J Haematol 2003 70 : 296 303.
-
(2003)
Eur J Haematol
, vol.70
, pp. 296-303
-
-
Olesen, L.H.1
Norgaard, J.M.2
Pallisgaard, N.3
Bukh, A.4
Hokland, P.5
-
23
-
-
9144271651
-
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - A Europe against cancer program
-
Beillard E, Pallisgaard N, van der Velden VH, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia 2003 17 : 2474 2486.
-
(2003)
Leukemia
, vol.17
, pp. 2474-2486
-
-
Beillard, E.1
Pallisgaard, N.2
Van Der Velden, V.H.3
-
24
-
-
0034949862
-
In-tube DNA methylation profiling by fluorescence melting curve analysis
-
Worm J, Aggerholm A, Guldberg P. In-tube DNA methylation profiling by fluorescence melting curve analysis. Clin Chem 2001 47 : 1183 1189.
-
(2001)
Clin Chem
, vol.47
, pp. 1183-1189
-
-
Worm, J.1
Aggerholm, A.2
Guldberg, P.3
-
25
-
-
10744229578
-
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
-
Hisa T, Spence SE, Rachel RA, et al. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J 2004 23 : 450 459.
-
(2004)
EMBO J
, vol.23
, pp. 450-459
-
-
Hisa, T.1
Spence, S.E.2
Rachel, R.A.3
-
26
-
-
0033036185
-
Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
-
Jacobs Y, Schnabel CA, Cleary ML. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol 1999 19 : 5134 5142.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5134-5142
-
-
Jacobs, Y.1
Schnabel, C.A.2
Cleary, M.L.3
-
27
-
-
2442575665
-
Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential
-
Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler PS, Tapscott SJ. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell 2004 14 : 465 477.
-
(2004)
Mol Cell
, vol.14
, pp. 465-477
-
-
Berkes, C.A.1
Bergstrom, D.A.2
Penn, B.H.3
Seaver, K.J.4
Knoepfler, P.S.5
Tapscott, S.J.6
-
28
-
-
3142743933
-
TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1
-
Rave-Harel N, Givens ML, Nelson SB, Duong HA, Coss D, Clark ME, Hall SB, Kamps MP, Mellon PL. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem 2004 279 : 30287 30297.
-
(2004)
J Biol Chem
, vol.279
, pp. 30287-30297
-
-
Rave-Harel, N.1
Givens, M.L.2
Nelson, S.B.3
Duong, H.A.4
Coss, D.5
Clark, M.E.6
Hall, S.B.7
Kamps, M.P.8
Mellon, P.L.9
-
29
-
-
0037179716
-
Active genes are tri-methylated at K4 of histone H3
-
Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T. Active genes are tri-methylated at K4 of histone H3. Nature 2002 419 : 407 411.
-
(2002)
Nature
, vol.419
, pp. 407-411
-
-
Santos-Rosa, H.1
Schneider, R.2
Bannister, A.J.3
Sherriff, J.4
Bernstein, B.E.5
Emre, N.C.6
Schreiber, S.L.7
Mellor, J.8
Kouzarides, T.9
-
30
-
-
23044459136
-
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
-
Alcalay M, Tiacci E, Bergomas R, et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood 2005 106 : 899 902.
-
(2005)
Blood
, vol.106
, pp. 899-902
-
-
Alcalay, M.1
Tiacci, E.2
Bergomas, R.3
-
31
-
-
41649119008
-
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
-
Garzon R, Garofalo M, Martelli MP, et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A 2008 105 : 3945 3950.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3945-3950
-
-
Garzon, R.1
Garofalo, M.2
Martelli, M.P.3
-
32
-
-
45149088440
-
Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations
-
Cilloni D, Messa F, Rosso V, et al. Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations. Leukemia 2008 22 : 1234 1240.
-
(2008)
Leukemia
, vol.22
, pp. 1234-1240
-
-
Cilloni, D.1
Messa, F.2
Rosso, V.3
-
33
-
-
41349103438
-
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia
-
Liu S, Liu Z, Xie Z, et al. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood 2008 111 : 2364 2373.
-
(2008)
Blood
, vol.111
, pp. 2364-2373
-
-
Liu, S.1
Liu, Z.2
Xie, Z.3
|