메뉴 건너뛰기




Volumn 83, Issue 5, 2009, Pages 439-448

The combined expression of HOXA4 and MEIS1 is an independent prognostic factor in patients with AML

Author keywords

Acute myeloid leukaemia; Epigenetics; Hox; Meis; Promoter methylation; Treatment outcome

Indexed keywords

CD135 ANTIGEN; GENOMIC DNA; HOX PROTEIN; HOXA 4 PROTEIN; MEIS 1 PROTEIN; NUCLEOPHOSMIN; REGULATOR PROTEIN; RNA; UNCLASSIFIED DRUG;

EID: 70349973619     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01309.x     Document Type: Article
Times cited : (31)

References (33)
  • 1
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial. the Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998 92 : 2322 2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 2
    • 33644798659 scopus 로고    scopus 로고
    • Molecular typing of adult acute myeloid leukaemia: Significance of translocations, tandem duplications, methylation, and selective gene expression profiling
    • Olesen LH, Aggerholm A, Andersen BL, Nyvold CG, Guldberg P, Norgaard JM, Hokland P. Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profiling. Br J Haematol 2005 131 : 457 467.
    • (2005) Br J Haematol , vol.131 , pp. 457-467
    • Olesen, L.H.1    Aggerholm, A.2    Andersen, B.L.3    Nyvold, C.G.4    Guldberg, P.5    Norgaard, J.M.6    Hokland, P.7
  • 5
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Frohling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, Kreitmeier S, Tobis K, Dohner H, Dohner K. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol 2004 22 : 624 633.
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3    Bihlmayr, J.4    Benner, A.5    Kreitmeier, S.6    Tobis, K.7    Dohner, H.8    Dohner, K.9
  • 6
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008 358 : 1909 1918.
    • (2008) N Engl J Med , vol.358 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 8
    • 33846582947 scopus 로고    scopus 로고
    • The role of HOX genes in malignant myeloid disease
    • Eklund EA. The role of HOX genes in malignant myeloid disease. Curr Opin Hematol 2007 14 : 85 9.
    • (2007) Curr Opin Hematol , vol.14 , pp. 85-9
    • Eklund, E.A.1
  • 10
    • 0037732933 scopus 로고    scopus 로고
    • Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
    • Debernardi S, Lillington DM, Chaplin T, Tomlinson S, Amess J, Rohatiner A, Lister TA, Young BD. Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events. Genes Chromosomes Cancer 2003 37 : 149 158.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 149-158
    • Debernardi, S.1    Lillington, D.M.2    Chaplin, T.3    Tomlinson, S.4    Amess, J.5    Rohatiner, A.6    Lister, T.A.7    Young, B.D.8
  • 11
    • 0029379593 scopus 로고
    • The specificity of homeotic gene function
    • Mann RS. The specificity of homeotic gene function. BioEssays 1995 17 : 855 863.
    • (1995) BioEssays , vol.17 , pp. 855-863
    • Mann, R.S.1
  • 13
    • 0032126633 scopus 로고    scopus 로고
    • Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
    • Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998 17 : 3714 3725.
    • (1998) EMBO J , vol.17 , pp. 3714-3725
    • Kroon, E.1    Krosl, J.2    Thorsteinsdottir, U.3    Baban, S.4    Buchberg, A.M.5    Sauvageau, G.6
  • 14
  • 15
    • 0142153982 scopus 로고    scopus 로고
    • Profiling aberrant DNA methylation in hematologic neoplasms: A view from the tip of the iceberg
    • Esteller M. Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg. Clin Immunol 2003 109 : 80 8.
    • (2003) Clin Immunol , vol.109 , pp. 80-8
    • Esteller, M.1
  • 16
    • 33644878393 scopus 로고    scopus 로고
    • Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
    • Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P. Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 2006 76 : 23 32.
    • (2006) Eur J Haematol , vol.76 , pp. 23-32
    • Aggerholm, A.1    Holm, M.S.2    Guldberg, P.3    Olesen, L.H.4    Hokland, P.5
  • 18
    • 3142733632 scopus 로고    scopus 로고
    • MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias
    • Lasa A, Carnicer MJ, Aventin A, Estivill C, Brunet S, Sierra J, Nomdedeu JF. MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. Leukemia 2004 18 : 1231 1237.
    • (2004) Leukemia , vol.18 , pp. 1231-1237
    • Lasa, A.1    Carnicer, M.J.2    Aventin, A.3    Estivill, C.4    Brunet, S.5    Sierra, J.6    Nomdedeu, J.F.7
  • 19
    • 34548819044 scopus 로고    scopus 로고
    • Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis
    • Strathdee G, Holyoake TL, Sim A, et al. Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis. Clin Cancer Res 2007 13 : 5048 5055.
    • (2007) Clin Cancer Res , vol.13 , pp. 5048-5055
    • Strathdee, G.1    Holyoake, T.L.2    Sim, A.3
  • 20
    • 0032724360 scopus 로고    scopus 로고
    • Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript
    • Pallisgaard N, Clausen N, Schroder H, Hokland P. Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript. Genes Chromosomes Cancer 1999 26 : 355 365.
    • (1999) Genes Chromosomes Cancer , vol.26 , pp. 355-365
    • Pallisgaard, N.1    Clausen, N.2    Schroder, H.3    Hokland, P.4
  • 21
    • 1442323788 scopus 로고    scopus 로고
    • Bisulfite conversion of genomic DNA for methylation analysis: Protocol simplification with higher recovery applicable to limited samples and increased throughput
    • Boyd VL, Zon G. Bisulfite conversion of genomic DNA for methylation analysis: protocol simplification with higher recovery applicable to limited samples and increased throughput. Anal Biochem 2004 326 : 278 280.
    • (2004) Anal Biochem , vol.326 , pp. 278-280
    • Boyd, V.L.1    Zon, G.2
  • 22
    • 0038556900 scopus 로고    scopus 로고
    • Validation and clinical implication of a quantitative real-time PCR determination of MDR1 gene expression: Comparison with semi-quantitative PCR in 101 patients with acute myeloid leukemia
    • Olesen LH, Norgaard JM, Pallisgaard N, Bukh A, Hokland P. Validation and clinical implication of a quantitative real-time PCR determination of MDR1 gene expression: comparison with semi-quantitative PCR in 101 patients with acute myeloid leukemia. Eur J Haematol 2003 70 : 296 303.
    • (2003) Eur J Haematol , vol.70 , pp. 296-303
    • Olesen, L.H.1    Norgaard, J.M.2    Pallisgaard, N.3    Bukh, A.4    Hokland, P.5
  • 23
    • 9144271651 scopus 로고    scopus 로고
    • Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - A Europe against cancer program
    • Beillard E, Pallisgaard N, van der Velden VH, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia 2003 17 : 2474 2486.
    • (2003) Leukemia , vol.17 , pp. 2474-2486
    • Beillard, E.1    Pallisgaard, N.2    Van Der Velden, V.H.3
  • 24
    • 0034949862 scopus 로고    scopus 로고
    • In-tube DNA methylation profiling by fluorescence melting curve analysis
    • Worm J, Aggerholm A, Guldberg P. In-tube DNA methylation profiling by fluorescence melting curve analysis. Clin Chem 2001 47 : 1183 1189.
    • (2001) Clin Chem , vol.47 , pp. 1183-1189
    • Worm, J.1    Aggerholm, A.2    Guldberg, P.3
  • 25
    • 10744229578 scopus 로고    scopus 로고
    • Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
    • Hisa T, Spence SE, Rachel RA, et al. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J 2004 23 : 450 459.
    • (2004) EMBO J , vol.23 , pp. 450-459
    • Hisa, T.1    Spence, S.E.2    Rachel, R.A.3
  • 26
    • 0033036185 scopus 로고    scopus 로고
    • Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
    • Jacobs Y, Schnabel CA, Cleary ML. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol 1999 19 : 5134 5142.
    • (1999) Mol Cell Biol , vol.19 , pp. 5134-5142
    • Jacobs, Y.1    Schnabel, C.A.2    Cleary, M.L.3
  • 27
    • 2442575665 scopus 로고    scopus 로고
    • Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential
    • Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler PS, Tapscott SJ. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell 2004 14 : 465 477.
    • (2004) Mol Cell , vol.14 , pp. 465-477
    • Berkes, C.A.1    Bergstrom, D.A.2    Penn, B.H.3    Seaver, K.J.4    Knoepfler, P.S.5    Tapscott, S.J.6
  • 30
    • 23044459136 scopus 로고    scopus 로고
    • Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
    • Alcalay M, Tiacci E, Bergomas R, et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood 2005 106 : 899 902.
    • (2005) Blood , vol.106 , pp. 899-902
    • Alcalay, M.1    Tiacci, E.2    Bergomas, R.3
  • 31
    • 41649119008 scopus 로고    scopus 로고
    • Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
    • Garzon R, Garofalo M, Martelli MP, et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A 2008 105 : 3945 3950.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3945-3950
    • Garzon, R.1    Garofalo, M.2    Martelli, M.P.3
  • 32
    • 45149088440 scopus 로고    scopus 로고
    • Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations
    • Cilloni D, Messa F, Rosso V, et al. Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations. Leukemia 2008 22 : 1234 1240.
    • (2008) Leukemia , vol.22 , pp. 1234-1240
    • Cilloni, D.1    Messa, F.2    Rosso, V.3
  • 33
    • 41349103438 scopus 로고    scopus 로고
    • Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia
    • Liu S, Liu Z, Xie Z, et al. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood 2008 111 : 2364 2373.
    • (2008) Blood , vol.111 , pp. 2364-2373
    • Liu, S.1    Liu, Z.2    Xie, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.