메뉴 건너뛰기




Volumn 14, Issue 2, 2007, Pages 85-89

The role of HOX genes in malignant myeloid disease

Author keywords

Gene transcription; Hox; Leukemogenesis; Myelopoiesis

Indexed keywords

GENE PRODUCT; HOMEODOMAIN PROTEIN; HOX PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MEIS; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

EID: 33846582947     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e32801684b6     Document Type: Review
Times cited : (79)

References (44)
  • 1
    • 0021717658 scopus 로고
    • Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila
    • Levine M, Rubin GM, Tjian R. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. Cell 1984; 38:667-673.
    • (1984) Cell , vol.38 , pp. 667-673
    • Levine, M.1    Rubin, G.M.2    Tjian, R.3
  • 3
    • 0024341769 scopus 로고
    • The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
    • Duboule E, Dolle P. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J 1989; 8:1497-1505.
    • (1989) EMBO J , vol.8 , pp. 1497-1505
    • Duboule, E.1    Dolle, P.2
  • 4
    • 0024592814 scopus 로고
    • Homologous gene clusters in insects and vertebrates
    • and HOM
    • Akam M. HOX and HOM: Homologous gene clusters in insects and vertebrates. Cell 1989; 57:347-349.
    • (1989) Cell , vol.57 , pp. 347-349
    • Akam, M.H.1
  • 5
    • 0028079924 scopus 로고
    • Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells
    • Sauvageau G, Lansdorp PM, Caves CJ, et al. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A 1994; 91:12223-12227.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12223-12227
    • Sauvageau, G.1    Lansdorp, P.M.2    Caves, C.J.3
  • 6
    • 0026692921 scopus 로고
    • Identification of homeobox-containing genes expressed in hematopoietic blast cells
    • Vieille-Grosjean I, Roullot V, Courtos G. Identification of homeobox-containing genes expressed in hematopoietic blast cells. Biochem Biophys Res Commun 1992; 185:785-792.
    • (1992) Biochem Biophys Res Commun , vol.185 , pp. 785-792
    • Vieille-Grosjean, I.1    Roullot, V.2    Courtos, G.3
  • 7
    • 0027981631 scopus 로고
    • Identification of homeobox gene expressed in human haemopoietic progenitor cells
    • Moretti P, Simmons P, Thomas P, et al. Identification of homeobox gene expressed in human haemopoietic progenitor cells. Gene 1994; 144:213-219.
    • (1994) Gene , vol.144 , pp. 213-219
    • Moretti, P.1    Simmons, P.2    Thomas, P.3
  • 8
    • 0029091845 scopus 로고
    • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
    • Sauvageau G, Thorsteinsdottir U, Eaves CJ, et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995; 9:1753-1765.
    • (1995) Genes Dev , vol.9 , pp. 1753-1765
    • Sauvageau, G.1    Thorsteinsdottir, U.2    Eaves, C.J.3
  • 9
    • 0032981197 scopus 로고    scopus 로고
    • Expression of HOX genes, HOX cofactors and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells
    • Kawagoe H, Humphries RK, Blair A, et al. Expression of HOX genes, HOX cofactors and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia 1999; 13:687-698.
    • (1999) Leukemia , vol.13 , pp. 687-698
    • Kawagoe, H.1    Humphries, R.K.2    Blair, A.3
  • 10
    • 0036173289 scopus 로고    scopus 로고
    • Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia
    • Drabkin HA, Parsy C, Gerguson K, et al. Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia. Leukemia 2002; 16:186-195.
    • (2002) Leukemia , vol.16 , pp. 186-195
    • Drabkin, H.A.1    Parsy, C.2    Gerguson, K.3
  • 11
    • 0027463832 scopus 로고
    • Characteristic patterns of HOX gene expression in different types of human leukemia
    • Celetti A, Barba P, Cillo C, et al. Characteristic patterns of HOX gene expression in different types of human leukemia. Int J Cancer 1993; 53:237-244.
    • (1993) Int J Cancer , vol.53 , pp. 237-244
    • Celetti, A.1    Barba, P.2    Cillo, C.3
  • 12
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286:531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 13
    • 2942653221 scopus 로고    scopus 로고
    • Hox expression in AML identified a distinct subset of patients with intermediate cytogenetics
    • Riche J, Zeng C, Baron A, et al. Hox expression in AML identified a distinct subset of patients with intermediate cytogenetics. Leukemia 2004; 18:1059-1063.
    • (2004) Leukemia , vol.18 , pp. 1059-1063
    • Riche, J.1    Zeng, C.2    Baron, A.3
  • 14
    • 0030942488 scopus 로고    scopus 로고
    • Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
    • Lawrence HJ, Helgason CD, Sauvageau G, et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 1997; 89:1922-1930.
    • (1997) Blood , vol.89 , pp. 1922-1930
    • Lawrence, H.J.1    Helgason, C.D.2    Sauvageau, G.3
  • 15
    • 0034000574 scopus 로고    scopus 로고
    • HoxA9 immortalizes a granulocyte macrophage colony stimulating factor dependant promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages independent of enforced Meis expression
    • Calvo KR, Sykes DB, Pasillas M, Kamps MP. HoxA9 immortalizes a granulocyte macrophage colony stimulating factor dependant promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages independent of enforced Meis expression. Mol Cell Biol 2000; 20:3274-3285.
    • (2000) Mol Cell Biol , vol.20 , pp. 3274-3285
    • Calvo, K.R.1    Sykes, D.B.2    Pasillas, M.3    Kamps, M.P.4
  • 16
    • 0035871680 scopus 로고    scopus 로고
    • Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
    • Buske C, Feuring-Buske M, Antonchuk J, et al. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood 2001; 97:2286-2292.
    • (2001) Blood , vol.97 , pp. 2286-2292
    • Buske, C.1    Feuring-Buske, M.2    Antonchuk, J.3
  • 17
    • 20844443663 scopus 로고    scopus 로고
    • Guenther MG, Jenner RG, Chevalier B, et al. Global and hox-specific roles for the MLL1 methyltransferase. PNAS 2005; 102:8603-8608. This study uses in-vivo and in-vitro techniques to localize sites of MLL binding in the promoters of ABD HOXA genes.
    • Guenther MG, Jenner RG, Chevalier B, et al. Global and hox-specific roles for the MLL1 methyltransferase. PNAS 2005; 102:8603-8608. This study uses in-vivo and in-vitro techniques to localize sites of MLL binding in the promoters of ABD HOXA genes.
  • 18
    • 0025833975 scopus 로고
    • Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
    • Ziemin-van der Poel S, McCabe NR, Gill HJ, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A 1991; 88:10735-10739.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10735-10739
    • Ziemin-van der Poel, S.1    McCabe, N.R.2    Gill, H.J.3
  • 19
    • 0026936328 scopus 로고
    • A trithorax like gene is interrupted by chromosome 11q23 translocation in acute leukaemias
    • Djabali M, Selleri L, Parry P, et al. A trithorax like gene is interrupted by chromosome 11q23 translocation in acute leukaemias. Nat Genet 1992; 2:113-118.
    • (1992) Nat Genet , vol.2 , pp. 113-118
    • Djabali, M.1    Selleri, L.2    Parry, P.3
  • 20
    • 18744373853 scopus 로고    scopus 로고
    • MLL targets SET domain methyltransferase activity of HOX gene promoters
    • Milne TA, Briggs SD, Brock HW, et al. MLL targets SET domain methyltransferase activity of HOX gene promoters. Mol Cell 2002; 10:1107-1117.
    • (2002) Mol Cell , vol.10 , pp. 1107-1117
    • Milne, T.A.1    Briggs, S.D.2    Brock, H.W.3
  • 22
    • 9244257908 scopus 로고    scopus 로고
    • An MLL-dependant HOX program drives hematopoietic progenitor expansion
    • Ernst P, Mabon M, Davidson AJ, et al. An MLL-dependant HOX program drives hematopoietic progenitor expansion. Current Biol 2004; 14:2063-2069.
    • (2004) Current Biol , vol.14 , pp. 2063-2069
    • Ernst, P.1    Mabon, M.2    Davidson, A.J.3
  • 23
    • 0038240453 scopus 로고    scopus 로고
    • Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: Dominance of HOX dysregulation
    • Ferrando AA, Armstrong SA, Neuberg DS, et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003; 102:262-268.
    • (2003) Blood , vol.102 , pp. 262-268
    • Ferrando, A.A.1    Armstrong, S.A.2    Neuberg, D.S.3
  • 24
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30:41-47.
    • (2002) Nat Genet , vol.30 , pp. 41-47
    • Armstrong, S.A.1    Staunton, J.E.2    Silverman, L.B.3
  • 25
    • 0034282527 scopus 로고    scopus 로고
    • Chromatin related properties of CBP fused to MLL generate a myelodysplastic like syndrome that evolves into myeloid leukemia
    • Lavau C, Du C, Thirman M, Zeleznik-Le N. Chromatin related properties of CBP fused to MLL generate a myelodysplastic like syndrome that evolves into myeloid leukemia. EMBO J 2000; 19:4655-4664.
    • (2000) EMBO J , vol.19 , pp. 4655-4664
    • Lavau, C.1    Du, C.2    Thirman, M.3    Zeleznik-Le, N.4
  • 26
    • 0034928761 scopus 로고    scopus 로고
    • The elongation domain of ELL is dispensable, but its ELL associated factor 1 interaction domain is essential for MLL-ELL induced leukemogenesis
    • Luo RT, Lavau C, Du. C, et al. The elongation domain of ELL is dispensable, but its ELL associated factor 1 interaction domain is essential for MLL-ELL induced leukemogenesis. Mol Cell Biol 2001; 21:5678-5687.
    • (2001) Mol Cell Biol , vol.21 , pp. 5678-5687
    • Luo, R.T.1    Lavau, C.2    Du, C.3
  • 27
    • 0034718552 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
    • Lavau C, Luo RT, Cu C, Thirman MJ. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Proc Natl Acad Sci U S A 2000; 26:10984-10989.
    • (2000) Proc Natl Acad Sci U S A , vol.26 , pp. 10984-10989
    • Lavau, C.1    Luo, R.T.2    Cu, C.3    Thirman, M.J.4
  • 28
    • 0032126633 scopus 로고    scopus 로고
    • HoxA9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
    • Kroon E, Krosl J, Thorsteinsdottir U, et al. HoxA9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998; 17:3714-3725.
    • (1998) EMBO J , vol.17 , pp. 3714-3725
    • Kroon, E.1    Krosl, J.2    Thorsteinsdottir, U.3
  • 29
    • 0036090290 scopus 로고    scopus 로고
    • Overexpression of the myeloid leukemia associated HoxA9 gene in bone marrow cells induces stem cell expansion
    • Thorsteinsdottir U, Mamo A, Kroon E, et al. Overexpression of the myeloid leukemia associated HoxA9 gene in bone marrow cells induces stem cell expansion. Blood 2002; 99:121-129.
    • (2002) Blood , vol.99 , pp. 121-129
    • Thorsteinsdottir, U.1    Mamo, A.2    Kroon, E.3
  • 30
    • 0034747741 scopus 로고    scopus 로고
    • Defining roles of HOX and MEIS1 genes in induction of acutemyeloid leukemia
    • Thorsteinsdottir U, Kroon E, Jerome L, et al. Defining roles of HOX and MEIS1 genes in induction of acutemyeloid leukemia. Mol Cell Biol 2001; 21:224-234.
    • (2001) Mol Cell Biol , vol.21 , pp. 224-234
    • Thorsteinsdottir, U.1    Kroon, E.2    Jerome, L.3
  • 31
    • 0031031880 scopus 로고    scopus 로고
    • Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia
    • Thorsteinsdottir U, Sauvageau G, Hough MR, et al. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol 1997; 17:495-505.
    • (1997) Mol Cell Biol , vol.17 , pp. 495-505
    • Thorsteinsdottir, U.1    Sauvageau, G.2    Hough, M.R.3
  • 32
    • 27144505698 scopus 로고    scopus 로고
    • Continuous MLL-ENL expression is necessary to establish a Hox code and maintain immortalization of hematopoietic progenitor cells
    • This study used an inducible murine model to demonstrate that aberrant HOX gene expression in differentiating myeloid progenitors requires sustained expression of MLL-fusion proteins in these cells
    • Horton SJ, Grier DG, McGonigle GJ, et al. Continuous MLL-ENL expression is necessary to establish a Hox code and maintain immortalization of hematopoietic progenitor cells. Cancer Res 2005; 65:9245-9252. This study used an inducible murine model to demonstrate that aberrant HOX gene expression in differentiating myeloid progenitors requires sustained expression of MLL-fusion proteins in these cells.
    • (2005) Cancer Res , vol.65 , pp. 9245-9252
    • Horton, S.J.1    Grier, D.G.2    McGonigle, G.J.3
  • 33
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependant on HoxA7 and HoxA9
    • Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependant on HoxA7 and HoxA9. Genes and Dev 2003; 17: 2298-2307.
    • (2003) Genes and Dev , vol.17 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 34
    • 85117739194 scopus 로고    scopus 로고
    • So CW, Karsunky H, Wong P, et al. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of HoxA7 or HoxA9. Blood 2005; 103:3192-3199. In this study committed myeloid progenitors from HoxA7 deficient, HoxA9 deficient or HoxA7 and A9 deficient mice were transduced with a vector to express the MLL-GAS7 fusion protein. Mice transplanted with this bone marrow develop AML in a similar manner to experiments with wild type bone marrow transduced with this construct.
    • So CW, Karsunky H, Wong P, et al. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of HoxA7 or HoxA9. Blood 2005; 103:3192-3199. In this study committed myeloid progenitors from HoxA7 deficient, HoxA9 deficient or HoxA7 and A9 deficient mice were transduced with a vector to express the MLL-GAS7 fusion protein. Mice transplanted with this bone marrow develop AML in a similar manner to experiments with wild type bone marrow transduced with this construct.
  • 35
    • 1442356858 scopus 로고    scopus 로고
    • HoxA9 influences the phenotype but not incidence of MLL-AF9 fusion gene leukemia
    • Kumar AR, Hudson WA, Chen W, et al. HoxA9 influences the phenotype but not incidence of MLL-AF9 fusion gene leukemia. Blood 2004; 103:1823-1828.
    • (2004) Blood , vol.103 , pp. 1823-1828
    • Kumar, A.R.1    Hudson, W.A.2    Chen, W.3
  • 36
    • 0028084756 scopus 로고
    • Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations
    • Caligiuri MA, Schichman SA, Strout MP, et al. Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations. Cancer Res 1994; 54:370-373.
    • (1994) Cancer Res , vol.54 , pp. 370-373
    • Caligiuri, M.A.1    Schichman, S.A.2    Strout, M.P.3
  • 37
    • 0032519826 scopus 로고    scopus 로고
    • Detection of unique ALL1 (MLL) fusion transcripots in normal human bone marrow and blood: Distinct origin of normal versus leukemic ALL1 fusion transcripts
    • Marcucci G, Strout MP, Bloomfield CD, Caligiuri MA. Detection of unique ALL1 (MLL) fusion transcripots in normal human bone marrow and blood: distinct origin of normal versus leukemic ALL1 fusion transcripts. Cancer Res 1998; 58:790-793.
    • (1998) Cancer Res , vol.58 , pp. 790-793
    • Marcucci, G.1    Strout, M.P.2    Bloomfield, C.D.3    Caligiuri, M.A.4
  • 38
    • 33746882054 scopus 로고    scopus 로고
    • Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;q13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression
    • This study identified a novel leukemia associated chromosomal translocation which is associated with dysregulated HOX gene expression
    • Camos M, Esteve J, Jares P, et al. Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;q13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression. Cancer Res 2006; 66:6947-6954. This study identified a novel leukemia associated chromosomal translocation which is associated with dysregulated HOX gene expression.
    • (2006) Cancer Res , vol.66 , pp. 6947-6954
    • Camos, M.1    Esteve, J.2    Jares, P.3
  • 39
    • 9044241254 scopus 로고    scopus 로고
    • Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosomal translocation t(7;11)(p15;p15) in human myeloid leukemia
    • Nakamura T, Largaespada DA, Lee MP, et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosomal translocation t(7;11)(p15;p15) in human myeloid leukemia. Nat Genet 1996; 12:154-158.
    • (1996) Nat Genet , vol.12 , pp. 154-158
    • Nakamura, T.1    Largaespada, D.A.2    Lee, M.P.3
  • 40
    • 9044249724 scopus 로고    scopus 로고
    • The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
    • Borrow J, Shearman AM, Stanton VP, et al. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet 1996; 12:159-167.
    • (1996) Nat Genet , vol.12 , pp. 159-167
    • Borrow, J.1    Shearman, A.M.2    Stanton, V.P.3
  • 41
    • 0032731168 scopus 로고    scopus 로고
    • Molecular heterogeneity of the NUP98/ HOXA9 fusion transcript in myelodysplastic syndromes associated with t(7;11)(p15;p15)
    • Hatano Y, Miura I, Nakamura T, et al. Molecular heterogeneity of the NUP98/ HOXA9 fusion transcript in myelodysplastic syndromes associated with t(7;11)(p15;p15). Brit J Haem 1999; 107:600-604.
    • (1999) Brit J Haem , vol.107 , pp. 600-604
    • Hatano, Y.1    Miura, I.2    Nakamura, T.3
  • 42
    • 0034121993 scopus 로고    scopus 로고
    • Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15)
    • Yamamoto K, Nakamura Y, Nakamura Y, Saito K, Furusawa. Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15). Br J Haematol 2000; 109:423-426.
    • (2000) Br J Haematol , vol.109 , pp. 423-426
    • Yamamoto, K.1    Nakamura, Y.2    Nakamura, Y.3    Saito, K.4    Furusawa5
  • 43
    • 0037142623 scopus 로고    scopus 로고
    • Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of HoxA9, HoxA7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of HoxA9 and Meis1
    • Calvo KR, Sykes DB, Pasillas MP, Kamps MP. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of HoxA9, HoxA7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of HoxA9 and Meis1. Oncogene 2002; 21:4247-4256.
    • (2002) Oncogene , vol.21 , pp. 4247-4256
    • Calvo, K.R.1    Sykes, D.B.2    Pasillas, M.P.3    Kamps, M.P.4
  • 44
    • 0035253860 scopus 로고    scopus 로고
    • Nup98-HOXA9 expression in hematopoietic stem cells induces chronic and acute myeloid leukemias in mice
    • Kroon E, Thorsteinsdottir U, Mayotte N, et al. Nup98-HOXA9 expression in hematopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J 2001; 20:350-361.
    • (2001) EMBO J , vol.20 , pp. 350-361
    • Kroon, E.1    Thorsteinsdottir, U.2    Mayotte, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.