Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: A comparative study in human hepatic cells and mesangial cells

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 3, 2007, Pages

  Chen, Yaxi ^a   Ruan, Xiong Z ^a,b   Li, Qiu ^a   Huang, Ailong ^a   Moorhead, John F ^b   Powis, Stephen H ^b   Varghese, Zac ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Hepatic cells; Inflammation; Kidney mesangial cells

Indexed keywords

COMPACTIN; CYTOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; STATINE DERIVATIVE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ARTICLE; CELL STRAIN HEPG2; CELL TYPE; CHOLESTEROL TRANSPORT; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEEDBACK SYSTEM; FOAM CELL; GENE EXPRESSION; GOLGI COMPLEX; HUMAN; HUMAN CELL; INFLAMMATION; LIVER CELL; MESANGIUM CELL; NEGATIVE FEEDBACK; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; TISSUE SPECIFICITY;

EID: 34548632934     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00209.2007     Document Type: Article

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