Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: Prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat

European Journal of Pain

Volumn 12, Issue 2, 2008, Pages 157-163

  Fernández Dueñas, Víctor ^a   Sánchez, Sílvia ^a   Planas, Eulàlia ^a   Poveda, Raquel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acetylsalicylic acid; Caffeine; Inflammation; Nociception; PGE 2; Synergy

Indexed keywords

ACETYLSALICYLIC ACID; CAFFEINE; CARRAGEENAN; PROSTAGLANDIN E2;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME IMMUNOASSAY; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CAFFEINE; CARRAGEENAN; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FOOT; INFLAMMATION; MALE; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 36549009555     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2007.03.485     Document Type: Article

References (38)

1. Abo-Salem O.M., Hayallah A.M., Bilkei-Gorzo A., Filipek B., Zimmer A., and Muller C.E. Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharm Exp Ther 308 (2003) 358-366
2. Bach P.H., Berndt W.O., Delzell E., Dubach U., Finn W.F., Fox J.M., et al. A safety assessment of fixed combinations of acetaminophen and acetylsalicylic acid, coformulated with caffeine. Ren Fail 20 (1998) 749-762
3. Camarasa J., Pubill D., and Escubedo E. Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. Brain Res 1111 (2006) 72-82
4. Castañeda-Hernandez G., Castillo-Mendez M.S., López-Munoz F.J., Granados-Soto V., and Flores-Murrieta F.J. Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat. Can J Physiol Pharmacol 72 (1994) 1127-1131
5. Díaz-Reval M.I., Ventura-Martínez R., Deciga-Campos M., and Terron J.A. Involvement of serotonin mechanisms in the antinociceptive effect of S({thorn})-Ketoprofen. Drug Dev Res 57 (2002) 187-192
6. Díaz-Reval M.I., Ventura-Martínez R., Hernandez-Delgadillo G.P., Dominguez-Ramirez A.M., and López-Munoz F.J. Effect of caffeine on antinociceptive action of ketoprofen in rats. Arch Med Res 32 (2001) 13-20
7. Diener H.C., Pfaffenrath V., Pageler L., Peil H., and Aicher B. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 25 (2005) 776-787
8. Engelhardt G., Mauz A.B., and Pairet M. Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology. Arzneimitteforschung 47 (1997) 917-927
9. 2a-receptors. Glia 18 (1996) 152-160
10. Fiebich B.L., Lieb K., Hull M., Aicher B., van R., Pairet M., et al. Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cells. Neuropharmacology 39 (2000) 2205-2213
11. Godfrey L., Yan L., Clarke G.D., Ledent C., Kitchen I., and Hourani S.M. Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice. Eur J Pharmacol 531 (2006) 80-86
12. Goldstein J., Silverstein S., Saper J.R., Ryan Jr. R.E., and Lipton R.B. Acetaminophen, aspirin and caffeine in combination versus ibuprophen for acute migraine: results from a multicenter, double-blind, randomized, parallel group, single-dose, placebo-controlled study. Headache 46 (2006) 444-453
13. Granados-Soto V., and Castañeda-Hernandez G. A review of the pharmacokinetic and pharmacodynamic factors in the potentiation of the antinociceptive effect of nonsteroidal anti-inflammatory drugs by caffeine. J Pharmacol Toxicol Meth 42 (1999) 67-72
14. Guay J., Bateman K., Gordon R., Mancini J., and Riendeau D. Carrageenan-induced paw oedema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. J Biol Chem 279 (2004) 24866-24872
15. Horrigan L.A., Kelly J.P., and Connor T.J. Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase. A pathway. Int Immunopharmacol 4 (2004) 1409-1417
16. López J.R., Domínguez-Ramírez A.M., Cook H.J., Bravo G., Díaz-Reval M.I., Déciga-Campos M., et al. Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats. Eur J Pharmacol 544 (2006) 31-38
17. Mercadante S., Serretta R., and Casuccio A. Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study. J Pain Symptom Manage 21 (2001) 369-372
18. Migliardi J.R., Armellino J.J., Friedman M., Gillings D.B., and Beaver W.T. Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 56 (1994) 576-586
19. Montesinos M.C., Yap J.S., Desai A., Posadas I., McCrary C.T., and Cronstein B.N. Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Arthritis Rheum 43 (2000) 656-663
20. Poveda R., Planas E., Pol O., Romero A., Sanchez S., and Puig M.M. Interaction between metamizol and tramadol in a model of acute visceral pain in rats. Eur J Pain 7 (2003) 439-448
21. Randall L.O., and Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111 4 (1957) 409-419
22. Romero A., Planas E., Poveda R., Sánchez S., Pol O., and Puig M.M. Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw. Eur J Pharmacol 511 (2005) 207-217
23. Sawynok J., and Yaksh T.L. Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacol Rev 45 (1993) 43-85
24. Sawynok J., Reid A.R., and Doak G.J. Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. Pain 61 (1995) 203-213
25. Sawynok J., and Liu X.J. Adenosine in the spinal cord and periphery: release and regulation of pain. Progress in neurobiology 69 (2003) 313-340
26. Tallarida R.J. Statistical analysis of drug combinations for synergism. Pain 49 (1992) 93-97
27. Tallarida R.J. Pharmatools Pro. Pharmacological Analysis Research Software (2001), Chapman & Hall/CRC Press, Boca Raton (FL)
28. Tallarida R.J. Drug synergism: its detection and applications. J Pharmacol Exp Ther 298 (2001) 865-872
29. Troster A., Sittl R., Singler B., Schmelz M., Schuttler J., and Koppert W. Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. Anesthesiology 105 (2006) 1016-1023
30. Ulcar R., Schuligoi R., Heinemann A., Santner B., and Amann R. Inhibition of prostaglandin biosynthesis in human endotoxin-stimulated peripheral blood monocytes: effects of caffeine. Pharmacology 67 (2003) 67-71
31. Vane J.R., Mitchell J.A., Appleton I., Tomlinson A., Bishop-Bailey D., and Croxtall J. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA 91 (1994) 2046-2050
32. Ventura-Martínez R., Deciga-Campos M., Díaz-Reval M.I., Gonzalez-Trujano M.E., and López-Munoz F.J. Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. Eur J Pharmacol 503 (2004) 43-48
33. Vinegar R., Truax J.F., Selph J.L., Welch R.M., White H.L., and Ellis C.H. Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat. Proc Soc Exp Biol Med 151 (1976) 556-560
34. Wu W.P., Hao J.X., Fredholm B.B., Wiesenfeld-Hallin Z., and Xu X.J. Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. Neurosci Lett 402 (2006) 164-166
35. Yaba G., Sezer Z., and Tekol Y. Interaction between venlafaxine and caffeine on antinociception in mice. Pharmazie 61 (2006) 60-62
36. Zhang Y., Shaffer A., Portanova J., Seibert K., and Isakson P.C. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. J Pharm Exper Ther 283 (1997) 1069-1075
37. Zhang W.Y. A benefit-risk assessment of caffeine as an analgesic adjuvant. Drug Saf 24 (2001) 1127-1142
38. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110