Separation of positional isomers of mono-poly(ethylene glycol)-modified octreotides by reversed-phase high-performance liquid chromatography

Journal of Chromatography A

Volumn 1216, Issue 45, 2009, Pages 7793-7797

  Park, Eun Ji ^a,b   Lee, Kang Choon ^b   Na, Dong Hee ^a  

^a Kyungsung University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Octreotide; PEGylation; Positional isomer; Reversed phase HPLC

Indexed keywords

CHROMATOGRAPHIC METHODS; DEGRADATION PRODUCTS; ENZYMATIC STABILITY; GRADIENT ELUTION; HIGH MOLECULAR WEIGHT; OCTREOTIDE; PEGYLATION; PHARMACOLOGICAL PROPERTIES; PHOSPHATE BUFFERS; POSITIONAL ISOMER; POSITIONAL ISOMERS; REVERSED PHASE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVERSED-PHASE HPLC; RP-HPLC; RP-HPLC METHOD; THERMAL STABILITY STUDIES;

ACETONITRILE; CHROMATOGRAPHIC ANALYSIS; DEGRADATION; ETHYLENE; ETHYLENE GLYCOL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOMERS; LIQUIDS; POLYETHYLENE OXIDES;

POLYETHYLENE GLYCOLS;

ACETONITRILE; BUFFER; MACROGOL DERIVATIVE; OCTREOTIDE; PHOSPHATE; TRYPSIN;

ARTICLE; CONTROLLED STUDY; DEGRADATION KINETICS; ELUTION; ENZYME STABILITY; ISOMER; MOLECULAR WEIGHT; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; THERMOSTABILITY;

CHROMATOGRAPHY, REVERSE-PHASE; ISOMERISM; MOLECULAR WEIGHT; OCTREOTIDE; POLYETHYLENE GLYCOLS;

EID: 70349792165     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.09.023     Document Type: Article

References (20)

1. Lamberts S.W., van der Lely A.J., de Herder W.W., and Hofland L.J. N. Engl. J. Med. 334 (1996) 246
2. Na D.H., Youn Y.S., Lee S.D., Son M.W., Kim W.B., DeLuca P.P., and Lee K.C. J. Control. Rel. 92 (2003) 291
3. Murty S.B., Goodman J., Thanoo B.C., and DeLuca P.P. AAPS PharmSciTech 4 (2003) article 50
4. Na D.H., Murty S.B., Lee K.C., Thanoo B.C., and DeLuca P.P. AAPS PharmSciTech 4 (2003) article 72
5. Na D.H., and DeLuca P.P. Pharm. Res. 22 (2005) 736
6. Murty S.B., Na D.H., Thanoo B.C., and DeLuca P.P. Int. J. Pharm. 297 (2005) 62
7. Sophocleous A.M., Zhang Y., and Schwendeman S.P. J. Control. Rel. 137 (2009) 179
8. Na D.H., Lee J.E., Jang S.W., and Lee K.C. AAPS PharmSciTech 8 (2007) article 43
9. Na D.H., Lee K.C., and DeLuca P.P. Pharm. Res. 22 (2005) 743
10. Park E.J., and Na D.H. Anal. Biochem. 380 (2008) 140
11. Veronese F.M., and Pasut G. Drug Discov. Today 10 (2005) 1451
12. Na D.H., Youn Y.S., Lee I.B., Park E.J., Park C.J., and Lee K.C. Pharm. Dev. Technol. 11 (2006) 513
13. Lee K.C., Moon S.C., Park M.O., Lee J.T., Na D.H., Yoo S.D., Lee H.S., and DeLuca P.P. Pharm. Res. 16 (1999) 818
14. Na D.H., Park E.J., Youn Y.S., Moon B.W., Moon Y.W., Jo Y.W., Lee S.H., Kim W.B., Sohn Y., and Lee K.C. Electrophoresis 25 (2004) 476
15. Na D.H., Park E.J., Jo Y.W., and Lee K.C. Anal. Biochem. 373 (2008) 207
16. Youn Y.S., Na D.H., Yoo S.D., Song S., and Lee K.C. J. Chromatogr. A 1061 (2004) 45
17. Na D.H., Youn Y.S., Park E.J., Lee J.M., Cho O.R., Lee K.R., Lee S.D., Yoo S.D., DeLuca P.P., and Lee K.C. J. Pharm. Sci. 93 (2004) 256
18. Grace M.J., Lee S., Bradshaw S., Chapman J., Spond J., Cox S., Delorenzo M., Brassard D., Wylie D., Cannon-Carlson S., Cullen C., Indelicato S., Voloch M., and Bordens R. J. Biol. Chem. 280 (2005) 6327
19. Subirats X., Bosch E., and Rosés M. J. Chromatogr. A 1121 (2006) 170
20. Kinstler O.B., Brems D.N., Lauren S.L., Paige A.G., Hamburger J.B., and Treuheit M.J. Pharm. Res. 13 (1996) 996